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  1. Book ; Online: Personalized medicine in epidemics

    Middelburg, Rutger A.

    2022  

    Author's details Editor Rutger A. Middelburg
    Keywords Medicine ; Pharmacology ; diabetes mellitus ; cluster analyses ; risk factors ; micro- and macrovascular disease ; hyperuricemia ; sex ; renal progression ; chronic kidney disease ; disability ; children ; oral health ; caries ; dental treatment ; personalized medicine ; precision medicine ; Covid-19 ; SARS CoV2 ; epidemiology ; host genetics ; viral genome ; early diagnosis ; type 1 diabetes mellitus ; COVID-19 ; epidemics ; diabetic ketoacidosis ; hypertension and type 2 diabetes mellitus comorbidity ; IgG ; N-glycosylation ; biomarkers ; tongue pressure ; aging ; community ; elderly ; tuberculosis ; pulmonary function ; respiratory symptoms ; quality of life ; hepatitis C virus ; diffuse large B-cell lymphoma ; survival ; fibrosis ; performance status ; liver toxicity ; abdominal adiposity ; adolescents ; blood pressure ; obesity ; Jordan ; boys ; lung cancer screening ; smoking ; willingness to screen ; education ; n/a
    Language English
    Size 1 Online-Ressource (ix, 147 Seiten), Illustrationen, Diagramme
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel
    Publishing country Switzerland
    Document type Book ; Online
    Note Printed edition of the special issue published in "Journal of personalized medicine" ; Open Access
    HBZ-ID HT021462017
    ISBN 978-3-0365-4207-2 ; 9783036542089 ; 3-0365-4207-8 ; 3036542086
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online: Personalized Medicine in Epidemics

    Middelburg, Rutger A.

    2022  

    Keywords Medicine ; Pharmacology ; diabetes mellitus ; cluster analyses ; risk factors ; micro- and macrovascular disease ; hyperuricemia ; sex ; renal progression ; chronic kidney disease ; disability ; children ; oral health ; caries ; dental treatment ; personalized medicine ; precision medicine ; Covid-19 ; SARS CoV2 ; epidemiology ; host genetics ; viral genome ; early diagnosis ; type 1 diabetes mellitus ; COVID-19 ; epidemics ; diabetic ketoacidosis ; hypertension and type 2 diabetes mellitus comorbidity ; IgG ; N-glycosylation ; biomarkers ; tongue pressure ; aging ; community ; elderly ; tuberculosis ; pulmonary function ; respiratory symptoms ; quality of life ; hepatitis C virus ; diffuse large B-cell lymphoma ; survival ; fibrosis ; performance status ; liver toxicity ; abdominal adiposity ; adolescents ; blood pressure ; obesity ; Jordan ; boys ; lung cancer screening ; smoking ; willingness to screen ; education ; n/a
    Language 0|e
    Size 1 electronic resource (160 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021610247
    ISBN 9783036542072 ; 3036542078
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article: Personalized Medicine in Epidemics.

    Middelburg, Rutger A

    Journal of personalized medicine

    2022  Volume 12, Issue 4

    Abstract: Before you lies the Special Issue "Personalized Medicine in Epidemics" [ ... ]. ...

    Abstract Before you lies the Special Issue "Personalized Medicine in Epidemics" [...].
    Language English
    Publishing date 2022-04-05
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm12040583
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Personalized Medicine in Epidemics

    Rutger A. Middelburg

    Journal of Personalized Medicine, Vol 12, Iss 4, p

    2022  Volume 583

    Abstract: Before you lies the Special Issue “Personalized Medicine in Epidemics” [.] ...

    Abstract Before you lies the Special Issue “Personalized Medicine in Epidemics” [.]
    Keywords n/a ; Medicine ; R
    Language English
    Publishing date 2022-04-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: COVID-19: How to make between-country comparisons.

    Middelburg, Rutger A / Rosendaal, Frits R

    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

    2020  Volume 96, Page(s) 477–481

    Abstract: Background: Different countries have adopted different containment and testing strategies for SARS-CoV-2. The difference in testing makes it difficult to compare the effect of different containment strategies. This study proposes methods to allow a ... ...

    Abstract Background: Different countries have adopted different containment and testing strategies for SARS-CoV-2. The difference in testing makes it difficult to compare the effect of different containment strategies. This study proposes methods to allow a direct comparison and presents the results.
    Design: Publicly available data on the numbers of reported COVID-19-related deaths between 01 January and 17 April 2020 were compared between countries.
    Results: The numbers of cases or deaths per 100,000 inhabitants gave severely biased comparisons between countries. Only the number of deaths expressed as a percentage of the number of deaths on day 25 after the first reported COVID-19-related death allowed a direct comparison between countries. From this comparison clear differences were observed between countries, associated with the timing of the implementation of containment measures.
    Conclusions: Comparisons between countries are only possible when simultaneously taking into account that the virus does not arrive in all countries simultaneously, absolute numbers are incomparable due to different population sizes, rates per 100,000 of the population are incomparable because not all countries are affected homogeneously, susceptibility to death by COVID-19 can differ between populations, and a death is only reported as a COVID-19-related death if the patient was diagnosed with SARS-CoV-2 infection. With the current methods, all these factors were accounted for and an unbiased direct comparison between countries was established. This comparison confirmed that early adoption of containment strategies is key in flattening the curve of the epidemic.
    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; Humans ; Pandemics ; Pneumonia, Viral/epidemiology ; Population Density ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-05-26
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 1331197-9
    ISSN 1878-3511 ; 1201-9712
    ISSN (online) 1878-3511
    ISSN 1201-9712
    DOI 10.1016/j.ijid.2020.05.066
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4516: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: COVID-19

    Middelburg, Rutger A. / Rosendaal, Frits R.

    International Journal of Infectious Diseases

    How to make between-country comparisons

    2020  Volume 96, Page(s) 477–481

    Keywords Microbiology (medical) ; Infectious Diseases ; General Medicine ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 1331197-9
    ISSN 1878-3511 ; 1201-9712
    ISSN (online) 1878-3511
    ISSN 1201-9712
    DOI 10.1016/j.ijid.2020.05.066
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    ab Jg. 2022: Lesesaal (EG)

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  7. Article: COVID-19: How to make between-country comparisons

    Middelburg, Rutger A / Rosendaal, Frits R

    Int J Infect Dis

    Abstract: BACKGROUND: Different countries have adopted different containment and testing strategies for SARS-CoV-2. The difference in testing makes it difficult to compare the effect of different containment strategies. This study proposes methods to allow a ... ...

    Abstract BACKGROUND: Different countries have adopted different containment and testing strategies for SARS-CoV-2. The difference in testing makes it difficult to compare the effect of different containment strategies. This study proposes methods to allow a direct comparison and presents the results. DESIGN: Publicly available data on the numbers of reported COVID-19-related deaths between 01 January and 17 April 2020 were compared between countries. RESULTS: The numbers of cases or deaths per 100,000 inhabitants gave severely biased comparisons between countries. Only the number of deaths expressed as a percentage of the number of deaths on day 25 after the first reported COVID-19-related death allowed a direct comparison between countries. From this comparison clear differences were observed between countries, associated with the timing of the implementation of containment measures. CONCLUSIONS: Comparisons between countries are only possible when simultaneously taking into account that the virus does not arrive in all countries simultaneously, absolute numbers are incomparable due to different population sizes, rates per 100,000 of the population are incomparable because not all countries are affected homogeneously, susceptibility to death by COVID-19 can differ between populations, and a death is only reported as a COVID-19-related death if the patient was diagnosed with SARS-CoV-2 infection. With the current methods, all these factors were accounted for and an unbiased direct comparison between countries was established. This comparison confirmed that early adoption of containment strategies is key in flattening the curve of the epidemic.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #32470605
    Database COVID19

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  8. Article ; Online: COVID-19

    Middelburg, Rutger A. / Rosendaal, Frits R.

    reponame:Expeditio Repositorio Institucional UJTL ; instname:Universidad de Bogotá Jorge Tadeo Lozano

    How to make between-country comparisons

    2020  

    Abstract: Background: Different countries have adopted different containment and testing strategies for SARS-CoV2. The difference in testing makes it difficult to compare the effect of different containment strategies. This study proposes methods to allow a direct ...

    Abstract Background: Different countries have adopted different containment and testing strategies for SARS-CoV2. The difference in testing makes it difficult to compare the effect of different containment strategies. This study proposes methods to allow a direct comparison and presents the results. Design: Publicly available data on the numbers of reported COVID-19-related deaths between 01 January and 17 April 2020 were compared between countries. Results: The numbers of cases or deaths per 100,000 inhabitants gave severely biased comparisons between countries. Only the number of deaths expressed as a percentage of the number of deaths on day 25 after the first reported COVID-19-related death allowed a direct comparison between countries. From this comparison clear differences were observed between countries, associated with the timing of the implementation of containment measures. Conclusions: Comparisons between countries are only possible when simultaneously taking into account that the virus does not arrive in all countries simultaneously, absolute numbers are incomparable due to different population sizes, rates per 100,000 of the population are incomparable because not all countries are affected homogeneously, susceptibility to death by COVID-19 can differ between populations, and a death is only reported as a COVID-19-related death if the patient was diagnosed with SARS-CoV-2 infection. With the current methods, all these factors were accounted for and an unbiased direct comparison between countries was established. This comparison confirmed that early adoption of containment strategies is key in flattening the curve of the epidemic
    Keywords COVID-19 ; Forecast ; Prevention ; Mortality ; Síndrome respiratorio agudo grave ; SARS-CoV-2 ; Coronavirus ; covid19
    Publisher Science Direct
    Publishing country co
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: COVID-19

    Rutger A. Middelburg / Frits R. Rosendaal

    International Journal of Infectious Diseases, Vol 96, Iss , Pp 477-

    How to make between-country comparisons

    2020  Volume 481

    Abstract: Background: Different countries have adopted different containment and testing strategies for SARS-CoV-2. The difference in testing makes it difficult to compare the effect of different containment strategies. This study proposes methods to allow a ... ...

    Abstract Background: Different countries have adopted different containment and testing strategies for SARS-CoV-2. The difference in testing makes it difficult to compare the effect of different containment strategies. This study proposes methods to allow a direct comparison and presents the results. Design: Publicly available data on the numbers of reported COVID-19-related deaths between 01 January and 17 April 2020 were compared between countries. Results: The numbers of cases or deaths per 100,000 inhabitants gave severely biased comparisons between countries. Only the number of deaths expressed as a percentage of the number of deaths on day 25 after the first reported COVID-19-related death allowed a direct comparison between countries. From this comparison clear differences were observed between countries, associated with the timing of the implementation of containment measures. Conclusions: Comparisons between countries are only possible when simultaneously taking into account that the virus does not arrive in all countries simultaneously, absolute numbers are incomparable due to different population sizes, rates per 100,000 of the population are incomparable because not all countries are affected homogeneously, susceptibility to death by COVID-19 can differ between populations, and a death is only reported as a COVID-19-related death if the patient was diagnosed with SARS-CoV-2 infection. With the current methods, all these factors were accounted for and an unbiased direct comparison between countries was established. This comparison confirmed that early adoption of containment strategies is key in flattening the curve of the epidemic.
    Keywords COVID-19 ; Forecast ; Prevention ; Mortality ; Infectious and parasitic diseases ; RC109-216 ; covid19
    Subject code 630
    Language English
    Publishing date 2020-07-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  10. Article ; Online: Transfusion of ever-pregnant donor red blood cells and mortality of male patients.

    Valk, Sarah J / Caram-Deelder, Camila / Groenwold, Rolf H H / Evers, Dorothea / De Vooght, Karen M K / Van de Kerkhof, Daan / Wondergem, Marielle J / Péquériaux, Nathalie C V / Hudig, Francisca / Zwaginga, Jaap Jan / Middelburg, Rutger A / Van der Bom, Johanna G

    Haematologica

    2024  

    Abstract: Previous studies found exposure to red blood cell transfusions from female donors who have been pregnant reduces survival in male patients compared to exposure to male donor products, but evidence is not consistent. We postulate the previously observed ... ...

    Abstract Previous studies found exposure to red blood cell transfusions from female donors who have been pregnant reduces survival in male patients compared to exposure to male donor products, but evidence is not consistent. We postulate the previously observed association is modified by offspring sex, with an expected increased mortality risk for male patients receiving units from female donors with sons. Here, marginal structural models were used to assess the association between exposure to units from ever-pregnant donors, ever-pregnant donors with sons and ever-pregnant donors with daughters, and mortality. Clinical data were collected on first-ever transfusion recipients in the Netherlands and donor data were supplemented with information about offspring sex and date of birth. In this analysis, 56,825 patients were included, of whom 8,288 died during follow-up. Exposure to red blood cell units from everpregnant donors with sons was not associated with increased all-cause mortality risk among male transfusion recipients (hazard ratio [HR] 0.91, 95% confidence interval 0.83-1.01). Exposure to ever-pregnant donors, irrespective of offspring sex, was associated with mortality in male patients aged between 18 and 50 years (ever-pregnant donors: HR 1.81, 95% CI 1.31-2.51) compared to male donor units, but was protective in female patients. This study suggests that the observed increased mortality risk for exposure to red blood cell units from parous female donors does not depend on offspring sex. The increased risk of mortality seen in younger adult male patients is consistent with previous observations, but the underlying biological mechanism could not be identified in this study.
    Language English
    Publishing date 2024-02-22
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2333-4
    ISSN 1592-8721 ; 0017-6567 ; 0390-6078
    ISSN (online) 1592-8721
    ISSN 0017-6567 ; 0390-6078
    DOI 10.3324/haematol.2023.283550
    Database MEDical Literature Analysis and Retrieval System OnLINE

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