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  1. Article ; Online: Time to Treat Severe Community-Acquired Pneumonia with Steroids?

    Metlay, Joshua P / Waterer, Grant W

    The New England journal of medicine

    2023  Volume 388, Issue 21, Page(s) 2001–2002

    MeSH term(s) Humans ; Glucocorticoids/therapeutic use ; Community-Acquired Infections/drug therapy ; Pneumonia/drug therapy
    Chemical Substances Glucocorticoids
    Language English
    Publishing date 2023-05-01
    Publishing country United States
    Document type Editorial
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMe2302544
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  2. Article ; Online: Corticosteroids and Severe Community-acquired Pneumonia: New Data, New Questions and a Swinging Pendulum.

    Waterer, Grant W / Metersky, Mark

    Archivos de bronconeumologia

    2023  Volume 59, Issue 12, Page(s) 793–794

    MeSH term(s) Humans ; Adrenal Cortex Hormones/therapeutic use ; Pneumonia/drug therapy ; Community-Acquired Infections/drug therapy
    Chemical Substances Adrenal Cortex Hormones
    Language Spanish
    Publishing date 2023-08-16
    Publishing country Spain
    Document type Editorial
    ZDB-ID 733126-5
    ISSN 1579-2129 ; 0300-2896
    ISSN (online) 1579-2129
    ISSN 0300-2896
    DOI 10.1016/j.arbres.2023.08.005
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  3. Article ; Online: Applying the lessons learned from coronavirus disease 2019 to improve pneumonia management.

    Waterer, Grant W

    Current opinion in infectious diseases

    2021  Volume 34, Issue 2, Page(s) 175–179

    Abstract: Purpose of review: Coronavirus disease 2019 (COVID-19) has produced an extraordinary amount of literature in a short time period. This review focuses on what the new literature has provided in terms of more general information about the management of ... ...

    Abstract Purpose of review: Coronavirus disease 2019 (COVID-19) has produced an extraordinary amount of literature in a short time period. This review focuses on what the new literature has provided in terms of more general information about the management of community-acquired pneumonia (CAP).
    Recent findings: Measures taken to reduce the spread of COVID-19 have caused a significant drop in influenza worldwide. Improvements in imaging, especially ultrasound, and especially in the application of rapid molecular diagnosis are likely to have significant impact on the management of CAP. Therapeutic advances are so far limited.
    Summary: COVID-19 has taught us that we can do far more to prevent seasonal influenza and its associated mortality, morbidity and economic cost. Improvements in imaging and pathogen diagnosis are welcome, as is the potential for secondary benefits of anti-COVID-19 therapies that may have reach effect on respiratory viruses other than severe acute respiratory syndrome coronavirus 2. As community-transmission is likely to persist for many years, recognition and treatment of severe acute respiratory syndrome coronavirus 2 will need to be incorporated into CAP guidelines moving forward.
    MeSH term(s) COVID-19/diagnosis ; COVID-19/epidemiology ; COVID-19/prevention & control ; COVID-19/therapy ; Clinical Laboratory Techniques ; Community-Acquired Infections/diagnosis ; Community-Acquired Infections/prevention & control ; Community-Acquired Infections/therapy ; Diagnostic Imaging ; Humans ; Infection Control ; Pneumonia/diagnosis ; Pneumonia/prevention & control ; Pneumonia/therapy ; SARS-CoV-2
    Language English
    Publishing date 2021-01-24
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 645085-4
    ISSN 1473-6527 ; 1535-3877 ; 0951-7375 ; 1355-834X
    ISSN (online) 1473-6527 ; 1535-3877
    ISSN 0951-7375 ; 1355-834X
    DOI 10.1097/QCO.0000000000000710
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  4. Article ; Online: Potential antibiotic resistant pathogens in community-acquired pneumonia: playing it safe is anything but.

    Waterer, Grant W

    The European respiratory journal

    2019  Volume 54, Issue 1

    MeSH term(s) Anti-Bacterial Agents ; Cohort Studies ; Community-Acquired Infections ; Humans ; Pneumonia
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2019-07-04
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.00870-2019
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    Zs.MO 292: Show issues

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  5. Article ; Online: Expert Review on Nonsurgical Management of Parapneumonic Effusion: Advances, Controversies, and New Directions.

    Fitzgerald, Deirdre B / Polverino, Eva / Waterer, Grant W

    Seminars in respiratory and critical care medicine

    2023  Volume 44, Issue 4, Page(s) 468–476

    Abstract: Parapneumonic effusion and empyema are rising in incidence worldwide, particularly in association with comorbidities in an aging population. Also driving this change is the widespread uptake of pneumococcal vaccines, leading to the emergence of ... ...

    Abstract Parapneumonic effusion and empyema are rising in incidence worldwide, particularly in association with comorbidities in an aging population. Also driving this change is the widespread uptake of pneumococcal vaccines, leading to the emergence of nonvaccine-type pneumococci and other bacteria. Early treatment with systemic antibiotics is essential but should be guided by local microbial guidelines and antimicrobial resistance patterns due to significant geographical variation. Thoracic ultrasound has emerged as a leading imaging technique in parapneumonic effusion, enabling physicians to characterize effusions, assess the underlying parenchyma, and safely guide pleural procedures. Drainage decisions remain based on longstanding criteria including the size of the effusion and fluid gram stain and biochemistry results. Small-bore chest drains appear to be as effective as large bore and are adequate for the delivery of intrapleural enzyme therapy (IET), which is now supported by a large body of evidence. The IET dosing regimen used in the UK Multicenter Sepsis Trial -2 has the most evidence available but data surrounding alternative dosing, concurrent and once-daily instillations, and novel fibrinolytic agents are promising. Prognostic scores used in pneumonia (e.g., CURB-65) tend to underestimate mortality in parapneumonic effusion/empyema. Scores specifically based on pleural infection have been developed but require validation in prospective cohorts.
    MeSH term(s) Humans ; Aged ; Prospective Studies ; Pleural Effusion/complications ; Fibrinolytic Agents ; Empyema/drug therapy ; Exudates and Transudates ; Pneumonia/drug therapy
    Chemical Substances Fibrinolytic Agents
    Language English
    Publishing date 2023-07-10
    Publishing country United States
    Document type Multicenter Study ; Journal Article
    ZDB-ID 1183617-9
    ISSN 1098-9048 ; 1069-3424
    ISSN (online) 1098-9048
    ISSN 1069-3424
    DOI 10.1055/s-0043-1769095
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  6. Article ; Online: Health Care-Associated Pneumonia: Is It Still a Useful Concept?

    Waterer, Grant W

    Clinics in chest medicine

    2018  Volume 39, Issue 4, Page(s) 765–773

    Abstract: Health care-associated pneumonia (HCAP) was introduced into guidelines because of concerns about the increasing prevalence of drug-resistant pathogens (DRPs) not covered by standard empirical therapy. We now know that DRPs are very localized phenomena ... ...

    Abstract "Health care-associated pneumonia (HCAP) was introduced into guidelines because of concerns about the increasing prevalence of drug-resistant pathogens (DRPs) not covered by standard empirical therapy. We now know that DRPs are very localized phenomena with low rates in most sites. Although HCAP risk factors are associated with a higher mortality, this is driven by comorbidities rather than the pathogens. Empirical coverage of DRPs has generally not resulted in better patient outcomes. A far more nuanced approach must be taken for patients with risk factors for DRPs taking into account the local cause and severity of disease.
    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Female ; Healthcare-Associated Pneumonia/diagnosis ; Healthcare-Associated Pneumonia/pathology ; Humans ; Male ; Prevalence ; Risk Factors
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2018-11-04
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 447455-7
    ISSN 1557-8216 ; 0272-5231
    ISSN (online) 1557-8216
    ISSN 0272-5231
    DOI 10.1016/j.ccm.2018.07.009
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  7. Article ; Online: Reply to Chahine, to Schuetz, and to Fabre

    Metlay, Joshua P / Waterer, Grant W

    American journal of respiratory and critical care medicine

    2020  Volume 201, Issue 6, Page(s) 746–747

    MeSH term(s) Community-Acquired Infections ; Humans ; Pneumonia ; Societies ; United States
    Language English
    Publishing date 2020-01-14
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.201910-2000LE
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  8. Article ; Online: Clinical Practice Guidelines Versus Actual Clinical Practice: The Pneumonia Paradigm.

    Rello, Jordi / Waterer, Grant W

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2020  Volume 73, Issue 7, Page(s) e1611–e1612

    MeSH term(s) Humans ; Pneumonia/diagnosis ; Pneumonia/drug therapy ; Sepsis
    Language English
    Publishing date 2020-09-24
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciaa1452
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  9. Article ; Online: Reply to Huttner

    Metlay, Joshua P / Waterer, Grant W

    American journal of respiratory and critical care medicine

    2020  Volume 201, Issue 10, Page(s) 1316–1317

    MeSH term(s) Adult ; Anti-Bacterial Agents ; Community-Acquired Infections ; Humans ; Pneumonia ; Societies ; United States
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2020-02-17
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202001-0164LE
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  10. Article ; Online: Treatment of Community-Acquired Pneumonia During the Coronavirus Disease 2019 (COVID-19) Pandemic.

    Metlay, Joshua P / Waterer, Grant W

    Annals of internal medicine

    2020  Volume 173, Issue 4, Page(s) 304–305

    MeSH term(s) Acute Disease ; Betacoronavirus ; COVID-19 ; Coinfection/epidemiology ; Coinfection/therapy ; Community-Acquired Infections/epidemiology ; Community-Acquired Infections/therapy ; Coronavirus Infections/epidemiology ; Humans ; Pandemics ; Pneumonia/epidemiology ; Pneumonia/microbiology ; Pneumonia/therapy ; Pneumonia, Viral/epidemiology ; SARS-CoV-2 ; United States
    Keywords covid19
    Language English
    Publishing date 2020-05-07
    Publishing country United States
    Document type Editorial ; Practice Guideline
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/M20-2189
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