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  1. Article ; Online: Beyond bulevirtide: Alternative therapeutic options for the management of hepatitis delta virus.

    Asselah, Tarik

    Journal of viral hepatitis

    2023  Volume 30 Suppl 1, Page(s) 33–38

    Abstract: Hepatitis delta virus (HDV) is a small RNA virus which needs Hepatitis B Surface Antigen for its envelope, for entry into hepatocytes and secretion. HDV chronic infection affects around 12 million people worldwide. HDV infection is believed to be the ... ...

    Abstract Hepatitis delta virus (HDV) is a small RNA virus which needs Hepatitis B Surface Antigen for its envelope, for entry into hepatocytes and secretion. HDV chronic infection affects around 12 million people worldwide. HDV infection is believed to be the most severe form of viral hepatitis, with a high risk of developing cirrhosis and hepatocellular carcinoma. Pegylated interferons has been used and recommended by guidelines, although not approved, with low efficacy and poor tolerability. Bulevirtide (entry inhibitor) has been recently conditionally approved by the European Medicines Agency. These treatments have many advantages, but they have also limitations since there are non-responders to these previous therapies. There is an urgent need to develop new drugs. In this article, we review antiviral treatments under development for HDV chronic infection (except bulevirtide reviewed in a specific article), including those in the HBV cure programme, outlining their respective mechanisms-of-action.
    MeSH term(s) Humans ; Hepatitis Delta Virus/genetics ; Persistent Infection ; Antiviral Agents/adverse effects ; Liver Neoplasms/drug therapy ; Hepatitis B virus
    Chemical Substances bulevirtide ; Antiviral Agents
    Language English
    Publishing date 2023-01-05
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1212497-7
    ISSN 1365-2893 ; 1352-0504
    ISSN (online) 1365-2893
    ISSN 1352-0504
    DOI 10.1111/jvh.13789
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4119: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: What is the Path Forward to Treat Hepatitis Delta Virus?: Old Treatments and New Options.

    Asselah, Tarik

    Clinics in liver disease

    2023  Volume 27, Issue 4, Page(s) 985–995

    Abstract: HDV use the cell enzymes for its own replication, and the HBsAg as an envelope. There is an urgent need to develop new drugs for chronic hepatitis D (CHD). Pegylated interferon alpha (PEG-IFNα) (direct-antiviral and immune modulator) has been used and ... ...

    Abstract HDV use the cell enzymes for its own replication, and the HBsAg as an envelope. There is an urgent need to develop new drugs for chronic hepatitis D (CHD). Pegylated interferon alpha (PEG-IFNα) (direct-antiviral and immune modulator) has been used and recommended by scientific guidelines, although not approved, with moderate efficacy and poor tolerability. There are several drugs in development which target the host: bulevirtide (BLV), lonafarnib (LNF), nucleic acid polymer, and others.
    MeSH term(s) Humans ; Hepatitis Delta Virus ; Antiviral Agents/therapeutic use ; Interferon-alpha/therapeutic use ; Hepatitis D, Chronic/drug therapy ; Hepatitis B Surface Antigens ; Hepatitis B virus ; Hepatitis D/drug therapy
    Chemical Substances Antiviral Agents ; Interferon-alpha ; Hepatitis B Surface Antigens
    Language English
    Publishing date 2023-07-14
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1472315-3
    ISSN 1557-8224 ; 1089-3261
    ISSN (online) 1557-8224
    ISSN 1089-3261
    DOI 10.1016/j.cld.2023.05.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book ; Conference proceedings: Proceedings of the 8th Paris Hepatitis Conference

    Marcellin, Patrick / Asselah, Tarik

    International Conference of the Management of Patients with Viral Hepatitis ; 12 - 13 January 2015, Paris, France

    (Liver international ; 35, Suppl. 1)

    2015  

    Event/congress Paris Hepatitis Conference (8., 2015, Paris)
    Author's details guest ed.: Tarik Asselah and Patrick Marcellin
    Series title Liver international ; 35, Suppl. 1
    Collection
    Language English
    Size 144 S. : Ill., graph. Darst.
    Publisher Wiley-Blackwell
    Publishing place Oxford
    Publishing country Great Britain
    Document type Book ; Conference proceedings
    HBZ-ID HT018598043
    Database Catalogue ZB MED Medicine, Health

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    Zs A 1632 -35,Suppl.1- not available for loan Zeitschriften-Lesesaal

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  4. Book: Hepatitis B virus

    Asselah, Tarik / Marcellin, Patrick

    (Clinics in liver disease ; 17,3)

    2013  

    Author's details ed. Tarik Asselah ; Patrick Marcellin
    Series title Clinics in liver disease ; 17,3
    Collection
    Language English
    Size X S., S. 375 - 506 : Ill., graph. Darst., Kt.
    Publisher Elsevier
    Publishing place New York, NY u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT017771974
    ISBN 978-0-323-18608-7 ; 0-323-18608-4
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    Se 1870 -17,3- verfügbar in Königswinter Königswinter

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  5. Book ; Conference proceedings: Proceedings of the 7th Paris Hepatitis Conference

    Marcellin, Patrick / Asselah, Tarik

    International Conference of the Management of Patients with Viral Hepatitis ; 13 - 14 January 2014, Paris, France

    (Liver international ; 34, Suppl. 1)

    2014  

    Event/congress Paris Hepatitis Conference (7, 2014, Paris)
    Author's details guest ed.: Patrick Marcellin and Tarik Asselah
    Series title Liver international ; 34, Suppl. 1
    Collection
    Language English
    Size 153 S. : Ill., graph. Darst.
    Publisher Wiley-Blackwell
    Publishing place Oxford
    Publishing country Great Britain
    Document type Book ; Conference proceedings
    HBZ-ID HT018215348
    Database Catalogue ZB MED Medicine, Health

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  6. Book ; Conference proceedings: Proceedings of the 6th Paris Hepatitis Conference

    Marcellin, Patrick / Asselah, Tarik

    International Conference of the Management of Patients with Viral Hepatitis ; 14 - 15 January 2013, Paris, France

    (Liver international ; 33, Suppl. 1)

    2013  

    Event/congress Paris Hepatitis Conference (6, 2013, Paris)
    Author's details guest ed.: Patrick Marcellin and Tarik Asselah
    Series title Liver international ; 33, Suppl. 1
    Collection
    Language English
    Size 199 S. : Ill., graph. Darst.
    Publisher Wiley-Blackwell
    Publishing place Oxford
    Publishing country Great Britain
    Document type Book ; Conference proceedings
    HBZ-ID HT017536641
    Database Catalogue ZB MED Medicine, Health

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  7. Book ; Conference proceedings: Proceedings of the 5th Paris Hepatitis Conference

    Marcellin, Patrick / Asselah, Tarik

    International Conference of the Management of Patients with Viral Hepatitis: Special Edition Hepatitis C [January 30 and 31, 2012]

    (Liver international ; 32, Suppl. 1)

    2012  

    Event/congress Paris Hepatitis Conference (5, 2012, Paris)
    Author's details guest ed.: Patrick Marcellin and Tarik Asselah
    Series title Liver international ; 32, Suppl. 1
    Collection
    Language English
    Size 156 S. : Ill., graph. Darst.
    Publisher Wiley-Blackwell
    Publishing place Oxford
    Publishing country Great Britain
    Document type Book ; Conference proceedings
    HBZ-ID HT017151066
    Database Catalogue ZB MED Medicine, Health

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    Zs A 1632 -32,Suppl.1- not available for loan Zeitschriften-Lesesaal

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  8. Article ; Online: Hepatitis D Virus Infection.

    Asselah, Tarik / Rizzetto, Mario

    The New England journal of medicine

    2023  Volume 389, Issue 1, Page(s) 58–70

    MeSH term(s) Humans ; Hepatitis Delta Virus/genetics ; Hepatitis D/complications ; Hepatitis D/diagnosis ; Hepatitis B Surface Antigens ; Hepatitis B virus
    Chemical Substances Hepatitis B Surface Antigens
    Language English
    Publishing date 2023-07-18
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMra2212151
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.34: Show issues Location:
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  9. Article ; Online: A village without hepatitis C in Egypt: will micro-elimination lead to macro-elimination?

    Asselah, Tarik

    The lancet. Gastroenterology & hepatology

    2018  Volume 3, Issue 11, Page(s) 734–736

    MeSH term(s) Egypt ; Hepacivirus ; Hepatitis C ; Humans
    Language English
    Publishing date 2018-07-18
    Publishing country Netherlands
    Document type Journal Article ; Comment
    ISSN 2468-1253
    ISSN (online) 2468-1253
    DOI 10.1016/S2468-1253(18)30178-X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Hepatitis-B virus: replication cycle, targets, and antiviral approaches.

    Nasser, Nour / Tonnerre, Pierre / Mansouri, Abdellah / Asselah, Tarik

    Current opinion in virology

    2023  Volume 63, Page(s) 101360

    Abstract: An estimated 257 million people are chronic carriers of hepatitis-B virus (HBV) infection, which resulted in around 1 million deaths, mainly due to hepatocellular carcinoma (HCC). Long-term nucleotide analog treatment of HBV infection is associated with ... ...

    Abstract An estimated 257 million people are chronic carriers of hepatitis-B virus (HBV) infection, which resulted in around 1 million deaths, mainly due to hepatocellular carcinoma (HCC). Long-term nucleotide analog treatment of HBV infection is associated with favorable prognosis, no disease progression, and a reduction of HCC risk, but lifelong treatments are required. A better understanding of HBV replication cycle and the host immune response will likely improve the identification of new targets for drug development. Studies are ongoing to determine if it is possible to successfully combine direct-acting antivirals (DAA) with an immunomodulatory therapy to allow increased cure rates. This review will start with summarizing the HBV replication cycle, recall current treatments, and then discuss potential targets and antiviral approaches in development to optimistically reach the HBV cure.
    MeSH term(s) Humans ; Hepatitis B virus/physiology ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Herpesvirus 1, Cercopithecine ; Carcinoma, Hepatocellular ; Liver Neoplasms/drug therapy ; Hepatitis C, Chronic/drug therapy ; Virus Replication
    Chemical Substances Antiviral Agents
    Language English
    Publishing date 2023-09-10
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2611378-8
    ISSN 1879-6265 ; 1879-6257
    ISSN (online) 1879-6265
    ISSN 1879-6257
    DOI 10.1016/j.coviro.2023.101360
    Database MEDical Literature Analysis and Retrieval System OnLINE

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