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  1. Article ; Online: COVID-19: My Perspective.

    Croft, Lori B

    JACC. Case reports

    2020  Volume 2, Issue 9, Page(s) 1423–1425

    Keywords covid19
    Language English
    Publishing date 2020-06-13
    Publishing country Netherlands
    Document type Editorial
    ISSN 2666-0849
    ISSN (online) 2666-0849
    DOI 10.1016/j.jaccas.2020.06.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: COVID-19

    Croft, Lori B.

    JACC: Case Reports

    2020  Volume 2, Issue 9, Page(s) 1423–1425

    Keywords covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ISSN 2666-0849
    DOI 10.1016/j.jaccas.2020.06.014
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: HIF-1α Cardioprotection in COVID-19 Patients.

    Wang, Bingyan J / Vadakke-Madathil, Sangeetha / Croft, Lori B / Brody, Rachel I / Chaudhry, Hina W

    JACC. Basic to translational science

    2022  Volume 7, Issue 1, Page(s) 67–69

    Language English
    Publishing date 2022-01-24
    Publishing country United States
    Document type Journal Article
    ISSN 2452-302X
    ISSN (online) 2452-302X
    DOI 10.1016/j.jacbts.2021.12.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Takotsubo Cardiomyopathy in COVID-19.

    Giustino, Gennaro / Croft, Lori B / Oates, Connor P / Rahman, Karishma / Lerakis, Stamatios / Reddy, Vivek Y / Goldman, Martin

    Journal of the American College of Cardiology

    2020  Volume 76, Issue 5, Page(s) 628–629

    Keywords covid19
    Language English
    Publishing date 2020-06-08
    Publishing country United States
    Document type Letter
    ZDB-ID 605507-2
    ISSN 1558-3597 ; 0735-1097
    ISSN (online) 1558-3597
    ISSN 0735-1097
    DOI 10.1016/j.jacc.2020.05.068
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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    Jg. 1995 - 2021: Lesesall (1.OG)
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    Zs.MO 196: Show issues

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  6. Article ; Online: Obstructive sleep apnoea and left ventricular diastolic dysfunction among first responders to the 9/11 World Trade Center terrorist attack: a cross-sectional study.

    Iyengar-Kapuganti, Rupa Lakshmi / Maceda, Cynara S / Croft, Lori B / Sawit, Simonette T / Crowley, Laura E / Woodward, Mark / McLaughlin, Mary Ann

    BMJ open

    2022  Volume 12, Issue 4, Page(s) e058366

    Abstract: Objectives: Obstructive sleep apnoea (OSA) is often linked to cardiovascular disease. A limited number of studies have reported an association between OSA and left ventricular diastolic dysfunction (LVDD). However, prior studies were performed on small ... ...

    Abstract Objectives: Obstructive sleep apnoea (OSA) is often linked to cardiovascular disease. A limited number of studies have reported an association between OSA and left ventricular diastolic dysfunction (LVDD). However, prior studies were performed on small patient populations. Studies have shown a high prevalence of OSA among first responders to the 9/11 World Trade Center (WTC) terrorist attack. We investigated the relationship between OSA and LVDD in a large population of WTC responders.
    Design: Cross-sectional study.
    Setting: One-time screening programme as part of the WTC-CHEST Study (NCT10466218), performed at a quaternary medical centre in New York City, from November 2011 to June 2014.
    Participants: A total of 1007 participants with mean age of 51 years of mostly non-Hispanic white men were evaluated. Patients from the WTC Health Program-Clinical Center of Excellence, who were over the age of 39 years, were eligible to participate.
    Results: Evaluation of those without OSA diagnosis showed no significant association with LVDD when comparing those screened (Berlin Questionnaire) as OSA high risk versus OSA low risk (p=0.101). Among those diagnosed with LVDD, there was a significant association when comparing those with and without patient-reported OSA (OR 1.50, 95% CI 1.13 to 2.00, p=0.005), but the significance was not maintained after adjusting for pertinent variables (OR 1.3, 0.94 to 1.75, p=0.119). Notably, comparing those with OSA diagnosis and those low risk of OSA, the OR for LVDD was significant (1.69, 1.24 to 2.31, p=0.001), and after adjusting for waist-hip ratio, diabetes and coronary artery calcium score percentile, the relationship remained significant (OR 1.45, 1.03 to 2.04, p=0.032).
    Conclusion: The strong association of OSA with LVDD in this population may inform future guidelines to recommend screening for LVDD in high-risk asymptomatic patients with OSA.
    MeSH term(s) Adult ; Cross-Sectional Studies ; Emergency Responders ; Humans ; Male ; Middle Aged ; September 11 Terrorist Attacks ; Sleep Apnea, Obstructive/complications ; Sleep Apnea, Obstructive/diagnosis ; Sleep Apnea, Obstructive/epidemiology ; Terrorism ; Ventricular Dysfunction, Left
    Language English
    Publishing date 2022-04-19
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2021-058366
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Improved scoring system for the electrocardiographic diagnosis of left ventricular hypertrophy.

    Braunstein, Eric D / Croft, Lori B / Halperin, Jonathan L / Liao, Steve L

    World journal of cardiology

    2019  Volume 11, Issue 3, Page(s) 94–102

    Abstract: Background: Left ventricular hypertrophy (LVH) is a common manifestation of cardiovascular disease and a risk factor for cardiovascular morbidity and mortality, but available methods for its electrocardiographic (ECG) diagnosis have limited accuracy.: ...

    Abstract Background: Left ventricular hypertrophy (LVH) is a common manifestation of cardiovascular disease and a risk factor for cardiovascular morbidity and mortality, but available methods for its electrocardiographic (ECG) diagnosis have limited accuracy.
    Aim: To investigate findings associated with LVH on ECG and developed an improved system for the diagnosis of LVH.
    Methods: A cohort study comparing ECG data acquired within 30 days of transthoracic echocardiography (TTE) was performed. Multivariate regression analysis identified ECG findings associated with increased LV mass and mass index. A scoring system was derived and performance compared to established criteria for LVH.
    Results: Data from 5486 outpatients with TTEs and corresponding ECGs were included in the derivation cohort, 333 (6.1%) of whom had LVH by TTE. In the primary regression analysis, findings associated with LVH were amplitudes of Q in V3, R in V6, S in V3, T in V6, P' in V1, P in V6, as well as R and T-axis discordance, R peak time in V6, QRS duration, weight, height, sex, and age. From this we derived a score consisting of 5 criteria, and validated it in an independent cohort of 910 patients. With a threshold of 1.5 points, sensitivity and specificity were 67.9% and 81.4%, and 62.5% and 83.2% in the derivation and validation cohorts, respectively. With a threshold of 2 points, sensitivity and specificity were 42.3% and 93.0%, and 37.5% and 93.4% in these cohorts.
    Conclusions: This score had superior sensitivity for detection of LVH by ECG while making a modest sacrifice in specificity compared to conventional criteria.
    Language English
    Publishing date 2019-04-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2573665-6
    ISSN 1949-8462
    ISSN 1949-8462
    DOI 10.4330/wjc.v11.i3.94
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Obstructive sleep apnoea and left ventricular diastolic dysfunction among first responders to the 9/11 World Trade Center terrorist attack

    Mark Woodward / Simonette T Sawit / Rupa Lakshmi Iyengar-Kapuganti / Cynara S Maceda / Lori B Croft / Laura E Crowley / Mary Ann McLaughlin

    BMJ Open, Vol 12, Iss

    a cross-sectional study

    2022  Volume 4

    Keywords Medicine ; R
    Language English
    Publishing date 2022-04-01T00:00:00Z
    Publisher BMJ Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: HIF1alpha cardioprotection in COVID-19 patients

    Wang, Bingyan Jessica / Vadakke-Madathil, Sangeetha / Croft, Lori B / Brody, Rachel I / Chaudhry, Hina W

    medRxiv

    Abstract: Importance SARS-CoV-2 infection directly causes severe acute respiratory illness, leading to systemic tissue hypoxia and ischemia including the heart. Myocardial cytopathy associated with hypoxic response has been largely overlooked in COVID-19 patients. ...

    Abstract Importance SARS-CoV-2 infection directly causes severe acute respiratory illness, leading to systemic tissue hypoxia and ischemia including the heart. Myocardial cytopathy associated with hypoxic response has been largely overlooked in COVID-19 patients. Additionally, histology analysis and cardiac function of COVID-19 cases are often reported separately, rendering an incomplete understanding of COVID-19 cardiac symptoms. Objective To examine the relationship between myocardial cellular responses to hypoxic stress versus cardiac functional alterations within the same COVID-19 patients. Design, Setting, and Participants Cellular hypoxia Inducible Factor 1 alpha (HIF1α) expression was analyzed by immunohistochemistry using post-mortem COVID-19 heart and lung tissues with known cardiac echocardiography records from a total of 8 patients. Clinical echocardiography data were obtained from Mount Sinai Heart between March to December, 2020. All gender and age groups were considered as long as cardiac involvement meets the preserved (EF > 50%) or moderate to severe (EF < 45%) criteria with confirmed SARS-CoV-2 infection. Cell-type specific subcellular localization of HIF1α expression and nuclear stability was examined by immunohistochemistry and transmission electronic microscopy (TEM). Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) was used to quantify apoptosis. Main Outcomes and Measures No planned outcomes of this study as this is a retrospective analysis based on post-mortem specimens exclusively. Results Cardiac HIF1α expression was found to be significantly higher in patients with preserved EF levels than it was in the low EF group. In the preserved EF group, HIF1α is protective against apoptosis predominantly in endothelial cells and cardiac fibroblasts. In the low EF group, HIF1α protects cardiomyocyte nuclear integrity as evident by its nuclear accumulation with nuclear envelope preservation. Conclusions and Relevance This study establishes a direct link of cardiac cellular responses to hypoxic stress with matching functional and histological data, serving as one of the first studies to bridge previous stand-alone clinical data and cellular data. The protective role of HIF1α in hearts may help predict cardiac involvement in not only COVID-19 patients, but also decipher the underlying mechanisms in other forms of viral cardiomyopathy.
    Keywords covid19
    Language English
    Publishing date 2021-08-07
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2021.08.05.21258160
    Database COVID19

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  10. Article: Takotsubo Cardiomyopathy in Males with Covid-19

    Giustino, Gennaro / Croft, Lori B / Oates, Connor P / Rahman, Karishma / Lerakis, Stamatios / Reddy, Vivek Y / Goldman, Martin

    J. Am. Coll. Cardiol

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #574659
    Database COVID19

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