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  1. Article ; Online: Enriching Lives: Geriatricians' Mission of Supportive Care for Older Persons.

    Boccardi, Virginia

    Geriatrics (Basel, Switzerland)

    2023  Volume 8, Issue 6

    Abstract: The growing older population, the increasing prevalence of chronic illnesses, and the pressing need to enhance the quality of end-of-life care have underscored the importance for geriatricians to focus on supportive and palliative measures. Within this ... ...

    Abstract The growing older population, the increasing prevalence of chronic illnesses, and the pressing need to enhance the quality of end-of-life care have underscored the importance for geriatricians to focus on supportive and palliative measures. Within this context, the emphasis on delivering comprehensive and person-centered care has become crucial, ensuring that individuals not only receive medical treatment but also experience comfort during chronic illness and in their final days. Nevertheless, a significant number of older individuals often find themselves in hospitals during their last moments, sometimes undergoing aggressive medical interventions even when facing terminal conditions. The challenge lies in the early recognition of the end-of-life phase, initiating timely supportive and palliative care in conjunction with conventional treatments, adopting a multidisciplinary approach, and providing crucial support to grieving family members. Despite being a relatively recent field, geriatric palliative care (GPC) still requires further development. With this perspective, I aimed to shed light on the challenges and best practices for enhancing care for individuals facing chronic critical illnesses and frailty.
    Language English
    Publishing date 2023-10-26
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2308-3417
    ISSN (online) 2308-3417
    DOI 10.3390/geriatrics8060106
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Autonomic dyshomeostasis in patients with diabetes mellitus during COVID-19.

    Boccardi, Virginia

    Nature reviews. Endocrinology

    2021  Volume 17, Issue 3, Page(s) 189

    MeSH term(s) Autonomic Nervous System ; COVID-19 ; Diabetes Mellitus/epidemiology ; Humans ; SARS-CoV-2
    Language English
    Publishing date 2021-01-15
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2489381-X
    ISSN 1759-5037 ; 1759-5029
    ISSN (online) 1759-5037
    ISSN 1759-5029
    DOI 10.1038/s41574-021-00466-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6336: Show issues Location:
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    Zs.MG 93: Show issues

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  3. Article ; Online: Improving geriatric outcomes through nutritional and immunonutritional strategies: Focus on surgical setting by a comprehensive evidence review.

    Boccardi, Virginia / Marano, Luigi

    Ageing research reviews

    2024  Volume 96, Page(s) 102272

    Abstract: The aging population worldwide has led to an increased request for surgical interventions in older, geriatric, and frail patients. However, all the physiological changes related to aging are associated with many challenges in the perioperative period, ... ...

    Abstract The aging population worldwide has led to an increased request for surgical interventions in older, geriatric, and frail patients. However, all the physiological changes related to aging are associated with many challenges in the perioperative period, strongly impacting surgical outcomes. Nutritional status plays a pivotal role in determining the resilience of older adults to surgical stress and their ability to recover postoperatively. It is well known that malnutrition, a prevalent concern in geriatrics, is linked to increased adverse outcomes, including morbidity and mortality. Recognizing the significance of preoperative nutritional screening, assessment, diagnosis, intervention, and monitoring is essential for optimizing surgical outcomes. In this context, immunonutrition, which involves the supplementation of specific nutrients to modulate immune responses, emerges as a promising strategy to mitigate the increased inflammatory response observed in geriatric surgical patients. This study reviews current literature on the impact of nutrition and immunonutrition on surgical outcomes in geriatrics, highlighting the potential benefits in terms of reduced complications, enhanced wound healing, and shortened hospital stays. Recognizing and addressing the specific nutritional needs of older persons undergoing surgery is essential for promoting successful surgical outcomes and improving overall quality of life in this vulnerable population.
    MeSH term(s) Humans ; Aged ; Aged, 80 and over ; Nutritional Status ; Nutrition Assessment ; Quality of Life ; Malnutrition/prevention & control ; Aging ; Geriatric Assessment
    Language English
    Publishing date 2024-03-15
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2075672-0
    ISSN 1872-9649 ; 1568-1637
    ISSN (online) 1872-9649
    ISSN 1568-1637
    DOI 10.1016/j.arr.2024.102272
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5579: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Intermediate Care in Italy: Addressing the Challenges and Opportunities for Person-Tailored Care.

    Boccardi, Virginia / Mecocci, Patrizia

    Geriatrics (Basel, Switzerland)

    2023  Volume 8, Issue 3

    Abstract: The concept of intermediate care is gaining increasing recognition in Italy as a critical strategy for improving quality of care and promoting the integration of healthcare services across different settings. This is driven by demographic changes and the ...

    Abstract The concept of intermediate care is gaining increasing recognition in Italy as a critical strategy for improving quality of care and promoting the integration of healthcare services across different settings. This is driven by demographic changes and the growing prevalence of chronic conditions. One of the key challenges in delivering intermediate care in Italy is ensuring that care is person-tailored, which requires a shift towards a more holistic approach that prioritizes individual preferences and values. This requires greater collaboration and communication across different healthcare settings and a coordinated approach to the delivery of care that promotes innovation and the use of technology to support remote monitoring and care delivery. Despite these challenges, intermediate care offers significant opportunities with which to enhance the quality of care, reduce healthcare costs, and promote social cohesion as well as community engagement. Overall, a coordinated and comprehensive approach is required to address the challenges and opportunities associated with intermediate care and to deliver person-tailored care that improves health outcomes as well as sustainability in Italy.
    Language English
    Publishing date 2023-05-30
    Publishing country Switzerland
    Document type Editorial
    ISSN 2308-3417
    ISSN (online) 2308-3417
    DOI 10.3390/geriatrics8030059
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: A narrative review on mild behavioural impairment: an exploration into its scientific perspectives.

    Cozza, Mariagiovanna / Boccardi, Virginia

    Aging clinical and experimental research

    2023  Volume 35, Issue 9, Page(s) 1807–1821

    Abstract: In clinical practice, the admission of patients with late-onset psychological and behavioural symptoms is frequent, regardless of the presence or absence of cognitive decline. These symptoms commonly occur in the prodromal stage of dementia and can ... ...

    Abstract In clinical practice, the admission of patients with late-onset psychological and behavioural symptoms is frequent, regardless of the presence or absence of cognitive decline. These symptoms commonly occur in the prodromal stage of dementia and can precede the onset of dementia. While the concept of Mild Cognitive Impairment (MCI) -which is defined as a level of cognitive impairment insufficient to impact daily functioning- is well established, the notion of Mild Behavioural Impairment (MBI) is not yet widely recognized. However, studies have demonstrated that the presence of MBI in both cognitively normal patients and individuals with MCI is associated with an increased risk of dementia progression. Thus, MBI may serve as a neurobehavioral indicator of pre-dementia risk states. This narrative review aims to discuss the evolution of the term, the relevant clinical aspects, and potential biomarkers that may contribute to the clinical definition of MBI. The objective is to assist clinicians in recognizing the diagnosis and differentiating it from psychiatric syndromes, as well as identifying possible etiologies of neurodegeneration.
    MeSH term(s) Humans ; Dementia/etiology ; Dementia/complications ; Neuropsychological Tests ; Cognitive Dysfunction/psychology
    Language English
    Publishing date 2023-07-01
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2104785-6
    ISSN 1720-8319 ; 1594-0667
    ISSN (online) 1720-8319
    ISSN 1594-0667
    DOI 10.1007/s40520-023-02472-1
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3343: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Silent cognitive frailty at the interplay between delirium and COVID-19.

    Boccardi, Mariangela / Boccardi, Virginia

    Asian journal of psychiatry

    2021  Volume 57, Page(s) 102565

    MeSH term(s) Aged ; COVID-19 ; Cognition ; Delirium ; Frailty ; Geriatric Assessment ; Humans ; SARS-CoV-2
    Language English
    Publishing date 2021-01-23
    Publishing country Netherlands
    Document type Letter ; Comment
    ZDB-ID 2456678-0
    ISSN 1876-2026 ; 1876-2018
    ISSN (online) 1876-2026
    ISSN 1876-2018
    DOI 10.1016/j.ajp.2021.102565
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  7. Article ; Online: Population Ageing: The Need for a Care Revolution in a World 2.0.

    Boccardi, Virginia

    Geriatrics (Basel, Switzerland)

    2019  Volume 4, Issue 3

    Abstract: In recent years, we have seen a substantial improvement in social and health conditions, with a significant increase in the human survival rate as never seen before [ ... ]. ...

    Abstract In recent years, we have seen a substantial improvement in social and health conditions, with a significant increase in the human survival rate as never seen before [...].
    Language English
    Publishing date 2019-08-14
    Publishing country Switzerland
    Document type Editorial
    ISSN 2308-3417
    ISSN (online) 2308-3417
    DOI 10.3390/geriatrics4030047
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  8. Article ; Online: Water intake, hydration and Parkinson's disease.

    Boccardi, Virginia / Mecocci, Patrizia

    Aging clinical and experimental research

    2022  Volume 34, Issue 12, Page(s) 3163

    MeSH term(s) Humans ; Drinking ; Parkinson Disease ; Water
    Chemical Substances Water (059QF0KO0R)
    Language English
    Publishing date 2022-11-08
    Publishing country Germany
    Document type Letter
    ZDB-ID 2104785-6
    ISSN 1720-8319 ; 1594-0667
    ISSN (online) 1720-8319
    ISSN 1594-0667
    DOI 10.1007/s40520-022-02285-8
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3343: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Exploring cerebral amyloid angiopathy: Insights into pathogenesis, diagnosis, and treatment.

    Cozza, Mariagiovanna / Amadori, Lucia / Boccardi, Virginia

    Journal of the neurological sciences

    2023  Volume 454, Page(s) 120866

    Abstract: Cerebral Amyloid Angiopathy (CAA) is a neurological disorder characterized by the deposition of amyloid plaques in the walls of cerebral blood vessels. This condition poses significant challenges in terms of understanding its underlying mechanisms, ... ...

    Abstract Cerebral Amyloid Angiopathy (CAA) is a neurological disorder characterized by the deposition of amyloid plaques in the walls of cerebral blood vessels. This condition poses significant challenges in terms of understanding its underlying mechanisms, accurate diagnosis, and effective treatment strategies. This article aims to shed light on the complexities of CAA by providing insights into its pathogenesis, diagnosis, and treatment options. The pathogenesis of CAA involves the accumulation of amyloid beta (Aβ) peptides in cerebral vessels, leading to vessel damage, impaired blood flow, and subsequent cognitive decline. Various genetic and environmental factors contribute to the development and progression of CAA, and understanding these factors is crucial for targeted interventions. Accurate diagnosis of CAA often requires advanced imaging techniques, such as magnetic resonance imaging (MRI) or positron emission tomography (PET) scans, to detect characteristic amyloid deposits in the brain. Early and accurate diagnosis enables appropriate management and intervention strategies. Treatment of CAA focuses on preventing further deposition of amyloid plaques, managing associated symptoms, and reducing the risk of complications such as cerebral hemorrhage. Currently, there are no disease-modifying therapies specifically approved for CAA. However, several experimental treatments targeting Aβ clearance and anti-inflammatory approaches are being investigated in clinical trials, offering hope for future therapeutic advancements.
    MeSH term(s) Humans ; Amyloid beta-Peptides/metabolism ; Plaque, Amyloid/pathology ; Cerebral Amyloid Angiopathy/complications ; Cerebral Amyloid Angiopathy/diagnostic imaging ; Cerebral Amyloid Angiopathy/therapy ; Brain/pathology ; Cerebral Hemorrhage/complications ; Alzheimer Disease/complications
    Chemical Substances Amyloid beta-Peptides
    Language English
    Publishing date 2023-11-02
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 80160-4
    ISSN 1878-5883 ; 0022-510X ; 0374-8642
    ISSN (online) 1878-5883
    ISSN 0022-510X ; 0374-8642
    DOI 10.1016/j.jns.2023.120866
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 308: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  10. Article ; Online: Psychological Wellbeing and Healthy Aging: Focus on Telomeres.

    Boccardi, Mariangela / Boccardi, Virginia

    Geriatrics (Basel, Switzerland)

    2019  Volume 4, Issue 1

    Abstract: Stress and depression are known to modulate the aging process, and might also affect telomere biology. In fact, exposure to some biochemical pathways involved in stress-related depression may contribute to an ''accelerated aging" phenotype, as well as ... ...

    Abstract Stress and depression are known to modulate the aging process, and might also affect telomere biology. In fact, exposure to some biochemical pathways involved in stress-related depression may contribute to an ''accelerated aging" phenotype, as well as the incidence of age-related diseases, including metabolic disorders and dementia. Basic studies support the notion that the telomere and telomerase system plays a pivotal role in the aging process and disease promotion. Interestingly, short and dysfunctional telomeres are associated with reduced lifespan, as shown in animal models. In this context, telomeres are very sensitive to stress, mindset, and lifestyle, and their rescue may be sufficient to restore cell and organism viability. This mini-review discusses conceptual models of healthy and active aging and their relationship with telomere biology and mental health.
    Language English
    Publishing date 2019-02-23
    Publishing country Switzerland
    Document type Journal Article ; Review
    ISSN 2308-3417
    ISSN (online) 2308-3417
    DOI 10.3390/geriatrics4010025
    Database MEDical Literature Analysis and Retrieval System OnLINE

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