LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 3763

Search options

  1. Article: The Vitamin D Receptor-BIM Axis Overcomes Cisplatin Resistance in Head and Neck Cancer.

    Khamis, Aya / Gül, Désirée / Wandrey, Madita / Lu, Qiang / Knauer, Shirley K / Reinhardt, Christoph / Strieth, Sebastian / Hagemann, Jan / Stauber, Roland H

    Cancers

    2022  Volume 14, Issue 20

    Abstract: ... the vitamin D receptor (VDR) as being significantly overexpressed in tumors of HNSCC patients (n = 604; ...

    Abstract Treatment success of head and neck squamous cell carcinoma (HNSCC) is often hindered by cisplatin resistance. As inherent and acquired therapy resistance counteracts improvement in long-term survival, novel multi-targeting strategies triggering cancer cell apoptosis are urgently required. Here, we identify the vitamin D receptor (VDR) as being significantly overexpressed in tumors of HNSCC patients (n = 604;
    Language English
    Publishing date 2022-10-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers14205131
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article: Vitamin D und atopische Erkrankungen.

    Reinhardt, D

    MMW Fortschritte der Medizin

    2013  Volume 155, Issue 16, Page(s) 29

    Title translation Vitamin D and atopic diseases.
    MeSH term(s) Eczema/epidemiology ; Female ; Humans ; Male ; Vitamin D/blood ; Vitamin D Deficiency/epidemiology
    Chemical Substances Vitamin D (1406-16-2)
    Language German
    Publishing date 2013-11-16
    Publishing country Germany
    Document type Journal Article ; Comment
    ZDB-ID 1478211-x
    ISSN 1438-3276
    ISSN 1438-3276
    DOI 10.1007/s15006-013-2159-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.20: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 72: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Correction to: Pentose degradation in archaea: Halorhabdus species degrade D-xylose, L-arabinose and D-ribose via bacterial-type pathways.

    Sutter, Jan-Moritz / Johnsen, Ulrike / Reinhardt, Andreas / Schönheit, Peter

    Extremophiles : life under extreme conditions

    2021  Volume 25, Issue 5-6, Page(s) 527

    Language English
    Publishing date 2021-09-27
    Publishing country Germany
    Document type Published Erratum
    ZDB-ID 1481278-2
    ISSN 1433-4909 ; 1431-0651
    ISSN (online) 1433-4909
    ISSN 1431-0651
    DOI 10.1007/s00792-021-01248-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article: Biochemical and Structural Characterisation of a Novel D-Lyxose Isomerase From the Hyperthermophilic Archaeon

    De Rose, Simone Antonio / Kuprat, Tom / Isupov, Michail N / Reinhardt, Andreas / Schönheit, Peter / Littlechild, Jennifer A

    Frontiers in bioengineering and biotechnology

    2021  Volume 9, Page(s) 711487

    Abstract: A novel D-lyxose isomerase has been identified within the genome of a hyperthermophilic archaeon ...

    Abstract A novel D-lyxose isomerase has been identified within the genome of a hyperthermophilic archaeon belonging to the
    Language English
    Publishing date 2021-08-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2719493-0
    ISSN 2296-4185
    ISSN 2296-4185
    DOI 10.3389/fbioe.2021.711487
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: It Takes Two to Tango: Activation of Protein Kinase D by Dimerization.

    Reinhardt, Ronja / Truebestein, Linda / Schmidt, Heiko A / Leonard, Thomas A

    BioEssays : news and reviews in molecular, cellular and developmental biology

    2020  Volume 42, Issue 4, Page(s) e1900222

    Abstract: ... domain in protein kinase D (PKD) has significant implications for its activation. PKD is a serine/threonine kinase ...

    Abstract The recent discovery and structure determination of a novel ubiquitin-like dimerization domain in protein kinase D (PKD) has significant implications for its activation. PKD is a serine/threonine kinase activated by the lipid second messenger diacylglycerol (DAG). It is an essential and highly conserved protein that is implicated in plasma membrane directed trafficking processes from the trans-Golgi network. However, many open questions surround its mechanism of activation, its localization, and its role in the biogenesis of cargo transport carriers. In reviewing this field, the focus is primarily on the mechanisms that control the activation of PKD at precise locations in the cell. In light of the new structural findings, the understanding of the mechanisms underlying PKD activation is critically evaluated, with particular emphasis on the role of dimerization in PKD autophosphorylation, and the provenance and recognition of the DAG that activates PKD.
    MeSH term(s) Animals ; Catalytic Domain ; Cell Membrane/metabolism ; Diglycerides/metabolism ; Dimerization ; Enzyme Activation ; Humans ; Phosphorylation ; Phylogeny ; Protein Binding ; Protein Domains ; Protein Kinase C/chemistry ; Protein Kinase C/genetics ; Protein Kinase C/metabolism ; Protein Processing, Post-Translational ; Signal Transduction ; trans-Golgi Network/metabolism
    Chemical Substances Diglycerides ; protein kinase D (EC 2.7.10.-) ; Protein Kinase C (EC 2.7.11.13)
    Language English
    Publishing date 2020-01-29
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 50140-2
    ISSN 1521-1878 ; 0265-9247
    ISSN (online) 1521-1878
    ISSN 0265-9247
    DOI 10.1002/bies.201900222
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2024: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Pentose degradation in archaea: Halorhabdus species degrade D-xylose, L-arabinose and D-ribose via bacterial-type pathways.

    Sutter, Jan-Moritz / Johnsen, Ulrike / Reinhardt, Andreas / Schönheit, Peter

    Extremophiles : life under extreme conditions

    2020  Volume 24, Issue 5, Page(s) 759–772

    Abstract: The degradation of the pentoses D-xylose, L-arabinose and D-ribose in the domain of archaea ... of these pathways are each clustered and were constitutively expressed. Selected enzymes involved in D-xylose ... isomerase and ribulokinase, were characterized. Further, D-ribose degradation in Halorhabdus species ...

    Abstract The degradation of the pentoses D-xylose, L-arabinose and D-ribose in the domain of archaea, in Haloferax volcanii and in Haloarcula and Sulfolobus species, has been shown to proceed via oxidative pathways to generate α-ketoglutarate. Here, we report that the haloarchaeal Halorhabdus species utilize the bacterial-type non-oxidative degradation pathways for pentoses generating xylulose-5-phosphate. The genes of these pathways are each clustered and were constitutively expressed. Selected enzymes involved in D-xylose degradation, xylose isomerase and xylulokinase, and those involved in L-arabinose degradation, arabinose isomerase and ribulokinase, were characterized. Further, D-ribose degradation in Halorhabdus species involves ribokinase, ribose-5-phosphate isomerase and D-ribulose-5-phosphate-3-epimerase. Ribokinase of Halorhabdus tiamatea and ribose-5-phosphate isomerase of Halorhabdus utahensis were characterized. This is the first report of pentose degradation via the bacterial-type pathways in archaea, in Halorhabdus species that likely acquired these pathways from bacteria. The utilization of bacterial-type pathways of pentose degradation rather than the archaeal oxidative pathways generating α-ketoglutarate might be explained by an incomplete gluconeogenesis in Halorhabdus species preventing the utilization of α-ketoglutarate in the anabolism.
    MeSH term(s) Arabinose/metabolism ; Bacteria ; Halobacteriaceae/enzymology ; Pentoses ; Ribose ; Xylose/metabolism
    Chemical Substances Pentoses ; Ribose (681HV46001) ; Xylose (A1TA934AKO) ; Arabinose (B40ROO395Z)
    Language English
    Publishing date 2020-08-05
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1481278-2
    ISSN 1433-4909 ; 1431-0651
    ISSN (online) 1433-4909
    ISSN 1431-0651
    DOI 10.1007/s00792-020-01192-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: D-galactose catabolism in archaea: operation of the DeLey-Doudoroff pathway in Haloferax volcanii.

    Tästensen, Julia-Beate / Johnsen, Ulrike / Reinhardt, Andreas / Ortjohann, Marius / Schönheit, Peter

    FEMS microbiology letters

    2020  Volume 367, Issue 1

    Abstract: The haloarchaeon Haloferax volcanii was found to grow on D-galactose as carbon and energy source ... Here we report a comprehensive analysis of D-galactose catabolism in H. volcanii. Genome analyses ... indicated a cluster of genes encoding putative enzymes of the DeLey-Doudoroff pathway for D-galactose ...

    Abstract The haloarchaeon Haloferax volcanii was found to grow on D-galactose as carbon and energy source. Here we report a comprehensive analysis of D-galactose catabolism in H. volcanii. Genome analyses indicated a cluster of genes encoding putative enzymes of the DeLey-Doudoroff pathway for D-galactose degradation including galactose dehydrogenase, galactonate dehydratase, 2-keto-3-deoxygalactonate kinase and 2-keto-3-deoxy-6-phosphogalactonate (KDPGal) aldolase. The recombinant galactose dehydrogenase and galactonate dehydratase showed high specificity for D-galactose and galactonate, respectively, whereas KDPGal aldolase was promiscuous in utilizing KDPGal and also the C4 epimer 2-keto-3-deoxy-6-phosphogluconate as substrates. Growth studies with knock-out mutants indicated the functional involvement of galactose dehydrogenase, galactonate dehydratase and KDPGal aldolase in D-galactose degradation. Further, the transcriptional regulator GacR was identified, which was characterized as an activator of genes of the DeLey-Doudoroff pathway. Finally, genes were identified encoding components of an ABC transporter and a knock-out mutant of the substrate binding protein indicated the functional involvement of this transporter in D-galactose uptake. This is the first report of D-galactose degradation via the DeLey-Doudoroff pathway in the domain of archaea.
    MeSH term(s) Carbohydrate Metabolism/genetics ; Enzymes/genetics ; Enzymes/metabolism ; Galactose/metabolism ; Gene Knockout Techniques ; Genes, Archaeal/genetics ; Haloferax volcanii/enzymology ; Haloferax volcanii/genetics ; Metabolic Networks and Pathways/genetics
    Chemical Substances Enzymes ; Galactose (X2RN3Q8DNE)
    Language English
    Publishing date 2020-02-10
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 752343-9
    ISSN 1574-6968 ; 0378-1097
    ISSN (online) 1574-6968
    ISSN 0378-1097
    DOI 10.1093/femsle/fnaa029
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1372: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Correction to: The Effects of Lifestyle and/or Vitamin D Supplementation Interventions on Pregnancy Outcomes: What Have we Learned from the DALI Studies?

    Harreiter, Jürgen / Desoye, Gernot / van Poppel, Mireille N M / Kautzky-Willer, Alexandra / Dunne, Fidelma / Corcoy, Rosa / Devlieger, Roland / Simmons, David / Adelantado, Juan M / Damm, Peter / Mathiesen, Elizabeth Reinhardt / Jensen, Dorte Moeller / Anderson, Lise Lotte T / Lapolla, Annunziata / Dalfrà, Maria G / Bertolotto, Alessandra / Wender-Ozegowska, Ewa / Zawiejska, Agnieszka / Hill, David J /
    Snoek, Frank J

    Current diabetes reports

    2020  Volume 20, Issue 8, Page(s) 35

    Abstract: The original version of this review article unfortunately contained a mistake. ...

    Abstract The original version of this review article unfortunately contained a mistake.
    Language English
    Publishing date 2020-06-22
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 2065167-3
    ISSN 1539-0829 ; 1534-4827
    ISSN (online) 1539-0829
    ISSN 1534-4827
    DOI 10.1007/s11892-020-01322-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5628: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: d-Ribose Catabolism in Archaea: Discovery of a Novel Oxidative Pathway in

    Johnsen, Ulrike / Sutter, Jan-Moritz / Reinhardt, Andreas / Pickl, Andreas / Wang, Rui / Xiang, Hua / Schönheit, Peter

    Journal of bacteriology

    2020  Volume 202, Issue 3

    Abstract: ... ...

    Abstract The
    MeSH term(s) Arabinose/metabolism ; Archaea/metabolism ; Haloarcula/metabolism ; Oxidation-Reduction ; Ribose/metabolism ; Xylose/metabolism
    Chemical Substances Ribose (681HV46001) ; Xylose (A1TA934AKO) ; Arabinose (B40ROO395Z)
    Language English
    Publishing date 2020-01-15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2968-3
    ISSN 1098-5530 ; 0021-9193
    ISSN (online) 1098-5530
    ISSN 0021-9193
    DOI 10.1128/JB.00608-19
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.50: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article: Effect of High Dose Active Vitamin D Therapy on the Development of Hypocalcemia After Subtotal Parathyroidectomy in Patients on Chronic Dialysis.

    Grube, Malina / Weber, Frank / Kahl, Anna Lena / Kribben, Andreas / Mülling, Nils / Reinhardt, Walter

    International journal of nephrology and renovascular disease

    2021  Volume 14, Page(s) 399–410

    Abstract: ... D immediately after PTx on the development of hypocalcemia.: Materials and methods ...

    Abstract Background: The period after parathyroidectomy (PTx) in dialysis patients is characterized by periods of severe hypocalcemia. This study aims to investigate the effect of high doses of active vitamin D immediately after PTx on the development of hypocalcemia.
    Materials and methods: We retrospectively reviewed 111 patients with secondary hyperparathyroidism receiving subtotal PTx between 2010 and 2019. A high dose group "HDG" (n = 67) receiving 12 µg alfacalcidol in combination with 8.550 mg calcium acetate per day, which was then adapted according to lab values, was compared with a low dose group "LDG" (n = 44) receiving up to 4 µg alfacalcidol per day. The laboratory values were recorded up to ten weeks postoperatively.
    Results: The assumed drops in parathyroid hormone (PTH) and calcium were observed in both groups after PTx. We observed significantly lower calcium values in the LDG between days 4 and 18 postoperatively than in the HDG (
    Conclusion: The period after PTx in dialysis patients is characterized by an expected drop in PTH and calcium within the first days. Ongoing high turnover is observed in the 2nd and 3rd week after PTx. Administering high doses of alfacalcidol combined with calcium acetate diminishes the episodes of severe hypocalcemia and the need for intravenous calcium.
    Language English
    Publishing date 2021-11-11
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2508160-3
    ISSN 1178-7058
    ISSN 1178-7058
    DOI 10.2147/IJNRD.S334227
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top