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  1. Article ; Online: Letter to the editor: in response to: Richard F Pollock & Patrick Biggar. Indirect methods of comparison of the safety of ferric derisomaltose, iron sucrose and ferric carboxymaltose in the treatment of iron deficiency anemia.

    Aksan, Aysegül / Dignass, Axel / Stein, Jürgen

    Expert review of hematology

    2021  Volume 15, Issue 4, Page(s) 383–384

    MeSH term(s) Anemia, Iron-Deficiency/drug therapy ; Disaccharides ; Ferric Compounds/adverse effects ; Ferric Oxide, Saccharated ; Humans ; Iron Deficiencies ; Maltose/analogs & derivatives
    Chemical Substances Disaccharides ; Ferric Compounds ; ferric carboxymaltose (6897GXD6OE) ; Maltose (69-79-4) ; ferric derisomaltose (AHU547PI9H) ; Ferric Oxide, Saccharated (FZ7NYF5N8L)
    Language English
    Publishing date 2021-02-10
    Publishing country England
    Document type Letter
    ZDB-ID 2516804-6
    ISSN 1747-4094 ; 1747-4086
    ISSN (online) 1747-4094
    ISSN 1747-4086
    DOI 10.1080/17474086.2021.1883948
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Bicelles Rich in both Sphingolipids and Cholesterol and Their Use in Studies of Membrane Proteins.

    Hutchison, James M / Shih, Kuo-Chih / Scheidt, Holger A / Fantin, Sarah M / Parson, Kristine F / Pantelopulos, George A / Harrington, Haley R / Mittendorf, Kathleen F / Qian, Shuo / Stein, Richard A / Collier, Scott E / Chambers, Melissa G / Katsaras, John / Voehler, Markus W / Ruotolo, Brandon T / Huster, Daniel / McFeeters, Robert L / Straub, John E / Nieh, Mu-Ping /
    Sanders, Charles R

    Journal of the American Chemical Society

    2020  Volume 142, Issue 29, Page(s) 12715–12729

    Abstract: How the distinctive lipid composition of mammalian plasma membranes impacts membrane protein structure is largely unexplored, partly because of the dearth of isotropic model membrane systems that contain abundant sphingolipids and cholesterol. This gap ... ...

    Abstract How the distinctive lipid composition of mammalian plasma membranes impacts membrane protein structure is largely unexplored, partly because of the dearth of isotropic model membrane systems that contain abundant sphingolipids and cholesterol. This gap is addressed by showing that
    MeSH term(s) Cholesterol/chemistry ; Cryoelectron Microscopy ; Humans ; Membrane Proteins/chemistry ; Sphingolipids/chemistry
    Chemical Substances Membrane Proteins ; Sphingolipids ; Cholesterol (97C5T2UQ7J)
    Language English
    Publishing date 2020-07-08
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.0c04669
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book ; Conference proceedings: The architecture of Richard Morris Hunt

    Hunt, Richard Morris / Stein, Susan R

    [exhibition ; The Metropolitan Museum of Art, New York, 20.3. - 15.6.1986, Octagon, Washington, DC, 20.7. - 28.9.1986; Chicago, Ill., The Art Institute 9.2. - 29.3.1987]

    (The history of architecture)

    1986  

    Institution Art Institute of Chicago
    Metropolitan Museum of Art
    Octagon
    Event/congress Exhibition (1986.03.20-06.15, NewYorkNY) ; Exhibition (1986.07.20-09.28, WashingtonDC) ; Exhibition (1987.02.09-03.29, ChicagoIll.)
    Author's details ed. by Susan R. Stein
    Series title The history of architecture
    Language English
    Size XIV, 192 S., zahlr. Ill.
    Publisher Univ. of Chicago Press
    Publishing place Chicago, Ill. u.a.
    Document type Book ; Conference proceedings
    Note Includes bibliographies and index
    ISBN 0226771687 ; 0226771695 ; 9780226771687 ; 9780226771694
    Database Former special subject collection: coastal and deep sea fishing

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  4. Book ; Conference proceedings: The architecture of Richard Morris Hunt

    Hunt, Richard Morris / Stein, Susan R

    [exhibition ; The Metropolitan Museum of Art, New York, 20.3. - 15.6.1986, Octagon, Washington, DC, 20.7. - 28.9.1986; Chicago, Ill., The Art Institute 9.2. - 29.3.1987]

    (The history of architecture)

    1986  

    Abstract: ... and reputation / Susan R. Stein -- Richard Morris Hunt and his influence on American Beaux-Arts ... Richard Morris Hunt, an introduction / Paul R. Baker -- Hunt in Paris / Richard Chafee -- Richard ...

    Institution Art Institute of Chicago
    Metropolitan Museum of Art
    Octagon
    Event/congress Exhibition (1986.03.20-06.15, NewYorkNY) ; Exhibition (1986.07.20-09.28, WashingtonDC) ; Exhibition (1987.02.09-03.29, ChicagoIll.)
    Author's details ed. by Susan R. Stein
    Series title The history of architecture
    Abstract Richard Morris Hunt, an introduction / Paul R. Baker -- Hunt in Paris / Richard Chafee -- Richard Morris Hunt, architectural innovator and father of a "distinctive" American school / Sarah Bradford Landau -- The Central Park gateways / Francis R. Kowsky -- The Lenox Library / David van Zanten -- Role and reputation / Susan R. Stein -- Richard Morris Hunt and his influence on American Beaux-Arts sculpture / Lewis I. Sharp -- Superb privacies / David Chase -- Hunt and the Metropolitan Museum of Art / Morrison H. Heckscher
    Language English
    Size XIV, 192 S., zahlr. Ill.
    Publisher Univ. of Chicago Press
    Publishing place Chicago, Ill. u.a.
    Document type Book ; Conference proceedings
    Note Includes bibliographies and index
    ISBN 0226771687 ; 0226771695 ; 9780226771687 ; 9780226771694
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  5. Article ; Online: Aging Affects the Efficacy of Platelet-Rich Plasma Treatment for Osteoarthritis.

    Chowdhary, Kuntal / Sahu, Amrita / Iijima, Hirotaka / Shinde, Sunita / Borg-Stein, Joanne / Ambrosio, Fabrisia

    American journal of physical medicine & rehabilitation

    2022  Volume 102, Issue 7, Page(s) 597–604

    Abstract: Objective: Despite the increased use of platelet-rich plasma in the treatment of osteoarthritis ... whether and how age of the platelet-rich plasma donor affects therapeutic efficacy is unclear.: Design ... In vitro, male osteoarthritic human chondrocytes were treated with platelet-rich plasma from young (18-35 ...

    Abstract Objective: Despite the increased use of platelet-rich plasma in the treatment of osteoarthritis, whether and how age of the platelet-rich plasma donor affects therapeutic efficacy is unclear.
    Design: In vitro, male osteoarthritic human chondrocytes were treated with platelet-rich plasma from young (18-35 yrs) or old (≥65 yrs) donors, and the chondrogenic profile was evaluated using immunofluorescent staining for two markers of chondrogenicity, type II collagen and SOX-9. In vivo, we used a within-subjects design to compare Osteoarthritis Research Society International scores in aged mouse knee joints injected with platelet-rich plasma from young or old individuals.
    Results: In vitro experiments revealed that platelet-rich plasma from young donors induced a more youthful chondrocyte phenotype, as evidenced by increased type II collagen ( P = 0.033) and SOX-9 expression ( P = 0.022). This benefit, however, was significantly blunted when cells were cultured with platelet-rich plasma from aged donors. Accordingly, in vivo studies revealed that animals treated with platelet-rich plasma from young donors displayed a significantly improved cartilage integrity when compared with knees injected with platelet-rich plasma from aged donors ( P = 0.019).
    Conclusions: Injection of platelet-rich plasma from a young individual induced a regenerative effect in aged cells and mice, whereas platelet-rich plasma from aged individuals showed no improvement in chondrocyte health or cartilage integrity.
    MeSH term(s) Humans ; Male ; Mice ; Animals ; Collagen Type II/metabolism ; Osteoarthritis/therapy ; Chondrocytes ; Aging ; Platelet-Rich Plasma/metabolism ; Osteoarthritis, Knee/therapy ; Injections, Intra-Articular
    Chemical Substances Collagen Type II
    Language English
    Publishing date 2022-12-07
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 219390-5
    ISSN 1537-7385 ; 0002-9491 ; 0894-9115
    ISSN (online) 1537-7385
    ISSN 0002-9491 ; 0894-9115
    DOI 10.1097/PHM.0000000000002161
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Campylobacter jejuni

    Stein, Richard A

    ACS infectious diseases

    2022  Volume 8, Issue 10, Page(s) 1981–1991

    Abstract: Glycans, one of the most diverse groups of macromolecules, are ubiquitous constituents of all cells and have many critical functions, including the interaction between microbes and their hosts. One of the best model organisms to study the host-pathogen ... ...

    Abstract Glycans, one of the most diverse groups of macromolecules, are ubiquitous constituents of all cells and have many critical functions, including the interaction between microbes and their hosts. One of the best model organisms to study the host-pathogen interaction, the gastrointestinal pathogen
    MeSH term(s) Autoimmune Diseases/complications ; Campylobacter Infections/complications ; Campylobacter Infections/microbiology ; Campylobacter jejuni ; Gangliosides ; Glycomics ; Guillain-Barre Syndrome ; Humans ; Sugars
    Chemical Substances Gangliosides ; Sugars
    Language English
    Publishing date 2022-09-22
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2373-8227
    ISSN (online) 2373-8227
    DOI 10.1021/acsinfecdis.2c00397
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Rosetta Energy Analysis of AlphaFold2 models: Point Mutations and Conformational Ensembles.

    Stein, Richard A / Mchaourab, Hassane S

    bioRxiv : the preprint server for biology

    2024  

    Abstract: There has been an explosive growth in the applications of AlphaFold2, and other structure prediction platforms, to accurately predict protein structures from a multiple sequence alignment (MSA) for downstream structural analysis. However, two outstanding ...

    Abstract There has been an explosive growth in the applications of AlphaFold2, and other structure prediction platforms, to accurately predict protein structures from a multiple sequence alignment (MSA) for downstream structural analysis. However, two outstanding questions persist in the field regarding the robustness of AlphaFold2 predictions of the consequences of point mutations and the completeness of its prediction of protein conformational ensembles. We combined our previously developed method SPEACH_AF with model relaxation and energetic analysis with Rosetta to address these questions. SPEACH_AF introduces residue substitutions across the MSA and not just within the input sequence. With respect to conformational ensembles, we combined SPEACH_AF and a new MSA subsampling method, AF_cluster, and for a benchmarked set of proteins, we found that the energetics of the conformational ensembles generated by AlphaFold2 correspond to those of experimental structures and explored by standard molecular dynamic methods. With respect to point mutations, we compared the structural and energetic consequences of having the mutation(s) in the input sequence versus in the whole MSA (SPEACH_AF). Both methods yielded models different from the wild-type sequence, with more robust changes when the mutation(s) were in the whole MSA. While our findings demonstrate the robustness of AlphaFold2 in analyzing point mutations and exploring conformational ensembles, they highlight the need for multi parameter structural and energetic analyses of these models to generate experimentally testable hypotheses.
    Language English
    Publishing date 2024-01-27
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.09.05.556364
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Bicelles Rich in both Sphingolipids and Cholesterol and Their Use in Studies of Membrane Proteins

    Hutchison, James M / Shih, Kuo-Chih / Scheidt, Holger A / Fantin, Sarah M / Parson, Kristine F / Pantelopulos, George A / Harrington, Haley R / Mittendorf, Kathleen F / Qian, Shuo / Stein, Richard A / Collier, Scott E / Chambers, Melissa G / Katsaras, John / Voehler, Markus W / Ruotolo, Brandon T / Huster, Daniel / McFeeters, Robert L / Straub, John E / Nieh, Mu-Ping /
    Sanders, Charles R

    Journal of the American Chemical Society. 2020 June 23, v. 142, no. 29

    2020  

    Abstract: ... cholesterol-rich (SCOR) lipid mixtures with phosphatidylcholine can be cosolubilized by n-dodecyl-β ...

    Abstract How the distinctive lipid composition of mammalian plasma membranes impacts membrane protein structure is largely unexplored, partly because of the dearth of isotropic model membrane systems that contain abundant sphingolipids and cholesterol. This gap is addressed by showing that sphingomyelin and cholesterol-rich (SCOR) lipid mixtures with phosphatidylcholine can be cosolubilized by n-dodecyl-β-melibioside to form bicelles. Small-angle X-ray and neutron scattering, as well as cryo-electron microscopy, demonstrate that these assemblies are stable over a wide range of conditions and exhibit the bilayered-disc morphology of ideal bicelles even at low lipid-to-detergent mole ratios. SCOR bicelles are shown to be compatible with a wide array of experimental techniques, as applied to the transmembrane human amyloid precursor C99 protein in this medium. These studies reveal an equilibrium between low-order oligomer structures that differ significantly from previous experimental structures of C99, providing an example of how ordered membranes alter membrane protein structure.
    Keywords amyloid ; cholesterol ; cryo-electron microscopy ; humans ; isotropy ; lipid composition ; membrane proteins ; neutrons ; phosphatidylcholines ; protein structure ; small-angle X-ray scattering ; sphingomyelins
    Language English
    Dates of publication 2020-0623
    Size p. 12715-12729.
    Publishing place American Chemical Society
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.0c04669
    Database NAL-Catalogue (AGRICOLA)

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  9. Article ; Online: Platelet rich plasma for hallux sesamoid injuries: a case series.

    Le, Hung M / Stracciolini, Andrea / Stein, Cynthia J / Quinn, Bridget J / Jackson, Sarah S

    The Physician and sportsmedicine

    2021  Volume 50, Issue 2, Page(s) 181–184

    Abstract: ... disabling. The role of orthobiologics such as platelet-rich plasma (PRP) in sesamoid injuries has not been ... sesamoids. Each site of injury was treated with one treatment of leukocyte-rich PRP. All three athletes were ...

    Abstract Objective: Hallux sesamoid injuries are well described and can be debilitating and chronically disabling. The role of orthobiologics such as platelet-rich plasma (PRP) in sesamoid injuries has not been reported. This study describes three cases of recalcitrant hallux sesamoid injuries in teenage athletes who returned to impact activities, pain free, following one treatment of PRP.
    Methods: This is a case-series study describing three teenage athletes presenting to a tertiary level pediatric sports medicine practice with chronic hallux sesamoid injuries.
    Results: The three patients (two female, one male) described in this case series were 13-, 16-, and 17-year-old athletes. Their primary sports were ballet, basketball, and Irish step dance, respectively. All three athletes received PRP: two received unilateral treatment (one tibial sesamoid, one fibular sesamoid) and one received treatment to bilateral tibial sesamoids. The average duration of symptoms prior to PRP was 52.5 weeks (14-128 weeks). The average time out of their primary sport was 48.7 weeks (20-78 weeks). Three of the 4 sesamoids treated with PRP were tibial sesamoids. Each site of injury was treated with one treatment of leukocyte-rich PRP. All three athletes were cleared to return to impact activities such as running and jumping at 6-9 weeks following PRP, specifically 9 weeks after the final PRP injection for the patient who underwent bilateral treatments.
    Conclusion: In the three cases provided of sesamoid injuries treated with PRP, the time to return to impact activities was less than reported for athletes not treated with PRP. Acknowledging that other management factors likely contributed to return to impact activities, this case series sets the groundwork for future research investigating the role of PRP with needle fenestration in the treatment of sesamoid injuries.
    MeSH term(s) Adolescent ; Athletes ; Child ; Dancing/injuries ; Female ; Hallux ; Humans ; Male ; Platelet-Rich Plasma ; Running ; Sesamoid Bones/diagnostic imaging ; Sesamoid Bones/injuries
    Language English
    Publishing date 2021-08-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 753046-8
    ISSN 2326-3660 ; 0091-3847
    ISSN (online) 2326-3660
    ISSN 0091-3847
    DOI 10.1080/00913847.2021.1964006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Epigenetic effects of short-chain fatty acids from the large intestine on host cells.

    Stein, Richard A / Riber, Leise

    microLife

    2023  Volume 4, Page(s) uqad032

    Abstract: Adult humans harbor at least as many microbial cells as eukaryotic ones. The largest compartment of this diverse microbial population, ...

    Abstract Adult humans harbor at least as many microbial cells as eukaryotic ones. The largest compartment of this diverse microbial population,
    Language English
    Publishing date 2023-06-16
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2633-6693
    ISSN (online) 2633-6693
    DOI 10.1093/femsml/uqad032
    Database MEDical Literature Analysis and Retrieval System OnLINE

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