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  1. Article ; Online: SIDS in Saudi Arabia: Reality or Myth?

    Aljerian, Khaldoon

    Fetal and pediatric pathology

    2022  Volume 42, Issue 1, Page(s) 167–170

    MeSH term(s) Humans ; Saudi Arabia/epidemiology ; Sudden Infant Death/epidemiology
    Language English
    Publishing date 2022-03-24
    Publishing country England
    Document type Letter
    ZDB-ID 2165508-X
    ISSN 1551-3823 ; 1551-3815 ; 1522-7952
    ISSN (online) 1551-3823
    ISSN 1551-3815 ; 1522-7952
    DOI 10.1080/15513815.2022.2053917
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2043: Show issues Location:
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  2. Article ; Online: FOXO1

    Aljerian, Khaldoon

    Fetal and pediatric pathology

    2022  Volume 42, Issue 3, Page(s) 385–393

    Abstract: Objective: ...

    Abstract Objective:
    MeSH term(s) Humans ; Rhabdomyosarcoma, Alveolar/diagnosis ; Rhabdomyosarcoma, Alveolar/genetics ; Saudi Arabia ; In Situ Hybridization, Fluorescence ; Translocation, Genetic ; Oncogene Proteins, Fusion/genetics ; Rhabdomyosarcoma ; Forkhead Box Protein O1/genetics ; PAX5 Transcription Factor/genetics
    Chemical Substances Oncogene Proteins, Fusion ; FOXO1 protein, human ; Forkhead Box Protein O1 ; PAX5 protein, human ; PAX5 Transcription Factor
    Language English
    Publishing date 2022-12-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2165508-X
    ISSN 1551-3823 ; 1551-3815 ; 1522-7952
    ISSN (online) 1551-3823
    ISSN 1551-3815 ; 1522-7952
    DOI 10.1080/15513815.2022.2154134
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2043: Show issues Location:
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  3. Article: Benign glandular schwannoma.

    Aljerian, Khaldoon

    Autopsy & case reports

    2022  Volume 12, Page(s) e2021398

    Abstract: We report a case of a benign glandular schwannoma in a 63-year-old male who presented with a solitary subcutaneous mass on the left knee, with no previous history of neurofibromatosis type 1. This histological subtype is rare, with only 38 cases reported ...

    Abstract We report a case of a benign glandular schwannoma in a 63-year-old male who presented with a solitary subcutaneous mass on the left knee, with no previous history of neurofibromatosis type 1. This histological subtype is rare, with only 38 cases reported in the literature. Some of the glands found in this patient resembled sweat glands. These lining stromal spindle cells were positive for S-100 but negative for EMA. S100 was faintly staining the glandular elements. All the glands in the tumor were positive for EMA, particularly at the luminal borders. They were also positive for pancytokeratin. The cystic areas variably show intraluminal, foamy, and hemosiderin-laden macrophages. The different glands expressed two patterns. Some of these were reactive for CK7 and low molecular weight keratin. Immunohistochemical workup is mandatory to assess the neoplastic nature of this glandular component.
    Language English
    Publishing date 2022-09-15
    Publishing country Brazil
    Document type Case Reports
    ZDB-ID 2815488-5
    ISSN 2236-1960
    ISSN 2236-1960
    DOI 10.4322/acr.2021.398
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  4. Article ; Online: EWSR1 rearrangement is not specific for hyalinizing clear cell carcinoma of salivary glands.

    Aljerian, Khaldoon

    Annals of diagnostic pathology

    2022  Volume 59, Page(s) 151946

    Abstract: Objective: In this study, we investigate the molecular rearrangement of EWSR1 in hyalinizing clear cell carcinoma (HCCC) (with and without eosinophilia) and clear cell variant of mucoepidermoid carcinoma (MEC) of salivary glands.: Method: We ... ...

    Abstract Objective: In this study, we investigate the molecular rearrangement of EWSR1 in hyalinizing clear cell carcinoma (HCCC) (with and without eosinophilia) and clear cell variant of mucoepidermoid carcinoma (MEC) of salivary glands.
    Method: We performed a molecular detection of HCCC (Group 1) and clear cell variant of MEC (Group 2). Group 1 consisted of 5 cases of typical HCCC and 5 cases of HCCC with eosinophilia. Group 2 encompassed 5 cases of clear-cell MEC. For both groups, we conducted a FISH analysis using EWSR1 dual color break-apart FISH probe (ZytoLight®, 22q12.2) and MAML2 dual color break-apart FISH probe (ZytoLight®, 11q21).
    Results: All analyzable cases of HCCC with or without eosinophilic components were negative for EWSR1 translocation. All cases of clear-cell MEC were positive for MAML2 translocation. No translocation was observed in HCCC.
    Conclusion: Our study showed that clear cells could cause diagnostic uncertainty and that EWSR1 can be detected in many primary neoplasms of salivary glands and metastatic tumors that were reported in salivary glands. We suggest that recommending EWSR1 as a diagnostic molecular marker for HCCC should be reconsidered.
    MeSH term(s) Adenocarcinoma, Clear Cell/diagnosis ; Adenocarcinoma, Clear Cell/genetics ; Adenocarcinoma, Clear Cell/pathology ; Carcinoma, Mucoepidermoid/diagnosis ; Carcinoma, Mucoepidermoid/genetics ; Humans ; In Situ Hybridization, Fluorescence ; RNA-Binding Protein EWS/genetics ; Salivary Gland Neoplasms/diagnosis ; Salivary Gland Neoplasms/genetics ; Salivary Gland Neoplasms/pathology ; Salivary Glands/pathology ; Transcription Factors ; Translocation, Genetic
    Chemical Substances EWSR1 protein, human ; RNA-Binding Protein EWS ; Transcription Factors
    Language English
    Publishing date 2022-03-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1440011-x
    ISSN 1532-8198 ; 1092-9134
    ISSN (online) 1532-8198
    ISSN 1092-9134
    DOI 10.1016/j.anndiagpath.2022.151946
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    Zs.A 5463: Show issues Location:
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  5. Article ; Online: Saudi physicians' perceptions of the validity of autopsy and its implications - Structural equation modeling.

    Aljerian, Khaldoon

    Journal of forensic and legal medicine

    2022  Volume 86, Page(s) 102320

    Abstract: Introduction: Although autopsy plays a vital role in forensic medicine, the rates have been recently declining around the world. We surveyed all interns and physicians at our hospital to determine how Saudi physicians viewed autopsies with regard to the ...

    Abstract Introduction: Although autopsy plays a vital role in forensic medicine, the rates have been recently declining around the world. We surveyed all interns and physicians at our hospital to determine how Saudi physicians viewed autopsies with regard to the challenges, priorities, and requirements, and also how they felt about autopsy-based research and postmortem examination techniques. The results shed light on how these constructs affected the physician's perception of the implications of autopsy.
    Methods: We prepared a cross-sectional study using a self-administered multiple-choice questionnaire distributed to interns and physicians at our institution. From a population of 596 physicians, we sampled 234. Structural equation modeling was used to assess 6 constructs and their 40 indicators.
    Results: The survey results demonstrated two main barriers for interns and physicians to perform autopsies: respect for the religious beliefs of the families of the deceased and respect for family mourning.
    Conclusion: Measures can be taken to improve autopsy rates, such as training of medical staff in communication and counselling, implementing a streamlined and stress-free process, and increasing public awareness of the benefits of autopsy through campaigns and educational programs. Among the many virtues of educating Saudi physicians and residents about the significance of increasing autopsy rates and familiarizing them with their procedures, developing professional competence among medico-legal experts cannot be overemphasized.
    MeSH term(s) Autopsy ; Cross-Sectional Studies ; Humans ; Latent Class Analysis ; Physicians ; Saudi Arabia ; Surveys and Questionnaires
    Language English
    Publishing date 2022-02-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2268721-X
    ISSN 1878-7487 ; 1752-928X
    ISSN (online) 1878-7487
    ISSN 1752-928X
    DOI 10.1016/j.jflm.2022.102320
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    Zs.A 4217: Show issues Location:
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  6. Article ; Online: Pathologist interobserver variability in diagnosing acute ascending intrauterine infection.

    Aljerian, Khaldoon

    Annals of diagnostic pathology

    2021  Volume 56, Page(s) 151874

    Abstract: The histologic diagnosis of acute ascending intrauterine infection permits a higher-efficacy identification of both subclinical infection and clinical chorioamnionitis, but procedures for placental pathology need to adopt a unified approach and work ... ...

    Abstract The histologic diagnosis of acute ascending intrauterine infection permits a higher-efficacy identification of both subclinical infection and clinical chorioamnionitis, but procedures for placental pathology need to adopt a unified approach and work toward reproducible grading and staging systems. We conducted a retrospective chart review of 696 placental records from single and multiple deliveries between January 2011 and February 2020. Then, we compared original diagnoses with diagnoses based on Redline criteria, which is an internationally recognized system of staging and grading. Of the 696 cases available for review, 255 had complete medical records. Findings showed a strong degree of agreement (90%-100%) between original investigators' histological diagnoses of acute ascending intrauterine infection and a review by researchers using Redline criteria. Although interobserver agreement was good, more education is needed on Redline criteria to avoid missed cases (primarily Stage 1), support protocols for pathologists and obstetricians/gynecologists in determining which cases need to be investigated, and the development of reporting standards for acute ascending intrauterine infection and feedback mechanisms during follow-up.
    MeSH term(s) Chorioamnionitis/diagnosis ; Chorioamnionitis/pathology ; Female ; Humans ; Observer Variation ; Pathologists ; Pregnancy ; Retrospective Studies
    Language English
    Publishing date 2021-12-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1440011-x
    ISSN 1532-8198 ; 1092-9134
    ISSN (online) 1532-8198
    ISSN 1092-9134
    DOI 10.1016/j.anndiagpath.2021.151874
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    Zs.A 5463: Show issues Location:
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  7. Article ; Online: Uterine transplant: an ethical framework analysis from a Middle Eastern perspective.

    Aljerian, Khaldoon

    Current medical research and opinion

    2021  Volume 37, Issue 6, Page(s) 1049–1060

    Abstract: Background: Significant advances in infertility treatment have been achieved over the past several decades, but women with uterine dysfunction, anomaly, or agenesis still need support to carry a pregnancy to term. Recently, advancements in surgical, ... ...

    Abstract Background: Significant advances in infertility treatment have been achieved over the past several decades, but women with uterine dysfunction, anomaly, or agenesis still need support to carry a pregnancy to term. Recently, advancements in surgical, anesthetic and immunosuppressive therapy have brought the idea of successful uterine transplant closer to reality, but many challenges must be overcome before uterine transplant can become more common, including ethical challenges related to the study and the conduct of this procedure.
    Methods: This was an updated ethical analysis of uterine transplant from a Middle Eastern perspective, using an established ethical framework that has been adapted for the analysis of research in non-Western cultures and developing countries.
    Results: Using the ethical framework, this analysis explored research developments in uterine transplant to date, using the following categories: collaborative partnership, social value, scientific validity, a fair selection of study population, favorable risk-benefit ratio, independent review, informed consent, and respect for recruited participants. The analysis revealed a significant need for region- and religion-specific ethical guidelines for uterine transplant procedures.
    Conclusions: The horizons of research need to expand by addressing and researching the ethical issues related to uterine transplant trials and clinical procedures.
    Limitations: Limitations included the challenges related to applying ethical analyses to work in developing countries, and the fact that this analysis was based on the views and interpretations of a single researcher.
    MeSH term(s) Ethical Analysis ; Female ; Humans ; Informed Consent ; Pregnancy ; Risk Assessment
    Language English
    Publishing date 2021-03-31
    Publishing country England
    Document type Journal Article
    ZDB-ID 80296-7
    ISSN 1473-4877 ; 0300-7995
    ISSN (online) 1473-4877
    ISSN 0300-7995
    DOI 10.1080/03007995.2021.1902296
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  8. Article ; Online: Factors Influencing Residents' Specialty Choices and Satisfaction: Impact of Gender, Career Motivation and Life Goals.

    Aljerian, Khaldoon

    Journal of surgical education

    2021  Volume 79, Issue 2, Page(s) 302–308

    Abstract: Objective: Resident physicians working in medical specialties play an essential role in the makeup of the healthcare workforce. However, there is little theoretical understanding of how different medical specialties are perceived or how residents' ... ...

    Abstract Objective: Resident physicians working in medical specialties play an essential role in the makeup of the healthcare workforce. However, there is little theoretical understanding of how different medical specialties are perceived or how residents' choices are made. Many factors can influence resident physicians' choice of specialty. Previous studies have looked at personality differences within specialties, but were unable to describe the heterogeneity of viewpoints that existed within each specialty. Our objective, was to gather information about factors related to resident's life goals and career motivation as a means of improving residency program design and enhancing the college's advisory capacity.
    Design: Our study used a self-report anonymous questionnaire to characterize the relationship between resident physicians' preferences and their choice of specialty.
    Setting: King Saud University & King Saud University Medical City.
    Participants: 353 residents.
    Results: The majority of respondents reported that their current specialty was one of their top three choices. Almost half were satisfied with their residency program, and 24.1% were very satisfied. Gender, specialty, and workload demonstrated significant associations with residency program satisfaction.
    Conclusions: Our findings highlight the effects of career motivation and life goals for resident physicians in enhancing their career satisfaction. Ensuring that residents are able to find time for personal needs has important consequences for their perceptions of wellbeing and may be an effective strategy for promoting career satisfaction.
    MeSH term(s) Career Choice ; Goals ; Humans ; Internship and Residency ; Medicine ; Motivation ; Surveys and Questionnaires
    Language English
    Publishing date 2021-10-23
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2277538-9
    ISSN 1878-7452 ; 1931-7204
    ISSN (online) 1878-7452
    ISSN 1931-7204
    DOI 10.1016/j.jsurg.2021.09.018
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  9. Article ; Online: Chorioamnionitis: Establishing a correlation between clinical and histological diagnosis.

    Aljerian, Khaldoon

    Indian journal of pathology & microbiology

    2020  Volume 63, Issue 1, Page(s) 44–48

    Abstract: Introduction: Chorioamnionitis that is associated with high rates of morbidity and mortality needs an early diagnosis for effective treatment. However, views are conflicting on the effectiveness of a clinical versus a histological diagnosis of the ... ...

    Abstract Introduction: Chorioamnionitis that is associated with high rates of morbidity and mortality needs an early diagnosis for effective treatment. However, views are conflicting on the effectiveness of a clinical versus a histological diagnosis of the disease. The accuracy of clinical diagnoses should be evaluated by determining their correlation with histopathological data.
    Methods: A total of 696 placental records from single and multiple pregnancies between January 2011 and February 2018 were collected and reviewed to determine if chorioamnionitis was present.
    Results: Of the 696 records, 255 had histological data available, and of these, histological evidence for chorioamnionitis was recorded in 135 (52.9%). Clinical chorioamnionitis diagnosis was insensitive (26.7%; 95% confidence interval 19.43%-34.96%) and inaccurate (61.1%; 95% confidence interval 54.90%-67.19%). As well, 73.3% of histologically positive chorioamnionitis cases were missed using clinical indicators.
    Discussion: Clinical diagnosis for chorioamnionitis is inaccurate; in our study, most of the positive cases were not diagnosed using clinical indicators. However, of the clinical indicators examined, maternal and fetal tachycardia were the most reliable.
    MeSH term(s) Adult ; Chorioamnionitis/diagnosis ; Chorioamnionitis/pathology ; Electronic Health Records ; Female ; Gestational Age ; Histological Techniques ; Humans ; Pregnancy ; Retrospective Studies ; Tachycardia ; Tertiary Care Centers ; Young Adult
    Language English
    Publishing date 2020-01-23
    Publishing country India
    Document type Journal Article
    ZDB-ID 197621-7
    ISSN 0974-5130 ; 0377-4929
    ISSN (online) 0974-5130
    ISSN 0377-4929
    DOI 10.4103/IJPM.IJPM_464_19
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  10. Article: Prevalence of Fetal Inflammatory Response Syndrome and Villitis of Unknown Etiology in the Placenta of Saudi Women and Their Association with Baby Sex.

    Aldahmash, Waleed / Aljerian, Khaldoon / Alwasel, Saleh

    Life (Basel, Switzerland)

    2024  Volume 14, Issue 1

    Abstract: Long-term health consequences are influenced by circumstances that occur during pregnancy. The convergence of the maternal and fetal circulations occurs in the placenta, which is the first organ to develop. Placental pathology provides an accurate ... ...

    Abstract Long-term health consequences are influenced by circumstances that occur during pregnancy. The convergence of the maternal and fetal circulations occurs in the placenta, which is the first organ to develop. Placental pathology provides an accurate diagnosis of amniotic sac inflammation, and pathological alterations in preterm placentas provide evidence for the causes of numerous perinatal pathologies, including spontaneous preterm births. This retrospective study aimed to re-examine placentas regarded as normal by the Obstetrics and Gynecology Department at our institution. Thirty-seven male and forty-seven female placentas were collected following full-term delivery, and the grading and staging of any evident inflammatory responses were evaluated and correlated with the babies' sex. Full-thickness placental samples that were considered normal and not sent to the histopathology department were obtained from the central and marginal regions of placental discs. Morphological examination of the fresh placenta was conducted, and fetal and maternal inflammatory response syndromes were assessed. In addition, placental villitis of unknown etiology (VUE) and chronic deciduitis were evaluated. Immunohistochemistry was performed to evaluate the patterns of inflammation in the placenta using anti-CD8 and anti-CD68 antibodies. The correlation between silent pathologies and clinical complications or the development of fetal inflammatory response syndrome was measured. In this study, 17 (20%) maternal and 10 (12%) fetal samples showed inflammatory responses. The frequencies of chronic deciduitis and VUE were higher among pregnant Saudi women than previously reported, probably because fetal inflammatory response syndrome goes unnoticed in Saudi Arabia. In addition, the prevalence of fetal and maternal inflammatory responses was higher in the placentas of the mothers of males than in those of females, suggesting that differences occur in the inflammatory response in the placenta depending on the sex of the newborn. Grading placental inflammation (in cases of VUE) typically predicts the degree of maternal anti-fetal cellular rejection; therefore, increasing the number of placental samples sent for microscopic inspection may be preferable because of their significance in identifying the causes of chronic disorders.
    Language English
    Publishing date 2024-01-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life14010079
    Database MEDical Literature Analysis and Retrieval System OnLINE

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