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Article: [Observation of effect of Wu Yun Liu Qi on reproductive hormones in varicocele patients].

Shi, Qing-Jing / Pan, Lian-Jun / Pan, Feng / Zhao, Dan / Zhang, Xing-Yuan / Li, Hai-Bo / Liao, Kai / Zhang, Feng-Lei

Zhonghua nan ke xue = National journal of andrology

2024 Volume 29, Issue 12, Page(s) 1018–1021

Abstract: ... of Wu Yun Liu Qi, and explore whether the cycle had effect on the roproductive hormone levels. Methods ... in 2016 than other years except 2018 and 2020( All P< 0.05). Conclusions: Shi Xiang factors of Wu Yun Liu ... Feng Mu Zai Quan obviously higher than other years excpet 2018( All P< 0.05). And T/E2 ratio was lower ...

Abstract	Objective： To observe roproductive hormone levels in varicocele patients during a cycle (6 years) of Wu Yun Liu Qi, and explore whether the cycle had effect on the roproductive hormone levels. Methods： Data of roproductive hormone levels in varicocele patients from 2015 to 2020 were analyzed retrospectively. FSH、LH、T、PRL、E2 levels and T/E2 ratio were compared among the six years. According to Chinese sexagenary cycle heavenly stems and earthly branches of each year from 2015 to 2020 its yunqi characteristics were determined. Results: Totally data of 848 cases of varicocele patients were collected from 2015 to 2020. Among which, in 2015 (Yiwei year) there were 57 cases, in 2016 (Bingshen year) 83 cases, in 2017 (Dingyou year ) 133 cases, in 2018(Wuxu year) 156 cases, in 2019(Sihai year) 274 cases, and in 2020(Gengzi year) 145 cases. The levels of FSH、LH、PRL、T were not diferrent statistically from the six years except individual year. However, the level of E2 in 2016 when the Yunqi was Shao Yang Xiang Huo Si Tian and Jue Yin Feng Mu Zai Quan obviously higher than other years excpet 2018( All P< 0.05). And T/E2 ratio was lower in 2016 than other years except 2018 and 2020( All P< 0.05). Conclusions: Shi Xiang factors of Wu Yun Liu Qi had effect on roproductive hormone levels in varicocele patients, showing by higher E2 level in Yinshen year when the Shi Xiang factors may have bad effect on human fertility.
MeSH term(s)	Male ; Humans ; Qi ; Varicocele ; Retrospective Studies ; Follicle Stimulating Hormone
Chemical Substances	Follicle Stimulating Hormone (9002-68-0)
Language	Chinese
Publishing date	2024-04-19
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	2267480-9
ISSN	1009-3591
ISSN	1009-3591
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Article ; Online: The effects of combined bromocriptine and Bu-shen-zhu-yun decoction on serum hormones, anxiety, and pregnancy in hyperprolactinemic infertility patients.

Feng, Hua / Zhong, Qiuxi / Zhou, Huifang / Jiang, Xiaoyue / Ding, Yinyin

Annals of palliative medicine

2022 Volume 10, Issue 12, Page(s) 12230–12243

Abstract: ... improve the long-term prognosis in HPRL. To analyze the effects of Bu-shen-zhu-yun decoction (BSZY-D ...

Abstract	Background: Prolactin (PRL) is a protein hormone secreted by the anterior pituitary gland that regulates pituitary hormones. Hyperprolactinemia (HPRL), a pathological phenomenon of excessive PRL, can cause infertility in severe cases and is currently treated mainly with Western drugs, such as bromocriptine, a dopamine agonist (DA). Unfortunately, DAs produce psychological side effects which limit their long-term use. Traditional Chinese medicine (TCM) has minimal side effects and good results spanning many years of research. The combined treatment of TCM and Western medicine may enhance treatment efficacy and improve the long-term prognosis in HPRL. To analyze the effects of Bu-shen-zhu-yun decoction (BSZY-D) combined with bromocriptine on serum hormones, anxiety, and pregnancy in hyperprolactinemic infertile patients. Methods: One hundred patients diagnosed with HPRL infertility from June 2020 to June 2021 in the gynecology clinic of Jiangsu Provincial Hospital of Traditional Chinese Medicine were selected and grouped by envelope method. After excluding patients who withdrew or missed visits, 37 cases assigned to the control group were treated with bromocriptine, and 40 cases assigned to the observation group were treated with bromocriptine combined with BSZY-D. The patients' PRL and kisspeptin (KP) serum indexes, improvements in infertility, Anxiety Self-Assessment Scale (SAS) scores, and improvements in the Insomnia Severity Index Scale (ISI) scores were compared between the two groups. Results: At 3 and 6 months of treatment, serum PRL, SAS, and ISI scores were significantly lower, and serum KP was significantly higher in the observation group than in the control group (P<0.05). During the study period, the pregnancy rates were 62.50% (25/40) and 37.84% (14/37) in the observation and control groups, respectively. The observation group also had significantly fewer early miscarriages [10.00% (4/40) vs. 32.43% (12/37)] and less adverse reactions [7.50% (3/40) vs. 24.32% (9/37)] than the control group (all P<0.05). Conclusions: The combination of bromocriptine with BSZY-D was superior to bromocriptine alone in treating HPRL and HPRL-related infertility, which also demonstrated a positive effect on patients' sleep and low mood.
MeSH term(s)	Anxiety ; Bromocriptine/therapeutic use ; Drugs, Chinese Herbal/therapeutic use ; Female ; Humans ; Hyperprolactinemia/drug therapy ; Infertility, Female ; Kisspeptins/blood ; Pregnancy ; Pregnancy Rate ; Prolactin/blood ; Sleep
Chemical Substances	Drugs, Chinese Herbal ; Kisspeptins ; Bromocriptine (3A64E3G5ZO) ; Prolactin (9002-62-4)
Language	English
Publishing date	2022-01-11
Publishing country	China
Document type	Clinical Trial ; Journal Article
ZDB-ID	2828544-X
ISSN	2224-5839 ; 2224-5839
ISSN (online)	2224-5839
ISSN	2224-5839
DOI	10.21037/apm-21-3111
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Bu-Shen-Zhu-Yun decoction induces PRLR deubiquitination and JAK2/STAT5 activation via CSN5

Feng, Hua / Zhou, Huifang / Lu, Jianxia / Zhang, Qing / Tang, Xingran / Shang, Yujie

Aging

2021 Volume 13, Issue 16, Page(s) 20418–20437

Abstract: Purpose: To determine the effect of Bu-Shen-Zhu-Yun Decoction (BSZY-D) on the kisspeptin ...

Abstract	Purpose: To determine the effect of Bu-Shen-Zhu-Yun Decoction (BSZY-D) on the kisspeptin through JAK2/STAT5 signaling pathway in hyperprolactinemia (HPRL) infertility. Method: SD rats were treated with BSZY-D for cerebrospinal fluid (CSF) extraction. GT1-7 cells were subjected to different treatments. The phosphorylation levels of JAK2 and STAT5, and the expressions of PRLR and kisspeptin of GT1-7 cells in different groups were detected by western blot, RT-qPCR and immunofluorescence. The expressions of CSN5 and GATA1 and other molecular features were checked by western blot, RT-PCR, co-immunoprecipitation and renilla luciferase activity. Results: The phosphorylation levels of JAK2 and STAT5, and the expressions of PRLR and kisspeptin in the HPRL group were significantly decreased, and these changes could be reversed after BSZY-D treatment. In addition, the presence of PRLR deubiquitination was detected in the HPRL group, which could be reversed by shRNA-CSN5, suggesting that BSZY-D played a role through targeting CSN5. The binding level of GATA1 and CSN5 promoter in the HPRL group was significantly decreased, but elevated in the HPRL (BSZY-D/CSF) group (P < 0.05). Conclusion: BSZY-D improved the transcription activity of GATA1 and increased the binding of GATA1 and CSN5. BSZY-D was involved in the deubiquitination of PRLR, which contributes to alleviating the symptoms of HPRL infertility.
MeSH term(s)	Animals ; COP9 Signalosome Complex/genetics ; COP9 Signalosome Complex/metabolism ; Drugs, Chinese Herbal/administration & dosage ; Female ; GATA1 Transcription Factor/genetics ; GATA1 Transcription Factor/metabolism ; Humans ; Hyperprolactinemia/drug therapy ; Hyperprolactinemia/genetics ; Hyperprolactinemia/metabolism ; Intracellular Signaling Peptides and Proteins/genetics ; Intracellular Signaling Peptides and Proteins/metabolism ; Janus Kinase 2/genetics ; Janus Kinase 2/metabolism ; Prolactin/genetics ; Prolactin/metabolism ; Rats ; Rats, Sprague-Dawley ; STAT5 Transcription Factor/genetics ; STAT5 Transcription Factor/metabolism ; Signal Transduction/drug effects
Chemical Substances	Drugs, Chinese Herbal ; GATA1 Transcription Factor ; Gata1 protein, rat ; Gps1 protein, rat ; Intracellular Signaling Peptides and Proteins ; STAT5 Transcription Factor ; Prolactin (9002-62-4) ; Jak2 protein, rat (EC 2.7.10.2) ; Janus Kinase 2 (EC 2.7.10.2) ; COP9 Signalosome Complex (EC 3.4.19.12)
Language	English
Publishing date	2021-08-23
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1945-4589
ISSN (online)	1945-4589
DOI	10.18632/aging.203426
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Article: [Effects of Yun Kang oral liquid on rats model of embryo implantation disorder].

Zheng, Xiang / Guo, Lin-Feng / Dai, Ming-Zhu / Lyu, Gui-Yuan / Chen, Su-Hong

Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology

2019 Volume 34, Issue 6, Page(s) 543–547

Abstract: ... exploring the role of Yun Kang oral liquid in protecting embryos.: Methods: The pregnant rats were ... dose groups of low, medium and high levels of Yun Kang oral liquid (YK-L, YK-M, YK-H), 11 in each group ... the doses of Yun Kang oral liquid were 4, 6, and 9 ml/kg, respectively.The rats in NC and MG were treated ...

Abstract	Objective: Through the establishment of abortion model caused by embryo implantation difficulties, exploring the role of Yun Kang oral liquid in protecting embryos. Methods: The pregnant rats were divided into 6 groups:normal control group (NC), model group (MG), dydrogesterone group (DT), and three dose groups of low, medium and high levels of Yun Kang oral liquid (YK-L, YK-M, YK-H), 11 in each group.From the first day of pregnancy, daily intragastric administration, the dose of DT group was 3.02 mg/kg, and the doses of Yun Kang oral liquid were 4, 6, and 9 ml/kg, respectively.The rats in NC and MG were treated with an equal volume of purified water for 10 days.On the third day of pregnancy, except for the NC group, the other groups were injected with mifepristone subcutaneously at the back of the neck at a dose of 5 mg/kg to cause an embryo implantation barrier model.On the 10th day of pregnancy, blood was collected from the abdominal aorta in each group.Serum follicle stimulating hormone (FSH), interferon-γ (IFN-γ) and interleukin (IL-4) were measured by enzyme-linked immunosorbent assay.The number of embryo implantation was observed in the uterus, and the pathological changes of the uterus were observed by HE staining. Results: Compared with the NC group, the number of embryo implantation and the serum levels of FSH and IL-4 in the MG group were decreased significantly ( Conclusions: Yun Kang oral liquid may improve the endometrial pathological changes and increase the number of embryo implantation by increasing the levels of serum sex hormone FSH and immune cytokine IL-4 in embryo implantation impediment rats.
MeSH term(s)	Animals ; Cytokines ; Embryo Implantation ; Female ; Interferon-gamma ; Pregnancy ; Rats ; Uterus
Chemical Substances	Cytokines ; Interferon-gamma (82115-62-6)
Language	Chinese
Publishing date	2019-04-29
Publishing country	China
Document type	Journal Article
ISSN	1000-6834
ISSN	1000-6834
DOI	10.12047/j.cjap.5687.2018.121
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book: Tian yun lan sheng ji

Feng, Mu

(Bai hua xiu zhen san wen ; 百花袖珍散文)

1980

Author's details	Feng mu
Series title	Bai hua xiu zhen san wen 百花袖珍散文
Keywords	Yunnan Sheng (China)
Language	Chinese
Size	2, 227 pages, illustrations, 17 cm
Edition	Di 1 ban
Publisher	Bai hua wen yi chu ban she
Publishing place	Tian jin
Document type	Book
Database	Former special subject collection: coastal and deep sea fishing

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Article ; Online: Effect of radiotherapy on the survival of patients with de novo stage IV breast cancer: A population-based propensity-score matched analysis.

Yu, Feng / Wu, Yun-Yun

Asian journal of surgery

2023 Volume 47, Issue 1, Page(s) 649–652

MeSH term(s)	Humans ; Female ; Breast Neoplasms/radiotherapy ; Breast Neoplasms/surgery ; Proportional Hazards Models ; Kaplan-Meier Estimate ; Propensity Score ; Patients ; Neoplasm Staging
Language	English
Publishing date	2023-10-05
Publishing country	Netherlands
Document type	Letter
ZDB-ID	1068461-x
ISSN	0219-3108 ; 1015-9584
ISSN (online)	0219-3108
ISSN	1015-9584
DOI	10.1016/j.asjsur.2023.09.151
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Article: Two new

Lu, Yun-Feng / Chai, Chun-Yue / Hui, Feng-Li

Frontiers in microbiology

2024 Volume 15, Page(s) 1287984

Abstract: ... The ... ...

Abstract	The genus
Language	English
Publishing date	2024-02-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2024.1287984
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Article:

Lin, Zhe-Li / Tan, Yun-Hong / Huang, Yun-Feng / Deng, Yun-Fei

PhytoKeys

2022 Volume 202, Page(s) 97–105

Abstract: ... ...

Abstract	Rungiafangdingiana
Language	English
Publishing date	2022-07-28
Publishing country	Bulgaria
Document type	Journal Article
ZDB-ID	2579891-1
ISSN	1314-2003 ; 1314-2011
ISSN (online)	1314-2003
ISSN	1314-2011
DOI	10.3897/phytokeys.202.86653
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Article ; Online: In Vivo Optical Coherence Elastography Unveils Spatial Variation of Human Corneal Stiffness.

Li, Guo-Yang / Feng, Xu / Yun, Seok-Hyun

IEEE transactions on bio-medical engineering

2024 Volume 71, Issue 5, Page(s) 1418–1429

Abstract: Objective: The mechanical properties of corneal tissues play a crucial role in determining corneal shape and have significant implications in vision care. This study aimed to address the challenge of obtaining accurate in vivo data for the human cornea.! ...

Abstract	Objective: The mechanical properties of corneal tissues play a crucial role in determining corneal shape and have significant implications in vision care. This study aimed to address the challenge of obtaining accurate in vivo data for the human cornea. Methods: We have developed a high-frequency optical coherence elastography (OCE) technique using shear-like antisymmetric (A0)-mode Lamb waves at frequencies above 10 kHz. Results: By incorporating an anisotropic, nonlinear constitutive model and utilizing the acoustoelastic theory, we gained quantitative insights into the influence of corneal tension on wave speeds and elastic moduli. Our study revealed significant spatial variations in the shear modulus of the corneal stroma on healthy subjects for the first time. Over an age span from 21 to 34 (N = 6), the central corneas exhibited a mean shear modulus of 87 kPa, while the corneal periphery showed a significant decrease to 44 kPa. The central cornea's shear modulus decreases with age with a slope of -19 +/- 8 kPa per decade, whereas the periphery showed non-significant age dependence. The limbus demonstrated an increased shear modulus exceeding 100 kPa. We obtained wave displacement profiles that are consistent with highly anisotropic corneal tissues. Conclusion: Our approach enabled precise measurement of corneal tissue elastic moduli in situ with high precision (<7%) and high spatial resolution (<1 mm). Our results revealed significant stiffness variation from the central to peripheral corneas. Significance: The high-frequency OCE technique holds promise for biomechanical evaluation in clinical settings, providing valuable information for refractive surgeries, degenerative disorder diagnoses, and intraocular pressure assessments.
MeSH term(s)	Humans ; Elasticity Imaging Techniques/methods ; Cornea/physiology ; Cornea/diagnostic imaging ; Adult ; Tomography, Optical Coherence/methods ; Elastic Modulus/physiology ; Male ; Young Adult ; Female ; Models, Biological
Language	English
Publishing date	2024-04-23
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	160429-6
ISSN	1558-2531 ; 0018-9294
ISSN (online)	1558-2531
ISSN	0018-9294
DOI	10.1109/TBME.2023.3338086
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Article ; Online: Two new phyllospheric species of

Lu, Yun-Feng / Chai, Chun-Yue / Hui, Feng-Li

MycoKeys

2024 Volume 101, Page(s) 81–94

Abstract: During our ongoing survey of basidiomycetous yeasts associated with plant leaves in virgin forest, ... ...

Abstract	During our ongoing survey of basidiomycetous yeasts associated with plant leaves in virgin forest, five
Language	English
Publishing date	2024-01-12
Publishing country	Bulgaria
Document type	Journal Article
ZDB-ID	2630648-7
ISSN	1314-4049 ; 1314-4049
ISSN (online)	1314-4049
ISSN	1314-4049
DOI	10.3897/mycokeys.101.114872
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