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  1. Article: COVID-19: Development of a robust mathematical model and simulation package with consideration for ageing population and time delay for control action and resusceptibility.

    Ng, Kok Yew / Gui, Meei Mei

    Physica D. Nonlinear phenomena

    2020  Volume 411, Page(s) 132599

    Abstract: The current global health emergency triggered by the pandemic COVID-19 is one of the greatest challenges we face in this generation. Computational simulations have played an important role to predict the development of the current pandemic. Such ... ...

    Abstract The current global health emergency triggered by the pandemic COVID-19 is one of the greatest challenges we face in this generation. Computational simulations have played an important role to predict the development of the current pandemic. Such simulations enable early indications on the future projections of the pandemic and is useful to estimate the efficiency of control action in the battle against the SARS-CoV-2 virus. The SEIR model is a well-known method used in computational simulations of infectious viral diseases and it has been widely used to model other epidemics such as Ebola, SARS, MERS, and influenza A. This paper presents a modified SEIRS model with additional exit conditions in the form of death rates and resusceptibility, where we can tune the exit conditions in the model to extend prediction on the current projections of the pandemic into three possible outcomes; death, recovery, and recovery with a possibility of resusceptibility. The model also considers specific information such as ageing factor of the population, time delay on the development of the pandemic due to control action measures, as well as resusceptibility with temporal immune response. Owing to huge variations in clinical symptoms exhibited by COVID-19, the proposed model aims to reflect better on the current scenario and case data reported, such that the spread of the disease and the efficiency of the control action taken can be better understood. The model is verified using two case studies based on the real-world data in South Korea and Northern Ireland.
    Keywords covid19
    Language English
    Publishing date 2020-06-09
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1466587-6
    ISSN 1872-8022 ; 0167-2789
    ISSN (online) 1872-8022
    ISSN 0167-2789
    DOI 10.1016/j.physd.2020.132599
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Robust Arm Impedocardiography Signal Quality Enhancement Using Recursive Signal Averaging and Multi-Stage Wavelet Denoising Methods for Long-Term Cardiac Contractility Monitoring Armbands.

    Escalona, Omar / Cullen, Nicole / Weli, Idongesit / McCallan, Niamh / Ng, Kok Yew / Finlay, Dewar

    Sensors (Basel, Switzerland)

    2023  Volume 23, Issue 13

    Abstract: Impedance cardiography (ICG) is a low-cost, non-invasive technique that enables the clinical assessment of haemodynamic parameters, such as cardiac output and stroke volume (SV). Conventional ICG recordings are taken from the patient's thorax. However, ... ...

    Abstract Impedance cardiography (ICG) is a low-cost, non-invasive technique that enables the clinical assessment of haemodynamic parameters, such as cardiac output and stroke volume (SV). Conventional ICG recordings are taken from the patient's thorax. However, access to ICG vital signs from the upper-arm brachial artery (as an associated surrogate) can enable user-convenient wearable armband sensor devices to provide an attractive option for gathering ICG trend-based indicators of general health, which offers particular advantages in ambulatory long-term monitoring settings. This study considered the upper arm ICG and control Thorax-ICG recordings data from 15 healthy subject cases. A prefiltering stage included a third-order Savitzky-Golay finite impulse response (FIR) filter, which was applied to the raw ICG signals. Then, a multi-stage wavelet-based denoising strategy on a beat-by-beat (BbyB) basis, which was supported by a recursive signal-averaging optimal thresholding adaptation algorithm for Arm-ICG signals, was investigated for robust signal quality enhancement. The performance of the BbyB ICG denoising was evaluated for each case using a 700 ms frame centred on the heartbeat ICG pulse. This frame was extracted from a 600-beat ensemble signal-averaged ICG and was used as the noiseless signal reference vector (gold standard frame). Furthermore, in each subject case, enhanced Arm-ICG and Thorax-ICG above a threshold of correlation of 0.95 with the noiseless vector enabled the analysis of beat inclusion rate (BIR%), yielding an average of 80.9% for Arm-ICG and 100% for Thorax-ICG, and BbyB values of the ICG waveform feature metrics A, B, C and VET accuracy and precision, yielding respective error rates (ER%) of 0.83%, 11.1%, 3.99% and 5.2% for Arm-IG, and 0.41%, 3.82%, 1.66% and 1.25% for Thorax-ICG, respectively. Hence, the functional relationship between ICG metrics within and between the arm and thorax recording modes could be characterised and the linear regression (Arm-ICG vs. Thorax-ICG) trends could be analysed. Overall, it was found in this study that recursive averaging, set with a 36 ICG beats buffer size, was the best Arm-ICG BbyB denoising process, with an average of less than 3.3% in the Arm-ICG time metrics error rate. It was also found that the arm SV versus thorax SV had a linear regression coefficient of determination (R
    MeSH term(s) Humans ; Cardiac Output/physiology ; Stroke Volume/physiology ; Cardiography, Impedance/methods ; Hemodynamics/physiology ; Monitoring, Ambulatory
    Language English
    Publishing date 2023-06-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s23135892
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Assessing the effects of time-dependent restrictions and control actions to flatten the curve of COVID-19 in Kazakhstan.

    Do, Ton Duc / Gui, Meei Mei / Ng, Kok Yew

    PeerJ

    2021  Volume 9, Page(s) e10806

    Abstract: This article presents the assessment of time-dependent national-level restrictions and control actions and their effects in fighting the COVID-19 pandemic. By analysing the transmission dynamics during the first wave of COVID-19 in the country, the ... ...

    Abstract This article presents the assessment of time-dependent national-level restrictions and control actions and their effects in fighting the COVID-19 pandemic. By analysing the transmission dynamics during the first wave of COVID-19 in the country, the effectiveness of the various levels of control actions taken to flatten the curve can be better quantified and understood. This in turn can help the relevant authorities to better plan for and control the subsequent waves of the pandemic. To achieve this, a deterministic population model for the pandemic is firstly developed to take into consideration the time-dependent characteristics of the model parameters, especially on the ever-evolving value of the reproduction number, which is one of the critical measures used to describe the transmission dynamics of this pandemic. The reproduction number alongside other key parameters of the model can then be estimated by fitting the model to real-world data using numerical optimisation techniques or by inducing ad-hoc control actions as recorded in the news platforms. In this article, the model is verified using a case study based on the data from the first wave of COVID-19 in the Republic of Kazakhstan. The model is fitted to provide estimates for two settings in simulations; time-invariant and time-varying (with bounded constraints) parameters. Finally, some forecasts are made using four scenarios with time-dependent control measures so as to determine which would reflect on the actual situations better.
    Language English
    Publishing date 2021-02-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2703241-3
    ISSN 2167-8359
    ISSN 2167-8359
    DOI 10.7717/peerj.10806
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: COVID-19

    Ng, Kok Yew / Gui, Meei Mei

    Physica D: Nonlinear Phenomena

    Development of a robust mathematical model and simulation package with consideration for ageing population and time delay for control action and resusceptibility

    2020  Volume 411, Page(s) 132599

    Keywords Statistical and Nonlinear Physics ; Condensed Matter Physics ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 1466587-6
    ISSN 1872-8022 ; 0167-2789
    ISSN (online) 1872-8022
    ISSN 0167-2789
    DOI 10.1016/j.physd.2020.132599
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Neural interface-based motor neuroprosthesis in post-stroke upper limb neurorehabilitation: An individual patient data meta-analysis.

    Lo, Yu Tung / Lim, Mervyn Jun Rui / Kok, Chun Yen / Wang, Shilin / Blok, Sebastiaan Zhiyong / Ang, Ting Yao / Ng, Vincent Yew Poh / Rao, Jai Prashanth / Chua, Karen Sui Geok

    Archives of physical medicine and rehabilitation

    2024  

    Abstract: Objective: To determine the efficacy of neural interface-, including brain-computer interface (BCI), based neurorehabilitation through conventional and individual patient data (IPD) meta-analysis, and to assess clinical parameters associated with ... ...

    Abstract Objective: To determine the efficacy of neural interface-, including brain-computer interface (BCI), based neurorehabilitation through conventional and individual patient data (IPD) meta-analysis, and to assess clinical parameters associated with positive response to neural interface-based neurorehabilitation.
    Data sources: PubMed, EMBASE, and Cochrane Library databases up to February 2022 were reviewed.
    Study selection: Studies using neural interface-controlled physical effectors (FES and/or powered exoskeletons) and reported Fugl-Meyer Assessment-upper extremity (FMA-UE) scores were identified. This meta-analysis was prospectively registered on PROSPERO (#CRD42022312428). PRISMA guidelines were followed.
    Data extraction: Change in FMA-UE scores were pooled to estimate the mean effect size. Subgroup analyses were performed on clinical parameters and neural interface parameters with both study-level variables and IPD.
    Data synthesis: Forty-six studies containing 617 patients were included. Twenty-nine studies involving 214 patients reported IPD. FMA-UE score increased by a mean of 5.23 (95% CI: 3.85 to 6.61). Systems that used motor attempt resulted in greater FMA-UE gain than motor imagery, as did training lasting >4 versus ≤4 weeks. On IPD analysis, the mean time-to-improvement above MCID was 12 weeks (95% CI: 7 to not reached). At 6 months, 58% improved above MCID (95% CI: 41 to 70%). Patients with severe impairment (p=0.042) and age >50 years (p=0.0022) correlated with the failure to improve above the MCID on univariate log-rank tests. However, these factors were only borderline significant on multivariate Cox analysis (HR 0.15, p = 0.08 and HR 0.47, p = 0.06, respectively).
    Conclusion: Neural interface-based motor rehabilitation resulted in significant though modest reductions in post-stroke impairment and should be considered for wider applications in stroke neurorehabilitation.
    Language English
    Publishing date 2024-04-03
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 80057-0
    ISSN 1532-821X ; 0003-9993
    ISSN (online) 1532-821X
    ISSN 0003-9993
    DOI 10.1016/j.apmr.2024.04.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book ; Online: Learning to Predict Grip Quality from Simulation

    Wucherer, Stefanie / McMurray, Robert / Ng, Kok Yew / Kerber, Florian

    Establishing a Digital Twin to Generate Simulated Data for a Grip Stability Metric

    2023  

    Abstract: A robust grip is key to successful manipulation and joining of work pieces involved in any industrial assembly process. Stability of a grip depends on geometric and physical properties of the object as well as the gripper itself. Current state-of-the-art ...

    Abstract A robust grip is key to successful manipulation and joining of work pieces involved in any industrial assembly process. Stability of a grip depends on geometric and physical properties of the object as well as the gripper itself. Current state-of-the-art algorithms can usually predict if a grip would fail. However, they are not able to predict the force at which the gripped object starts to slip, which is critical as the object might be subjected to external forces, e.g. when joining it with another object. This research project aims to develop a AI-based approach for a grip metric based on tactile sensor data capturing the physical interactions between gripper and object. Thus, the maximum force that can be applied to the object before it begins to slip should be predicted before manipulating the object. The RGB image of the contact surface between the object and gripper jaws obtained from GelSight tactile sensors during the initial phase of the grip should serve as a training input for the grip metric. To generate such a data set, a pull experiment is designed using a UR 5 robot. Performing these experiments in real life to populate the data set is time consuming since different object classes, geometries, material properties and surface textures need to be considered to enhance the robustness of the prediction algorithm. Hence, a simulation model of the experimental setup has been developed to both speed up and automate the data generation process. In this paper, the design of this digital twin and the accuracy of the synthetic data are presented. State-of-the-art image comparison algorithms show that the simulated RGB images of the contact surface match the experimental data. In addition, the maximum pull forces can be reproduced for different object classes and grip scenarios. As a result, the synthetically generated data can be further used to train the neural grip metric network.

    Comment: 7 pages, 7 figures
    Keywords Computer Science - Robotics ; Electrical Engineering and Systems Science - Image and Video Processing ; Electrical Engineering and Systems Science - Signal Processing
    Subject code 006
    Publishing date 2023-02-06
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article: COVID-19: Development of A Robust Mathematical Model and Simulation Package with Consideration for Ageing Population and Time Delay for Control Action and Resusceptibility

    Kok Ng Yew / Meei Gui Mei

    Abstract: The current global health emergency triggered by the COVID-19 pandemic is one of the greatest challenges mankind face in this generation. Computational simulations have played an important role to predict the development of the current pandemic. Such ... ...

    Abstract The current global health emergency triggered by the COVID-19 pandemic is one of the greatest challenges mankind face in this generation. Computational simulations have played an important role to predict the development of the current pandemic. Such simulations enable early indications on the future projections of the pandemic and is useful to estimate the efficiency of control action in the battle against the SARS-CoV-2 virus. The SEIR model is a well-known method used in computational simulations of infectious viral diseases and it has been widely used to model other epidemics such as Ebola, SARS, MERS, and influenza A. This paper presents a modified SEIRS model with additional exit conditions in the form of death rates and resusceptibiliy, where we can tune the exit conditions in the model to extend prediction on the current projections of the pandemic into three possible outcomes; death, recovery, and recovery with a possibility of resusceptibility. The model also considers specific information such as ageing factor of the population, time delay on the development of the pandemic due to control action measures, as well as resusceptiblity with temporary immune response. Owing to huge variations in clinical symptoms exhibited by COVID-19, the proposed model aims to reflect better on the current scenario and case data reported, such that the spread of the disease and the efficiency of the control action taken can be better understood. The model is verified using two case studies for verification and prediction studies, based on the real-world data in South Korea and Northern Ireland, respectively.
    Keywords covid19
    Publisher arxiv
    Document type Article
    Database COVID19

    Kategorien

  8. Article ; Online: Assessing the effects of time-dependent restrictions and control actions to flatten the curve of COVID-19 in Kazakhstan

    Ton Duc Do / Meei Mei Gui / Kok Yew Ng

    PeerJ, Vol 9, p e

    2021  Volume 10806

    Abstract: This article presents the assessment of time-dependent national-level restrictions and control actions and their effects in fighting the COVID-19 pandemic. By analysing the transmission dynamics during the first wave of COVID-19 in the country, the ... ...

    Abstract This article presents the assessment of time-dependent national-level restrictions and control actions and their effects in fighting the COVID-19 pandemic. By analysing the transmission dynamics during the first wave of COVID-19 in the country, the effectiveness of the various levels of control actions taken to flatten the curve can be better quantified and understood. This in turn can help the relevant authorities to better plan for and control the subsequent waves of the pandemic. To achieve this, a deterministic population model for the pandemic is firstly developed to take into consideration the time-dependent characteristics of the model parameters, especially on the ever-evolving value of the reproduction number, which is one of the critical measures used to describe the transmission dynamics of this pandemic. The reproduction number alongside other key parameters of the model can then be estimated by fitting the model to real-world data using numerical optimisation techniques or by inducing ad-hoc control actions as recorded in the news platforms. In this article, the model is verified using a case study based on the data from the first wave of COVID-19 in the Republic of Kazakhstan. The model is fitted to provide estimates for two settings in simulations; time-invariant and time-varying (with bounded constraints) parameters. Finally, some forecasts are made using four scenarios with time-dependent control measures so as to determine which would reflect on the actual situations better.
    Keywords COVID-19 ; Coronavirus ; Modelling ; SEIRD ; Time-dependent analysis ; Medicine ; R ; Biology (General) ; QH301-705.5
    Subject code 530
    Language English
    Publishing date 2021-02-01T00:00:00Z
    Publisher PeerJ Inc.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: COVID-19: Development of a robust mathematical model and simulation package with consideration for ageing population and time delay for control action and resusceptibility

    Ng, Kok Yew / Gui, Meei Mei

    Phys D Nonlinear Phenom

    Abstract: The current global health emergency triggered by the pandemic COVID-19 is one of the greatest challenges we face in this generation. Computational simulations have played an important role to predict the development of the current pandemic. Such ... ...

    Abstract The current global health emergency triggered by the pandemic COVID-19 is one of the greatest challenges we face in this generation. Computational simulations have played an important role to predict the development of the current pandemic. Such simulations enable early indications on the future projections of the pandemic and is useful to estimate the efficiency of control action in the battle against the SARS-CoV-2 virus. The SEIR model is a well-known method used in computational simulations of infectious viral diseases and it has been widely used to model other epidemics such as Ebola, SARS, MERS, and influenza A. This paper presents a modified SEIRS model with additional exit conditions in the form of death rates and resusceptibility, where we can tune the exit conditions in the model to extend prediction on the current projections of the pandemic into three possible outcomes; death, recovery, and recovery with a possibility of resusceptibility. The model also considers specific information such as ageing factor of the population, time delay on the development of the pandemic due to control action measures, as well as resusceptibility with temporal immune response. Owing to huge variations in clinical symptoms exhibited by COVID-19, the proposed model aims to reflect better on the current scenario and case data reported, such that the spread of the disease and the efficiency of the control action taken can be better understood. The model is verified using two case studies based on the real-world data in South Korea and Northern Ireland.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #591421
    Database COVID19

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  10. Book ; Online: COVID-19

    Ng, Kok Yew / Gui, Meei Mei

    Development of a Robust Mathematical Model and Simulation Package with Consideration for Ageing Population and Time Delay for Control Action and Resusceptibility

    2020  

    Abstract: The current global health emergency triggered by the pandemic COVID-19 is one of the greatest challenges mankind face in this generation. Computational simulations have played an important role to predict the development of the current pandemic. Such ... ...

    Abstract The current global health emergency triggered by the pandemic COVID-19 is one of the greatest challenges mankind face in this generation. Computational simulations have played an important role to predict the development of the current pandemic. Such simulations enable early indications on the future projections of the pandemic and is useful to estimate the efficiency of control action in the battle against the SARS-CoV-2 virus. The SEIR model is a well-known method used in computational simulations of infectious viral diseases and it has been widely used to model other epidemics such as Ebola, SARS, MERS, and influenza A. This paper presents a modified SEIRS model with additional exit conditions in the form of death rates and resusceptibility, where we can tune the exit conditions in the model to extend prediction on the current projections of the pandemic into three possible outcomes; death, recovery, and recovery with a possibility of resusceptibility. The model also considers specific information such as ageing factor of the population, time delay on the development of the pandemic due to control action measures, as well as resusceptibility with temporal immune response. Owing to huge variations in clinical symptoms exhibited by COVID-19, the proposed model aims to reflect better on the current scenario and case data reported, such that the spread of the disease and the efficiency of the control action taken can be better understood. The model is verified using two case studies for verification and prediction studies, based on the real-world data in South Korea and Northern Ireland, respectively.

    Comment: 14 pages, 9 figures, To appear in Physica D: Nonlinear Phenomena (2020)
    Keywords Quantitative Biology - Populations and Evolution ; covid19
    Subject code 612
    Publishing date 2020-04-04
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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