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Article: Total RNA Isolation from Separately Established Monolayer and Hydrogel Cultures of Human Glioblastoma Cell Line.

Jogalekar, Manasi P / Serrano, Elba E

2019 Volume 9, Issue 14

Abstract: Astrocytoma is an invasive carcinoma occurring in the nervous system and currently lacks effective treatment options. A deeper understanding of the mechanisms of tumorigenesis and tumor progression is needed in order to develop novel therapeutic ... ...

Abstract	Astrocytoma is an invasive carcinoma occurring in the nervous system and currently lacks effective treatment options. A deeper understanding of the mechanisms of tumorigenesis and tumor progression is needed in order to develop novel therapeutic strategies. Recent advances in
Language	English
Publishing date	2019-09-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	2833269-6
ISSN	2331-8325
ISSN	2331-8325
DOI	10.21769/BioProtoc.3305
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Article ; Online: SARS-CoV-2 variants: A double-edged sword?

Jogalekar, Manasi P / Veerabathini, Anurag / Gangadaran, Prakash

Experimental biology and medicine (Maywood, N.J.)

2021 Volume 246, Issue 15, Page(s) 1721–1726

Abstract: Since the worldwide emergence of the COVID-19 outbreak, there have been international concerns about the possible viral evolution into variants with underlying mutations that may contribute to their increased transmissibility, disease severity, risk of ... ...

Abstract	Since the worldwide emergence of the COVID-19 outbreak, there have been international concerns about the possible viral evolution into variants with underlying mutations that may contribute to their increased transmissibility, disease severity, risk of death, and their potential escape from the immune response or may even lead to its extinction. Rigorous surveillance has revealed the variants harboring mutations in the spike protein, the main target of neutralizing antibodies generated through vaccination or herd immunity. In this review, we have highlighted major SARS-CoV-2 variants as well as other local strains along with their specific mutations, suspected changes in their characteristics, and their impact on the current pandemic and vaccine efficacy. We have also emphasized the need to develop widely protective interventions to curb further transmission of variants.
MeSH term(s)	COVID-19/epidemiology ; COVID-19/prevention & control ; COVID-19 Vaccines/pharmacology ; Host-Pathogen Interactions ; Humans ; Mutation ; SARS-CoV-2/genetics ; SARS-CoV-2/pathogenicity
Chemical Substances	COVID-19 Vaccines
Language	English
Publishing date	2021-05-22
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	4015-0
ISSN	1535-3699 ; 1525-1373 ; 0037-9727
ISSN (online)	1535-3699 ; 1525-1373
ISSN	0037-9727
DOI	10.1177/15353702211014146
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Article ; Online: COVID-19: Antiviral agents and enzyme inhibitors/receptor blockers in development.

Jogalekar, Manasi P / Veerabathini, Anurag / Patel, Ankit B

Experimental biology and medicine (Maywood, N.J.)

2021 Volume 246, Issue 13, Page(s) 1533–1540

Abstract: Novel 2019 coronavirus (severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2]) and coronavirus disease 2019 (COVID-19), the respiratory syndrome it causes, have shaken the world to its core by infecting and claiming the lives of many people since ... ...

Abstract	Novel 2019 coronavirus (severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2]) and coronavirus disease 2019 (COVID-19), the respiratory syndrome it causes, have shaken the world to its core by infecting and claiming the lives of many people since originating in December 2019 in Wuhan, China. World Health Organization and several states have declared a pandemic situation and state of emergency, respectively. As there is no treatment for COVID-19, several research institutes and pharmaceutical companies are racing to find a cure. Advances in computational approaches have allowed the screening of massive antiviral compound libraries to identify those that may potentially work against SARS-CoV-2. Antiviral agents developed in the past to combat other viruses are being repurposed. At the same time, new vaccine candidates are being developed and tested in preclinical/clinical settings. This review provides a detailed overview of select repurposed drugs, their mechanism of action, associated toxicities, and major clinical trials involving these agents.
MeSH term(s)	Angiotensin Receptor Antagonists/therapeutic use ; Antiviral Agents/therapeutic use ; COVID-19/drug therapy ; Clinical Trials as Topic ; Drug Development ; Enzyme Inhibitors/therapeutic use ; Humans
Chemical Substances	Angiotensin Receptor Antagonists ; Antiviral Agents ; Enzyme Inhibitors
Language	English
Publishing date	2021-03-23
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	4015-0
ISSN	1535-3699 ; 1525-1373 ; 0037-9727
ISSN (online)	1535-3699 ; 1525-1373
ISSN	0037-9727
DOI	10.1177/1535370221999989
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Article: Morphometric analysis of a triple negative breast cancer cell line in hydrogel and monolayer culture environments.

Jogalekar, Manasi P / Serrano, Elba E

PeerJ

2018 Volume 6, Page(s) e4340

Abstract: Triple negative breast cancer (TNBC) is a belligerent carcinoma that is unresponsive to targeted receptor therapies. Development of new treatment strategies would benefit from an expanded repertoire ... ...

Abstract	Triple negative breast cancer (TNBC) is a belligerent carcinoma that is unresponsive to targeted receptor therapies. Development of new treatment strategies would benefit from an expanded repertoire of
Language	English
Publishing date	2018-02-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	2703241-3
ISSN	2167-8359
ISSN	2167-8359
DOI	10.7717/peerj.4340
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Article ; Online: Recent developments in autophagy-targeted therapies in cancer.

Jogalekar, Manasi P / Veerabathini, Anurag / Gangadaran, Prakash

Experimental biology and medicine (Maywood, N.J.)

2020 Volume 246, Issue 2, Page(s) 207–212

Abstract: Autophagy plays a crucial role in cellular development and differentiation as well as in the maintenance of homeostasis in healthy cells. Autophagy is well documented in neurodegenerative disorders, aging, and infectious diseases. However, recognizing ... ...

Abstract	Autophagy plays a crucial role in cellular development and differentiation as well as in the maintenance of homeostasis in healthy cells. Autophagy is well documented in neurodegenerative disorders, aging, and infectious diseases. However, recognizing its significance in cancer has always been challenging due to its tumor-promoting and suppressive attributes. Various modulators targeting key components of autophagy machinery directly or indirectly have been developed over the years, and have shown promising results in preclinical models. Some of these compounds are even being tested in clinical trials for safety and efficacy. A detailed review of strategies used to target autophagy in cancer is presented including our opinion on developing better therapies and outstanding issues.
MeSH term(s)	Animals ; Autophagy/genetics ; Clinical Trials as Topic ; Disease Progression ; Genes, Tumor Suppressor ; Humans ; Molecular Targeted Therapy ; Neoplasms/genetics ; Neoplasms/pathology ; Neoplasms/therapy
Language	English
Publishing date	2020-11-09
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	4015-0
ISSN	1535-3699 ; 1525-1373 ; 0037-9727
ISSN (online)	1535-3699 ; 1525-1373
ISSN	0037-9727
DOI	10.1177/1535370220966545
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Article ; Online: Novel 2019 coronavirus: Genome structure, clinical trials, and outstanding questions.

Jogalekar, Manasi P / Veerabathini, Anurag / Gangadaran, Prakash

Experimental biology and medicine (Maywood, N.J.)

2020 Volume 245, Issue 11, Page(s) 964–969

Abstract: Impact statement: Early availability of the sequence, the genetic material of SARS-CoV-2 (the virus that causes COVID-19), has prompted efforts towards identifying a safe and effective vaccine in the current public health emergency. To that end, ... ...

Abstract	Impact statement: Early availability of the sequence, the genetic material of SARS-CoV-2 (the virus that causes COVID-19), has prompted efforts towards identifying a safe and effective vaccine in the current public health emergency. To that end, understanding the pathophysiology of disease is crucial for scientists around the world. Since conventional vaccine development and manufacturing may take several years, it is important to think about alternative strategies that we could use to mitigate imminent catastrophe. We hope that this article will open up new avenues and provide insights that could potentially save hundreds of lives affected by COVID-19.
MeSH term(s)	Adenosine Monophosphate/analogs & derivatives ; Adenosine Monophosphate/therapeutic use ; Alanine/analogs & derivatives ; Alanine/therapeutic use ; Antiviral Agents/therapeutic use ; Betacoronavirus/drug effects ; Betacoronavirus/genetics ; COVID-19 ; China/epidemiology ; Communicable Disease Control/methods ; Coronavirus Infections/diagnosis ; Coronavirus Infections/drug therapy ; Coronavirus Infections/epidemiology ; Coronavirus Infections/prevention & control ; Genome, Viral/genetics ; Humans ; Middle East Respiratory Syndrome Coronavirus/genetics ; Pandemics/prevention & control ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/prevention & control ; Severe acute respiratory syndrome-related coronavirus/genetics ; SARS-CoV-2 ; Serine Proteinase Inhibitors/therapeutic use
Chemical Substances	Antiviral Agents ; Serine Proteinase Inhibitors ; remdesivir (3QKI37EEHE) ; Adenosine Monophosphate (415SHH325A) ; Alanine (OF5P57N2ZX)
Keywords	covid19
Language	English
Publishing date	2020-04-19
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	4015-0
ISSN	1535-3699 ; 1525-1373 ; 0037-9727
ISSN (online)	1535-3699 ; 1525-1373
ISSN	0037-9727
DOI	10.1177/1535370220920540
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Article ; Online: CAR T-Cell-Based gene therapy for cancers: new perspectives, challenges, and clinical developments.

Jogalekar, Manasi P / Rajendran, Ramya Lakshmi / Khan, Fatima / Dmello, Crismita / Gangadaran, Prakash / Ahn, Byeong-Cheol

Frontiers in immunology

2022 Volume 13, Page(s) 925985

Abstract: Chimeric antigen receptor (CAR)-T cell therapy is a progressive new pillar in immune cell therapy for cancer. It has yielded remarkable clinical responses in patients with B-cell leukemia or lymphoma. Unfortunately, many challenges remain to be addressed ...

Abstract	Chimeric antigen receptor (CAR)-T cell therapy is a progressive new pillar in immune cell therapy for cancer. It has yielded remarkable clinical responses in patients with B-cell leukemia or lymphoma. Unfortunately, many challenges remain to be addressed to overcome its ineffectiveness in the treatment of other hematological and solidtumor malignancies. The major hurdles of CAR T-cell therapy are the associated severe life-threatening toxicities such as cytokine release syndrome and limited anti-tumor efficacy. In this review, we briefly discuss cancer immunotherapy and the genetic engineering of T cells and, In detail, the current innovations in CAR T-cell strategies to improve efficacy in treating solid tumors and hematologic malignancies. Furthermore, we also discuss the current challenges in CAR T-cell therapy and new CAR T-cell-derived nanovesicle therapy. Finally, strategies to overcome the current clinical challenges associated with CAR T-cell therapy are included as well.
MeSH term(s)	Genetic Therapy/adverse effects ; Hematologic Neoplasms/genetics ; Hematologic Neoplasms/therapy ; Humans ; Immunotherapy, Adoptive/adverse effects ; Neoplasms/genetics ; Neoplasms/therapy ; T-Lymphocytes
Language	English
Publishing date	2022-07-22
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2022.925985
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Article ; Online: Tumor microenvironment signaling and therapeutics in cancer progression.

Goenka, Anshika / Khan, Fatima / Verma, Bhupender / Sinha, Priyanka / Dmello, Crismita C / Jogalekar, Manasi P / Gangadaran, Prakash / Ahn, Byeong-Cheol

Cancer communications (London, England)

2023 Volume 43, Issue 5, Page(s) 525–561

Abstract: Tumor development and metastasis are facilitated by the complex interactions between cancer cells and their microenvironment, which comprises stromal cells and extracellular matrix (ECM) components, among other factors. Stromal cells can adopt new ... ...

Abstract	Tumor development and metastasis are facilitated by the complex interactions between cancer cells and their microenvironment, which comprises stromal cells and extracellular matrix (ECM) components, among other factors. Stromal cells can adopt new phenotypes to promote tumor cell invasion. A deep understanding of the signaling pathways involved in cell-to-cell and cell-to-ECM interactions is needed to design effective intervention strategies that might interrupt these interactions. In this review, we describe the tumor microenvironment (TME) components and associated therapeutics. We discuss the clinical advances in the prevalent and newly discovered signaling pathways in the TME, the immune checkpoints and immunosuppressive chemokines, and currently used inhibitors targeting these pathways. These include both intrinsic and non-autonomous tumor cell signaling pathways in the TME: protein kinase C (PKC) signaling, Notch, and transforming growth factor (TGF-β) signaling, Endoplasmic Reticulum (ER) stress response, lactate signaling, Metabolic reprogramming, cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) and Siglec signaling pathways. We also discuss the recent advances in Programmed Cell Death Protein 1 (PD-1), Cytotoxic T-Lymphocyte Associated Protein 4 (CTLA4), T-cell immunoglobulin mucin-3 (TIM-3) and Lymphocyte Activating Gene 3 (LAG3) immune checkpoint inhibitors along with the C-C chemokine receptor 4 (CCR4)- C-C class chemokines 22 (CCL22)/ and 17 (CCL17), C-C chemokine receptor type 2 (CCR2)- chemokine (C-C motif) ligand 2 (CCL2), C-C chemokine receptor type 5 (CCR5)- chemokine (C-C motif) ligand 3 (CCL3) chemokine signaling axis in the TME. In addition, this review provides a holistic understanding of the TME as we discuss the three-dimensional and microfluidic models of the TME, which are believed to recapitulate the original characteristics of the patient tumor and hence may be used as a platform to study new mechanisms and screen for various anti-cancer therapies. We further discuss the systemic influences of gut microbiota in TME reprogramming and treatment response. Overall, this review provides a comprehensive analysis of the diverse and most critical signaling pathways in the TME, highlighting the associated newest and critical preclinical and clinical studies along with their underlying biology. We highlight the importance of the most recent technologies of microfluidics and lab-on-chip models for TME research and also present an overview of extrinsic factors, such as the inhabitant human microbiome, which have the potential to modulate TME biology and drug responses.
MeSH term(s)	Humans ; Tumor Microenvironment ; Neoplasms/metabolism ; Signal Transduction ; Neoplastic Processes ; Receptors, Chemokine/therapeutic use ; Chemokines/pharmacology ; Chemokines/therapeutic use
Chemical Substances	Receptors, Chemokine ; Chemokines
Language	English
Publishing date	2023-04-02
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2523-3548
ISSN (online)	2523-3548
DOI	10.1002/cac2.12416
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Article ; Online: Prebiotic Potential and Value-Added Products Derived from

Sankarapandian, Vidya / Nitharsan, Kirubakaran / Parangusadoss, Kavitha / Gangadaran, Prakash / Ramani, Prasanna / Venmathi Maran, Balu Alagar / Jogalekar, Manasi P

Biotech (Basel (Switzerland))

2022 Volume 11, Issue 2

Abstract: Lately, microalgae-based value-added products have been gaining market value because they moderate the dependency on fossil fuel and high-value chemical products. To this end, the purpose of this study was to develop prebiotic products from the ... ...

Abstract	Lately, microalgae-based value-added products have been gaining market value because they moderate the dependency on fossil fuel and high-value chemical products. To this end, the purpose of this study was to develop prebiotic products from the microalgae
Language	English
Publishing date	2022-04-26
Publishing country	Switzerland
Document type	Journal Article
ISSN	2673-6284
ISSN (online)	2673-6284
DOI	10.3390/biotech11020013
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Article: An Update on the Effectiveness of Probiotics in the Prevention and Treatment of Cancer.

Sankarapandian, Vidya / Venmathi Maran, Balu Alagar / Rajendran, Ramya Lakshmi / Jogalekar, Manasi P / Gurunagarajan, Sridharan / Krishnamoorthy, Rajapandiyan / Gangadaran, Prakash / Ahn, Byeong-Cheol

Life (Basel, Switzerland)

2022 Volume 12, Issue 1

Abstract: Probiotics are living microbes that play a significant role in protecting the host in various ways. Gut microbiota is one of the key players in maintaining homeostasis. Cancer is considered one of the most significant causes of death worldwide. Although ... ...

Abstract	Probiotics are living microbes that play a significant role in protecting the host in various ways. Gut microbiota is one of the key players in maintaining homeostasis. Cancer is considered one of the most significant causes of death worldwide. Although cancer treatment has received much attention in recent years, the number of people suffering from neoplastic syndrome continues to increase. Despite notable improvements in the field of cancer therapy, tackling cancer has been challenging due to the multiple properties of cancer cells and their ability to evade the immune system. Probiotics alter the immunological and cellular responses by enhancing the epithelial barrier and stimulating the production of anti-inflammatory, antioxidant, and anticarcinogenic compounds, thereby reducing cancer burden and growth. The present review focuses on the various mechanisms underlying the role of probiotics in the prevention and treatment of cancer.
Language	English
Publishing date	2022-01-02
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662250-6
ISSN	2075-1729
ISSN	2075-1729
DOI	10.3390/life12010059
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