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  1. Book ; Online: The Role of Toll-Like Receptors (TLR) in Infection and Inflammation

    Kircheis, Ralf / Planz, Oliver

    2023  

    Keywords Medicine ; hepatitis C virus ; infection ; innate immunity ; Toll-like receptor ; cytokines ; Omicron ; spike protein ; SARS-CoV-2 ; COVID-19 ; cytokine storm ; NF-kappaB ; Toll-like receptor (TLR) ; monoclonal antibody TLR4 ; compression force ; MAPKs ; AKT ; human PDL ; sterile inflammation ; TLR ; immune system ; inflammation ; antiviral ; polymorphism ; sepsis ; septic shock ; TLR7 ; TLR8 ; 2'-O-ribose-methylation ; RNase T2 ; immune activation ; CD14 ; LPS ; hop ; TLR4 ; oligonucleotide ; sncRNA ; endocytosis ; broad-spectrum ; antiviral agent ; nucleolin ; virus entry ; immunoregulation ; RNA therapeutics ; TLR7 (Toll-like receptor 7) ; MUC1 (Mucin 1) ; aluminum adjuvant ; tumor vaccine ; immunotherapy ; toll-like receptor-2 (TLR2) ; advanced glycation end products (AGEs) ; aquaporin-3 (AQP3) ; histone deacetylase inhibitor ; diabetes ; keratinocytes ; skin ; n/a ; TLR4-RAGE crosstalk ; glucose ; lipopolysaccharide (LPS) ; inflammatory ; alveolar macrophages
    Language English
    Size 1 electronic resource (236 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel
    Document type Book ; Online
    Note English
    HBZ-ID HT030377719
    ISBN 9783036576145 ; 3036576142
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Editorial: The role of toll-like receptors and their related signaling pathways in viral infection and inflammation.

    Planz, Oliver / Kircheis, Ralf

    Frontiers in immunology

    2024  Volume 15, Page(s) 1363958

    MeSH term(s) Humans ; Toll-Like Receptors ; Signal Transduction ; Inflammation ; Virus Diseases
    Chemical Substances Toll-Like Receptors
    Language English
    Publishing date 2024-01-19
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2024.1363958
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Coagulopathies after Vaccination against SARS-CoV-2 May Be Derived from a Combined Effect of SARS-CoV-2 Spike Protein and Adenovirus Vector-Triggered Signaling Pathways.

    Kircheis, Ralf

    International journal of molecular sciences

    2021  Volume 22, Issue 19

    Abstract: Novel coronavirus SARS-CoV-2 has resulted in a global pandemic with worldwide 6-digit infection rates and thousands of death tolls daily. Enormous efforts are undertaken to achieve high coverage of immunization to reach herd immunity in order to stop the ...

    Abstract Novel coronavirus SARS-CoV-2 has resulted in a global pandemic with worldwide 6-digit infection rates and thousands of death tolls daily. Enormous efforts are undertaken to achieve high coverage of immunization to reach herd immunity in order to stop the spread of SARS-CoV-2 infection. Several SARS-CoV-2 vaccines based on mRNA, viral vectors, or inactivated SARS-CoV-2 virus have been approved and are being applied worldwide. However, the recent increased numbers of normally very rare types of thromboses associated with thrombocytopenia have been reported, particularly in the context of the adenoviral vector vaccine ChAdOx1 nCoV-19 from Astra Zeneca. The statistical prevalence of these side effects seems to correlate with this particular vaccine type, i.e., adenoviral vector-based vaccines, but the exact molecular mechanisms are still not clear. The present review summarizes current data and hypotheses for molecular and cellular mechanisms into one integrated hypothesis indicating that coagulopathies, including thromboses, thrombocytopenia, and other related side effects, are correlated to an interplay of the two components in the vaccine, i.e., the spike antigen and the adenoviral vector, with the innate and immune systems, which under certain circumstances can imitate the picture of a limited COVID-19 pathological picture.
    MeSH term(s) Adenoviridae/immunology ; Animals ; COVID-19/immunology ; COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; COVID-19 Vaccines/immunology ; ChAdOx1 nCoV-19 ; Genetic Vectors/adverse effects ; Genetic Vectors/immunology ; Humans ; Purpura, Thrombocytopenic, Idiopathic/etiology ; Purpura, Thrombocytopenic, Idiopathic/immunology ; SARS-CoV-2/immunology ; Spike Glycoprotein, Coronavirus/adverse effects ; Spike Glycoprotein, Coronavirus/immunology ; Thrombocytopenia/etiology ; Thrombocytopenia/immunology ; Thrombosis/etiology ; Thrombosis/immunology ; Vaccination/adverse effects
    Chemical Substances COVID-19 Vaccines ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2 ; ChAdOx1 nCoV-19 (B5S3K2V0G8)
    Language English
    Publishing date 2021-10-06
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms221910791
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Coagulopathies after Vaccination against SARS-CoV-2 May Be Derived from a Combined Effect of SARS-CoV-2 Spike Protein and Adenovirus Vector-Triggered Signaling Pathways

    Ralf Kircheis

    International Journal of Molecular Sciences, Vol 22, Iss 10791, p

    2021  Volume 10791

    Abstract: Novel coronavirus SARS-CoV-2 has resulted in a global pandemic with worldwide 6-digit infection rates and thousands of death tolls daily. Enormous efforts are undertaken to achieve high coverage of immunization to reach herd immunity in order to stop the ...

    Abstract Novel coronavirus SARS-CoV-2 has resulted in a global pandemic with worldwide 6-digit infection rates and thousands of death tolls daily. Enormous efforts are undertaken to achieve high coverage of immunization to reach herd immunity in order to stop the spread of SARS-CoV-2 infection. Several SARS-CoV-2 vaccines based on mRNA, viral vectors, or inactivated SARS-CoV-2 virus have been approved and are being applied worldwide. However, the recent increased numbers of normally very rare types of thromboses associated with thrombocytopenia have been reported, particularly in the context of the adenoviral vector vaccine ChAdOx1 nCoV-19 from Astra Zeneca. The statistical prevalence of these side effects seems to correlate with this particular vaccine type, i.e., adenoviral vector-based vaccines, but the exact molecular mechanisms are still not clear. The present review summarizes current data and hypotheses for molecular and cellular mechanisms into one integrated hypothesis indicating that coagulopathies, including thromboses, thrombocytopenia, and other related side effects, are correlated to an interplay of the two components in the vaccine, i.e., the spike antigen and the adenoviral vector, with the innate and immune systems, which under certain circumstances can imitate the picture of a limited COVID-19 pathological picture.
    Keywords SARS-CoV-2 ; spike protein ; thrombosis ; thrombocytopenia ; vaccine-induced immune thrombotic thrombocytopenia (VITT) ; NF-kappaB ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Language English
    Publishing date 2021-10-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: The Role of Toll-like Receptors (TLRs) and Their Related Signaling Pathways in Viral Infection and Inflammation.

    Kircheis, Ralf / Planz, Oliver

    International journal of molecular sciences

    2023  Volume 24, Issue 7

    Abstract: Toll-like receptors (TLRs) belong to a powerful system for the recognition and elimination of pathogen-associated molecular patterns (PAMPs) from bacteria, viruses, and other pathogens [ ... ]. ...

    Abstract Toll-like receptors (TLRs) belong to a powerful system for the recognition and elimination of pathogen-associated molecular patterns (PAMPs) from bacteria, viruses, and other pathogens [...].
    MeSH term(s) Humans ; Toll-Like Receptors/metabolism ; Signal Transduction ; Inflammation ; Virus Diseases ; Bacteria/metabolism ; Immunity, Innate
    Chemical Substances Toll-Like Receptors
    Language English
    Publishing date 2023-04-04
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24076701
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book ; Online: Coagulapathies after vaccination against SARS-CoV-2 may be derived from a combination effect of SARS-CoV-2 spike protein and adenovirus vector-triggered signaling pathways

    Kircheis, Ralf

    2021  

    Abstract: The novel coronavirus SARS-CoV-2 has resulted in a global pandemic with worldwide 6-digital infection rates and thousands death tolls daily. Enormeous effords are undertaken to achieve high coverage of immunization in order to reach herd immunity to stop ...

    Abstract The novel coronavirus SARS-CoV-2 has resulted in a global pandemic with worldwide 6-digital infection rates and thousands death tolls daily. Enormeous effords are undertaken to achieve high coverage of immunization in order to reach herd immunity to stop spreading of SARS-CoV-2 infection. Several SARS-CoV-2 vaccines, based either on mRNA, viral vectors, or inactivated SARS-CoV-2 virus have been approved and are being applied worldwide. However, recently increased numbers of normally very rare types of thromboses associated with thrombocytopenia have been reported in particular in the context of the adenoviral vector vaccine ChAdOx1 nCoV-19 from Astra Zeneca. While statistical prevalence of these side effects seem to correlate with this particular vaccine type, i.e. adenonoviral vector based vaccines, the exact molecular mechanisms are still not clear. The present review summarizes current data and hypotheses for molecular and cellular mechanisms into one integrated hypothesis indicating that coagulopathies, including thromboses, thrombocytopenia and other related side effects are correlated to an interplay of the two components in the vaccine, i.e. the spike antigen and the adenoviral vector, with the innate and immune system which under certain circumstances can imitate the picture of a limited COVID-19 pathological picture.
    Keywords Quantitative Biology - Cell Behavior ; Quantitative Biology - Biomolecules ; Quantitative Biology - Molecular Networks
    Publishing date 2021-08-31
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  7. Article ; Online: The Role of Toll-like Receptors (TLRs) and Their Related Signaling Pathways in Viral Infection and Inflammation

    Ralf Kircheis / Oliver Planz

    International Journal of Molecular Sciences, Vol 24, Iss 6701, p

    2023  Volume 6701

    Abstract: Toll-like receptors (TLRs) belong to a powerful system for the recognition and elimination of pathogen-associated molecular patterns (PAMPs) from bacteria, viruses, and other pathogens [.] ...

    Abstract Toll-like receptors (TLRs) belong to a powerful system for the recognition and elimination of pathogen-associated molecular patterns (PAMPs) from bacteria, viruses, and other pathogens [.]
    Keywords n/a ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Language English
    Publishing date 2023-04-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Could a Lower Toll-like Receptor (TLR) and NF-κB Activation Due to a Changed Charge Distribution in the Spike Protein Be the Reason for the Lower Pathogenicity of Omicron?

    Kircheis, Ralf / Planz, Oliver

    International journal of molecular sciences

    2022  Volume 23, Issue 11

    Abstract: The novel SARS-CoV-2 Omicron variant B.1.1.529, which emerged in late 2021, is currently active worldwide, replacing other variants, including the Delta variant, due to an enormously increased infectivity. Multiple substitutions and deletions in the N- ... ...

    Abstract The novel SARS-CoV-2 Omicron variant B.1.1.529, which emerged in late 2021, is currently active worldwide, replacing other variants, including the Delta variant, due to an enormously increased infectivity. Multiple substitutions and deletions in the N-terminal domain (NTD) and the receptor binding domain (RBD) in the spike protein collaborate with the observed increased infectivity and evasion from therapeutic monoclonal antibodies and vaccine-induced neutralizing antibodies after primary/secondary immunization. In contrast, although three mutations near the S1/S2 furin cleavage site were predicted to favor cleavage, observed cleavage efficacy is substantially lower than in the Delta variant and also lower compared to the wild-type virus correlating with significantly lower TMPRSS2-dependent replication in the lungs, and lower cellular syncytium formation. In contrast, the Omicron variant shows high TMPRSS2-independent replication in the upper airway organs, but lower pathogenicity in animal studies and clinics. Based on recent data, we present here a hypothesis proposing that the changed charge distribution in the Omicron's spike protein could lead to lower activation of Toll-like receptors (TLRs) in innate immune cells, resulting in lower NF-κB activation, furin expression, and viral replication in the lungs, and lower immune hyper-activation.
    MeSH term(s) Animals ; COVID-19 ; Furin/genetics ; Furin/metabolism ; NF-kappa B ; SARS-CoV-2/genetics ; Spike Glycoprotein, Coronavirus/metabolism ; Toll-Like Receptors ; Virulence
    Chemical Substances NF-kappa B ; Spike Glycoprotein, Coronavirus ; Toll-Like Receptors ; spike protein, SARS-CoV-2 ; Furin (EC 3.4.21.75)
    Language English
    Publishing date 2022-05-25
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23115966
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Could a Lower Toll-like Receptor (TLR) and NF-κB Activation Due to a Changed Charge Distribution in the Spike Protein Be the Reason for the Lower Pathogenicity of Omicron?

    Ralf Kircheis / Oliver Planz

    International Journal of Molecular Sciences, Vol 23, Iss 5966, p

    2022  Volume 5966

    Abstract: The novel SARS-CoV-2 Omicron variant B.1.1.529, which emerged in late 2021, is currently active worldwide, replacing other variants, including the Delta variant, due to an enormously increased infectivity. Multiple substitutions and deletions in the N- ... ...

    Abstract The novel SARS-CoV-2 Omicron variant B.1.1.529, which emerged in late 2021, is currently active worldwide, replacing other variants, including the Delta variant, due to an enormously increased infectivity. Multiple substitutions and deletions in the N-terminal domain (NTD) and the receptor binding domain (RBD) in the spike protein collaborate with the observed increased infectivity and evasion from therapeutic monoclonal antibodies and vaccine-induced neutralizing antibodies after primary/secondary immunization. In contrast, although three mutations near the S1/S2 furin cleavage site were predicted to favor cleavage, observed cleavage efficacy is substantially lower than in the Delta variant and also lower compared to the wild-type virus correlating with significantly lower TMPRSS2-dependent replication in the lungs, and lower cellular syncytium formation. In contrast, the Omicron variant shows high TMPRSS2-independent replication in the upper airway organs, but lower pathogenicity in animal studies and clinics. Based on recent data, we present here a hypothesis proposing that the changed charge distribution in the Omicron’s spike protein could lead to lower activation of Toll-like receptors (TLRs) in innate immune cells, resulting in lower NF-κB activation, furin expression, and viral replication in the lungs, and lower immune hyper-activation.
    Keywords Omicron ; spike protein ; SARS-CoV-2 ; COVID-19 ; cytokine storm ; NF-kappaB ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 570
    Language English
    Publishing date 2022-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  10. Book ; Thesis: Biologische Aktivität von gentechnisch hergestellten Mutanten des humanen Tumor-Nekrose-Faktors

    Kircheis, Ralf

    1991  

    Author's details vorgelegt von Ralf Kircheis
    Size 94, [20] Bl. : Ill., graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Berlin, Humboldt-Univ., Diss., 1991
    HBZ-ID HT004169121
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    92 E 1886 order for loan Magazin

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