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  1. Article ; Online: Controlled attenuation parameter for the assessment of fatty liver in patients with type 1 diabetes mellitus: which cutoffs to choose?

    Smyk, Wiktor / Krawczyk, Marcin

    Polish archives of internal medicine

    2024  Volume 134, Issue 1

    MeSH term(s) Humans ; Diabetes Mellitus, Type 1/complications ; Elasticity Imaging Techniques ; Fatty Liver/diagnostic imaging
    Language English
    Publishing date 2024-01-29
    Publishing country Poland
    Document type Journal Article ; Comment
    ZDB-ID 123500-x
    ISSN 1897-9483 ; 0032-3772
    ISSN (online) 1897-9483
    ISSN 0032-3772
    DOI 10.20452/pamw.16613
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  2. Article ; Online: Artificial replication cohort: Leveraging AI-fabricated data for genetic studies.

    Smyk, Wiktor / Adrych, Krystian / Krawczyk, Marcin

    Liver international : official journal of the International Association for the Study of the Liver

    2024  

    Abstract: Recent advancements in artificial intelligence (AI) present both opportunities and challenges within the scientific community. This study explores the capability of AI to replicate findings from genetic research, focusing on findings from prior work. ... ...

    Abstract Recent advancements in artificial intelligence (AI) present both opportunities and challenges within the scientific community. This study explores the capability of AI to replicate findings from genetic research, focusing on findings from prior work. Using an AI model without exposing any raw data, we created a dataset that closely mirrors the results of our original study, illustrating the ease of fabricating datasets with authenticity. This approach highlights the risks associated with AI misuse in scientific research. The study emphasizes the critical importance of maintaining the integrity of scientific inquiry in an era increasingly influenced by advanced AI technologies.
    Language English
    Publishing date 2024-03-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2102783-3
    ISSN 1478-3231 ; 1478-3223
    ISSN (online) 1478-3231
    ISSN 1478-3223
    DOI 10.1111/liv.15890
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  3. Article: Serum Level of Vitamin D Is Associated with Severity of Coronary Atherosclerosis in Postmenopausal Women.

    Dziedzic, Ewelina Anna / Smyk, Wiktor / Sowińska, Izabela / Dąbrowski, Marek / Jankowski, Piotr

    Biology

    2021  Volume 10, Issue 11

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2021-11-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2661517-4
    ISSN 2079-7737
    ISSN 2079-7737
    DOI 10.3390/biology10111139
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  4. Article ; Conference proceedings: [No title information]

    Weber, Susanne N. / Brödel, Susan / Kruk, Beata / Smyk, Wiktor / Milkiewicz, Piotr / Lambert, Irina / Krawczyk, Marcin

    Zeitschrift für Gastroenterologie

    2023  Volume 61, Issue 01

    Event/congress 39. Jahrestagung der Deutschen Arbeitsgemeinschaft zum Studium der Leber, Bochum, 2023-01-27
    Language German
    Publishing date 2023-01-01
    Publisher Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 201387-3
    ISSN 1439-7803 ; 0044-2771 ; 0172-8504
    ISSN (online) 1439-7803
    ISSN 0044-2771 ; 0172-8504
    DOI 10.1055/s-0042-1759971
    Database Thieme publisher's database

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  5. Article ; Conference proceedings: [No title information]

    Janik, Maciej / Smyk, Wiktor / Kruk, Beata / Szczepankiewicz, Benedykt / Górnicka, Barbara / Weber, Susanne N. / Milkiewicz, Piotr / Krawczyk, Marcin

    Zeitschrift für Gastroenterologie

    2023  Volume 61, Issue 01

    Event/congress 39. Jahrestagung der Deutschen Arbeitsgemeinschaft zum Studium der Leber, Bochum, 2023-01-27
    Language German
    Publishing date 2023-01-01
    Publisher Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 201387-3
    ISSN 1439-7803 ; 0044-2771 ; 0172-8504
    ISSN (online) 1439-7803
    ISSN 0044-2771 ; 0172-8504
    DOI 10.1055/s-0042-1759945
    Database Thieme publisher's database

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  6. Article ; Online: Serum Level of Vitamin D Is Associated with Severity of Coronary Atherosclerosis in Postmenopausal Women

    Ewelina Anna Dziedzic / Wiktor Smyk / Izabela Sowińska / Marek Dąbrowski / Piotr Jankowski

    Biology, Vol 10, Iss 1139, p

    2021  Volume 1139

    Abstract: Background: Postmenopausal women experience rapid progression of coronary artery disease. Vitamin D deficiency appears to be a modifiable risk factor for cardiovascular diseases. This study aimed to analyze the impact of 25-hydroxyvitamin D3 (25(OH)D) ... ...

    Abstract Background: Postmenopausal women experience rapid progression of coronary artery disease. Vitamin D deficiency appears to be a modifiable risk factor for cardiovascular diseases. This study aimed to analyze the impact of 25-hydroxyvitamin D3 (25(OH)D) level on the severity of coronary atherosclerosis and its potential cardioprotective effect in postmenopausal women. Material and Methods: The study prospectively recruited 351 women in postmenopausal age undergoing coronary angiography. The severity of coronary atherosclerosis was assessed using the Coronary Artery Surgery Study Score (CASSS). A level of 25(OH)D was measured with electrochemiluminescence. Results: Women with more severe coronary atherosclerosis have significantly lower 25(OH)D serum level ( p = 0.0001). Vitamin D (β = −0.02; p = 0.016), hypertension (β = 0.44; p = 0.025), age (β = 0.02; p = 0.003), and history of MI (β = 0.63; p < 0.0001), were shown as CASSS determinants. Age, hyperlipidemia, and history of MI were found to determine the level of vitamin D (all p < 0.05). Women with a three-vessel disease hospitalized due to ACS, with a history of MI, hyperlipidemia and hypertension presented the lowest vitamin D level. Conclusions: Our study showed that lower serum 25(OH)D in postmenopausal women is associated with more significant stenosis in the coronary arteries. Therefore, we suggest considering low vitamin D level as a potential risk factor for coronary artery disease.
    Keywords 25(OH)D ; atherosclerosis ; coronary artery disease ; Coronary Artery Surgery Study ; estrogen deficiency ; myocardial infarction ; Biology (General) ; QH301-705.5
    Subject code 610
    Language English
    Publishing date 2021-11-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: MTARC1

    Kalinowski, Piotr / Smyk, Wiktor / Nowosad, Małgorzata / Paluszkiewicz, Rafał / Michałowski, Łukasz / Ziarkiewicz-Wróblewska, Bogna / Weber, Susanne N / Milkiewicz, Piotr / Lammert, Frank / Zieniewicz, Krzysztof / Krawczyk, Marcin

    International journal of molecular sciences

    2022  Volume 23, Issue 24

    Abstract: The severity of hepatic steatosis is modulated by genetic variants, such as patatin-like phospholipase domain containing 3 ( ...

    Abstract The severity of hepatic steatosis is modulated by genetic variants, such as patatin-like phospholipase domain containing 3 (
    Language English
    Publishing date 2022-12-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms232415825
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  8. Article: Serum Level of Vitamin D Is Associated with Severity of Coronary Atherosclerosis in Postmenopausal Women

    Dziedzic, Ewelina Anna / Smyk, Wiktor / Sowińska, Izabela / Dąbrowski, Marek / Jankowski, Piotr

    Biology. 2021 Nov. 05, v. 10, no. 11

    2021  

    Abstract: Background: Postmenopausal women experience rapid progression of coronary artery disease. Vitamin D deficiency appears to be a modifiable risk factor for cardiovascular diseases. This study aimed to analyze the impact of 25-hydroxyvitamin D3 (25(OH)D) ... ...

    Abstract Background: Postmenopausal women experience rapid progression of coronary artery disease. Vitamin D deficiency appears to be a modifiable risk factor for cardiovascular diseases. This study aimed to analyze the impact of 25-hydroxyvitamin D3 (25(OH)D) level on the severity of coronary atherosclerosis and its potential cardioprotective effect in postmenopausal women. Material and Methods: The study prospectively recruited 351 women in postmenopausal age undergoing coronary angiography. The severity of coronary atherosclerosis was assessed using the Coronary Artery Surgery Study Score (CASSS). A level of 25(OH)D was measured with electrochemiluminescence. Results: Women with more severe coronary atherosclerosis have significantly lower 25(OH)D serum level (p = 0.0001). Vitamin D (β = −0.02; p = 0.016), hypertension (β = 0.44; p = 0.025), age (β = 0.02; p = 0.003), and history of MI (β = 0.63; p < 0.0001), were shown as CASSS determinants. Age, hyperlipidemia, and history of MI were found to determine the level of vitamin D (all p < 0.05). Women with a three-vessel disease hospitalized due to ACS, with a history of MI, hyperlipidemia and hypertension presented the lowest vitamin D level. Conclusions: Our study showed that lower serum 25(OH)D in postmenopausal women is associated with more significant stenosis in the coronary arteries. Therefore, we suggest considering low vitamin D level as a potential risk factor for coronary artery disease.
    Keywords 25-hydroxycholecalciferol ; angiography ; blood serum ; cardioprotective effect ; coronary artery disease ; coronary vessels ; electrochemiluminescence ; hyperlipidemia ; hypertension ; postmenopause ; risk factors ; surgery
    Language English
    Dates of publication 2021-1105
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2661517-4
    ISSN 2079-7737
    ISSN 2079-7737
    DOI 10.3390/biology10111139
    Database NAL-Catalogue (AGRICOLA)

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  9. Article ; Online: COVID-19 and non-alcoholic fatty liver disease: Two intersecting pandemics.

    Portincasa, Piero / Krawczyk, Marcin / Smyk, Wiktor / Lammert, Frank / Di Ciaula, Agostino

    European journal of clinical investigation

    2020  Volume 50, Issue 10, Page(s) e13338

    Abstract: Background: Initial evidence from China suggests that most vulnerable subjects to COVID-19 infection suffer from pre-existing illness, including metabolic abnormalities. The pandemic characteristics and high-lethality rate of COVID-19 infection have ... ...

    Abstract Background: Initial evidence from China suggests that most vulnerable subjects to COVID-19 infection suffer from pre-existing illness, including metabolic abnormalities. The pandemic characteristics and high-lethality rate of COVID-19 infection have raised concerns about interactions between virus pathobiology and components of the metabolic syndrome.
    Methods: We harmonized the information from the recent existing literature on COVID-19 acute pandemic and mechanisms of damage in non-alcoholic fatty liver disease (NAFLD), as an example of chronic (non-communicable) metabolic pandemic.
    Results: COVID-19-infected patients are more fragile with underlying metabolic illness, including hypertension, cardiovascular disease, type 2 diabetes, chronic lung diseases (e.g. asthma, chronic obstructive pulmonary disease and emphysema) and metabolic syndrome. During metabolic abnormalities, expansion of metabolically active fat ('overfat condition') parallels chronic inflammatory changes, development of insulin resistance and accumulation of fat in configuring NAFLD. The deleterious interplay of inflammatory pathways chronically active in NAFLD and acutely in COVID-19-infected patients, can explain liver damage in a subgroup of patients and might condition a worse outcome in metabolically compromised NAFLD patients. In a subgroup of patients with NAFLD, the underlying liver fibrosis might represent an additional and independent risk factor for severe COVID-19 illness, irrespective of metabolic comorbidities.
    Conclusions: NAFLD can play a role in the outcome of COVID-19 illness due to frequent association with comorbidities. Initial evidences suggest that increased liver fibrosis in NAFLD might affect COVID-19 outcome. In addition, long-term monitoring of post-COVID-19 NAFLD patients is advisable, to document further deterioration of liver damage. Further studies are required in this field.
    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; Coronavirus Infections/immunology ; Coronavirus Infections/metabolism ; Cytokine Release Syndrome/immunology ; Humans ; Inflammation/immunology ; Insulin Resistance ; Liver/immunology ; Liver/metabolism ; Metabolic Syndrome/epidemiology ; Metabolic Syndrome/immunology ; Metabolic Syndrome/metabolism ; Non-alcoholic Fatty Liver Disease/epidemiology ; Non-alcoholic Fatty Liver Disease/immunology ; Non-alcoholic Fatty Liver Disease/metabolism ; Pandemics ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/immunology ; Pneumonia, Viral/metabolism ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-08-26
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 186196-7
    ISSN 1365-2362 ; 0014-2972 ; 0960-135X
    ISSN (online) 1365-2362
    ISSN 0014-2972 ; 0960-135X
    DOI 10.1111/eci.13338
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  10. Article ; Online: COVID-19: Focus on the lungs but do not forget the gastrointestinal tract.

    Smyk, Wiktor / Janik, Maciej K / Portincasa, Piero / Milkiewicz, Piotr / Lammert, Frank / Krawczyk, Marcin

    European journal of clinical investigation

    2020  Volume 50, Issue 9, Page(s) e13276

    Abstract: The coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 was declared in the last weeks as global pandemic. Currently affecting more than 5 000 000 individuals worldwide, COVID-19 is most commonly associated with symptoms caused by the acute ... ...

    Abstract The coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 was declared in the last weeks as global pandemic. Currently affecting more than 5 000 000 individuals worldwide, COVID-19 is most commonly associated with symptoms caused by the acute respiratory distress syndrome (ARDS). As the number of infected individuals increases, we are learning that not only lungs, but also other organs can be affected by the virus. The gastrointestinal symptoms, for example diarrhoea, vomiting, nausea or abdominal pain, are frequent in patients with COVID-19. Moreover, alimentary tract symptoms may precede the respiratory presentation of SARS-CoV-2 infection. This can lead to delayed diagnosis and inappropriate management of infected patients. In addition, SARS-CoV-2 nucleic acid can be detected in faeces of infected patients and rectal swabs are even reported to remain positive for a longer period of time than nasopharyngeal swabs. Here, we aim to provide an update on the gastrointestinal involvement of COVID-19 presenting the symptoms that can be encountered in infected patients. We address the role of angiotensin-converting enzyme 2 (ACE2), as a functional receptor for SARS-CoV-2, which also was found in the gastrointestinal tract. Finally, we briefly discuss faecal shedding of SARS-CoV-2 and its potential role in the pathogenesis of the disease.
    MeSH term(s) Angiotensin-Converting Enzyme 2 ; Biomarkers/blood ; COVID-19 ; Comorbidity ; Coronavirus Infections/epidemiology ; Coronavirus Infections/physiopathology ; Disease Transmission, Infectious/prevention & control ; Disease Transmission, Infectious/statistics & numerical data ; Female ; Gastrointestinal Diseases/epidemiology ; Gastrointestinal Diseases/physiopathology ; Humans ; Male ; Pandemics/statistics & numerical data ; Peptidyl-Dipeptidase A/blood ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/physiopathology ; Prognosis ; Respiratory Distress Syndrome/diagnostic imaging ; Respiratory Distress Syndrome/epidemiology ; Risk Assessment
    Chemical Substances Biomarkers ; Peptidyl-Dipeptidase A (EC 3.4.15.1) ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
    Keywords covid19
    Language English
    Publishing date 2020-07-05
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 186196-7
    ISSN 1365-2362 ; 0014-2972 ; 0960-135X
    ISSN (online) 1365-2362
    ISSN 0014-2972 ; 0960-135X
    DOI 10.1111/eci.13276
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