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  1. Article ; Online: Synthesis of 25-Hydroxy-provitamin D

    Wojtkielewicz, Agnieszka / Baj, Aneta / Majewski, Adam D / Wysocka, Joanna / Morzycki, Jacek W

    The Journal of organic chemistry

    2024  Volume 89, Issue 3, Page(s) 1648–1656

    Abstract: A new synthetic route to 25-hydroxy-provitamin ... ...

    Abstract A new synthetic route to 25-hydroxy-provitamin D
    Language English
    Publishing date 2024-01-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 123490-0
    ISSN 1520-6904 ; 0022-3263
    ISSN (online) 1520-6904
    ISSN 0022-3263
    DOI 10.1021/acs.joc.3c02305
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4473: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  2. Article: Trace Elements in Alzheimer's Disease and Dementia: The Current State of Knowledge.

    Tyczyńska, Magdalena / Gędek, Marta / Brachet, Adam / Stręk, Wojciech / Flieger, Jolanta / Teresiński, Grzegorz / Baj, Jacek

    Journal of clinical medicine

    2024  Volume 13, Issue 8

    Abstract: Changes in trace element concentrations are being wildly considered when it comes to neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. This study aims to present the role that trace elements play in the central nervous ... ...

    Abstract Changes in trace element concentrations are being wildly considered when it comes to neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. This study aims to present the role that trace elements play in the central nervous system. Moreover, we reviewed the mechanisms involved in their neurotoxicity. Low zinc concentrations, as well as high levels of copper, manganese, and iron, activate the signalling pathways of the inflammatory, oxidative and nitrosative stress response. Neurodegeneration occurs due to the association between metals and proteins, which is then followed by aggregate formation, mitochondrial disorder, and, ultimately, cell death. In Alzheimer's disease, low Zn levels suppress the neurotoxicity induced by β-amyloid through the selective precipitation of aggregation intermediates. High concentrations of copper, iron and manganese cause the aggregation of intracellular α-synuclein, which results in synaptic dysfunction and axonal transport disruption. Parkinson's disease is caused by the accumulation of Fe in the midbrain dopaminergic nucleus, and the pathogenesis of multiple sclerosis derives from Zn deficiency, leading to an imbalance between T cell functions. Aluminium disturbs the homeostasis of other metals through a rise in the production of oxygen reactive forms, which then leads to cellular death. Selenium, in association with iron, plays a distinct role in the process of ferroptosis. Outlining the influence that metals have on oxidoreduction processes is crucial to recognising the pathophysiology of neurodegenerative diseases and may provide possible new methods for both their avoidance and therapy.
    Language English
    Publishing date 2024-04-19
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13082381
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Hepatokines, bile acids and ketone bodies are novel Hormones regulating energy homeostasis.

    Garruti, Gabriella / Baj, Jacek / Cignarelli, Angelo / Perrini, Sebastio / Giorgino, Francesco

    Frontiers in endocrinology

    2023  Volume 14, Page(s) 1154561

    Abstract: Current views show that an impaired balance partly explains the fat accumulation leading to obesity. Fetal malnutrition and early exposure to endocrine-disrupting compounds also contribute to obesity and impaired insulin secretion and/or sensitivity. The ...

    Abstract Current views show that an impaired balance partly explains the fat accumulation leading to obesity. Fetal malnutrition and early exposure to endocrine-disrupting compounds also contribute to obesity and impaired insulin secretion and/or sensitivity. The liver plays a major role in systemic glucose homeostasis through hepatokines secreted by hepatocytes. Hepatokines influence metabolism through autocrine, paracrine, and endocrine signaling and mediate the crosstalk between the liver, non-hepatic target tissues, and the brain. The liver also synthetizes bile acids (BAs) from cholesterol and secretes them into the bile. After food consumption, BAs mediate the digestion and absorption of fat-soluble vitamins and lipids in the duodenum. In recent studies, BAs act not simply as fat emulsifiers but represent endocrine molecules regulating key metabolic pathways. The liver is also the main site of the production of ketone bodies (KBs). In prolonged fasting, the brain utilizes KBs as an alternative to CHO. In the last few years, the ketogenic diet (KD) became a promising dietary intervention. Studies on subjects undergoing KD show that KBs are important mediators of inflammation and oxidative stress. The present review will focus on the role played by hepatokines, BAs, and KBs in obesity, and diabetes prevention and management and analyze the positive effects of BAs, KD, and hepatokine receptor analogs, which might justify their use as new therapeutic approaches for metabolic and aging-related diseases.
    MeSH term(s) Humans ; Ketone Bodies/metabolism ; Bile Acids and Salts ; Hormones ; Obesity/metabolism ; Homeostasis
    Chemical Substances Ketone Bodies ; Bile Acids and Salts ; Hormones
    Language English
    Publishing date 2023-05-19
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2023.1154561
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: An Overview of the Spices Used for the Prevention and Potential Treatment of Gastric Cancer.

    Kostelecka, Katarzyna / Bryliński, Łukasz / Komar, Olga / Michalczyk, Justyna / Miłosz, Agata / Biłogras, Jan / Woliński, Filip / Forma, Alicja / Baj, Jacek

    Cancers

    2024  Volume 16, Issue 8

    Abstract: Gastric cancer (GC) ranks third in terms of cancer-related deaths and is the fifth most commonly diagnosed type of cancer. Its risk factors ... ...

    Abstract Gastric cancer (GC) ranks third in terms of cancer-related deaths and is the fifth most commonly diagnosed type of cancer. Its risk factors include
    Language English
    Publishing date 2024-04-22
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers16081611
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Nutritional Supplements for Skin Health-A Review of What Should Be Chosen and Why.

    Januszewski, Jacek / Forma, Alicja / Zembala, Julita / Flieger, Michał / Tyczyńska, Magdalena / Dring, James Curtis / Dudek, Iga / Świątek, Kamila / Baj, Jacek

    Medicina (Kaunas, Lithuania)

    2023  Volume 60, Issue 1

    Abstract: Supplementation of micronutrients is considered to be crucial in the reinforcement of the skin's barrier. In this paper, 14 nutritional compounds commonly used in food or pharmaceutic industries were analyzed in terms of influencing skin conditions. The ... ...

    Abstract Supplementation of micronutrients is considered to be crucial in the reinforcement of the skin's barrier. In this paper, 14 nutritional compounds commonly used in food or pharmaceutic industries were analyzed in terms of influencing skin conditions. The major objective of this paper was to provide a narrative review of the available literature regarding several chosen compounds that are currently widely recommended as supplements that aim to maintain proper and healthy skin conditions. We conducted a review of the literature from PubMed, Scopus, and Web of Science until September 2023 without any other restrictions regarding the year of the publication. Ultimately, we reviewed 238 articles, including them in this review. Each of the reviewed compounds, including vitamin A, vitamin C, vitamin D, vitamin E, curcumin, chlorella, Omega-3, biotin,
    MeSH term(s) Humans ; Chlorella ; Skin ; Dietary Supplements ; Psoriasis ; Vitamins
    Chemical Substances Vitamins
    Language English
    Publishing date 2023-12-29
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina60010068
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6270: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Determination of Cyanide in Blood for Forensic Toxicology Purposes-A Novel Nci Gc-Ms/Ms Technique.

    Osak, Marcin / Buszewicz, Grzegorz / Baj, Jacek / Teresiński, Grzegorz

    Molecules (Basel, Switzerland)

    2021  Volume 26, Issue 18

    Abstract: One of the recently evolving methods for cyanide determination in body fluids is GC-MS, following extractive alkylation with pentafluorobenzyl bromide or ... ...

    Abstract One of the recently evolving methods for cyanide determination in body fluids is GC-MS, following extractive alkylation with pentafluorobenzyl bromide or pentafluorobenzyl
    MeSH term(s) Cyanides ; Forensic Toxicology ; Gas Chromatography-Mass Spectrometry ; Tandem Mass Spectrometry
    Chemical Substances Cyanides
    Language English
    Publishing date 2021-09-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules26185638
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  7. Article ; Online: The Future of Morphological Science Education: Learning and Teaching Anatomy in the Wake of the COVID-19 Pandemic.

    Maani, Amr / Forma, Alicja / Brachet, Adam / Czarnek, Katarzyna / Alashkham, Abduelmenem / Baj, Jacek

    International journal of environmental research and public health

    2023  Volume 20, Issue 7

    Abstract: The COVID-19 Pandemic has conveyed an unprecedented worldwide challenge. Although there is much emphasis on caring for patients and communities, the high incidence of SARS-CoV-2 had seriously disturbed education and calls for prompt as well as serious ... ...

    Abstract The COVID-19 Pandemic has conveyed an unprecedented worldwide challenge. Although there is much emphasis on caring for patients and communities, the high incidence of SARS-CoV-2 had seriously disturbed education and calls for prompt as well as serious consideration from educators in medical schools. The necessity to teach and prepare prospective medics, as well as clinicians, has certainly not been as intense as it is currently. The global effects of coronavirus disease 2019 may cause a permanent change in the education of future clinicians. The COVID-19 era presented logistical and practical obstacles and fears for the patients' well-being, taking into consideration the fact that students may be potential channels for the spread of the virus when asymptomatic and may get infected while being in training and attending lectures. This paper discusses the present state of morphological science education, depicting the effect of COVID-19 on learning environments, as well as highlights the probable effects of COVID-19 on medical instruction in the future.
    MeSH term(s) Humans ; COVID-19/epidemiology ; SARS-CoV-2 ; Pandemics ; Prospective Studies ; Education, Distance ; Students, Medical ; Teaching
    Language English
    Publishing date 2023-04-03
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph20075367
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Common fibular nerve palsy due to the Fabella: A review.

    Woliński, Filip / Bryliński, Łukasz / Kostelecka, Katarzyna / Teresiński, Grzegorz / Buszewicz, Grzegorz / Baj, Jacek

    Clinical anatomy (New York, N.Y.)

    2023  Volume 37, Issue 1, Page(s) 73–80

    Abstract: One of the most common nerve palsies - common fibular nerve palsy - can be caused by the variant small sesamoid bone in the posterolateral compartment of the knee joint known as the fabella. We compared and reviewed all reported cases of common fibular ... ...

    Abstract One of the most common nerve palsies - common fibular nerve palsy - can be caused by the variant small sesamoid bone in the posterolateral compartment of the knee joint known as the fabella. We compared and reviewed all reported cases of common fibular nerve palsy due to fabellae in the English literature. Compression can develop spontaneously or post-surgically (total knee arthroplasty). Symptoms progress rapidly to complete foot drop. Among all the cases reviewed, 68.42% were males with a median age of 39.39 years. Fabella compression was more common in the left common fibular nerve (CFN) (63.16%). Both big (23 × 20 × 16 mm) and small (5 × 5 mm) fabellae can be responsible for compression. While diagnosis can be problematic, the treatment (either surgical fabellectomy or conservative) is relatively easy and brings quick improvement.
    MeSH term(s) Male ; Humans ; Adult ; Female ; Peroneal Neuropathies/etiology ; Peroneal Neuropathies/surgery ; Peroneal Neuropathies/diagnosis ; Peroneal Nerve ; Knee Joint ; Sesamoid Bones/surgery ; Paralysis/complications
    Language English
    Publishing date 2023-06-28
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1025505-9
    ISSN 1098-2353 ; 0897-3806
    ISSN (online) 1098-2353
    ISSN 0897-3806
    DOI 10.1002/ca.24089
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2592: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article: Technological Advances in a Therapy of Primary Open-Angle Glaucoma: Insights into Current Nanotechnologies.

    Zembala, Julita / Forma, Alicja / Zembala, Roksana / Januszewski, Jacek / Zembala, Patryk / Adamowicz, Dominik / Teresiński, Grzegorz / Buszewicz, Grzegorz / Flieger, Jolanta / Baj, Jacek

    Journal of clinical medicine

    2023  Volume 12, Issue 18

    Abstract: Glaucoma is a leading cause of irreversible blindness and is characterized by increased intraocular pressure (IOP) and progressive optic nerve damage. The current therapeutic approaches for glaucoma management, such as eye drops and oral medications, ... ...

    Abstract Glaucoma is a leading cause of irreversible blindness and is characterized by increased intraocular pressure (IOP) and progressive optic nerve damage. The current therapeutic approaches for glaucoma management, such as eye drops and oral medications, face challenges including poor bioavailability, low patient compliance, and limited efficacy. In recent years, nanotechnology has emerged as a promising approach to overcome these limitations and revolutionize glaucoma treatment. In this narrative review, we present an overview of the novel nanotechnologies employed in the treatment of primary open-angle glaucoma. Various nanosystems, including liposomes, niosomes, nanoparticles, and other nanostructured carriers, have been developed to enhance the delivery and bioavailability of antiglaucoma drugs. They offer advantages such as a high drug loading capacity, sustained release, improved corneal permeability, and targeted drug delivery to the ocular tissues. The application of nanotechnologies in glaucoma treatment represents a transformative approach that addresses the limitations of conventional therapies. However, further research is needed to optimize the formulations, evaluate long-term safety, and implement these nanotechnologies into clinical practice. With continued advancements in nanotechnology, the future holds great potential for improving the management and outcomes of glaucoma, ultimately preserving vision and improving the lives of millions affected by this debilitating disease.
    Language English
    Publishing date 2023-09-06
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12185798
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Clinical significance of Left-Sided Gallbladder for laparoscopic cholecystectomy and hepatectomy.

    Szymoniuk, Michał / Brachet, Adam / Ciejka, Karol / Zielkowska, Alicja / Błaszczyk, Jan / Burdan, Oliwia / Baj, Jacek

    Polski przeglad chirurgiczny

    2023  Volume 95, Issue 4, Page(s) 1–5

    Abstract: A left-sided gallbladder (LSG) represents a rare anatomical variation defined by the location of the gallbladder to the left side of the liver falciform and round ligaments, which is often not discovered until surgery. The reported prevalence of this ... ...

    Abstract A left-sided gallbladder (LSG) represents a rare anatomical variation defined by the location of the gallbladder to the left side of the liver falciform and round ligaments, which is often not discovered until surgery. The reported prevalence of this ectopia ranges from 0.2% to 1.1%, however, those values may be underestimated. It is mostly an asymptomatic condition, thus not causing the patient any harm, and being few reported cases in the current literature. Based on clinical presentation and standard diagnostic procedures, LSG can remain undetected and represent accidental intraoperative finding. The attempts to explain the cause of this anomaly have been different, but the numerous variations described do not allow a clear definition of its origin. Although this debate is still open, it is of considerable importance to know that LSG is frequently associated with alterations of both the portal branches and the intrahepatic biliary tree. The association of these anomalies, therefore, represents an important risk of complications in cases when surgical treatment is necessary. In this context, our literature review aimed to summarize possible anatomical anomalies coexisting with LSG and discuss the clinical significance of the LSG, when the patient requires cholecystectomy or hepatectomy.
    MeSH term(s) Female ; Humans ; Gallbladder/surgery ; Cholecystectomy, Laparoscopic/methods ; Hepatectomy ; Clinical Relevance
    Language English
    Publishing date 2023-02-08
    Publishing country Poland
    Document type Review ; Journal Article
    ZDB-ID 128732-1
    ISSN 2299-2847 ; 0032-373X
    ISSN (online) 2299-2847
    ISSN 0032-373X
    DOI 10.5604/01.3001.0016.2124
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 375: Show issues Location:
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