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  1. Article ; Online: Equity in patient care in the intensive care unit.

    Kotfis, Katarzyna / Olusanya, Segun / Modra, Lucy

    Intensive care medicine

    2024  Volume 50, Issue 2, Page(s) 291–293

    MeSH term(s) Humans ; Intensive Care Units ; Patient Care
    Language English
    Publishing date 2024-01-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0340-0964 ; 0342-4642 ; 0935-1701
    DOI 10.1007/s00134-023-07310-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1089: Show issues Location:
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  2. Article ; Online: Discussions on VT4COVID.

    Boncyk, Christina / Kotfis, Katarzyna / Ely, E Wesley

    The Lancet. Respiratory medicine

    2023  Volume 11, Issue 11, Page(s) e89

    Language English
    Publishing date 2023-05-14
    Publishing country England
    Document type Letter
    ZDB-ID 2686754-0
    ISSN 2213-2619 ; 2213-2600
    ISSN (online) 2213-2619
    ISSN 2213-2600
    DOI 10.1016/S2213-2600(23)00343-0
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  3. Article ; Online: Intensive care unit delirium-a decade of learning.

    Kotfis, Katarzyna / Ely, E Wesley / Shehabi, Yahya

    The Lancet. Respiratory medicine

    2023  Volume 11, Issue 7, Page(s) 584–586

    MeSH term(s) Humans ; Intensive Care Units ; Risk Factors ; Delirium/etiology ; Critical Care
    Language English
    Publishing date 2023-07-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2686754-0
    ISSN 2213-2619 ; 2213-2600
    ISSN (online) 2213-2619
    ISSN 2213-2600
    DOI 10.1016/S2213-2600(23)00222-9
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  4. Article: Editorial: The ABCDEF bundle: Laying the foundations for long term wellness in ICU survivors.

    Vargas, Maria / Buonanno, Pasquale / Kotfis, Katarzyna / Marra, Annachiara

    Frontiers in medicine

    2022  Volume 9, Page(s) 1056056

    Language English
    Publishing date 2022-10-21
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2022.1056056
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  5. Article ; Online: Cardiovascular-Kidney-Metabolic Syndrome: Association with Adverse Events After Major Noncardiac Surgery.

    Roth, Sebastian / M'Pembele, René / Matute, Purificación / Kotfis, Katarzyna / Larmann, Jan / Lurati Buse, Giovanna

    Anesthesia and analgesia

    2024  

    Abstract: Background: The American Heart Association (AHA) recently defined the cardiovascular-kidney-metabolic syndrome (CKM) as a new entity to address the complex interactions between heart, kidneys, and metabolism. The aim of this study was to assess the ... ...

    Abstract Background: The American Heart Association (AHA) recently defined the cardiovascular-kidney-metabolic syndrome (CKM) as a new entity to address the complex interactions between heart, kidneys, and metabolism. The aim of this study was to assess the outcome impact of CKM syndrome in patients undergoing noncardiac surgery.
    Methods: This is a secondary analysis of a prospective international cohort study including patients aged ≥45 years with increased cardiovascular risk undergoing noncardiac surgery. Main exposure was CKM syndrome according to the AHA definition. The primary end point was a composite of major adverse cardiovascular events (MACE) 30 days after surgery. Secondary end points included all-cause mortality and non-MACE complications (Clavien-Dindo class ≥3).
    Results: This analysis included 14,634 patients (60.8% male, mean age = 72±8 years). MACE occurred in 308 patients (2.1%), and 335 patients (2.3%) died. MACE incidence by CKM stage was as follows: CKM 0: 5/367 = 1.4% (95% confidence interval [CI], 0.4%-3.2%); CKM 1: 3/367 = 0.8% (95% CI, 0.2%-2.4%); CKM 2: 102/7440 = 1.4% (95% CI, 1.1%-1.7%); CKM 3: 27/953 = 2.8% (95% CI, 1.9%-4.1%); CKM 4a: 164/5357 = 3.1% (95% CI, 2.6%-3.6%); CKM 4b: 7/150 = 4.7% (95% CI, 1.9%-9.4%). In multivariate logistic regression, CKM stage ≥3 was independently associated with MACE, mortality, and non-MACE complications, respectively (MACE: OR 2.26 [95% CI, 1.78-2.87]; mortality: OR 1.42 [95% CI: 1.13 -1.78]; non-MACE complications: OR 1.11 [95% CI: 1.03-1.20]).
    Conclusion: The newly defined CKM syndrome is associated with increased morbidity and mortality after non-cardiac surgery. Thus, cardiovascular, renal, and metabolic disorders should be regarded in mutual context in this setting.
    Language English
    Publishing date 2024-04-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80032-6
    ISSN 1526-7598 ; 0003-2999
    ISSN (online) 1526-7598
    ISSN 0003-2999
    DOI 10.1213/ANE.0000000000006975
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  6. Article ; Online: Act now! Critical care roles and obligations during an urban war.

    Bielka, Kateryna / Kotfis, Katarzyna / Poropatich, Ronald / Pinsky, Michael R

    Critical care (London, England)

    2022  Volume 26, Issue 1, Page(s) 65

    MeSH term(s) Critical Care ; Humans
    Language English
    Publishing date 2022-03-21
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2041406-7
    ISSN 1466-609X ; 1364-8535
    ISSN (online) 1466-609X
    ISSN 1364-8535
    DOI 10.1186/s13054-022-03951-z
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    Zs.A 5517: Show issues Location:
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  7. Article ; Online: COVID-19: gastrointestinal symptoms and potential sources of SARS-CoV-2 transmission.

    Kotfis, Katarzyna / Skonieczna-Żydecka, Karolina

    Anaesthesiology intensive therapy

    2020  Volume 52, Issue 2, Page(s) 171–172

    MeSH term(s) Angiotensin-Converting Enzyme 2 ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/complications ; Coronavirus Infections/etiology ; Coronavirus Infections/transmission ; Gastrointestinal Diseases/etiology ; Humans ; Liver Diseases/etiology ; Pandemics ; Peptidyl-Dipeptidase A/physiology ; Pneumonia, Viral/complications ; Pneumonia, Viral/etiology ; Pneumonia, Viral/transmission ; SARS-CoV-2
    Chemical Substances Peptidyl-Dipeptidase A (EC 3.4.15.1) ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
    Keywords covid19
    Language English
    Publishing date 2020-03-12
    Publishing country Poland
    Document type Letter
    ISSN 1731-2531
    ISSN (online) 1731-2531
    DOI 10.5114/ait.2020.93867
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  8. Article ; Online: The spectrum of psychological disorders in family members of patients suffering from delirium associated with critical illness: a prospective, observational study.

    Kotfis, Katarzyna / Maj, Patrycja / Szylińska, Aleksandra / Pankowiak, Maria / Reszka, Elżbieta / Ely, E Wesley / Marra, Annachiara

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 4562

    Abstract: During intensive care unit admission, relatives of critically ill patients can experience emotional distress. The authors hypothesized that families of patients who are diagnosed with intensive care unit (ICU) delirium experience more profound depression ...

    Abstract During intensive care unit admission, relatives of critically ill patients can experience emotional distress. The authors hypothesized that families of patients who are diagnosed with intensive care unit (ICU) delirium experience more profound depression and anxiety disorders related to stress than do families of patients without delirium. We performed a prospective observational single-center study including families of adult patients (age above 18 years) hospitalized in a 17-bed ICU of a university hospital for at least 48 h who completed research questionnaires at day 2 after admission and day 30 after initial evaluation using dedicated questionnaires (HADS, CECS, IES, PTSD-C). A total of 98 family members of patients hospitalized in the ICU were included in the final analysis (50 family members whose relatives were CAM-ICU positive (DEL+), and 48 family members of patients without delirium (DEL-)). No statistically significant differences in demographics and psychosocial data were found between the groups. In the follow-up 30 days after the first conversation with a family member, the mean PTSD score for the relatives of patients with delirium was 11.02 (Me = 13.0; SD = 5.74), and the mean score for nondelirious patients' family members was 6.42 (Me = 5.5; SD = 5.50; p < 0.001). A statistically significant increase in IES scores for family members of patients with delirium was observed for total PTSD (p = 0.001), IES-intrusion (p < 0.001), and IES-hyperarousal (p = 0.002). The prevalence of anxiety symptoms, depression, and posttraumatic stress disorder (PTSD) was higher in families of patients diagnosed with ICU delirium within 48 h of admission to the ICU. No factors increasing the depth of these disorders in family members of patients with ICU delirium were identified. Taking appropriate actions and thus providing families with appropriate support will contribute to the understanding of unfavorable emotional states, including anxiety, stress, depression, anger, agitation, or avoidance.
    MeSH term(s) Adult ; Humans ; Adolescent ; Critical Illness/psychology ; Prospective Studies ; Anxiety/epidemiology ; Anxiety/psychology ; Stress Disorders, Post-Traumatic/psychology ; Intensive Care Units ; Family/psychology ; Delirium/epidemiology ; Depression/epidemiology ; Depression/psychology
    Language English
    Publishing date 2024-02-24
    Publishing country England
    Document type Observational Study ; Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-53968-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Concentration of Apoptotic Factors in Bronchoalveolar Lavage Fluid, as Potential Brain-Lung Oxygen Relationship, Correspond to the Severity of Brain Injury.

    Siwicka-Gieroba, Dorota / Terpilowska, Sylwia / Robba, Chiara / Kotfis, Katarzyna / Wojcik-Zaluska, Alicja / Dabrowski, Wojciech

    Journal of integrative neuroscience

    2023  Volume 22, Issue 2, Page(s) 49

    Abstract: Background: The mechanism of acute brain injury initiates a cascade of consequences which can directly cause lung damage, and this can contribute to poor neurological outcomes. The aim of this study was to evaluate concentration of different apoptotic ... ...

    Abstract Background: The mechanism of acute brain injury initiates a cascade of consequences which can directly cause lung damage, and this can contribute to poor neurological outcomes. The aim of this study was to evaluate concentration of different apoptotic molecules in the bronchoalveolar lavage fluid (BALF) in patients after severe brain injury and to correlate them with selected clinical variables and mortality.
    Methods: Patients with brain injury receiving BALF operation were included in the study. BALF samples were collected within the first 6-8 hours after traumatic brain injury (A) and at days 3 (B) and 7 (C) after admission to the intensive care unit (ICU). Changes in the BALF nuclear-encoded protein (Bax), apoptotic regulatory protein (Bcl-2), pro-apoptotic protein (p53) and its upregulated modulator (PUMA), apoptotic protease factor 1 (APAF-1), Bcl-2 associated agonist of cell death (BAD) and caspase-activated DNase (CAD) were analysed. These values were correlated with the selected oxygenation parameters, Rotterdam computed tomography (CT) score, the Glasgow Coma Score and 28-day mortality.
    Results: We found a significant increase in the concentration of selected apoptotic factors at admission (A), at day 3 (B) and day 7 (C) after severe brain damage contrasted with baseline level A (
    Conclusions: Activation of different apoptotic pathways seems to be an important process occurring in the lungs of patients in the early phases after severe brain trauma. Levels of apoptotic factors in the BALF correlates with the severity of brain injury.
    MeSH term(s) Humans ; Bronchoalveolar Lavage Fluid ; Oxygen ; Lung ; Brain Injuries ; Brain ; Proto-Oncogene Proteins c-bcl-2 ; Brain Injuries, Traumatic ; Apoptosis Regulatory Proteins
    Chemical Substances Oxygen (S88TT14065) ; Proto-Oncogene Proteins c-bcl-2 ; Apoptosis Regulatory Proteins
    Language English
    Publishing date 2023-03-30
    Publishing country Singapore
    Document type Journal Article
    ZDB-ID 2136427-8
    ISSN 0219-6352
    ISSN 0219-6352
    DOI 10.31083/j.jin2202049
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  10. Article ; Online: Biomarkers and Mechanisms of Oxidative Stress-Last 20 Years of Research with an Emphasis on Kidney Damage and Renal Transplantation.

    Tejchman, Karol / Kotfis, Katarzyna / Sieńko, Jerzy

    International journal of molecular sciences

    2021  Volume 22, Issue 15

    Abstract: Oxidative stress is an imbalance between pro- and antioxidants that adversely influences the organism in various mechanisms and on many levels. Oxidative damage occurring concomitantly in many cellular structures may cause a deterioration of function, ... ...

    Abstract Oxidative stress is an imbalance between pro- and antioxidants that adversely influences the organism in various mechanisms and on many levels. Oxidative damage occurring concomitantly in many cellular structures may cause a deterioration of function, including apoptosis and necrosis. The damage leaves a molecular "footprint", which can be detected by specific methodology, using certain oxidative stress biomarkers. There is an intimate relationship between oxidative stress, inflammation, and functional impairment, resulting in various diseases affecting the entire human body. In the current narrative review, we strengthen the connection between oxidative stress mechanisms and their active compounds, emphasizing kidney damage and renal transplantation. An analysis of reactive oxygen species (ROS), antioxidants, products of peroxidation, and finally signaling pathways gives a lot of promising data that potentially will modify cell responses on many levels, including gene expression. Oxidative damage, stress, and ROS are still intensively exploited research subjects. We discuss compounds mentioned earlier as biomarkers of oxidative stress and present their role documented during the last 20 years of research. The following keywords and MeSH terms were used in the search: oxidative stress, kidney, transplantation, ischemia-reperfusion injury, IRI, biomarkers, peroxidation, and treatment.
    MeSH term(s) Acute Kidney Injury/history ; Acute Kidney Injury/metabolism ; Acute Kidney Injury/pathology ; Animals ; Biomarkers/metabolism ; History, 21st Century ; Humans ; Kidney/metabolism ; Kidney/pathology ; Kidney Transplantation ; Oxidative Stress ; Reactive Oxygen Species/metabolism ; Reperfusion Injury/history ; Reperfusion Injury/metabolism ; Reperfusion Injury/pathology
    Chemical Substances Biomarkers ; Reactive Oxygen Species
    Language English
    Publishing date 2021-07-27
    Publishing country Switzerland
    Document type Historical Article ; Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms22158010
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