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  1. Article: Editorial: Multimodality Imaging in Valvular Heart Disease.

    Treibel, Thomas A / Bennett, Jonathan / Cavalcante, João L

    Frontiers in cardiovascular medicine

    2021  Volume 8, Page(s) 708889

    Language English
    Publishing date 2021-07-19
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2021.708889
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  2. Article ; Online: Percutaneous Treatment of Severe Aortic Regurgitation After Surgical Mitral Valve Repair.

    Toscano, Evelina / Ahmed, Mahmoud Saad / Patel, Kush P / Treibel, Thomas / Kennon, Simon / Baumbach, Andreas

    JACC. Case reports

    2023  Volume 28, Page(s) 102131

    Abstract: A 54-year-old woman who had recently undergone surgical mitral and tricuspid valve repair was diagnosed with severe aortic regurgitation. She was scheduled for percutaneous treatment and underwent successful transcatheter aortic valve implantation with a ...

    Abstract A 54-year-old woman who had recently undergone surgical mitral and tricuspid valve repair was diagnosed with severe aortic regurgitation. She was scheduled for percutaneous treatment and underwent successful transcatheter aortic valve implantation with a 27-mm Trilogy valve (JenaValve Technology). The case documents feasibility of percutaneous treatment in the presence of a mitral ring.
    Language English
    Publishing date 2023-11-22
    Publishing country Netherlands
    Document type Case Reports
    ISSN 2666-0849
    ISSN (online) 2666-0849
    DOI 10.1016/j.jaccas.2023.102131
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  3. Article ; Online: Heart failure and excess mortality after aortic valve replacement in aortic stenosis.

    Aziminia, Nikoo / Nitsche, Christian / Mravljak, Rok / Bennett, Jonathan / Thornton, George D / Treibel, Thomas A

    Expert review of cardiovascular therapy

    2023  Volume 21, Issue 3, Page(s) 193–210

    Abstract: Introduction: In aortic stenosis (AS), the heart transitions from adaptive compensation to an AS cardiomyopathy and eventually leads to decompensation with heart failure. Better understanding of the underpinning pathophysiological mechanisms is required ...

    Abstract Introduction: In aortic stenosis (AS), the heart transitions from adaptive compensation to an AS cardiomyopathy and eventually leads to decompensation with heart failure. Better understanding of the underpinning pathophysiological mechanisms is required in order to inform strategies to prevent decompensation.
    Areas covered: In this review, we therefore aim to appraise the current pathophysiological understanding of adaptive and maladaptive processes in AS, appraise potential avenues of adjunctive therapy before or after AVR and highlight areas of further research in the management of heart failure post AVR.
    Expert opinion: Tailored strategies for the timing of intervention accounting for individual patient's response to the afterload insult are underway, and promise to guide better management in the future. Further clinical trials of adjunctive pharmacological and device therapy to either cardioprotect prior to intervention or promote reverse remodeling and recovery after intervention are needed to mitigate the risk of heart failure and excess mortality.
    MeSH term(s) Humans ; Aortic Valve/surgery ; Hypertrophy, Left Ventricular/surgery ; Heart Valve Prosthesis Implantation/adverse effects ; Ventricular Function, Left ; Aortic Valve Stenosis/surgery ; Heart Failure ; Ventricular Remodeling/physiology
    Language English
    Publishing date 2023-03-29
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 2192343-7
    ISSN 1744-8344 ; 1477-9072
    ISSN (online) 1744-8344
    ISSN 1477-9072
    DOI 10.1080/14779072.2023.2186853
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  4. Article ; Online: Comparison of the Recent Updates to the ACC/AHA and ESC Guidelines for the Management of Valvular Heart Disease: Similarities and Differences.

    Laskar, Nabila / Badiani, Sveeta / Treibel, Thomas / Bhattacharyya, Sanjeev / Lloyd, Guy

    Current cardiology reports

    2023  Volume 25, Issue 3, Page(s) 147–156

    Abstract: Purpose of review: There have been several advances in the diagnosis and management of valvular heart disease (VHD) over the last decade. These have been reflected in the latest European and North American guidelines, although both contain significant ... ...

    Abstract Purpose of review: There have been several advances in the diagnosis and management of valvular heart disease (VHD) over the last decade. These have been reflected in the latest European and North American guidelines, although both contain significant similarities and differences. In this review, we highlight the important overlaps and variations between the updated guidelines and their previous versions to help guide the general cardiologist.
    Recent findings: There has been extensive revision on the use of percutaneous treatments, the indications for intervention in asymptomatic VHD, and perioperative bridging therapies. The updated guidelines provide new recommendations in many aspects of VHD; however, there remain significant gaps in the role of biomarkers in VHD and the long-term outcomes of novel oral anticoagulants (NOACs) and transcatheter therapies.
    MeSH term(s) Humans ; Administration, Oral ; Anticoagulants/therapeutic use ; Heart Valve Diseases/diagnosis ; Heart Valve Diseases/drug therapy ; Cardiologists
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2023-01-28
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2055373-0
    ISSN 1534-3170 ; 1523-3782
    ISSN (online) 1534-3170
    ISSN 1523-3782
    DOI 10.1007/s11886-023-01840-7
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    Zs.A 5524: Show issues Location:
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  5. Article ; Online: Extracellular Volume Imaging in Aortic Stenosis During Routine Pre-TAVR Cardiac Computed Tomography.

    Treibel, Thomas A / Patel, Kush P / Cavalcante, João L

    JACC. Cardiovascular imaging

    2020  Volume 13, Issue 12, Page(s) 2602–2604

    MeSH term(s) Aortic Valve/diagnostic imaging ; Aortic Valve/surgery ; Aortic Valve Stenosis/diagnostic imaging ; Aortic Valve Stenosis/surgery ; Humans ; Predictive Value of Tests ; Prognosis ; Transcatheter Aortic Valve Replacement
    Language English
    Publishing date 2020-10-28
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2491503-8
    ISSN 1876-7591 ; 1936-878X
    ISSN (online) 1876-7591
    ISSN 1936-878X
    DOI 10.1016/j.jcmg.2020.08.023
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  6. Article ; Online: Model-free phasor image analysis of quantitative myocardial T

    Franssen, Wouter M J / Treibel, Thomas A / Seraphim, Andreas / Weingärtner, Sebastian / Terenzi, Camilla

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 19840

    Abstract: Model-free phasor image analysis, well established in fluorescence lifetime imaging and only recently applied to qMRI [Formula: see text] data processing, is here adapted and validated for myocardial qMRI [Formula: see text] mapping. Contrarily to ... ...

    Abstract Model-free phasor image analysis, well established in fluorescence lifetime imaging and only recently applied to qMRI [Formula: see text] data processing, is here adapted and validated for myocardial qMRI [Formula: see text] mapping. Contrarily to routine mono-exponential fitting procedures, phasor enables mapping the lifetime information from all image voxels to a single plot, without resorting to any regression fitting analysis, and describing multi-exponential qMRI decays without biases due to violated modelling assumptions. In this feasibility study, we test the performance of our recently developed full-harmonics phasor method for unravelling partial-volume effects, motion or pathological tissue alteration, respectively on a numerically-simulated dataset, a healthy subject scan, and two pilot patient datasets. Our results show that phasor analysis can be used, as alternative method to fitting analysis or other model-free approaches, to identify motion artifacts or partial-volume effects at the myocardium-blood interface as characteristic deviations, or delineations of scar and remote myocardial tissue in patient data.
    MeSH term(s) Humans ; Image Processing, Computer-Assisted/methods ; Optical Imaging/methods ; Myocardium
    Language English
    Publishing date 2022-11-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-23872-9
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  7. Article ; Online: Synthetic extracellular volume fraction-state of play.

    Treibel, Thomas A / Moon, James C

    Wiener klinische Wochenschrift

    2017  Volume 130, Issue 5-6, Page(s) 165–167

    Language English
    Publishing date 2017-11-07
    Publishing country Austria
    Document type Editorial ; Comment
    ZDB-ID 200462-8
    ISSN 1613-7671 ; 0043-5325 ; 0300-5178
    ISSN (online) 1613-7671
    ISSN 0043-5325 ; 0300-5178
    DOI 10.1007/s00508-017-1287-7
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    Zs.A 902: Show issues Location:
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  8. Article ; Online: Myocardial Hypoperfusion in Severe Aortic Stenosis Is Reversed Early After Aortic Valve Replacement.

    Thornton, George D / Bennett, Jonathan B / Nitsche, Christian / Gama, Francisco / Aziminia, Nikoo / Knott, Kristopher / Davies, Rhodri H / Moon, James C / Kellman, Peter / Treibel, Thomas A

    JACC. Cardiovascular imaging

    2024  

    Language English
    Publishing date 2024-04-13
    Publishing country United States
    Document type Letter
    ZDB-ID 2491503-8
    ISSN 1876-7591 ; 1936-878X
    ISSN (online) 1876-7591
    ISSN 1936-878X
    DOI 10.1016/j.jcmg.2024.03.008
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    Zs.A 6846: Show issues Location:
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  9. Article ; Online: High-definition blood flow imaging improves quantification of left ventricular volumes and ejection fraction.

    Gama, Francisco / Custódio, Pedro / Tsagkridi, Aliki / Moon, James / Lloyd, Guy / Treibel, Thomas A / Bhattacharyya, Sanjeev

    European heart journal. Cardiovascular Imaging

    2023  Volume 25, Issue 2, Page(s) 278–284

    Abstract: Aims: The accuracy and reproducibility of echocardiography to quantify left ventricular ejection fraction (LVEF) is limited due to image quality. High-definition blood flow imaging is a new technique which improves cavity delineation without the need ... ...

    Abstract Aims: The accuracy and reproducibility of echocardiography to quantify left ventricular ejection fraction (LVEF) is limited due to image quality. High-definition blood flow imaging is a new technique which improves cavity delineation without the need for medication or intravenous access. We sought to examine the impact of high-definition blood flow imaging on accuracy and reproducibility of LV systolic function assessment.
    Methods and results: Prospective observational study of consecutive patients undergoing 2D and 3D transthoracic echocardiography (TTE), high-definition blood flow imaging, and cardiac magnetic resonance (CMR) within 1 h of each other. Left ventricular systolic function characterized by left ventricular end-systolic volumes and left ventricular end-diastolic volumes and LVEF were measured. Seventy-six patients were included. Correlation of 2D TTE with CMR was modest (r = 0.68) with a worse correlation in patients with three or more segments not visualized (r = 0.58). High-definition blood flow imaging was feasible in all patients, and the correlation of LVEF with CMR was excellent (r = 0.88). The differences between 2D, high-definition blood flow, and 3D TTE compared to CMR were 5 ± 9%, 2 ± 5%, and 1 ± 3%, respectively. The proportion of patients where the grade of LV function was correctly classified improved from 72.3% using 2D TTE to 92.8% using high-definition blood flow imaging. 3D TTE also had excellent correlation with CMR (r = 0.97) however was only feasible in 72.4% of patients.
    Conclusion: High-definition blood flow imaging is highly feasible and significantly improves the diagnostic accuracy and grading of LV function compared to 2D echocardiography.
    MeSH term(s) Humans ; Stroke Volume ; Ventricular Function, Left ; Reproducibility of Results ; Ventricular Dysfunction, Left ; Heart Ventricles/diagnostic imaging ; Echocardiography, Three-Dimensional/methods
    Language English
    Publishing date 2023-09-27
    Publishing country England
    Document type Observational Study ; Journal Article
    ZDB-ID 2638345-7
    ISSN 2047-2412 ; 2047-2404
    ISSN (online) 2047-2412
    ISSN 2047-2404
    DOI 10.1093/ehjci/jead245
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    Zs.A 5614: Show issues Location:
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  10. Article ; Online: Improved reproducibility for myocardial ASL: Impact of physiological and acquisition parameters.

    Božić-Iven, Maša / Rapacchi, Stanislas / Tao, Qian / Pierce, Iain / Thornton, George / Nitsche, Christian / Treibel, Thomas A / Schad, Lothar R / Weingärtner, Sebastian

    Magnetic resonance in medicine

    2023  Volume 91, Issue 1, Page(s) 118–132

    Abstract: Purpose: To investigate and mitigate the influence of physiological and acquisition-related parameters on myocardial blood flow (MBF) measurements obtained with myocardial Arterial Spin Labeling (myoASL).: Methods: A Flow-sensitive Alternating ... ...

    Abstract Purpose: To investigate and mitigate the influence of physiological and acquisition-related parameters on myocardial blood flow (MBF) measurements obtained with myocardial Arterial Spin Labeling (myoASL).
    Methods: A Flow-sensitive Alternating Inversion Recovery (FAIR) myoASL sequence with bSSFP and spoiled GRE (spGRE) readout is investigated for MBF quantification. Bloch-equation simulations and phantom experiments were performed to evaluate how variations in acquisition flip angle (FA), acquisition matrix size (AMS), heart rate (HR) and blood
    Results: Simulated and phantom experiments showed a strong dependence on AMS and FA (
    Conclusion: Our results show that physiological and acquisition-related factors can lead to spurious changes in myoASL-MBF if not accounted for. Using individual
    MeSH term(s) Humans ; Reproducibility of Results ; Coronary Circulation/physiology ; Myocardium ; Heart Rate ; Phantoms, Imaging ; Myocardial Perfusion Imaging/methods
    Language English
    Publishing date 2023-09-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 605774-3
    ISSN 1522-2594 ; 0740-3194
    ISSN (online) 1522-2594
    ISSN 0740-3194
    DOI 10.1002/mrm.29834
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