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  1. Article ; Online: The psychology, legality, ethics and medical aspects of organ donation by minors.

    Ashwin, A / Cherukuri, S D / Rammohan, A

    Transplantation reviews (Orlando, Fla.)

    2024  Volume 38, Issue 2, Page(s) 100832

    Abstract: Any individual who has not attained the chronological age of legal majority as per national law is termed a minor. The concept of living donation (LD) has always been a subject of ethical debate and further compounding the controversy is the question of ... ...

    Abstract Any individual who has not attained the chronological age of legal majority as per national law is termed a minor. The concept of living donation (LD) has always been a subject of ethical debate and further compounding the controversy is the question of LD by minors. The decision for a minor to donate poses a special challenge as it involves a close family unit of parent-child relationship. Such an emotionally loaded situation wherein questions of attachment, perceived duties, moral obligation are likely to cloud a truly informed consent on the part of the minor to donation, who may find themselves in a vulnerable position. Furthermore, a minor's cognitive ability to comprehend the gravity of LD and when required defy parental coercion need to be elucidates before a minor is accepted for LD. Experts have set out stringent conditions which need to be met prior to the exceptional circumstance that a minor is considered for organ donation. Such donations should require parental permission, child's assent and the involvement of a paediatric-trained donor advocacy team. This article debates the question of minors acting as live donors from ethical, medical, psychosocial and legal viewpoints with an aim to present internationally defined circumstances when a minor may morally participate as a LD, thereby laying the foundation for future deliberations in this regard using traditional metrics to juxtapose divergent courses of action.
    MeSH term(s) Child ; Humans ; Organ Transplantation ; Tissue and Organ Procurement ; Living Donors ; Informed Consent
    Language English
    Publishing date 2024-01-19
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 639400-0
    ISSN 1557-9816 ; 0955-470X
    ISSN (online) 1557-9816
    ISSN 0955-470X
    DOI 10.1016/j.trre.2024.100832
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Negative effects of COVID-19 pandemic on adolescent health: Insights, perspectives, and recommendations.

    Ashwin, Aparajita / Cherukuri, Sathya D / Rammohan, Ashwin

    Journal of global health

    2022  Volume 12, Page(s) 3009

    MeSH term(s) Adolescent ; Adolescent Health ; COVID-19 ; Humans ; Pandemics/prevention & control ; SARS-CoV-2
    Language English
    Publishing date 2022-05-21
    Publishing country Scotland
    Document type Journal Article
    ZDB-ID 2741629-X
    ISSN 2047-2986 ; 2047-2986
    ISSN (online) 2047-2986
    ISSN 2047-2986
    DOI 10.7189/jogh.12.03009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Post-transplant immunosuppression and COVID-19: From a double whammy to a mixed blessing.

    Rammohan, Ashwin

    World journal of transplantation

    2020  Volume 10, Issue 9, Page(s) 267–276

    Abstract: The coronavirus pandemic (COVID-19) has had an unprecedented effect on various disease processes and their management. COVID-19 is likely to have a complex pathophysiological interplay with the post-transplant patients; one affecting the clinical course ... ...

    Abstract The coronavirus pandemic (COVID-19) has had an unprecedented effect on various disease processes and their management. COVID-19 is likely to have a complex pathophysiological interplay with the post-transplant patients; one affecting the clinical course and outcome of the other. In the absence of validated data from trials, there is strong dependence on experience based on previous similar epidemics (SARS/MERS), and from consensus based on expert opinions. Despite the fact that our knowledge is rapidly evolving with time, there still is relatively limited objective data on the effect of COVID-19 on the human body. Numerous questions remain unanswered, one of which involves the management of immunosuppression in the post-transplant recipient during this contagion. The core tenet of which continues to be that of establishing an equipoise between infection and rejection. This review summarises the current knowledge on immune interactions of the virus, the immunomodulatory effects that may be at play, and its relation to the art of immunosuppression.
    Keywords covid19
    Language English
    Publishing date 2020-09-05
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2220-3230
    ISSN 2220-3230
    DOI 10.5500/wjt.v10.i9.267
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Prediction and Management of Small-for-size Syndrome in Living Donor Liver Transplantation: Methodology of the ILTS-iLDLT-LTSI Consensus Conference.

    Rela, Mohamed / Rammohan, Ashwin / Bhangui, Prashant / Emond, Jean

    Transplantation

    2023  Volume 107, Issue 10, Page(s) 2098–2100

    MeSH term(s) Humans ; Liver Transplantation/adverse effects ; Liver Transplantation/methods ; Living Donors ; Consensus ; Liver/surgery
    Language English
    Publishing date 2023-08-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208424-7
    ISSN 1534-6080 ; 0041-1337
    ISSN (online) 1534-6080
    ISSN 0041-1337
    DOI 10.1097/TP.0000000000004768
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 488: Show issues Location:
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  5. Article ; Online: Portal Hemodynamics in Liver Resection and Transplantation.

    Rela, Mohamed / Rammohan, Ashwin / Rajalingam, Rajesh / Clavien, Pierre-Alain

    Annals of surgery

    2024  

    Abstract: The hepatic blood supply and its several homeostatic and pathologic processes has always been a matter of great interest. Many views commonly held today are derived from an earlier era, but major reorientations have occurred recently in almost all ... ...

    Abstract The hepatic blood supply and its several homeostatic and pathologic processes has always been a matter of great interest. Many views commonly held today are derived from an earlier era, but major reorientations have occurred recently in almost all aspects of knowledge of the role and regulation of hepatic blood flow. Moreover, with the advent of liver transplantation (LT), especially living donor LT (LDLT) there has been a resurgence of interest in attempting to comprehend this deceptively simple topic. It is nonetheless important to concede that even though our knowledge on the practical modulation of hepatic hemodynamics has expanded enormously, there still remain the need to explore the depths of our remaining ignorance to further improve outcomes in LDLT. This review focuses on the current view, controversies and gaps in knowledge of the hepatic vascular bed, with an emphasis on the importance of portal hemodynamics in liver disease and its impact on liver regeneration and LT.
    Language English
    Publishing date 2024-04-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 340-2
    ISSN 1528-1140 ; 0003-4932
    ISSN (online) 1528-1140
    ISSN 0003-4932
    DOI 10.1097/SLA.0000000000006304
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  6. Article ; Online: The Current Status of Endotherapy in the Management of Biliary Strictures After Right Lobe Living Donor Liver Transplantation.

    Rela, Mohamed / Rammohan, Ashwin

    Transplantation

    2021  Volume 106, Issue 2, Page(s) 241–242

    MeSH term(s) Cholestasis/diagnostic imaging ; Cholestasis/etiology ; Cholestasis/surgery ; Constriction, Pathologic ; Humans ; Liver ; Liver Transplantation/adverse effects ; Living Donors
    Language English
    Publishing date 2021-03-15
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 208424-7
    ISSN 1534-6080 ; 0041-1337
    ISSN (online) 1534-6080
    ISSN 0041-1337
    DOI 10.1097/TP.0000000000003739
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 488: Show issues Location:
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    Zs.MO 509: Show issues

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  7. Article ; Online: Liver Transplantation for Non-Resectable Colorectal Liver Metastases

    Ashwin Rammohan

    Iranian Journal of Colorectal Research, Vol 6, Iss

    2018  Volume 4

    Abstract: Improved results following liver transplantation (LT) over the past 20 years have led clinicians to push boundaries and expand itsindications. LT in non-resectable colorectal liver metastases (NCRLM) is being revisited with an aim to radically improve ... ...

    Abstract Improved results following liver transplantation (LT) over the past 20 years have led clinicians to push boundaries and expand itsindications. LT in non-resectable colorectal liver metastases (NCRLM) is being revisited with an aim to radically improve survival.By utilizing new tools for preoperative patient selection, modern operative techniques for LT and an aggressive attitude againstmetastases, long-term survival, and even cure could be expected. This paper reviews the current status of liver transplantation forNCRLM with an eye on the future.
    Keywords non-resectable colorectal liver metastases ; liver transplantation ; review ; Medicine ; R
    Language English
    Publishing date 2018-09-01T00:00:00Z
    Publisher Shiraz University of Medical Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: Robotic donor hepatectomy: Are we there yet?

    Rammohan, Ashwin / Rela, Mohamed

    World journal of gastrointestinal surgery

    2021  Volume 13, Issue 7, Page(s) 668–677

    Abstract: In living donor liver transplantation (LDLT) the safety of the live donor (LD) is of paramount importance. Despite all efforts, the morbidity rates approach 25%-40% with conventional open donor hepatectomy (DH) operations. However, most of these ... ...

    Abstract In living donor liver transplantation (LDLT) the safety of the live donor (LD) is of paramount importance. Despite all efforts, the morbidity rates approach 25%-40% with conventional open donor hepatectomy (DH) operations. However, most of these complications are related to the operative wound and despite increased self- esteem and satisfaction in various quality of life analyses on LD, the most common grievance is that of the scar. Performing safe and precise DH through a conventional laparoscopic approach is a formidable task with a precipitous learning curve for the whole team. Due to the ramifications the donor operation carries for the donor, the recipient, the transplant team and for the LDLT program in general, the development and acceptance of minimally invasive DH (MIDH) has been slow. The robotic surgical system overcomes the reduced visualization, restricted range of motion and physiological tremor associated with laparoscopic surgery and allows for a comparatively easier transition from technical feasibility to reproducibility. However, many questions especially with regards to standardization of surgical technique, comparison of outcomes, understanding of the learning curve,
    Language English
    Publishing date 2021-07-27
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2573700-4
    ISSN 1948-9366
    ISSN 1948-9366
    DOI 10.4240/wjgs.v13.i7.668
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  9. Article ; Online: Lateral transition-metal dichalcogenide heterostructures for high efficiency thermoelectric devices.

    Bharadwaj, Sathwik / Ramasubramaniam, Ashwin / Ram-Mohan, L R

    Nanoscale

    2022  Volume 14, Issue 32, Page(s) 11750–11759

    Abstract: Monolayer transition-metal dichalcogenides (TMDC) have emerged as promising candidates for thermoelectric applications due to their large effective mass and low thermal conductivity. In this article, we study the thermoelectric performance of lateral ... ...

    Abstract Monolayer transition-metal dichalcogenides (TMDC) have emerged as promising candidates for thermoelectric applications due to their large effective mass and low thermal conductivity. In this article, we study the thermoelectric performance of lateral TMDC heterostructures within a multiscale quantum transport framework. Both n-type and p-type lateral heterostructures are considered for all possible combinations of semiconducting TMDCs: MoS
    Language English
    Publishing date 2022-08-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 2515664-0
    ISSN 2040-3372 ; 2040-3364
    ISSN (online) 2040-3372
    ISSN 2040-3364
    DOI 10.1039/d2nr01609e
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Why are there so many liver transplants from living donors in Asia and so few in Europe and the US?

    Rela, Mohamed / Rammohan, Ashwin

    Journal of hepatology

    2021  Volume 75, Issue 4, Page(s) 975–980

    Abstract: Acceptance of liver transplantation (LT) as an established treatment modality for end-stage liver disease has led to an exponential increase in the demand for organs, resulting in an ever-increasing gap between the availability of organs and the number ... ...

    Abstract Acceptance of liver transplantation (LT) as an established treatment modality for end-stage liver disease has led to an exponential increase in the demand for organs, resulting in an ever-increasing gap between the availability of organs and the number of sick patients waiting for them. Interestingly, influenced by cultural, socio-economic and other constraints, the West and the East have attempted to address this problem of shortage in different ways. Living donor LT (LDLT) became polarised to the East with over 90% of LT in this region being LDLT. On the other hand, the West chose to concentrate their efforts on optimising the use of cadaveric livers with techniques such as split LT, or by using extended criteria donors (including donation after cardiac death donors) and machine perfusion devices etc. Consequently, LDLT did not find the widespread acceptance it did in the East and hence over 90% of all LT are DDLT in this region. We review each regions' perspective and attempt to provide a globally viable roadmap to bridge the widening gap between the demand and availability of livers for LT.
    MeSH term(s) Asia ; Europe ; Humans ; Liver Transplantation/methods ; Liver Transplantation/statistics & numerical data ; Living Donors/psychology ; Living Donors/statistics & numerical data ; Tissue and Organ Procurement/methods ; Tissue and Organ Procurement/standards ; Tissue and Organ Procurement/statistics & numerical data ; United States
    Language English
    Publishing date 2021-06-08
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 605953-3
    ISSN 1600-0641 ; 0168-8278
    ISSN (online) 1600-0641
    ISSN 0168-8278
    DOI 10.1016/j.jhep.2021.05.036
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