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  1. Article ; Online: Assessing Surface Adsorption in Cyclic Olefin Copolymer Microfluidic Devices Using Two-Dimensional Nano Liquid Chromatography-Micro Free Flow Electrophoresis Separations.

    Douma, Cecilia C / Bowser, Michael T

    Analytical chemistry

    2023  Volume 95, Issue 50, Page(s) 18379–18387

    Abstract: Surface interactions are a concern in microscale separations, where analyte adsorption can decrease the speed, sensitivity, and resolution otherwise achieved by miniaturization. Here, we functionally characterize the surface adsorption of hot-embossed ... ...

    Abstract Surface interactions are a concern in microscale separations, where analyte adsorption can decrease the speed, sensitivity, and resolution otherwise achieved by miniaturization. Here, we functionally characterize the surface adsorption of hot-embossed cyclic olefin copolymer (COC) micro free-flow electrophoresis (μFFE) devices using two-dimensional nLC × μFFE separations, which introduce a 3- to 5 s plug of analyte into the device and measure temporal broadening that arises from surface interactions. COC is an attractive material for microfluidic devices, but little is known about its potential for surface adsorption in applications with continuous fluid flow and temporal measurements. Adsorption was minimal for three small molecule dyes: positively charged rhodamine 123, negatively charged fluorescein, and neutral rhodamine 110. Temporal peak widths for the three dyes ranged from 3 to 7 s and did not change significantly with increasing transit distance. Moderate adsorption was observed for Chromeo P503-labeled myoglobin and cytochrome
    Language English
    Publishing date 2023-12-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1508-8
    ISSN 1520-6882 ; 0003-2700
    ISSN (online) 1520-6882
    ISSN 0003-2700
    DOI 10.1021/acs.analchem.3c03014
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    Zs.A 4033: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  2. Article: Fabrication of µFFE Devices in COC via Hot Embossing with a 3D-Printed Master Mold.

    LeMon, Matthew B / Douma, Cecilia C / Burke, Gretchen S / Bowser, Michael T

    Micromachines

    2023  Volume 14, Issue 9

    Abstract: The fabrication of high-performance microscale devices in substrates with optimal material properties while keeping costs low and maintaining the flexibility to rapidly prototype new designs remains an ongoing challenge in the microfluidics field. To ... ...

    Abstract The fabrication of high-performance microscale devices in substrates with optimal material properties while keeping costs low and maintaining the flexibility to rapidly prototype new designs remains an ongoing challenge in the microfluidics field. To this end, we have fabricated a micro free-flow electrophoresis (µFFE) device in cyclic olefin copolymer (COC) via hot embossing using a PolyJet 3D-printed master mold. A room-temperature cyclohexane vapor bath was used to clarify the device and facilitate solvent-assisted thermal bonding to fully enclose the channels. Device profiling showed 55 µm deep channels with no detectable feature degradation due to solvent exposure. Baseline separation of fluorescein, rhodamine 110, and rhodamine 123, was achieved at 150 V. Limits of detection for these fluorophores were 2 nM, 1 nM, and 10 nM, respectively, and were comparable to previously reported values for glass and 3D-printed devices. Using PolyJet 3D printing in conjunction with hot embossing, the full design cycle, from initial design to production of fully functional COC µFFE devices, could be completed in as little as 6 days without the need for specialized clean room facilities. Replicate COC µFFE devices could be produced from an existing embossing mold in as little as two hours.
    Language English
    Publishing date 2023-09-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2620864-7
    ISSN 2072-666X
    ISSN 2072-666X
    DOI 10.3390/mi14091728
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  3. Article: Sex-Specific Differences in Hip Muscle Cross-sectional Area and Fatty Infiltration in Patients With Femoroacetabular Impingement Syndrome.

    Douma, Mirjam V / Casartelli, Nicola C / Sutter, Reto / Leunig, Michael / Maffiuletti, Nicola A

    Orthopaedic journal of sports medicine

    2023  Volume 11, Issue 1, Page(s) 23259671221147528

    Abstract: Background: Patients with femoroacetabular impingement syndrome (FAIS) show sex-specific differences in hip muscle function, hip morphology, and symptoms. Possible differences in hip muscle characteristics between men and women with FAIS are unknown.: ...

    Abstract Background: Patients with femoroacetabular impingement syndrome (FAIS) show sex-specific differences in hip muscle function, hip morphology, and symptoms. Possible differences in hip muscle characteristics between men and women with FAIS are unknown.
    Purpose: To compare hip muscle cross-sectional area (CSA) and fatty infiltration between men and women with FAIS and investigate possible associations with patient-reported outcomes.
    Study design: Cohort study; Level of evidence, 3.
    Methods: We retrospectively analyzed preoperative axial pelvic magnetic resonance imaging scans of 104 patients (54 women) who underwent hip surgery for FAIS. The main outcome measures were side-to-side percentage asymmetry in hip muscle CSA and involved-side fatty infiltration as measured with the Goutallier scale for a total of 10 hip muscles. Patient-reported outcomes included duration of hip symptoms, iHOT-12 (12-item International Hip Outcome Tool), and Hip Sports Activity Scale.
    Results: Women showed larger hip abductor muscle CSA asymmetry than men (
    Conclusion: Patients with FAIS demonstrated few sex-specific quantitative and qualitative alterations of hip muscles. Women showed greater hip abductor muscle atrophy than men, particularly for the gluteus medius, while men showed a higher degree of fatty infiltration in this same muscle. The duration of hip symptoms was not associated with muscle atrophy. Patient-reported hip pain/function and sport activity level were only moderately associated with isolated muscular variables.
    Language English
    Publishing date 2023-01-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2706251-X
    ISSN 2325-9671
    ISSN 2325-9671
    DOI 10.1177/23259671221147528
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  4. Article: McCloskey and the Dutch

    Douma, Michael J

    The journal of private enterprise Bd. XXXII , 4, Seite 49-57

    capitalist rhetoric and the economic history of Holland

    2017  

    Author's details Michael J. Douma
    Keywords Dutch ; Holland ; Netherlands ; institutions ; rhetoric ; McCloskey
    Language English
    Publishing place Martin, Tenn.
    Document type Article
    ZDB-ID 1107843-1
    ISSN 0890-913X
    Database ECONomics Information System

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  5. Article ; Online: COVID-19: The Waterloo of governments, healthcare systems, and large health organizations.

    Douma, Michael / Imprialos, Konstantinos P / Patoulias, Dimitrios / Katsimardou, Alexandra / Stavropoulos, Konstantinos

    European journal of internal medicine

    2020  Volume 77, Page(s) 153–155

    MeSH term(s) Betacoronavirus ; COVID-19 ; Communicable Disease Control/organization & administration ; Coronavirus Infections/diagnosis ; Coronavirus Infections/epidemiology ; Coronavirus Infections/therapy ; Critical Care/organization & administration ; Delivery of Health Care ; Government ; Humans ; Pandemics ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/therapy ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-06-02
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 1038679-8
    ISSN 1879-0828 ; 0953-6205
    ISSN (online) 1879-0828
    ISSN 0953-6205
    DOI 10.1016/j.ejim.2020.05.043
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    Zs.A 2608: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  6. Article: Skin microcirculation dynamics are impaired in patients with rheumatoid arthritis and no cardiovascular comorbidities.

    Anyfanti, Panagiota / Gavriilaki, Eleni / Dolgyras, Panagiotis / Nikolaidou, Barbara / Dimitriadou, Antonia / Lazaridis, Antonios / Mastrogiannis, Konstantinos / Koletsos, Nikolaos / Triantafyllou, Areti / Dimitroulas, Theodoros / Aslanidis, Spyros / Doumas, Michael / Douma, Stella / Gkaliagkousi, Eugenia

    Clinical and experimental rheumatology

    2023  Volume 41, Issue 7, Page(s) 1507–1515

    Abstract: Objectives: Rheumatoid arthritis (RA) is associated with increased cardiovascular disease (CVD) risk. Microvascular endothelial dysfunction contributes to the development of vascular injury and subsequent CVD. We hypothesised that RA patients exhibit ... ...

    Abstract Objectives: Rheumatoid arthritis (RA) is associated with increased cardiovascular disease (CVD) risk. Microvascular endothelial dysfunction contributes to the development of vascular injury and subsequent CVD. We hypothesised that RA patients exhibit blunted microvascular reactivity regardless of CVD risk factors and investigated potential associations with coronary microvascular perfusion and surrogate markers of CVD.
    Methods: This case-control study recruited RA patients and non-RA individuals in the absence of cardiovascular comorbidities. Skin microvascular reactivity was dynamically assessed using laser speckle contrast imaging coupled with post-occlusive reactive hyperaemia protocol. Applanation tonometry was applied to assess subendocardial viability ratio, an index of myocardial microvascular perfusion, and central arterial stiffness [carotid-femoral pulse wave velocity (PWV), augmentation index]. Peripheral arterial stiffness (carotid PWV, β-stiffness index) and carotid atherosclerosis (intima-media thickness) were assessed with carotid ultrasound software.
    Results: Skin microvascular responses before and following reperfusion [baseline flux, occlusion flux, time-to-peak, peak magnitude, peak-to-baseline magnitude, baseline cutaneous vascular conductance (CVC), and percentage increase in CVC] were significantly impaired in RA patients (n=35) compared to controls (n=35). Presence of RA independently predicted altered microvascular reactivity in multivariate analysis. Skin microcirculation dynamics significantly correlated with coronary microvascular perfusion and peripheral arterial stiffness, yet not carotid atherosclerosis, even after adjustment for CVD risk factors.
    Conclusions: Patients with RA present impaired microvascular reactivity regardless of CVD risk factors at a preclinical stage preceding CVD. Assessment of skin microvascular dysfunction may reflect a state of generalised vasculopathy, including myocardial microvascular abnormalities, and serve as a non-invasive surrogate indicator of CVD risk in RA.
    MeSH term(s) Humans ; Carotid Intima-Media Thickness ; Pulse Wave Analysis/adverse effects ; Microcirculation ; Case-Control Studies ; Arthritis, Rheumatoid/complications ; Carotid Artery Diseases/etiology ; Atherosclerosis/etiology ; Vascular Stiffness ; Risk Factors
    Language English
    Publishing date 2023-01-26
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 605886-3
    ISSN 1593-098X ; 0392-856X
    ISSN (online) 1593-098X
    ISSN 0392-856X
    DOI 10.55563/clinexprheumatol/nf05o4
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    Zs.A 2002: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  7. Article: Knee Dislocation: A Case Report, Diagnostic Vascular Work-Up, and Literature Review.

    Douma, Matthijs R / Burg, Michael D / Dijkstra, Björn L

    Case reports in emergency medicine

    2017  Volume 2017, Page(s) 9745025

    Abstract: Knee dislocation is an uncommon, potentially limb-threatening, knee injury. Most often caused by high-velocity trauma, it can also result from low- or even ultra-low-velocity trauma. Rapid identification of the injury, reduction, and definitive ... ...

    Abstract Knee dislocation is an uncommon, potentially limb-threatening, knee injury. Most often caused by high-velocity trauma, it can also result from low- or even ultra-low-velocity trauma. Rapid identification of the injury, reduction, and definitive management are necessary to minimize neurovascular damage. We present a case of rotatory anterolateral knee dislocation sustained during a twisting sports-related event. Special emphasis is placed on diagnosing vascular injuries associated with knee dislocations.
    Language English
    Publishing date 2017-02-22
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2684646-9
    ISSN 2090-6498 ; 2090-648X
    ISSN (online) 2090-6498
    ISSN 2090-648X
    DOI 10.1155/2017/9745025
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  8. Article ; Online: Cornelius J. Jaenen, Promotors, Planters, and Pioneers

    Michael J. Douma

    BMGN : Low Countries Historical Review, Vol 128, Iss

    The Course and Context of Belgian Settlement in Western Canada

    2013  Volume 2

    Keywords Migration ; History (General) and history of Europe ; D ; History (General) ; D1-2009
    Publishing date 2013-06-01T00:00:00Z
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Cornelius J. Jaenen, Promotors, Planters, and Pioneers

    Michael J. Douma

    BMGN : Low Countries Historical Review, Vol 128, Iss 2, Pp 28-

    The Course and Context of Belgian Settlement in Western Canada

    2013  Volume 28

    Keywords Migration ; History (General) and history of Europe ; D ; History (General) ; D1-2009
    Publishing date 2013-06-01T00:00:00Z
    Publisher Utrecht University Library Open Access Journals
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Patients with autoimmune chronic inflammatory diseases present increased biomarkers of thromboinflammation and endothelial dysfunction in the absence of flares and cardiovascular comorbidities.

    Anyfanti, Panagiota / Gavriilaki, Eleni / Nikolaidou, Barbara / Yiannaki, Efthalia / Lazaridis, Antonios / Papadopoulos, Nikolaos / Douma, Stella / Doumas, Michael / Gkaliagkousi, Eugenia

    Journal of thrombosis and thrombolysis

    2021  Volume 53, Issue 1, Page(s) 10–16

    Abstract: Cardiovascular risk is increased in patients with autoimmune rheumatic diseases. Endothelial, erythrocyte and platelet microvesicles (MVs) are elevated in patients with cardiovascular diseases and represent novel markers of endothelial dysfunction and ... ...

    Abstract Cardiovascular risk is increased in patients with autoimmune rheumatic diseases. Endothelial, erythrocyte and platelet microvesicles (MVs) are elevated in patients with cardiovascular diseases and represent novel markers of endothelial dysfunction and thromboinflammation. We tested whether their levels are increased in patients with autoimmune rheumatic diseases (ARDs) in the absence of disease flare and cardiovascular comorbidities. Well-controlled patients with rheumatoid arthritis or systemic lupus erythematosus were studied, provided they were free from cardiovascular comorbidities and established cardiovascular disease. We additionally studied (a) a control group consisting of healthy volunteers and (b) a reference group including patients with stable coronary artery disease (CAD). MVs were measured using a standardized flow cytometry protocol. In a population of 74 participants, patients with ARDs (n = 17) presented increased levels of both endothelial (283.3 ± 195.0/μL vs 168.5 ± 54.8/μL, p = 0.029) and platelet MVs (374.0 ± 275.3/μL vs 225.7 ± 101.1/μL, p = 0.046) compared to controls (n = 34), whereas erythrocyte MVs did not significantly differ. In addition, patients with ARDs showed similar levels of endothelial MVs compared to CAD patients (n = 23) (283.3 ± 195.0/μL vs 297.0 ± 211.8/μL, p = 0.846). Platelet MVs were significantly associated with disease duration, and erythrocyte MVs with patients' perceived disease activity. In conclusion, increased levels of endothelial and platelet MVs may be evident in patients with ARDs, even in the absence of disease flares and before the establishment of cardiovascular complications. Levels of endothelial MVs resemble those of patients with profound atherothrombotic profile. The prognostic potential of MVs in terms of cardiovascular disease prevention warrants further investigation in patients with ARDs.
    MeSH term(s) Biomarkers ; Cell-Derived Microparticles ; Humans ; Inflammation ; Thromboinflammation ; Thrombosis
    Chemical Substances Biomarkers
    Language English
    Publishing date 2021-07-05
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1230645-9
    ISSN 1573-742X ; 0929-5305
    ISSN (online) 1573-742X
    ISSN 0929-5305
    DOI 10.1007/s11239-021-02517-0
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    Zs.A 4352: Show issues Location:
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