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  1. Article ; Online: Letter to editor: Clinical outcomes of acute pancreatitis in COVID-19 hospitalizations in the United States.

    Rao, Adishwar / Agrawal, Akriti / Ali, Hassam / Gangwani, Manesh Kumar / Chandan, Saurabh / Dahiya, Dushyant Singh

    Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.

    2024  

    Language English
    Publishing date 2024-04-13
    Publishing country Switzerland
    Document type Letter
    ZDB-ID 2056680-3
    ISSN 1424-3911 ; 1424-3903
    ISSN (online) 1424-3911
    ISSN 1424-3903
    DOI 10.1016/j.pan.2024.04.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: New-onset diabetes with sodium-glucose cotransporter-2 inhibitors in prediabetes: An updated meta-analysis and possible mechanisms.

    Singh, Awadhesh Kumar / Singh, Akriti / Singh, Ritu

    Diabetes & metabolic syndrome

    2023  Volume 17, Issue 6, Page(s) 102789

    Abstract: Background and aims: A recent systematic review and meta-analysis studied the effect of sodium-glucose cotransporter-2 inhibitors (SGLT2i) on new-onset diabetes (NOD) in adults with prediabetes having chronic kidney disease and heart failure. In light ... ...

    Abstract Background and aims: A recent systematic review and meta-analysis studied the effect of sodium-glucose cotransporter-2 inhibitors (SGLT2i) on new-onset diabetes (NOD) in adults with prediabetes having chronic kidney disease and heart failure. In light of other large randomized controlled trials (RCTs) of SGLT2i published after this meta-analysis that also reported the NOD outcome in adults with prediabetes, it is of interest to update the NOD outcome with SGLT2i.
    Methods: A systemic search in the PubMed and Embase electronic database was made until March 31, 2023, using specific MeSH keywords following PRISMA protocol. Subsequently, we conducted a meta-analysis using the random effects model while applying the inverse variance-weighted averages of pooled logarithmic hazard ratio (HR). Heterogeneity was measured using Higgins I
    Results: This meta-analysis of five RCTs (N = 6752) found a significant reduction in NOD (HR 0.81; 95% CI, 0.69-0.94; P = 0.005) with SGLT2i in adults with prediabetes without any heterogeneity (I
    Conclusions: SGLT2i has the potential to reduce NOD in adults with prediabetes. Since no effect on HbA1c reduction was seen in adults with prediabetes in all five RCTs included in this meta-analysis, it is conceivable that reduction in NOD is not related to the masking of blood glucose exerted by SGLT2i. However, only an adequately powered trial of SGLT2i in people with prediabetes with a sufficient wash-out period will confirm these findings.
    MeSH term(s) Humans ; Blood Glucose ; Prediabetic State/drug therapy ; Sodium-Glucose Transporter 2 Inhibitors/therapeutic use ; Sodium-Glucose Transporter 2 Inhibitors/pharmacology
    Chemical Substances Blood Glucose ; Sodium-Glucose Transporter 2 Inhibitors
    Language English
    Publishing date 2023-05-24
    Publishing country Netherlands
    Document type Meta-Analysis ; Journal Article
    ZDB-ID 2273766-2
    ISSN 1878-0334 ; 1871-4021
    ISSN (online) 1878-0334
    ISSN 1871-4021
    DOI 10.1016/j.dsx.2023.102789
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  3. Article ; Online: Synthesis and Nonlinear Optical Behavior of Thermally Stable Chromophores Based on 9,9-Dimethyl-9

    Shivani / Mishra, Akriti / Kaur, Paramjit / Singh, Kamaljit

    ACS omega

    2022  Volume 7, Issue 43, Page(s) 39045–39060

    Abstract: Improvement in the first hyperpolarizability ( ... ...

    Abstract Improvement in the first hyperpolarizability (β
    Language English
    Publishing date 2022-10-21
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.2c04795
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  4. Article: Cardiovascular and Renal Outcomes With Sodium-Glucose Cotransporter-2 Inhibitors and Dipeptidyl Peptidase-4 Inhibitors Combination Therapy: A Meta-Analysis of Randomized Cardiovascular Outcome Trials.

    Singh, Awadhesh Kumar / Singh, Akriti / Singh, Ritu

    Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists

    2023  Volume 29, Issue 7, Page(s) 509–516

    Abstract: Objective: The cardiovascular (CV) and renal benefits of sodium-glucose cotransporter-2 inhibitors (SGLT2i) in people with type 2 diabetes are well known. However, similar beneficial effects of SGLT2i in combination with dipeptidyl peptidase-4 ... ...

    Abstract Objective: The cardiovascular (CV) and renal benefits of sodium-glucose cotransporter-2 inhibitors (SGLT2i) in people with type 2 diabetes are well known. However, similar beneficial effects of SGLT2i in combination with dipeptidyl peptidase-4 inhibitors (DPP4i) are unknown. It is of interest to explore a trial-level meta-analysis to fill this knowledge gap.
    Methods: A literature search was conducted in the PubMed and Embase databases until January 31, 2023. All CV outcome trials (CVOTs) reporting the CV and renal outcomes of SGLT2i with or without background DPP4i therapy against the placebo were retrieved. A meta-analysis was subsequently conducted by applying the inverse variance-weighted averages of pooled logarithmic hazard ratio using primarily random-effects analysis.
    Results: This meta-analysis showed that the beneficial 3-point major adverse cardiovascular events composite (3 CVOTs; N = 32 418), the composite of CV death or heart failure hospitalization (hHF) (4 CVOTs; N = 37 687), hHF (3 CVOTs; N = 27 545), CV death (4 CVOTs; N = 34 565), and renal outcomes (2 CVOTs; N = 25 406) with SGLT2i were similar with or without background DPP4i therapy against the placebo (P
    Conclusion: Beneficial CV and renal effects of SGLT2i are similar against the placebo regardless of background DPP4i therapy.
    MeSH term(s) Humans ; Dipeptidyl-Peptidase IV Inhibitors/therapeutic use ; Diabetes Mellitus, Type 2/drug therapy ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/prevention & control ; Sodium-Glucose Transporter 2 Inhibitors/therapeutic use ; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases/therapeutic use ; Glucose/therapeutic use ; Sodium/therapeutic use ; Hypoglycemic Agents/therapeutic use ; Heart Failure/chemically induced ; Heart Failure/drug therapy
    Chemical Substances Dipeptidyl-Peptidase IV Inhibitors ; Sodium-Glucose Transporter 2 Inhibitors ; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases (EC 3.4.14.-) ; Glucose (IY9XDZ35W2) ; Sodium (9NEZ333N27) ; Hypoglycemic Agents
    Language English
    Publishing date 2023-04-08
    Publishing country United States
    Document type Meta-Analysis ; Journal Article
    ZDB-ID 1473503-9
    ISSN 1530-891X
    ISSN 1530-891X
    DOI 10.1016/j.eprac.2023.04.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Intralesional methotrexate is effective in the treatment of recalcitrant lesions of tumor stage mycosis fungoides.

    Agrawal, Akriti / Tyagi, Shilpi / Singh, Saurabh

    Dermatologic therapy

    2022  Volume 35, Issue 11, Page(s) e15880

    MeSH term(s) Humans ; Methotrexate ; Mycosis Fungoides/pathology ; Skin Neoplasms/pathology
    Chemical Substances Methotrexate (YL5FZ2Y5U1)
    Language English
    Publishing date 2022-10-10
    Publishing country United States
    Document type Letter
    ZDB-ID 1354801-3
    ISSN 1529-8019 ; 1396-0296
    ISSN (online) 1529-8019
    ISSN 1396-0296
    DOI 10.1111/dth.15880
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  6. Article ; Online: Lymphocytic emperipolesis in breast carcinoma on cytology smears-A curious finding!

    Jindal, Akriti / Kapatia, Gargi / Rana, Manjit Kaur / Singh, Mahendra Pratap

    Cytopathology : official journal of the British Society for Clinical Cytology

    2023  Volume 34, Issue 5, Page(s) 510–511

    Abstract: In this article, we discuss an intimidating finding of lymphocytic emperipolesis which was observed in breast carcinoma cells on cytology smears. ...

    Abstract In this article, we discuss an intimidating finding of lymphocytic emperipolesis which was observed in breast carcinoma cells on cytology smears.
    MeSH term(s) Humans ; Female ; Breast Neoplasms/diagnosis ; Breast Neoplasms/pathology ; Lymphocytes/pathology ; Emperipolesis ; Cytodiagnosis
    Language English
    Publishing date 2023-06-19
    Publishing country England
    Document type Letter
    ZDB-ID 1034190-0
    ISSN 1365-2303 ; 0956-5507 ; 1350-4037
    ISSN (online) 1365-2303
    ISSN 0956-5507 ; 1350-4037
    DOI 10.1111/cyt.13264
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  7. Article ; Online: Mechanical, Modal and Harmonic Behavior Analysis of Jute and Hemp Fiber Reinforced Polymer Composite

    Savendra Pratap Singh / Akriti Dutt / Chetan Kumar Hirwani

    Journal of Natural Fibers, Vol 20, Iss

    2023  Volume 1

    Abstract: In this study, the dynamic structural and mechanical properties of the polymer composite with natural fiber reinforcement have been investigated experimentally and numerically. First of all, three different types, one-, three- and five-layered jute-epoxy ...

    Abstract In this study, the dynamic structural and mechanical properties of the polymer composite with natural fiber reinforcement have been investigated experimentally and numerically. First of all, three different types, one-, three- and five-layered jute-epoxy and hemp-epoxy laminated composite, have been manufactured using the hand lay-up method. The tensile strength, bending strength and shear strength of the fabricated composite material have been investigated experimentally using Universal Testing Machine. The density is measured using a density measurement kit using Archimedes principle. Further, frequency and damping factors are also investigated using a vibration test setup. Later on, the numerical model is developed in finite element-based software ANSYS. Different natural frequency modes and corresponding damping factors have been investigated numerically. The mechanical and structural characteristics obtained experimentally and numerically are analyzed and discussed in detail. From the investigation, it is found that the hemp-epoxy composite has a greater strength and stiffness compared to the jute-epoxy composite, irrespective of the number of fiber layers used. Further, it is also found that with the increase in fiber layers or fiber percentage in the composite, the strength and stiffness of the fabricated composite increase significantly.
    Keywords natural frequency ; composite ; jute and hemp ; damping factor ; mode shape ; harmonic response ; Science ; Q ; Textile bleaching ; dyeing ; printing ; etc ; TP890-933
    Subject code 621
    Language English
    Publishing date 2023-04-01T00:00:00Z
    Publisher Taylor & Francis Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: The spectrum of ABO and rhesus blood group systems in a blood center in Southern Karnataka

    Rashmi Budha / Brilsee Simeon / Satish Belagatti / Akriti Singh

    Acta Medica International, Vol 10, Iss 2, Pp 112-

    2023  Volume 116

    Abstract: Introduction: Hereditary characteristics, such as ABO and Rhesus (Rh) blood group antigens, are helpful for population genetic studies, for settling medicolegal disputes, and most vitally immunologic safety of blood during transfusion. Having firm ... ...

    Abstract Introduction: Hereditary characteristics, such as ABO and Rhesus (Rh) blood group antigens, are helpful for population genetic studies, for settling medicolegal disputes, and most vitally immunologic safety of blood during transfusion. Having firm knowledge of blood grouping is essential for managing the collection of blood banks. It can lower the likelihood of morbidity and mortality brought on by lack of blood in specific areas. The objective of our study was to screen and determine the frequencies of the occurrence of ABO and Rh blood groups among residents from both the urban and rural populations of the South Karnataka region. Materials and Methods: This was a retrospective study. The study was conducted in a blood center and included all the donors from January 17 to December 22. Hemoglobin estimation was estimated by copper sulfate method and ERMA INC-PCE-210 3-Part analyzer. After blood bank validation, Tulip Diagnostics Limited standard anti-sera of anti-A, anti-B, and anti-D were used to conduct antigen–antibody slide agglutination test to determine the ABO grouping and Rh typing following blood donation. Simple percentages were used to report data on the ABO and Rh blood group distribution patterns. Results: Out of 19497 donors, predominant age group was 25–29 years (29.46%). The male:female ratio was 108:1. Voluntary donors (91.03%) were more than replacement donors, with predominant donors being Rh positive. Maximum donors had the blood group O (42.5%), followed by B > A > AB. There were also four Bombay blood group donors in our study. Conclusion: Good knowledge and understanding of blood grouping have an imperative involvement in the management of blood bank inventory. It can help to minimize the morbidity and mortality rate due to lack of blood in a particular geographical area.
    Keywords abo ; blood groups ; donors ; rhesus ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Efficacy and safety of imeglimin in type 2 diabetes: A systematic review and meta-analysis of randomized placebo-controlled trials.

    Singh, Awadhesh Kumar / Singh, Akriti / Singh, Ritu / Misra, Anoop

    Diabetes & metabolic syndrome

    2023  Volume 17, Issue 2, Page(s) 102710

    Abstract: Background & aims: Imeglimin is a novel new oral compound recently approved for treating type 2 diabetes (T2D) in India. We conducted a systematic review and meta-analysis to evaluate the efficacy of imeglimin in people with T2D in the approved dose of ... ...

    Abstract Background & aims: Imeglimin is a novel new oral compound recently approved for treating type 2 diabetes (T2D) in India. We conducted a systematic review and meta-analysis to evaluate the efficacy of imeglimin in people with T2D in the approved dose of 1000 mg twice daily (BID).
    Methods: We systematically searched the database of PubMed until December 20, 2022, and retrieved all published double-blind, randomized, placebo-controlled trials (RCTs) conducted with imeglimin 1000 mg BID, using appropriate keywords and MeSH terms. A meta-analysis was conducted to study the HbA1c lowering effect of imeglimin 1000 mg BID in people with T2D using the Comprehensive meta-analysis (CMA) software Version 3, Biostat Inc. Englewood, NJ, USA.
    Results: Of the seven Phase 2 studies and three Phase 3 studies conducted so far, only three published double-blind RCTs have reported the efficacy and safety of imeglimin 1000 mg BID against the placebo. Our meta-analysis using the random-effects model from two monotherapy studies (n = 360) showed imeglimin 1000 mg BID reduce HbA1c significantly (Δ -0.9%, 95% Confidence Interval [CI], -1.1 to -0.74%; P < 0.0001) against the placebo, without any heterogeneity (I
    Conclusions: This meta-analysis found a significant HbA1c lowering effect of imeglimin in people with T2D with an acceptable tolerability profile. Still, larger and longer studies are needed.
    MeSH term(s) Humans ; Glycated Hemoglobin ; Diabetes Mellitus, Type 2/drug therapy ; Triazines/therapeutic use ; India ; Randomized Controlled Trials as Topic
    Chemical Substances imeglimin (UU226QGU97) ; Glycated Hemoglobin ; Triazines
    Language English
    Publishing date 2023-01-20
    Publishing country Netherlands
    Document type Meta-Analysis ; Systematic Review ; Journal Article ; Review
    ZDB-ID 2273766-2
    ISSN 1878-0334 ; 1871-4021
    ISSN (online) 1878-0334
    ISSN 1871-4021
    DOI 10.1016/j.dsx.2023.102710
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  10. Article ; Online: A split scalp study to evaluate the effects of platelet rich plasma prepared by two different methods in androgenetic alopecia.

    Budania, Anil / Mandal, Saptarshi / Agrawal, Akriti / Lahoria, Utkrist / Pathania, Yashdeep Singh

    The Australasian journal of dermatology

    2023  Volume 64, Issue 2, Page(s) 278–281

    MeSH term(s) Humans ; Scalp ; Alopecia/therapy ; Platelet-Rich Plasma ; Treatment Outcome
    Language English
    Publishing date 2023-04-10
    Publishing country Australia
    Document type Letter
    ZDB-ID 138052-7
    ISSN 1440-0960 ; 0004-8380
    ISSN (online) 1440-0960
    ISSN 0004-8380
    DOI 10.1111/ajd.14030
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