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  1. Article ; Online: Res-SE-ConvNet: A Deep Neural Network for Hypoxemia Severity Prediction for Hospital In-Patients Using Photoplethysmograph Signal.

    Mahmud, Talha Ibn / Imran, Sheikh Asif / Shahnaz, Celia

    IEEE journal of translational engineering in health and medicine

    2022  Volume 10, Page(s) 4901409

    Abstract: Determining the severity level of hypoxemia, the scarcity of saturated oxygen (SpO2) in the human body, is very important for the patients, a matter which has become even more significant during the outbreak of Covid-19 variants. Although the widespread ... ...

    Abstract Determining the severity level of hypoxemia, the scarcity of saturated oxygen (SpO2) in the human body, is very important for the patients, a matter which has become even more significant during the outbreak of Covid-19 variants. Although the widespread usage of Pulse Oximeter has helped the doctors aware of the current level of SpO2 and thereby determine the hypoxemia severity of a particular patient, the high sensitivity of the device can lead to the desensitization of the care-givers, resulting in slower response to actual hypoxemia event. There has been research conducted for the detection of severity level using various parameters and bio-signals and feeding them in a machine learning algorithm. However, in this paper, we have proposed a new residual-squeeze-excitation-attention based convolutional network (Res-SE-ConvNet) using only Photoplethysmography (PPG) signal for the comfortability of the patient. Unlike the other methods, the proposed method has outperformed the standard state-of-art methods as the result shows 96.5% accuracy in determining 3 class severity problems with 0.79 Cohen Kappa score. This method has the potential to aid the patients in receiving the benefit of an automatic and faster clinical decision support system, thus handling the severity of hypoxemia.
    MeSH term(s) Humans ; Photoplethysmography ; COVID-19/diagnosis ; SARS-CoV-2 ; Neural Networks, Computer ; Oxygen ; Hypoxia/diagnosis ; Hospitals
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2022-10-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2696555-0
    ISSN 2168-2372 ; 2168-2372
    ISSN (online) 2168-2372
    ISSN 2168-2372
    DOI 10.1109/JTEHM.2022.3217428
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: COVID-19: Management.

    Mahmud, Talha / Ansarie, Mosavir

    JPMA. The Journal of the Pakistan Medical Association

    2020  Volume 70Suppl 3, Issue 5, Page(s) S64–S68

    Abstract: Coronavirus disease (COVID-19) has grasped the world including Pakistan. Clinical features of this disease are variable, ranging from asymptomatic to critical disease. In this unprecedented global war, the Pakistan Chest Society has written a guideline ... ...

    Abstract Coronavirus disease (COVID-19) has grasped the world including Pakistan. Clinical features of this disease are variable, ranging from asymptomatic to critical disease. In this unprecedented global war, the Pakistan Chest Society has written a guideline for quick review for the specialists providing care to suspected or confirmed patients. This review highlights the approach to a patient with COVID-19, including definition of the various syndromes of the disease, the abnormal laboratory parameters and outlines the therapeutic measures which are currently under investigation.
    MeSH term(s) Antiviral Agents/adverse effects ; Antiviral Agents/therapeutic use ; Betacoronavirus ; Coronavirus Infections/complications ; Coronavirus Infections/diagnosis ; Coronavirus Infections/drug therapy ; Coronavirus Infections/therapy ; Humans ; Monitoring, Physiologic ; Pakistan ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/therapy ; Practice Guidelines as Topic ; Respiratory Distress Syndrome, Adult ; Sepsis
    Chemical Substances Antiviral Agents
    Keywords covid19
    Language English
    Publishing date 2020-06-09
    Publishing country Pakistan
    Document type Journal Article
    ZDB-ID 603873-6
    ISSN 0030-9982
    ISSN 0030-9982
    DOI 10.5455/JPMA.13
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Res-SE-ConvNet

    Talha Ibn Mahmud / Sheikh Asif Imran / Celia Shahnaz

    IEEE Journal of Translational Engineering in Health and Medicine, Vol 10, Pp 1-

    A Deep Neural Network for Hypoxemia Severity Prediction for Hospital In-Patients Using Photoplethysmograph Signal

    2022  Volume 9

    Abstract: Determining the severity level of hypoxemia, the scarcity of saturated oxygen (SpO2) in the human body, is very important for the patients, a matter which has become even more significant during the outbreak of Covid-19 variants. Although the widespread ... ...

    Abstract Determining the severity level of hypoxemia, the scarcity of saturated oxygen (SpO2) in the human body, is very important for the patients, a matter which has become even more significant during the outbreak of Covid-19 variants. Although the widespread usage of Pulse Oximeter has helped the doctors aware of the current level of SpO2 and thereby determine the hypoxemia severity of a particular patient, the high sensitivity of the device can lead to the desensitization of the care-givers, resulting in slower response to actual hypoxemia event. There has been research conducted for the detection of severity level using various parameters and bio-signals and feeding them in a machine learning algorithm. However, in this paper, we have proposed a new residual-squeeze-excitation-attention based convolutional network (Res-SE-ConvNet) using only Photoplethysmography (PPG) signal for the comfortability of the patient. Unlike the other methods, the proposed method has outperformed the standard state-of-art methods as the result shows 96.5% accuracy in determining 3 class severity problems with 0.79 Cohen Kappa score. This method has the potential to aid the patients in receiving the benefit of an automatic and faster clinical decision support system, thus handling the severity of hypoxemia.
    Keywords Saturated oxygen ; attention ; feature map ; excitation ; deep learning ; Computer applications to medicine. Medical informatics ; R858-859.7 ; Medical technology ; R855-855.5
    Subject code 006
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher IEEE
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Parenting Practices and Aggression in Childhood Behaviour Disorders

    Fatima Rahman / Shazia Maqbool / Anam Ali / Talha Mahmud / Hina Azhar / Aisha Farid

    Pakistan Armed Forces Medical Journal, Vol 73, Iss

    2023  Volume 1

    Abstract: Objective: To determine the association between parenting practices and aggression in children with behaviour disorders. Study Design: Cross-sectional study. Place and Duration of Study: Children Hospital and Institute of Child Health, Lahore Pakistan, ... ...

    Abstract Objective: To determine the association between parenting practices and aggression in children with behaviour disorders. Study Design: Cross-sectional study. Place and Duration of Study: Children Hospital and Institute of Child Health, Lahore Pakistan, from Nov 2020 to Jan 2021. Methodology: Parents of children and eighty-five children between the ages of 3 to 12 years with the diagnosis of behaviour disorders (autism spectrum disorder, attention deficit hyperactive disorder, social communication disorder) and showing aggressive behaviour were enrolled. The multidimensional assessment of parenting scale was used to assess positive(proactive parenting, positive reinforcement, warmth and supportiveness) and negative (hostility, lax control, physical control) parenting practices. The modified overt aggression scale was used to assess aggression, including verbal aggression,aggression against property, auto-aggression (towards self), and physical aggression (towards others). Correlation and multiple regression analysis were done. Results: Among negative practices, it was found that leniency and inconsistent parenting (lax control) was significant positive predictor of aggression (p<0.01) in children with behaviour disorders. Supportiveness was a significant negative predictor of verbal aggression (p<0.01), while physical control positively predicted total aggression (p<0.05). Among positive parenting practices, positive reinforcement decreased auto aggression (p<0.05) in children with behaviour disorders. Lower maternal education correlated with more aggressive behaviours (p<0.05) in these children. Conclusion: Negative parenting practices may lead to aggression in children with behaviour disorders. While positive reinforcement by parents may encourage less self-harm in these children and help improve their behaviour problems.
    Keywords Aggression ; Attention deficit hyperactive disorder (ADHD) ; Autism spectrum disorder (ASD) ; Childhood behavior disorders ; Parenting practices ; Social communication disorder (SCD) ; Medicine ; R ; Medicine (General) ; R5-920
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher Army Medical College Rawalpindi
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: COVID-19: Management

    Mahmud, Talha / Ansarie, Mosavir

    J Pak Med Assoc

    Abstract: Coronavirus disease (COVID-19) has grasped the world including Pakistan. Clinical features of this disease are variable, ranging from asymptomatic to critical disease. In this unprecedented global war, the Pakistan Chest Society has written a guideline ... ...

    Abstract Coronavirus disease (COVID-19) has grasped the world including Pakistan. Clinical features of this disease are variable, ranging from asymptomatic to critical disease. In this unprecedented global war, the Pakistan Chest Society has written a guideline for quick review for the specialists providing care to suspected or confirmed patients. This review highlights the approach to a patient with COVID-19, including definition of the various syndromes of the disease, the abnormal laboratory parameters and outlines the therapeutic measures which are currently under investigation.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #32515388
    Database COVID19

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  6. Article ; Online: Cytokines and their role as immunotherapeutics and vaccine Adjuvants: The emerging concepts.

    Rahman, Tanjilur / Das, Ayan / Abir, Mehedy Hasan / Nafiz, Iqbal Hossain / Mahmud, Aar Rafi / Sarker, Md Rifat / Emran, Talha Bin / Hassan, Mohammad Mahmudul

    Cytokine

    2023  Volume 169, Page(s) 156268

    Abstract: Cytokines are a protein family comprising interleukins, lymphokines, chemokines, monokines and interferons. They are significant constituents of the immune system, and they act in accordance with specific cytokine inhibiting compounds and receptors for ... ...

    Abstract Cytokines are a protein family comprising interleukins, lymphokines, chemokines, monokines and interferons. They are significant constituents of the immune system, and they act in accordance with specific cytokine inhibiting compounds and receptors for the regulation of immune responses. Cytokine studies have resulted in the establishment of newer therapies which are being utilized for the treatment of several malignant diseases. The advancement of these therapies has occurred from two distinct strategies. The first strategy involves administrating the recombinant and purified cytokines, and the second strategy involves administrating the therapeutics which inhibits harmful effects of endogenous and overexpressed cytokines. Colony stimulating factors and interferons are two exemplary therapeutics of cytokines. An important effect of cytokine receptor antagonist is that they can serve as anti-inflammatory agents by altering the treatments of inflammation disorder, therefore inhibiting the effects of tumour necrosis factor. In this article, we have highlighted the research behind the establishment of cytokines as therapeutics and vaccine adjuvants, their role of immunotolerance, and their limitations.
    MeSH term(s) Cytokines/metabolism ; Adjuvants, Vaccine ; Interferons/physiology ; Immunologic Factors ; Interleukins/physiology ; Immunotherapy
    Chemical Substances Cytokines ; Adjuvants, Vaccine ; Interferons (9008-11-1) ; Immunologic Factors ; Interleukins
    Language English
    Publishing date 2023-06-13
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1018055-2
    ISSN 1096-0023 ; 1043-4666
    ISSN (online) 1096-0023
    ISSN 1043-4666
    DOI 10.1016/j.cyto.2023.156268
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Knowledge, attitudes and practices regarding zoonotic diseases among cat and dog owners in Bangladesh.

    Mamun, Tajul Islam / Mahmud, Md Wakil / Dey, Shuvankar Chandra / Fahim, Md Asif Al / Raihan, Md Abu Talha / Tuhin, Rumman Hossain / Sima, Sajeda Afroz / Akter, Suchona

    Preventive veterinary medicine

    2024  Volume 226, Page(s) 106166

    Abstract: The close relationship between human and companion animals like cats and dogs raises public health concerns regarding the potential transmission of zoonotic diseases in Bangladesh. The study aimed to evaluate the cat and dog owners' knowledge, attitudes, ...

    Abstract The close relationship between human and companion animals like cats and dogs raises public health concerns regarding the potential transmission of zoonotic diseases in Bangladesh. The study aimed to evaluate the cat and dog owners' knowledge, attitudes, practices, and risk perception concerning zoonotic diseases for designing effective interventions and reducing disease transmission. A cross-sectional survey was conducted among 480 pet owners in various region of Bangladesh. For data collection, a structured, closed-ended questions were implemented. The data collection was anonymous and individuals were chosen through a random selection method. Responses were classified to evaluate comprehensive knowledge, using a threshold value of ≥65%. Quantitative score was created to measure Knowledge, Attitudes, and Practices, and these scores were divided into categories of good and poor knowledge, positive and negative attitudes, as well as correct and incorrect practices. The analysis included the application of both descriptive statistics and logistic regression analysis. The findings showed that females made up more than half of the survey participants (55.2%), with the predominant pet owned being cats (73.1%). Overall, only a small portion (21.25%) of the survey respondents demonstrated good knowledge about the topic as measured by a dichotomous outcome. A larger proportion of participants (84.58%) exhibited a positive attitude towards zoonotic diseases. However, when it came to correct practices, about one-third (29.79%) of performed satisfactorily. It is noteworthy that 90.4% of the participants exhibited a high level of understanding regarding the transmission of rabies through dog bites. The knowledge and practices of owners were markedly impacted by their education, occupation, and geographic location. Furthermore, 48.1% identified 'social media' as their primary source of information, and 80.0% regarded vaccination as a preventive measure. The study reveals gaps in knowledge and practices of risks regarding zoonotic diseases among pet owners in Bangladesh. It is crucial to implement focused educational initiatives and preventative measures to effectively tackle gaps in knowledge concerning zoonotic diseases and to avert potential infections.
    Language English
    Publishing date 2024-03-07
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 43399-8
    ISSN 1873-1716 ; 0167-5877
    ISSN (online) 1873-1716
    ISSN 0167-5877
    DOI 10.1016/j.prevetmed.2024.106166
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Pulmonary embolism, thrombocytopenia, and antiphospholipid syndrome.

    Mahmud, Talha

    Journal of Ayub Medical College, Abbottabad : JAMC

    2011  Volume 23, Issue 4, Page(s) 138–141

    Abstract: This case report describes a young non-smoker male masquerading under the diagnosis of community acquired pneumonia who was found to have respiratory symptoms attributed to bilateral pulmonary emboli. There was also evidence of thrombocytopenia and ... ...

    Abstract This case report describes a young non-smoker male masquerading under the diagnosis of community acquired pneumonia who was found to have respiratory symptoms attributed to bilateral pulmonary emboli. There was also evidence of thrombocytopenia and proximal deep venous thrombosis of right lower limb. He underwent further investigations and was found to have positive anti-cardiolipin antibodies, lupus anticoagulant and prolonged activated partial thromboplastin time due to antiphospholipid antibody syndrome. This article highlights the importance of consideration of earlier diagnosis in younger patients with congenital thrombophilias that carries potential for prevention and treatment of life threatening thromboembolic manifestations.
    MeSH term(s) Anticoagulants/therapeutic use ; Antiphospholipid Syndrome/complications ; Antiphospholipid Syndrome/diagnosis ; Antiphospholipid Syndrome/drug therapy ; Diagnosis, Differential ; Humans ; Male ; Positron-Emission Tomography ; Pulmonary Embolism/complications ; Pulmonary Embolism/diagnosis ; Pulmonary Embolism/drug therapy ; Radiography, Thoracic ; Thrombocytopenia/complications ; Thrombocytopenia/diagnosis ; Thrombocytopenia/drug therapy ; Tomography, X-Ray Computed ; Ultrasonography, Doppler ; Young Adult
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2011-10
    Publishing country Pakistan
    Document type Case Reports ; Journal Article
    ZDB-ID 2192473-9
    ISSN 1025-9589
    ISSN 1025-9589
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Intractable cough due to endobronchial chondroma.

    Mahmud, Talha / Nasim, Zanobia / Saqib, Muhammad / Fatima, Saira

    Respiratory medicine case reports

    2019  Volume 29, Page(s) 100968

    Abstract: A 62-year-old man, suffering from bronchial asthma was evaluated due to intractable cough. His dyspnea was controlled but cough remained unresponsive to escalation of asthma management steps. Cough occurred in bouts, especially during night time and was ... ...

    Abstract A 62-year-old man, suffering from bronchial asthma was evaluated due to intractable cough. His dyspnea was controlled but cough remained unresponsive to escalation of asthma management steps. Cough occurred in bouts, especially during night time and was occasionally productive of mucoid sputum. Other than bilateral rhonchi on chest auscultation, remaining systemic examination was unremarkable. CT chest showed a mass lesion in the bronchus intermedius that was confirmed on bronchoscopy and was removed after electrocautery snare excision. Histopathology of the lesion was consistent with endobronchial chondroma. The patient experienced a dramatic resolution of cough post tumor removal. Follow up bronchoscopy after 24 months revealed no tumor recurrence.
    Language English
    Publishing date 2019-11-14
    Publishing country England
    Document type Case Reports
    ZDB-ID 2666110-X
    ISSN 2213-0071
    ISSN 2213-0071
    DOI 10.1016/j.rmcr.2019.100968
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: An AIDS patient with multiple opportunistic infections.

    Mahmud, Talha

    Journal of Ayub Medical College, Abbottabad : JAMC

    2010  Volume 22, Issue 2, Page(s) 210–213

    Abstract: A patient was diagnosed having advanced acquired immunodeficiency syndrome (AIDS) who suffered from various pulmonary and extrapulmonary infective complications. A number of opportunistic infections were diagnosed and prompt treatment was initiated. Due ... ...

    Abstract A patient was diagnosed having advanced acquired immunodeficiency syndrome (AIDS) who suffered from various pulmonary and extrapulmonary infective complications. A number of opportunistic infections were diagnosed and prompt treatment was initiated. Due to his low CD4+ lymphocyte count that carries a higher morbidity and mortality, he experienced clinical worsening even with treatment and could not survive through this Black Death.
    MeSH term(s) AIDS-Related Opportunistic Infections/diagnosis ; AIDS-Related Opportunistic Infections/microbiology ; AIDS-Related Opportunistic Infections/therapy ; Humans ; Male ; Middle Aged
    Language English
    Publishing date 2010-04
    Publishing country Pakistan
    Document type Case Reports ; Journal Article
    ZDB-ID 2192473-9
    ISSN 1025-9589
    ISSN 1025-9589
    Database MEDical Literature Analysis and Retrieval System OnLINE

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