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  1. Article: Complement: a global immunometabolic regulator in amyotrophic lateral sclerosis.

    Lo, Martin W / Lee, John D

    Neural regeneration research

    2020  Volume 16, Issue 6, Page(s) 1210–1211

    Language English
    Publishing date 2020-12-02
    Publishing country India
    Document type Journal Article
    ZDB-ID 2388460-5
    ISSN 1876-7958 ; 1673-5374
    ISSN (online) 1876-7958
    ISSN 1673-5374
    DOI 10.4103/1673-5374.300441
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Complement: Bridging the innate and adaptive immune systems in sterile inflammation.

    Lo, Martin W / Woodruff, Trent M

    Journal of leukocyte biology

    2020  Volume 108, Issue 1, Page(s) 339–351

    Abstract: The complement system is a collection of soluble and membrane-bound proteins that together act as a powerful amplifier of the innate and adaptive immune systems. Although its role in infection is well established, complement is becoming increasingly ... ...

    Abstract The complement system is a collection of soluble and membrane-bound proteins that together act as a powerful amplifier of the innate and adaptive immune systems. Although its role in infection is well established, complement is becoming increasingly recognized as a key contributor to sterile inflammation, a chronic inflammatory process often associated with noncommunicable diseases. In this context, damaged tissues release danger signals and trigger complement, which acts on a range of leukocytes to augment and bridge the innate and adaptive immune systems. Given the detrimental effect of chronic inflammation, the complement system is therefore well placed as an anti-inflammatory drug target. In this review, we provide a general outline of the sterile activators, effectors, and targets of the complement system and a series of examples (i.e., hypertension, cancer, allograft transplant rejection, and neuroinflammation) that highlight complement's ability to bridge the 2 arms of the immune system.
    MeSH term(s) Adaptive Immunity ; Animals ; Complement System Proteins/immunology ; Graft Rejection/immunology ; Humans ; Immune System/immunology ; Immune System/pathology ; Immunity, Innate ; Inflammation/immunology
    Chemical Substances Complement System Proteins (9007-36-7)
    Language English
    Publishing date 2020-03-17
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 605722-6
    ISSN 1938-3673 ; 0741-5400
    ISSN (online) 1938-3673
    ISSN 0741-5400
    DOI 10.1002/JLB.3MIR0220-270R
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 603: Show issues Location:
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  3. Article ; Online: Impact of corticosteroids on efficacy of BCMA targeted CAR-T therapy in multiple myeloma.

    Duvalyan, Eva / Shah, Nina / Lo, Mimi / Martin, Thomas / Wolf, Jeffrey L / Chung, Alfred / Arora, Shagun / Huang, Chiung-Yu / Wong, Sandy W

    Leukemia & lymphoma

    2023  Volume 64, Issue 11, Page(s) 1888–1891

    MeSH term(s) Humans ; Multiple Myeloma/drug therapy ; Receptors, Chimeric Antigen ; B-Cell Maturation Antigen ; Immunotherapy, Adoptive ; Adrenal Cortex Hormones/therapeutic use
    Chemical Substances Receptors, Chimeric Antigen ; B-Cell Maturation Antigen ; Adrenal Cortex Hormones
    Language English
    Publishing date 2023-08-21
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1042374-6
    ISSN 1029-2403 ; 1042-8194
    ISSN (online) 1029-2403
    ISSN 1042-8194
    DOI 10.1080/10428194.2023.2240920
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    Zs.A 2997: Show issues Location:
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  4. Article ; Online: Factors associated with consuming unhealthy food in school children: A population-based study from Hong Kong.

    Huang, Junjie / Chan, Sze Chai / Pang, Wing Sze / Chow, Shui Hang / Fung, Yat Ching / Keung, Vera M W / Cheung, Calvin K M / Lo, Amelia S C / Mui, Lancelot W H / Lee, Albert / Wong, Martin C S

    Health science reports

    2024  Volume 7, Issue 3, Page(s) e1964

    Abstract: Background and aims: Unhealthy diets were found to be the main contributor to the overweight problem among adolescents. In this study, we aim to identify the factors causing unhealthy eating habits in adolescents.: Methods: School-aged children and ... ...

    Abstract Background and aims: Unhealthy diets were found to be the main contributor to the overweight problem among adolescents. In this study, we aim to identify the factors causing unhealthy eating habits in adolescents.
    Methods: School-aged children and adolescents participated in this cross-sectional observational study with additional school and parental consent. A self-administered survey was conducted by 30 primary schools and 25 secondary schools. Participants were asked about the frequency of consuming unhealthy food and the types of unhealthy food consumed. A descriptive analysis was performed to demonstrate the proportions of characteristics. The prevalence of the outcome among participants of various factors was also analyzed using separate binary regression models.
    Results: A total of 4884 responses were collected. Among primary school students (grade 4, mean age: 10.06), people who (1) were actively gaining weight (aOR: 1.651, 95% CI 1.006-2.708,
    Conclusion: Several lifestyle and health factors were significantly associated with unhealthy eating behaviors in school-aged children and adolescents in Hong Kong, sharing similarities with many other countries. In conjunction with implementing a policy that addresses factors for unhealthy eating habits, further research should investigate potential interventions targeting these factors to ultimately tackle the overweight and obesity concern for children and adolescents in Hong Kong.
    Language English
    Publishing date 2024-03-11
    Publishing country United States
    Document type Journal Article
    ISSN 2398-8835
    ISSN (online) 2398-8835
    DOI 10.1002/hsr2.1964
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  5. Article ; Online: COVID-19: Complement, Coagulation, and Collateral Damage.

    Lo, Martin W / Kemper, Claudia / Woodruff, Trent M

    Journal of immunology (Baltimore, Md. : 1950)

    2020  Volume 205, Issue 6, Page(s) 1488–1495

    Abstract: Coronavirus disease of 2019 (COVID-19) is a highly contagious respiratory infection that is caused by the severe acute respiratory syndrome coronavirus 2. Although most people are immunocompetent to the virus, a small group fail to mount an effective ... ...

    Abstract Coronavirus disease of 2019 (COVID-19) is a highly contagious respiratory infection that is caused by the severe acute respiratory syndrome coronavirus 2. Although most people are immunocompetent to the virus, a small group fail to mount an effective antiviral response and develop chronic infections that trigger hyperinflammation. This results in major complications, including acute respiratory distress syndrome, disseminated intravascular coagulation, and multiorgan failure, which all carry poor prognoses. Emerging evidence suggests that the complement system plays a key role in this inflammatory reaction. Indeed, patients with severe COVID-19 show prominent complement activation in their lung, skin, and sera, and those individuals who were treated with complement inhibitors all recovered with no adverse reactions. These and other studies hint at complement's therapeutic potential in these sequalae, and thus, to support drug development, in this review, we provide a summary of COVID-19 and review complement's role in COVID-19 acute respiratory distress syndrome and coagulopathy.
    MeSH term(s) Animals ; Betacoronavirus/immunology ; Blood Coagulation/drug effects ; Blood Coagulation Disorders/immunology ; Blood Coagulation Disorders/virology ; COVID-19 ; Complement Activation/drug effects ; Complement Activation/physiology ; Complement Inactivating Agents/therapeutic use ; Complement System Proteins/drug effects ; Coronavirus Infections/blood ; Coronavirus Infections/complications ; Coronavirus Infections/immunology ; Humans ; Inflammation/immunology ; Inflammation/virology ; Pandemics ; Pneumonia, Viral/blood ; Pneumonia, Viral/complications ; Pneumonia, Viral/immunology ; Respiratory Distress Syndrome/virology ; SARS-CoV-2
    Chemical Substances Complement Inactivating Agents ; Complement System Proteins (9007-36-7)
    Keywords covid19
    Language English
    Publishing date 2020-07-22
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 3056-9
    ISSN 1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
    ISSN (online) 1550-6606
    ISSN 0022-1767 ; 1048-3233 ; 1047-7381
    DOI 10.4049/jimmunol.2000644
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    Ud II Zs.37: Show issues Location:
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  6. Article ; Online: Intensity of Cyclophosphamide-Based Bridging Therapy Before Chimeric Antigen Receptor T Cell Therapy in Myeloma.

    Zafar, Aneeqa / Huang, Chiung-Yu / Lo, Mimi / Arora, Shagun / Chung, Alfred / Wong, Sandy W / Wolf, Jeffrey / Martin, Thomas G / Shah, Nina / Banerjee, Rahul

    Transplantation and cellular therapy

    2023  Volume 29, Issue 8, Page(s) 504.e1–504.e7

    Abstract: Patients receiving autologous chimeric antigen receptor T cell (CAR-T) therapy for multiple myeloma (MM) may require bridging therapy (BT) before CAR-T infusion to maintain some level of disease control. Alkylators, such as cyclophosphamide (Cy), are ... ...

    Abstract Patients receiving autologous chimeric antigen receptor T cell (CAR-T) therapy for multiple myeloma (MM) may require bridging therapy (BT) before CAR-T infusion to maintain some level of disease control. Alkylators, such as cyclophosphamide (Cy), are often used in regimens, either in high-intensity regimens, such as modified hyperCVAD (cyclophosphamide, vincristine, doxorubicin, and dexamethasone), or once-weekly regimens, such as KCd (carfilzomib, cyclophosphamide, and dexamethasone). However, there is no consensus regarding the optimal BT alkylator dose intensity in MM. We performed a single-center analysis of all instances of BT before planned autologous CAR-T for MM during a 5-year period ending in April 2022. We classified bridging regimens into 3 cohorts: (1) hyperfractionated Cy (HyperCy) with inpatient Cy every 12 to 24 hours or as a continuous i.v. infusion; (2) less intensive Cy dosing (WeeklyCy), such as KCd; and (3) NonCy, in which no alkylators were used in BT. Demographic, disease-related, and treatment-related characteristics were collected for all patients. The 3 BT cohorts were compared using the Fisher exact test, Kruskal-Wallis test, and log-rank test, as appropriate. We identified 70 discrete BT instances among 64 unique patients, including 29 (41%) with HyperCy, 23 (33%) with WeeklyCy, and 18 (26%) with NonCy. The median total Cy dosing during BT in the 3 groups were 2100 mg/m
    MeSH term(s) Humans ; Multiple Myeloma/drug therapy ; Receptors, Chimeric Antigen/genetics ; Receptors, Chimeric Antigen/therapeutic use ; Retrospective Studies ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Neoplasm Recurrence, Local/drug therapy ; Cyclophosphamide/therapeutic use ; Dexamethasone/therapeutic use ; Cell- and Tissue-Based Therapy
    Chemical Substances Receptors, Chimeric Antigen ; Cyclophosphamide (8N3DW7272P) ; Dexamethasone (7S5I7G3JQL)
    Language English
    Publishing date 2023-05-26
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3062231-1
    ISSN 2666-6367
    ISSN (online) 2666-6367
    DOI 10.1016/j.jtct.2023.05.016
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    Zs.A 5082: Show issues Location:
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  7. Article: Factors Associated with Vaccination Uptake among Young Children: A Follow-Up Study of 1799 Toddlers.

    Huang, Junjie / Cheung, Calvin K M / Keung, Vera M W / Lo, Amelia S C / Chan, Sze Chai / Pang, Wing Sze / Li, Queenie H Y / Mui, Lancelot W H / Lee, Albert / Wong, Martin C S

    Vaccines

    2023  Volume 11, Issue 3

    Abstract: Childhood vaccination is crucial to protect young children from harmful infectious diseases. This study aimed to investigate the recent childhood immunization rate of recommended and additional vaccinations and identify the factors affecting the ... ...

    Abstract Childhood vaccination is crucial to protect young children from harmful infectious diseases. This study aimed to investigate the recent childhood immunization rate of recommended and additional vaccinations and identify the factors affecting the vaccination uptake of young children in Hong Kong. The self-administrated questionnaires were distributed to parents of toddlers aged 2 to 5. They were asked to provide information on (1) socioeconomic demographic factors; (2) experiences during pregnancy; and (3) the medical history of the toddler. A total of 1799 responses were collected. Children were more likely to be fully vaccinated when they were at a younger age (aOR = 0.61, 95% CI: 0.48-0.78,
    Language English
    Publishing date 2023-02-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines11030535
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  8. Article ; Online: Photocobilins integrate B

    Zhang, Shaowei / Jeffreys, Laura N / Poddar, Harshwardhan / Yu, Yuqi / Liu, Chuanyang / Patel, Kaylee / Johannissen, Linus O / Zhu, Lingyun / Cliff, Matthew J / Yan, Cunyu / Schirò, Giorgio / Weik, Martin / Sakuma, Michiyo / Levy, Colin W / Leys, David / Heyes, Derren J / Scrutton, Nigel S

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 2740

    Abstract: Photoreceptor proteins utilise chromophores to sense light and trigger a biological response. The discovery that adenosylcobalamin (or coenzyme ... ...

    Abstract Photoreceptor proteins utilise chromophores to sense light and trigger a biological response. The discovery that adenosylcobalamin (or coenzyme B
    MeSH term(s) Photochemistry ; Bile Pigments ; Biliverdine ; Bacterial Proteins/metabolism ; Photoreceptors, Microbial/chemistry ; Light
    Chemical Substances Bile Pigments ; Biliverdine (O9MIA842K9) ; Bacterial Proteins ; Photoreceptors, Microbial
    Language English
    Publishing date 2024-03-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-024-46995-1
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  9. Article ; Online: In Reply to Song et al, and In Reply to Brown and Carlson.

    Grimm, Jimm / Mahadevan, Anand / Brown, J Martin / Carlson, David J / Brenner, David J / Lo, Simon S / Song, Chang W / Cho, L Chinsoo

    International journal of radiation oncology, biology, physics

    2021  Volume 110, Issue 1, Page(s) 253–254

    Language English
    Publishing date 2021-04-17
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 197614-x
    ISSN 1879-355X ; 0360-3016
    ISSN (online) 1879-355X
    ISSN 0360-3016
    DOI 10.1016/j.ijrobp.2021.02.021
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  10. Article ; Online: Genetics of Hypoplastic Left Heart Syndrome.

    Benson, D Woodrow / Martin, Lisa J / Lo, Cecilia W

    The Journal of pediatrics

    2016  Volume 173, Page(s) 25–31

    MeSH term(s) Humans ; Hypoplastic Left Heart Syndrome/diagnosis ; Hypoplastic Left Heart Syndrome/genetics ; Hypoplastic Left Heart Syndrome/therapy
    Language English
    Publishing date 2016
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3102-1
    ISSN 1097-6833 ; 0022-3476
    ISSN (online) 1097-6833
    ISSN 0022-3476
    DOI 10.1016/j.jpeds.2016.02.052
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