LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 182

Search options

  1. Book: Turoctocog alfa pegol (N8-GP, Esperoct)

    Miesbach, Wolfgang

    ein Faktor VIII mit verlängerter Halbwertszeit als neue Therapieoption bei Hämophilie A

    (Hämostaseologie : Drug report ; [40, 1], Beilage (Februar 2020) ; Transfusionsmedizin : Drug report ; [10], Beilage (Februar 2020))

    2020  

    Author's details Autoren Maximilian Gerhardt
    Series title Hämostaseologie : Drug report ; [40, 1], Beilage (Februar 2020)
    Transfusionsmedizin : Drug report ; [10], Beilage (Februar 2020)
    Hämostaseologie
    Transfusionsmedizin
    Hämostaseologie
    Transfusionsmedizin
    Collection Hämostaseologie
    Transfusionsmedizin
    Hämostaseologie
    Transfusionsmedizin
    Language German
    Size 11 Seiten, Illustrationen, Diagramme
    Publisher Thieme
    Publishing place Stuttgart
    Publishing country Germany
    Document type Book
    HBZ-ID HT020526327
    Database Catalogue ZB MED Medicine, Health

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 1631 -[40,1],Beil.- not available for loan Zeitschriften-Lesesaal

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Which patients should be considered for gene therapy.

    Miesbach, Wolfgang

    Journal of viral hepatitis

    2024  Volume 31 Suppl 1, Page(s) 9–13

    Abstract: Gene therapy for haemophilia, utilizing adeno-associated viral vectors (AAVs) and coagulation factor genes, have demonstrated promising results, leading to recent approvals and introduction of the first gene therapy products into clinical practice. For ... ...

    Abstract Gene therapy for haemophilia, utilizing adeno-associated viral vectors (AAVs) and coagulation factor genes, have demonstrated promising results, leading to recent approvals and introduction of the first gene therapy products into clinical practice. For successful and safe use, there are predefined inclusion and exclusion criteria, and the treatment process and associated risks should be thoroughly understood and long-term safety and efficacy carefully evaluated during follow up. As gene therapy becomes more accessible outside of clinical study centers, continuous evaluation of patient eligibility for subsequent AAV-based treatments becomes essential. Thorough evaluation of factors such as liver condition, anti-AAV status, and medical history ensures that gene therapy maximizing benefits while minimizing risks. Apart from fulfilling the established inclusion and exclusion criteria, the success of gene therapy is greatly influenced by the motivation and willingness of patients to accept temporary constraints, such as regular laboratory monitoring, potential use of immunosuppressants, and thorough documentation. Furthermore, various patient-related factors play a significant role in the management and outcomes of gene therapy, making a comprehensive evaluation essential. With the accumulation of more data, there is potential for the expansion of certain inclusion criteria, which may allow for a larger number of eligible patients to benefit from gene therapy. Empowering patients through shared decision-making enables them to thoroughly consider the therapy's potential benefits and risks.
    MeSH term(s) Humans ; Genetic Therapy/adverse effects ; Genetic Therapy/methods ; Hemophilia A/therapy ; Hemophilia A/genetics
    Language English
    Publishing date 2024-04-12
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1212497-7
    ISSN 1365-2893 ; 1352-0504
    ISSN (online) 1365-2893
    ISSN 1352-0504
    DOI 10.1111/jvh.13900
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 4119: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Book: Gerinnungsfaktoren mit verlängerter Halbwertszeit

    Miesbach, Wolfgang / Schöb, Michael / Flommersfeld, Sabine

    Erfahrungsberichte mit Elocta und Alprolix bei Hämophilie A und B

    (Transfusionsmedizin : Case report ; [9,4], Beilage (November 2019))

    2019  

    Author's details Herausgeber und Autoren Prof. Wolfgang Miesbach, Dr. Sabine Flommersfeld, Dr. Michael Schöb
    Series title Transfusionsmedizin : Case report ; [9,4], Beilage (November 2019)
    Transfusionsmedizin
    Transfusionsmedizin
    Collection Transfusionsmedizin
    Transfusionsmedizin
    Language German
    Size 11 Seiten, Illustrationen, Diagramme
    Publisher Thieme
    Publishing place Stuttgart
    Publishing country Germany
    Document type Book
    HBZ-ID HT020293283
    Database Catalogue ZB MED Medicine, Health

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 6977 -[9,4],Beil.- verfügbar in Königswinter Königswinter

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: GTH 2023: The Patient as a Benchmark.

    Miesbach, Wolfgang / Seifried, Erhard

    Hamostaseologie

    2023  Volume 43, Issue 1, Page(s) 5–6

    Language English
    Publishing date 2023-03-23
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 801512-0
    ISSN 2567-5761 ; 0720-9355
    ISSN (online) 2567-5761
    ISSN 0720-9355
    DOI 10.1055/a-1916-7764
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1631: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article: Gentherapie der Hämophilie

    Miesbach, Wolfgang

    Kompendium ... Hämatologie, Onkologie

    2021  Volume -, Issue Nov., Page(s) 59

    Language German
    Document type Article
    ZDB-ID 2966540-1
    ISSN 2628-3581
    Database Current Contents Medicine

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6008: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Perioperative management for patients with von Willebrand disease: Defining the optimal approach.

    Miesbach, Wolfgang

    European journal of haematology

    2020  Volume 105, Issue 4, Page(s) 365–377

    Abstract: von Willebrand disease (VWD) is the most common inherited bleeding disorder characterised by a quantitative or qualitative deficiency in von Willebrand factor (VWF). During invasive surgical procedures, patients with VWD require additional treatment to ... ...

    Abstract von Willebrand disease (VWD) is the most common inherited bleeding disorder characterised by a quantitative or qualitative deficiency in von Willebrand factor (VWF). During invasive surgical procedures, patients with VWD require additional treatment to maintain haemostasis; however, due to the complexity of VWD, there is a lack of consensus on the optimal management. In the perioperative period, patients are usually treated with VWF and factor FVIII (FVIII)-containing concentrates to provide an immediate haemostatic response to prevent excessive bleeding during both elective and emergency surgery. With the introduction of recombinant VWF (rVWF), there is a need for guidance on the use of the various VWF products in the perioperative period for all types of patients and surgeries. This review provides an overview of the current evidence for the surgical management of patients with VWD and, summarises the optimal treatment approach during the perioperative period, and highlights key unanswered questions and the research needed to address the evidence gaps.
    MeSH term(s) Biomarkers ; Blood Coagulation ; Clinical Decision-Making ; Deamino Arginine Vasopressin/administration & dosage ; Disease Management ; Disease Susceptibility ; Humans ; Perioperative Care/methods ; Severity of Illness Index ; Thromboembolism/diagnosis ; Thromboembolism/etiology ; Thromboembolism/prevention & control ; von Willebrand Diseases/blood ; von Willebrand Diseases/diagnosis ; von Willebrand Diseases/etiology ; von Willebrand Diseases/therapy ; von Willebrand Factor/administration & dosage ; von Willebrand Factor/genetics
    Chemical Substances Biomarkers ; von Willebrand Factor ; Deamino Arginine Vasopressin (ENR1LLB0FP)
    Language English
    Publishing date 2020-07-03
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 392482-8
    ISSN 1600-0609 ; 0902-4441
    ISSN (online) 1600-0609
    ISSN 0902-4441
    DOI 10.1111/ejh.13462
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 323: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Pathological Role of Angiotensin II in Severe COVID-19.

    Miesbach, Wolfgang

    TH open : companion journal to thrombosis and haemostasis

    2020  Volume 4, Issue 2, Page(s) e138–e144

    Abstract: The activated renin-angiotensin system induces a prothrombotic state resulting from the imbalance between coagulation and fibrinolysis. Angiotensin II is the central effector molecule of the activated renin-angiotensin system and is degraded by the ... ...

    Abstract The activated renin-angiotensin system induces a prothrombotic state resulting from the imbalance between coagulation and fibrinolysis. Angiotensin II is the central effector molecule of the activated renin-angiotensin system and is degraded by the angiotensin-converting enzyme 2 to angiotensin (1-7). The novel coronavirus infection (classified as COVID-19) is caused by the new coronavirus SARS-CoV-2 and is characterized by an exaggerated inflammatory response that can lead to severe manifestations such as acute respiratory distress syndrome, sepsis, and death in a proportion of patients, mostly elderly patients with preexisting comorbidities. SARS-CoV-2 uses the angiotensin-converting enzyme 2 receptor to enter the target cells, resulting in activation of the renin-angiotensin system. After downregulating the angiotensin-converting enzyme 2, the vasoconstrictor angiotensin II is increasingly produced and its counterregulating molecules angiotensin (1-7) reduced. Angiotensin II increases thrombin formation and impairs fibrinolysis. Elevated levels were strongly associated with viral load and lung injury in patients with severe COVID-19. Therefore, the complex clinical picture of patients with severe complications of COVID-19 is triggered by the various effects of highly expressed angiotensin II on vasculopathy, coagulopathy, and inflammation. Future treatment options should focus on blocking the thrombogenic and inflammatory properties of angiotensin II in COVID-19 patients.
    Keywords covid19
    Language English
    Publishing date 2020-06-26
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2901738-5
    ISSN 2512-9465 ; 2567-3459
    ISSN (online) 2512-9465
    ISSN 2567-3459
    DOI 10.1055/s-0040-1713678
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 7138: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Phase 3 study of recombinant von Willebrand factor in patients with severe von Willebrand disease who are undergoing elective surgery: Comment.

    Miesbach, Wolfgang

    Journal of thrombosis and haemostasis : JTH

    2019  Volume 17, Issue 8, Page(s) 1403–1405

    MeSH term(s) Elective Surgical Procedures ; Factor VIII ; Humans ; von Willebrand Diseases ; von Willebrand Factor
    Chemical Substances von Willebrand Factor ; Factor VIII (9001-27-8)
    Language English
    Publishing date 2019-05-14
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2112661-6
    ISSN 1538-7836 ; 1538-7933
    ISSN (online) 1538-7836
    ISSN 1538-7933
    DOI 10.1111/jth.14472
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5805: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 295: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Book: Älter werden mit Hämophilie

    Eichler, Hermann / Kindermann-Isakovic, Carola / Krammer-Steiner, Beate / Miesbach, Wolfgang / Staritz, Peter

    2020  

    Author's details Hermann Eichler, Carola Kindermann, Beate Krammer-Steiner, Wolfgang Miesbach, Peter Staritz
    Keywords Hämophile Veränderungen ; Blutungsmuster ; altersbedingte Veränderungen ; Therapie ; Bewegung ; Ernährung ; Psyche ; Agil bleiben ; Organe ; Depression ; Sozialrecht
    Language German
    Size 110 Seiten, Illustrationen, 22 cm, 246 g
    Edition 1. Auflage
    Publisher TRIAS
    Publishing place Stuttgart
    Publishing country Germany
    Document type Book
    HBZ-ID HT020382516
    ISBN 978-3-432-10330-3 ; 3-432-10330-1 ; 9783432103327 ; 3432103328
    Database Catalogue ZB MED Medicine, Health

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Vel 2 available for loan (reading room) Lesesaal EG Gesundheitsliteratur

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: "Liver-related aspects of gene therapy for hemophilia: need for collaborations with hepatologists": reply.

    Miesbach, Wolfgang / Foster, Graham R / Peyvandi, Flora

    Journal of thrombosis and haemostasis : JTH

    2023  Volume 21, Issue 8, Page(s) 2307–2308

    Language English
    Publishing date 2023-07-17
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2112661-6
    ISSN 1538-7836 ; 1538-7933
    ISSN (online) 1538-7836
    ISSN 1538-7933
    DOI 10.1016/j.jtha.2023.04.030
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5805: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 295: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top