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  1. Article: Editorial: Reviews on the effect of COVID-19 on kidney diseases diagnosis, management, and outcomes.

    Chan, Kam Wa / Gong, Nianqiao / Abu Jawdeh, Bassam G

    Frontiers in medicine

    2023  Volume 10, Page(s) 1148402

    Language English
    Publishing date 2023-03-10
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2023.1148402
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Editorial

    Kam Wa Chan / Nianqiao Gong / Bassam G. Abu Jawdeh

    Frontiers in Medicine, Vol

    Reviews on the effect of COVID-19 on kidney diseases diagnosis, management, and outcomes

    2023  Volume 10

    Keywords COVID ; acute kidney injury ; chronic kidney disease ; transplant ; dialysis ; Medicine (General) ; R5-920
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: Global REnal Involvement of CORonavirus Disease 2019 (RECORD): A Systematic Review and Meta-Analysis of Incidence, Risk Factors, and Clinical Outcomes.

    Chan, Kam Wa / Yu, Kam Yan / Lee, Pak Wing / Lai, Kar Neng / Tang, Sydney Chi-Wai

    Frontiers in medicine

    2021  Volume 8, Page(s) 678200

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2021-05-25
    Publishing country Switzerland
    Document type Systematic Review
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2021.678200
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book ; Online: Faculty Opinions recommendation of Renal Involvement and Early Prognosis in Patients with COVID-19 Pneumonia.

    Tang, Sydney / Chan, Kam Wa

    Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature

    2020  

    Keywords covid19
    Publisher Faculty Opinions Ltd
    Publishing country uk
    Document type Book ; Online
    DOI 10.3410/f.737847327.793575511
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: Immunogenicity and Safety of COVID-19 Vaccines in Patients Receiving Renal Replacement Therapy: A Systematic Review and Meta-Analysis.

    Ma, Becky Mingyao / Tam, Anthony Raymond / Chan, Kam Wa / Ma, Maggie Kam Man / Hung, Ivan Fan Ngai / Yap, Desmond Yat Hin / Chan, Tak Mao

    Frontiers in medicine

    2022  Volume 9, Page(s) 827859

    Abstract: Background: Systematic data on the efficacy and safety of COVID-19 vaccine in patients on renal replacement therapy (RRT) remains limited. We conducted a meta-analysis on the efficacy and safety of COVID-19 vaccine in patients on RRT.: Methods: ... ...

    Abstract Background: Systematic data on the efficacy and safety of COVID-19 vaccine in patients on renal replacement therapy (RRT) remains limited. We conducted a meta-analysis on the efficacy and safety of COVID-19 vaccine in patients on RRT.
    Methods: Eligible studies were identified by systematic literature search in four electronic databases. Twenty-seven studies (4,264 patients) were included for meta-analysis. 99% patients received mRNA vaccine.
    Results: Patients on RRT showed inferior seropositivity after two-dosed COVID-19 vaccine, 44% lower than the general population. Kidney transplant recipients (KTRs) had significantly lower seropositivity than patients on haemodialysis (HD) or peritoneal dialysis (PD) (26.1 vs. 84.3% and 92.4% respectively,
    Conclusion: Patients on RRT, particularly KTRs, had significantly reduced antibody response after two-dosed COVID-19 vaccination. Vaccination is generally well tolerated.
    Systematic review registration: https://www.crd.york.ac.uk/prospero/, identifier: CRD42021261879.
    Language English
    Publishing date 2022-03-09
    Publishing country Switzerland
    Document type Systematic Review
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2022.827859
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: SYmptom-Based STratification of DiabEtes Mellitus by Renal Function Decline (SYSTEM): A Retrospective Cohort Study and Modeling Assessment.

    Chan, Kam Wa / Chow, Tak Yee / Yu, Kam Yan / Xu, Yulong / Zhang, Nevin Lianwen / Wong, Vivian Taam / Li, Saimei / Tang, Sydney Chi Wai

    Frontiers in medicine

    2021  Volume 8, Page(s) 682090

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2021-06-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2021.682090
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  7. Article: Potential Therapeutic Targets of Rehmannia Formulations on Diabetic Nephropathy: A Comparative Network Pharmacology Analysis.

    Chan, Kam Wa / Yu, Kam Yan / Yiu, Wai Han / Xue, Rui / Lok, Sarah Wing-Yan / Li, Hongyu / Zou, Yixin / Ma, Jinyuan / Lai, Kar Neng / Tang, Sydney Chi-Wai

    Frontiers in pharmacology

    2022  Volume 13, Page(s) 794139

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2022-03-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2022.794139
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  8. Article ; Online: Long-term outcomes of add-on direct renin inhibition in igA nephropathy: a propensity score-matched cohort study.

    Lie, Davina N W / Chan, Kam Wa / Tang, Alexander H N / Chan, Anthony T P / Chan, Gary C W / Lai, Kar Neng / Tang, Sydney Chi-Wai

    Journal of nephrology

    2023  Volume 36, Issue 2, Page(s) 407–416

    Abstract: Introduction: The long-term clinical outcomes in biopsy proven IgAN patients treated with aliskiren on top of a maximally tolerated dose of ACEi/ARB remain unknown.: Methods: Patients with IgAN treated with a direct renin inhibitor and ACEi/ARB for ... ...

    Abstract Introduction: The long-term clinical outcomes in biopsy proven IgAN patients treated with aliskiren on top of a maximally tolerated dose of ACEi/ARB remain unknown.
    Methods: Patients with IgAN treated with a direct renin inhibitor and ACEi/ARB for at least 6 months were compared with a 1:1 propensityscore-matched cohort (including MEST-C score and the 12-months pre-exposure slope of eGFR matching) who received ACEi/ARB without aliskiren exposure to compute the hazard ratio of reaching the primary endpoint of a composite of 40% reduction in eGFR, initiation of KRT and all-cause mortality. Secondary outcome measures included changes in mean UPCR, blood pressure, eGFR, incidence of hyperkalemia and other adverse events during follow-up.
    Results: After a median follow-up of 2.5 years, 8/36 (22.2%) aliskiren-treated patients and 6/36 (16.7%) control patients reached the primary composite outcome (HR = 1.60; 95% CI 0.52-4.88; P = 0.412). Aliskiren treatment increased the risk of ≥ 40% eGFR decline (HR = 1.60; 95% CI 0.52-4.88; P = 0.412), and hyperkalemia (HR = 8.60; 95% CI 0.99-73.64; P = 0.050). At 10.8 years, renal composite outcome was reached in 69.4% vs 58.3% (HR = 2.16; 95% CI 1.18-3.98; P = 0.013) of patients in the aliskiren and control groups, respectively. The mean UPCR reduction between treatment and control was not statistically different (52.7% vs 42.5%; 95% CI 0.63-2.35; P = 0.556). The mean intergroup difference in eGFR decline over 60 months was 7.75 ± 3.95 ml/min/1.73 m
    Conclusion: Among patients with IgAN, add-on aliskiren was associated with less favorable long-term kidney outcomes despite an initial anti-proteinuric effect.
    MeSH term(s) Humans ; Renin ; Cohort Studies ; Angiotensin-Converting Enzyme Inhibitors/adverse effects ; Angiotensin Receptor Antagonists/therapeutic use ; Glomerulonephritis, IGA/complications ; Glomerulonephritis, IGA/drug therapy ; Hyperkalemia/drug therapy ; Propensity Score ; Amides/adverse effects ; Fumarates/adverse effects
    Chemical Substances Renin (EC 3.4.23.15) ; aliskiren (502FWN4Q32) ; Angiotensin-Converting Enzyme Inhibitors ; Angiotensin Receptor Antagonists ; Amides ; Fumarates
    Language English
    Publishing date 2023-01-11
    Publishing country Italy
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1093991-x
    ISSN 1724-6059 ; 1120-3625 ; 1121-8428
    ISSN (online) 1724-6059
    ISSN 1120-3625 ; 1121-8428
    DOI 10.1007/s40620-022-01530-7
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3369: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Long Non-coding RNA Neat1, NLRP3 Inflammasome, and Acute Kidney Injury.

    Xue, Rui / Yiu, Wai Han / Chan, Kam Wa / Lok, Sarah W Y / Zou, Yixin / Ma, Jingyuan / Li, Hongyu / Chan, Loretta Y Y / Huang, Xiao Ru / Lai, Kar Neng / Lan, Hui Yao / Tang, Sydney C W

    Journal of the American Society of Nephrology : JASN

    2024  

    Abstract: Background: Acute kidney injury (AKI) is common in hospitalized patients and is associated with high mortality. Inflammation plays a key role in the pathophysiology of AKI. Long non-coding RNAs (lncRNAs) are increasingly recognized as regulators of the ... ...

    Abstract Background: Acute kidney injury (AKI) is common in hospitalized patients and is associated with high mortality. Inflammation plays a key role in the pathophysiology of AKI. Long non-coding RNAs (lncRNAs) are increasingly recognized as regulators of the inflammatory and immune response, but its role in AKI remains unclear.
    Methods: We explored the role of lncRNA Neat1 in (1) a cross-sectional and a longitudinal cohort of AKI in human; (2) three murine models of septic and aseptic AKI and (3) cultured C1.1 mouse kidney tubular cells.
    Results: In human, hospitalized patients with AKI (n=66) demonstrated significantly increased lncRNA Neat1 levels in urinary sediment cells and buffy coat versus control participants (n=152) from a primary care clinic; and among 6 kidney transplant recipients, Neat1 levels were highest immediately after transplant surgery followed by a prompt decline to normal levels in parallel with recovery of kidney function. In mice with AKI induced by sepsis (via LPS injection or cecal ligation and puncture) and renal ischemia-reperfusion, kidney tubular Neat1 was increased versus sham-operated mice. Knockdown of Neat1 in the kidney using short hairpin RNA preserved kidney function, suppressed overexpression of the AKI biomarker NGAL, leukocyte infiltration and both intrarenal and systemic inflammatory cytokines IL-6, CCL-2 and IL-1β. In LPS-treated C1.1 cells, Neat1 was overexpressed via TLR4/NF-κB signaling, and translocated from the cell nucleus into the cytoplasm where it promoted activation of NLRP3 inflammasomes via binding with the scaffold protein Rack1. Silencing Neat1 ameliorated LPS-induced cell inflammation, whereas its overexpression upregulated IL-6 and CCL-2 expression even without LPS stimulation.
    Conclusions: Our findings demonstrate a pathogenic role of Neat1 induction in human and mice during AKI with alleviation of kidney injury in 3 experimental models of septic and aseptic AKI after knockdown of Neat1. LPS/TLR4-induced Neat1 overexpression in tubular epithelial cells increases the inflammatory response by binding with the scaffold protein, Rack1, to activate NLRP3 inflammasomes.
    Language English
    Publishing date 2024-04-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1085942-1
    ISSN 1533-3450 ; 1046-6673
    ISSN (online) 1533-3450
    ISSN 1046-6673
    DOI 10.1681/ASN.0000000000000362
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    Zs.A 3344: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Effectiveness of Integrative Chinese-Western Medicine for Chronic Kidney Disease and Diabetes: A Retrospective Cohort Study.

    Chan, Kam Wa / Chow, Tak Yee / Yu, Kam Yan / Feng, Yibin / Lao, Lixing / Bian, Zhaoxiang / Wong, Vivian Taam / Tang, Sydney Chi-Wai

    The American journal of Chinese medicine

    2022  Volume 50, Issue 2, Page(s) 371–388

    Abstract: Diabetes and chronic kidney disease (CKD) are pandemic, requiring more therapeutic options. This retrospective cohort evaluated the effectiveness, safety profile and prescription pattern of a pilot integrative medicine service program in Hong Kong. Data ... ...

    Abstract Diabetes and chronic kidney disease (CKD) are pandemic, requiring more therapeutic options. This retrospective cohort evaluated the effectiveness, safety profile and prescription pattern of a pilot integrative medicine service program in Hong Kong. Data from 38 patients with diabetes and CKD enrolled to receive 48-week individualized add-on Chinese medicine (CM) were retrieved from the electronically linked hospital database. A 1:1 cohort was generated with patients from the same source and matched by propensity score. The primary outcomes are the change of estimated glomerular filtration rate (eGFR) and urine albumin-to-creatinine ratio (UACR) analyzed by analysis of covariance and mixed regression model adjusted for baseline eGFR, age, gender, duration of diabetes history, history of hypertension, diabetic retinopathy, and the use of insulin and angiotensin-converting enzyme inhibitor/angiotensin receptor blocker. The rate of adverse events and the change of key biochemical parameters were analyzed. After a median of 51 weeks, patients who received add-on CM had stabilized eGFR (difference in treatment period: 0.74 ml/min/1.73m
    MeSH term(s) China ; Cohort Studies ; Diabetes Mellitus, Type 2/drug therapy ; Humans ; Integrative Medicine ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/drug therapy ; Retrospective Studies
    Language English
    Publishing date 2022-02-07
    Publishing country Singapore
    Document type Journal Article
    ZDB-ID 193085-0
    ISSN 1793-6853 ; 0090-2942 ; 0192-415X
    ISSN (online) 1793-6853
    ISSN 0090-2942 ; 0192-415X
    DOI 10.1142/S0192415X2250015X
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1110: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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