Result 1 - 10 of total 75
Eur. J. Risk Regul.
| Keywords | covid19 |
|---|---|
| Publisher | WHO |
| Document type | Article |
| Note | WHO #Covidence: #38583 |
| Database | COVID19 |
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European Journal of Risk Regulation
Testing the Limits of Human Rights
2020 Volume 11, Issue 2, Page(s) 317–325
| Keywords | Safety Research ; covid19 |
|---|---|
| Language | English |
| Publisher | Cambridge University Press (CUP) |
| Publishing country | uk |
| Document type | Article ; Online |
| ZDB-ID | 2600871-3 |
| ISSN | 2190-8249 ; 1867-299X |
| ISSN (online) | 2190-8249 |
| ISSN | 1867-299X |
| DOI | 10.1017/err.2020.27 |
| Database | BASE - Bielefeld Academic Search Engine (life sciences selection) |
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The journal of allergy and clinical immunology. In practice
2021 Volume 9, Issue 9, Page(s) 3528–3529
| MeSH term(s) | Asthma/drug therapy ; Biological Products/therapeutic use ; Humans ; Pulmonary Eosinophilia |
|---|---|
| Chemical Substances | Biological Products |
| Language | English |
| Publishing date | 2021-09-10 |
| Publishing country | United States |
| Document type | Letter ; Comment |
| ZDB-ID | 2843237-X |
| ISSN | 2213-2201 ; 2213-2198 |
| ISSN (online) | 2213-2201 |
| ISSN | 2213-2198 |
| DOI | 10.1016/j.jaip.2021.05.044 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 7086: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
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2023 Volume 14, Page(s) 1257398
Abstract: Introduction: Common variable immunodeficiency (CVID) is the most prevalent symptomatic primary immunodeficiency. CVID is a heterogeneous disorder with a presumed multifactorial etiology. Intravenous or subcutaneous immunoglobulin replacement therapy ( ... ...
| Abstract | Introduction: Common variable immunodeficiency (CVID) is the most prevalent symptomatic primary immunodeficiency. CVID is a heterogeneous disorder with a presumed multifactorial etiology. Intravenous or subcutaneous immunoglobulin replacement therapy (IgRT) can prevent severe infections but not underlying immune dysregulation. Methods: In this study, we evaluated the serum concentrations of proinflammatory (TNF-α, IL-1β, IL-6) and immunoregulatory cytokines (IL-10), as well as lipopolysaccharide (LPS) and soluble CD14 (sCD14) in CVID individuals with infectious only (INF-CVID), and those with additional systemic autoimmune and inflammatory disorders (NIC-CVID), and healthy donors (HD). Results: Our results showed increased serum concentrations of TNF-α, IL-1β, IL-6, and IL-10 in both INF-CVID and NIC-CVID subjects compared to HD. However, elevations of TNF-α, IL-1β, IL-6, and IL-10 were significantly more marked in NIC-CVID than INF-CVID. Additionally, LPS concentrations were increased only in NIC-CVID but not in INF-CVID compared to HD. Circulating levels of sCD14 were significantly increased in NIC-CVID compared to both INF-CVID and HD. Discussion: These findings indicate persistent cytokine dysregulation despite IgRT in individuals with CVID. Moreover, the circulating cytokine profile reveals the heterogeneity of immune dysregulation in different subgroups of CVID subjects. |
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| MeSH term(s) | Humans ; Cytokines ; Interleukin-10 ; Interleukin-6 ; Tumor Necrosis Factor-alpha ; Lipopolysaccharides ; Lipopolysaccharide Receptors ; Common Variable Immunodeficiency ; Immunoglobulins |
| Chemical Substances | Cytokines ; Interleukin-10 (130068-27-8) ; Interleukin-6 ; Tumor Necrosis Factor-alpha ; Lipopolysaccharides ; Lipopolysaccharide Receptors ; Immunoglobulins |
| Language | English |
| Publishing date | 2023-09-28 |
| Publishing country | Switzerland |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2606827-8 |
| ISSN | 1664-3224 ; 1664-3224 |
| ISSN (online) | 1664-3224 |
| ISSN | 1664-3224 |
| DOI | 10.3389/fimmu.2023.1257398 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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ChemEngineering, Vol 4, Iss 1, p
Acidity–Activity Relationship in O-Xylene Hydrotreating
2020 Volume 4
Abstract: Transition metal sulfide catalysts are actually the most performing catalytic materials in crude oil hydrotreating (HDT), for energetic purposes. However, these systems suffer from several drawbacks that limit their exploitation. Aiming to meet the even ... ...
| Abstract | Transition metal sulfide catalysts are actually the most performing catalytic materials in crude oil hydrotreating (HDT), for energetic purposes. However, these systems suffer from several drawbacks that limit their exploitation. Aiming to meet the even more stringent environmental requirement, through a remarkable improvement of HDT performance in the presence of refractory feedstock (i.e., in terms of activity, selectivity, and stability), a deeper knowledge of the structure−activity relationship of catalysts must be achieved. Therefore, in this study, CoMo/γ-Al 2 O 3 and NiMo/γ-Al 2 O 3 catalysts were characterized and tested in the o-xylene hydrogenation model reaction, assessing the influence of both support acidity and catalyst acid strength on reaction pathway by employing γ-Al 2 O 3 and Y-Type zeolite as acid reference materials. A clear relationship between concentration and strength of acid sites and the performance of the catalytic materials was established. Cobalt based catalyst (CoMoS x ) proves a higher acidic character with respect to Nickel (NiMoS x ), prompting isomerization reactions preferentially, also reflecting a greater o-xylene conversion. The different chemical properties of metals also affect the catalytic pathway, leading on the CoMoS x system to the preferential formation of p-xylene isomer with respect to m-xylene. |
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| Keywords | n/a ; Chemistry ; QD1-999 |
| Subject code | 540 |
| Language | English |
| Publishing date | 2020-01-01T00:00:00Z |
| Publisher | MDPI AG |
| Document type | Article ; Online |
| Database | BASE - Bielefeld Academic Search Engine (life sciences selection) |
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2021 Volume 12, Page(s) 712915
Abstract: Common variable immunodeficiency (CVID) is the most common symptomatic primary antibody immunodeficiency, characterized by reduced serum levels of IgG, IgA, and/or IgM. The vast majority of CVID patients have polygenic inheritance. Immune dysfunction in ... ...
| Abstract | Common variable immunodeficiency (CVID) is the most common symptomatic primary antibody immunodeficiency, characterized by reduced serum levels of IgG, IgA, and/or IgM. The vast majority of CVID patients have polygenic inheritance. Immune dysfunction in CVID can frequently involve the gastrointestinal tract and lung. Few studies have started to investigate the gut microbiota profile in CVID patients. Overall, the results suggest that in CVID patients there is a reduction of alpha and beta diversity compared to controls. In addition, these patients can exhibit increased plasma levels of lipopolysaccharide (LPS) and markers (sCD14 and sCD25) of systemic immune cell activation. CVID patients with enteropathy exhibit decreased IgA expression in duodenal tissue. Mouse models for CVID unsatisfactorily recapitulate the polygenic causes of human CVID. The molecular pathways by which gut microbiota contribute to systemic inflammation and possibly tumorigenesis in CVID patients remain poorly understood. Several fundamental questions concerning the relationships between gut microbiota and the development of chronic inflammatory conditions, autoimmune disorders or cancer in CVID patients remain unanswered. Moreover, it is unknown whether it is possible to modify the microbiome and the outcome of CVID patients through specific therapeutic interventions. |
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| MeSH term(s) | Animals ; Antigens, CD19/genetics ; Antigens, CD19/immunology ; Antigens, CD19/metabolism ; Biomarkers ; Common Variable Immunodeficiency/diagnosis ; Common Variable Immunodeficiency/etiology ; Common Variable Immunodeficiency/metabolism ; Common Variable Immunodeficiency/therapy ; Diet Therapy ; Disease Management ; Disease Susceptibility/immunology ; Dysbiosis ; Fecal Microbiota Transplantation ; Feedback, Physiological ; Gastrointestinal Microbiome/immunology ; Humans ; Immunity, Mucosal ; Inflammation/diagnosis ; Inflammation/etiology ; Intestinal Mucosa/immunology ; Intestinal Mucosa/metabolism ; Intestinal Mucosa/microbiology ; Neoplasms/etiology ; Organ Specificity/genetics ; Organ Specificity/immunology ; Risk |
| Chemical Substances | Antigens, CD19 ; Biomarkers |
| Language | English |
| Publishing date | 2021-08-02 |
| Publishing country | Switzerland |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't ; Review |
| ZDB-ID | 2606827-8 |
| ISSN | 1664-3224 ; 1664-3224 |
| ISSN (online) | 1664-3224 |
| ISSN | 1664-3224 |
| DOI | 10.3389/fimmu.2021.712915 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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Journal of clinical immunology
2024 Volume 44, Issue 2, Page(s) 59
Abstract: The long-term effects of SARS-CoV-2 infection represent a relevant global health problem. Long COVID (LC) is defined as a complex of signs and symptoms developed during or after SARS-CoV-2 infection and lasting > 12 weeks. In common variable ... ...
| Abstract | The long-term effects of SARS-CoV-2 infection represent a relevant global health problem. Long COVID (LC) is defined as a complex of signs and symptoms developed during or after SARS-CoV-2 infection and lasting > 12 weeks. In common variable immunodeficiency (CVID) patients, we previously reported higher risk of hospitalization and death during SARS-CoV-2 infection, as well as prolonged swab positivity and frequent reinfections. The aim of the present study was to assess the risk of LC in an Italian cohort of CVID patients. We used a translated version of the survey proposed by Centers for Disease Control and Prevention (CDC) to collect data on LC. In the enrolled cohort of 175 CVID patients, we found a high prevalence of LC (65.7%). The most frequent LC symptoms were fatigue (75.7%), arthralgia/myalgia (48.7%), and dyspnea (41.7%). The majority of patients (60%) experienced prolonged symptoms, for at least 6 months after infection. In a multivariate analysis, the presence of complicated phenotype (OR 2.44, 95% CI 1.88-5.03; p = 0.015), obesity (OR 11.17, 95% CI 1.37-90.95; p = 0.024), and female sex (OR 2.06, 95% CI 1.09-3.89; p = 0.024) significantly correlated with the development of LC. In conclusion, in this multicenter observational cohort study, we demonstrated that CVID patients present an increased prevalence of LC when compared to the general population. Improved awareness on the risk of LC in CVID patients could optimize management of this new and alarming complication of SARS-CoV-2 infection. |
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| MeSH term(s) | United States ; Humans ; Female ; Post-Acute COVID-19 Syndrome ; COVID-19/epidemiology ; Common Variable Immunodeficiency/epidemiology ; Prevalence ; SARS-CoV-2 ; Italy/epidemiology |
| Language | English |
| Publishing date | 2024-02-06 |
| Publishing country | Netherlands |
| Document type | Multicenter Study ; Observational Study ; Journal Article |
| ZDB-ID | 779361-3 |
| ISSN | 1573-2592 ; 0271-9142 |
| ISSN (online) | 1573-2592 |
| ISSN | 0271-9142 |
| DOI | 10.1007/s10875-024-01656-2 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 1640: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG) |
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2022 Volume 11, Issue 23
Abstract: Background: The COVID-19 pandemic had a relevant impact on the organization of intensive care units (ICU) and may have reduced the overall compliance with healthcare-associated infections (HAIs) prevention programs. Invasively ventilated patients are at ...
| Abstract | Background: The COVID-19 pandemic had a relevant impact on the organization of intensive care units (ICU) and may have reduced the overall compliance with healthcare-associated infections (HAIs) prevention programs. Invasively ventilated patients are at high risk of ICU-associated infection, but there is little evidence regarding the impact of the pandemic on their occurrence in non-COVID-19 patients. Moreover, little is known of antibiotic prescription trends in the ICU during the first wave of the pandemic. The purpose of this investigation is to assess the incidence, characteristics, and risk factors for ICU-associated HAIs in a population of invasively ventilated patients affected by non-COVID-19 acute respiratory failure (ARF) admitted to the ICU in the first wave of the COVID-19 pandemic, and to evaluate the ICU antimicrobial prescription strategies. Moreover, we compared HAIs and antibiotic use to a cohort of ARF patients admitted to the ICU the year before the pandemic during the same period. Methods: this is a retrospective, single-centered cohort study conducted at S. Anna University Hospital (Ferrara, Italy). We enrolled patients admitted to the ICU for acute respiratory failure requiring invasive mechanical ventilation (MV) between February and April 2020 (intra-pandemic group, IP) and February and April 2019 (before the pandemic group, PP). We excluded patients admitted to the ICU for COVID-19 pneumonia. We recorded patients' baseline characteristics, ICU-associated procedures and devices. Moreover, we evaluated antimicrobial therapy and classified it as prophylactic, empirical or target therapy, according to the evidence of infection at the time of prescription and to the presence of a positive culture sample. We compared the results of the two groups (PP and IP) to assess differences between the two years. Results: One hundred and twenty-eight patients were screened for inclusion and 83 patients were analyzed, 45 and 38 in the PP and I group, respectively. We found a comparable incidence of HAIs (62.2% vs. 65.8%, Conclusions: ICU admission for non-COVID-19 ARF during the first wave of the SARS-CoV-2 pandemic was not associated with an increased risk of ICU-associated HAIs. Nevertheless, ICU prescription of antimicrobial therapy changed and significantly decreased during the pandemic. |
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| Language | English |
| Publishing date | 2022-11-29 |
| Publishing country | Switzerland |
| Document type | Journal Article |
| ZDB-ID | 2662592-1 |
| ISSN | 2077-0383 |
| ISSN | 2077-0383 |
| DOI | 10.3390/jcm11237080 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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2023 Volume 14, Page(s) 1231242
Abstract: Introduction: In patients with Common Variable Immunodeficiency, malignancy has been reported as the leading cause of death in adults, with a high risk of B-cell lymphomas and gastric cancer.: Methods: We conducted a five-year prospective study ... ...
| Abstract | Introduction: In patients with Common Variable Immunodeficiency, malignancy has been reported as the leading cause of death in adults, with a high risk of B-cell lymphomas and gastric cancer. Methods: We conducted a five-year prospective study aiming to update the incidence and mortality of gastric cancer and the incidence of gastric precancerous lesions in 512 CVID patients who underwent a total of 400 upper gastrointestinal endoscopies. Results: In the pre-pandemic period, 0.58 endoscopies were performed per patient/year and in the COVID-19 period, 0.39 endoscopies were performed per patient/year. Histology revealed areas with precancerous lesions in about a third of patients. Patients who had more than one gastroscopy during the study period were more likely to have precancerous lesions. Two patients received a diagnosis of gastric cancer in the absence of Helicobacter pylori infection. The overall prevalence of Helicobacter pylori infection in biopsy specimens was 19.8% and related only to active gastritis. Among patients who had repeated gastroscopies, about 20% progressed to precancerous lesions, mostly independent of Helicobacter pylori. Discussion: While gastric cancer accounted for one in five deaths from CVID in our previous survey, no gastric cancer deaths were recorded in the past five years, likely consistent with the decline in stomach cancer mortality observed in the general population. However, during the COVID-19 pandemic, cancer screening has been delayed. Whether such a delay or true decline could be the reason for the lack of gastric cancer detection seen in CVID may become clear in the coming years. Due to the high incidence of precancerous lesions, we cannot rely on observed and predicted trends in gastric cancer mortality and strongly recommend tailored surveillance programs. |
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| MeSH term(s) | Adult ; Humans ; Stomach Neoplasms/pathology ; Helicobacter Infections/complications ; Helicobacter Infections/epidemiology ; Helicobacter Infections/diagnosis ; Prospective Studies ; Common Variable Immunodeficiency/epidemiology ; Common Variable Immunodeficiency/complications ; Pandemics ; Helicobacter pylori ; Gastroscopy/adverse effects ; Precancerous Conditions/pathology |
| Language | English |
| Publishing date | 2023-10-06 |
| Publishing country | Switzerland |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2606827-8 |
| ISSN | 1664-3224 ; 1664-3224 |
| ISSN (online) | 1664-3224 |
| ISSN | 1664-3224 |
| DOI | 10.3389/fimmu.2023.1231242 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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Catalysts, Vol 12, Iss 293, p
2022 Volume 293
Abstract: The conversion of carbon dioxide into value-added products is progressively gaining momentum. Several strategies have been used to develop technologies that reduce the net emissions of CO 2 . The utilisation of CO 2 could either contribute to carbon ... ...
| Abstract | The conversion of carbon dioxide into value-added products is progressively gaining momentum. Several strategies have been used to develop technologies that reduce the net emissions of CO 2 . The utilisation of CO 2 could either contribute to carbon recycling. In this paper, the transformation of CO 2 was investigated in a coelectrolysis cell constituted of a solid polymer electrolyte, a carbon-supported CuO-Ag composite cathode and NiFeOx anode. Noncritical raw materials were synthesised according to the oxalate method and investigated in an alkaline environment. Low-carbon alcohols were obtained with a specific selectivity for ethanol and methanol over the CuO-Ag/KB cathode. The reaction rates at 1.6 V and 1.8 V cell voltages have been determined in steady-state experiments using NaHCO 3 supporting electrolyte recirculated at the anode. |
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| Keywords | renewables ; CO 2 reduction ; zero-gap electrochemical cell ; synthetic alcohols ; CRM-free catalyst ; Chemical technology ; TP1-1185 ; Chemistry ; QD1-999 |
| Language | English |
| Publishing date | 2022-03-01T00:00:00Z |
| Publisher | MDPI AG |
| Document type | Article ; Online |
| Database | BASE - Bielefeld Academic Search Engine (life sciences selection) |
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