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  1. Article: Possibility of Relapse of COVID19 in Asymptomatic Cases and Risk Assessment.

    Syal, Kirtimaan

    Indian journal of clinical biochemistry : IJCB

    2022  Volume 37, Issue 4, Page(s) 507–508

    Language English
    Publishing date 2022-03-15
    Publishing country India
    Document type Journal Article
    ZDB-ID 1033583-3
    ISSN 0974-0422 ; 0970-1915
    ISSN (online) 0974-0422
    ISSN 0970-1915
    DOI 10.1007/s12291-022-01029-9
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  2. Article ; Online: COVID-19: Herd immunity and convalescent plasma transfer therapy.

    Syal, Kirtimaan

    Journal of medical virology

    2020  Volume 92, Issue 9, Page(s) 1380–1382

    MeSH term(s) COVID-19/immunology ; COVID-19/therapy ; Humans ; Immunity, Herd ; Immunization, Passive
    Keywords covid19
    Language English
    Publishing date 2020-07-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.25870
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  3. Article ; Online: Guidelines on newly identified limitations of diagnostic tools for COVID-19 and consequences.

    Syal, Kirtimaan

    Journal of medical virology

    2020  Volume 93, Issue 4, Page(s) 1837–1842

    Abstract: Coronavirus disease 2019 (COVID-19) caused by coronavirus has spread worldwide and has become the deadliest pandemic of the 21st century. Such rapid spread is predominantly attributed to the poor diagnosis and its asymptomatic transmission. In the ... ...

    Abstract Coronavirus disease 2019 (COVID-19) caused by coronavirus has spread worldwide and has become the deadliest pandemic of the 21st century. Such rapid spread is predominantly attributed to the poor diagnosis and its asymptomatic transmission. In the absence of treatment regime, timely diagnosis is the best available remedy that can restrict its spread. An early diagnosis of COVID-19 is critical for determining the line of treatment and preventing long term complications in the infected subject. Unfortunately, available rapid antigen and antibody kits are known to be erroneous whereas reverse transcription polymerase chain reaction based tests are expensive, viral load dependent and at times inconclusive. In current scenario, the false-negative results imposed a major risk to the individual patient care and also to the efforts for containing the spread at the population level, where as false positives are traumatic for families and can lead to improper treatment resulting in severe complications. In this article, the limitations of available diagnostic procedures have been elaborated and plausible combination approach has been advised.
    MeSH term(s) Antibodies, Viral/blood ; Antigens, Viral/analysis ; COVID-19/diagnosis ; COVID-19 Nucleic Acid Testing/standards ; COVID-19 Serological Testing/standards ; COVID-19 Testing/standards ; False Negative Reactions ; False Positive Reactions ; Humans ; SARS-CoV-2/immunology ; SARS-CoV-2/isolation & purification ; Sensitivity and Specificity ; Specimen Handling
    Chemical Substances Antibodies, Viral ; Antigens, Viral
    Keywords covid19
    Language English
    Publishing date 2020-12-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.26673
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  5. Article ; Online: COVID‐19

    Syal, Kirtimaan

    Journal of Medical Virology

    Herd immunity and convalescent plasma transfer therapy

    2020  Volume 92, Issue 9, Page(s) 1380–1382

    Keywords Virology ; Infectious Diseases ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.25870
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: Newly identified limitations of diagnostic tools for COVID-19 and consequences

    Syal, Kirtimaan

    J. med. virol

    Abstract: COVID-19 caused by coronavirus has spread worldwide and has become the deadliest pandemic of the 21st century. Such rapid spread is predominantly attributed to the poor diagnosis and its asymptomatic transmission. In the absence of treatment regime, ... ...

    Abstract COVID-19 caused by coronavirus has spread worldwide and has become the deadliest pandemic of the 21st century. Such rapid spread is predominantly attributed to the poor diagnosis and its asymptomatic transmission. In the absence of treatment regime, timely diagnosis is the best available remedy that can restrict its spread. An early diagnosis of COVID-19 is critical for determining the line of treatment and preventing long term complications in the infected subject. Unfortunately, available rapid antigen and antibody kits are known to be erroneous whereas RT-PCR based tests are expensive, viral load dependent and at times inconclusive. In current scenario, the false-negative results imposed a major risk to the individual patient care and also to the efforts for containing the spread at the population level, where as false positives are traumatic for families and can lead to improper treatment resulting in severe complications. In this article, the limitations of available diagnostic procedures have been elaborated and plausible combination approach has been advised. This article is protected by copyright. All rights reserved.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #926575
    Database COVID19

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  7. Article ; Online: Novel Method for Quantitative Estimation of Biofilms.

    Syal, Kirtimaan

    Current microbiology

    2017  Volume 74, Issue 10, Page(s) 1194–1199

    Abstract: ... by the proposed protocol. For ease in referring, this method has been described as the Syal method for biofilm ...

    Abstract Biofilm protects bacteria from stress and hostile environment. Crystal violet (CV) assay is the most popular method for biofilm determination adopted by different laboratories so far. However, biofilm layer formed at the liquid-air interphase known as pellicle is extremely sensitive to its washing and staining steps. Early phase biofilms are also prone to damage by the latter steps. In bacteria like mycobacteria, biofilm formation occurs largely at the liquid-air interphase which is susceptible to loss. In the proposed protocol, loss of such biofilm layer was prevented. In place of inverting and discarding the media which can lead to the loss of the aerobic biofilm layer in CV assay, media was removed from the formed biofilm with the help of a syringe and biofilm layer was allowed to dry. The staining and washing steps were avoided, and an organic solvent-tetrahydrofuran (THF) was deployed to dissolve the biofilm, and the absorbance was recorded at 595 nm. The protocol was tested for biofilm estimation of E. coli, B. subtilis and M. smegmatis, and compared with the traditional CV assays. Isoniazid drug molecule, a known inhibitor of M. smegmatis biofilm, was tested and its inhibitory effects were quantified by the proposed protocol. For ease in referring, this method has been described as the Syal method for biofilm quantification. This new method was found to be useful for the estimation of early phase biofilm and aerobic biofilm layer formed at the liquid-air interphase. The biofilms formed by all three tested bacteria-B. subtilis, E. coli and M. smegmatis, were precisely quantified.
    MeSH term(s) Bacterial Physiological Phenomena ; Bacteriological Techniques ; Biofilms/drug effects ; Escherichia coli/drug effects ; Escherichia coli/physiology
    Language English
    Publishing date 2017-07-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 134238-1
    ISSN 1432-0991 ; 0343-8651
    ISSN (online) 1432-0991
    ISSN 0343-8651
    DOI 10.1007/s00284-017-1304-0
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  8. Article ; Online: BCG vaccine fails to prevent the reactivation of latent tuberculosis.

    Syal, Kirtimaan

    Medical hypotheses

    2016  Volume 88, Page(s) 82

    MeSH term(s) Antibiotics, Antitubercular/therapeutic use ; Humans ; Models, Biological ; Tuberculosis/prevention & control ; Vitamin A/therapeutic use ; Vitamin D/therapeutic use
    Chemical Substances Antibiotics, Antitubercular ; Vitamin A (11103-57-4) ; Vitamin D (1406-16-2)
    Language English
    Publishing date 2016-03
    Publishing country United States
    Document type Comment ; Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 193145-3
    ISSN 1532-2777 ; 0306-9877
    ISSN (online) 1532-2777
    ISSN 0306-9877
    DOI 10.1016/j.mehy.2015.11.015
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  9. Article ; Online: Multi epitope vaccine candidate design against

    Devarakonda, Yogeshwar / Reddy, M V N Janaradhan / Neethu, R S / Chandran, Aneesh / Syal, Kirtimaan

    Journal of biomolecular structure & dynamics

    2023  Volume 41, Issue 22, Page(s) 12654–12667

    Abstract: Streptococcus pneumonia, ...

    Abstract Streptococcus pneumonia,
    MeSH term(s) Child ; Humans ; Amino Acid Sequence ; Epitopes, T-Lymphocyte ; Vaccines, Subunit ; Streptococcus pneumoniae ; Epitopes, B-Lymphocyte ; Computational Biology ; Molecular Docking Simulation
    Chemical Substances Epitopes, T-Lymphocyte ; Vaccines, Subunit ; Epitopes, B-Lymphocyte
    Language English
    Publishing date 2023-01-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 49157-3
    ISSN 1538-0254 ; 0739-1102
    ISSN (online) 1538-0254
    ISSN 0739-1102
    DOI 10.1080/07391102.2023.2167123
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  10. Article: An Unusual Presentation of Superior Mesenteric Venous Occlusion in Mild COVID-19.

    Batra, Sakshi / Nair, Asha G / Syal, Kirtimaan

    Indian journal of clinical biochemistry : IJCB

    2022  Volume 38, Issue 2, Page(s) 275–278

    Abstract: SARS-CoV-2, an etiological agent of COVID-19, has been reported to inflict remarkably diverse manifestations in different subjects across the globe. Though patients with COVID-19 predominantly have fever, respiratory and constitutional symptoms, atypical ...

    Abstract SARS-CoV-2, an etiological agent of COVID-19, has been reported to inflict remarkably diverse manifestations in different subjects across the globe. Though patients with COVID-19 predominantly have fever, respiratory and constitutional symptoms, atypical presentations are becoming increasingly evident. COVID-19 may predispose to both venous and arterial thromboembolism due to excessive inflammation, hypoxia, immobilization, and diffuse intravascular coagulation in moderate to severe symptomatic cases. In this case report, we are reporting thromboembolic complications of COVID-19 in a mild symptomatic subject incidentally diagnosed with mesenteric venous occlusion with no abdominal symptoms. Early recognition of the abdominal symptoms, diagnosis, initiation of anticoagulants, and timely surgical intervention may improvise the outcome in a patient with COVID-19 infection-induced mesenteric thrombosis. Superior mesenteric artery and venous thrombosis may lead to subsequent ischemia necessitating emergency laparotomy. Thus, the usage of low-dose anticoagulants in all the patients of COVID-19 irrespective of the categorization into mild, moderate, and severe COVID-19 disease should be considered.
    Language English
    Publishing date 2022-08-10
    Publishing country India
    Document type Case Reports
    ZDB-ID 1033583-3
    ISSN 0974-0422 ; 0970-1915
    ISSN (online) 0974-0422
    ISSN 0970-1915
    DOI 10.1007/s12291-022-01067-3
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