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  1. Article ; Online: Correction to: COVID‑19: The crucial role of blood coagulation and fibrinolysis.

    Coccheri, Sergio

    Internal and emergency medicine

    2020  Volume 16, Issue 1, Page(s) 253

    Keywords covid19
    Language English
    Publishing date 2020-10-22
    Publishing country Italy
    Document type Published Erratum
    ZDB-ID 2454173-4
    ISSN 1970-9366 ; 1828-0447
    ISSN (online) 1970-9366
    ISSN 1828-0447
    DOI 10.1007/s11739-020-02533-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6673: Show issues Location:
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  2. Article ; Online: COVID-19: The crucial role of blood coagulation and fibrinolysis.

    Coccheri, Sergio

    Internal and emergency medicine

    2020  Volume 15, Issue 8, Page(s) 1369–1373

    Abstract: The overflow of studies in the recent literature on COVID-19 often gives provisional or contradictory results and therefore deserves pauses of reflection and reconsideration. In fact, knowledges of pathophysiology of this new disease are still in ... ...

    Abstract The overflow of studies in the recent literature on COVID-19 often gives provisional or contradictory results and therefore deserves pauses of reflection and reconsideration. In fact, knowledges of pathophysiology of this new disease are still in development and hence originate discussions and interpretations. Regarding the role of blood coagulation and fibrinolysis, these mechanisms should be considered as crucial especially in severe cases. It is proposed to consider two distinct phenotypes of thrombotic manifestations: the current "thromboembolic type" also occurring in other kinds of sepsis, and the diffuse micro-thrombotic type, prevailing in the lungs but sometimes extending to other organs. Both types can induce severe disease and are potentially lethal. The micro-thrombotic pattern, more specific for COVID-19, results from a massive activation of coagulation strictly coupled with a hyper-intense inflammatory and immune reaction. This results in widespread occlusive thrombotic micro-angiopathy with destruction of alveoli and obstructive neoangiogenesis. The involvement of fibrinolysis, often neglected, confers a double faceted process of activation/inhibition, finally conducive to a fibrinolytic shutdown that reinforces persistence of micro-thrombi. Considering these peculiar mechanisms, it seems evident that both prophylactic and therapeutic effects of current anti-thrombotic drugs cannot be taken for granted and need therefore new specific and rigorous controlled trials.
    MeSH term(s) Blood Coagulation/drug effects ; Blood Coagulation/physiology ; COVID-19 ; Coronavirus Infections/complications ; Coronavirus Infections/drug therapy ; Fibrinolysis/drug effects ; Fibrinolysis/physiology ; Humans ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/drug therapy ; Thrombolytic Therapy/methods
    Keywords covid19
    Language English
    Publishing date 2020-08-03
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2454173-4
    ISSN 1970-9366 ; 1828-0447
    ISSN (online) 1970-9366
    ISSN 1828-0447
    DOI 10.1007/s11739-020-02443-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  3. Book ; Conference proceedings: Reports from the 17th International Congress on Thrombosis

    Coccheri, Sergio

    invited reports to symposia, free papers ; Bologna, Italy, October 26 - 30, 2002

    2002  

    Event/congress International Congress on Thrombosis (17, 2002, Bologna)
    Author's details ed. Sergio Coccheri
    Keywords Thrombosis
    Language English
    Size XIII, 318 S. : Ill., graph. Darst.
    Publisher Monduzzi
    Publishing place Bologna
    Publishing country Italy
    Document type Book ; Conference proceedings
    HBZ-ID HT013499819
    ISBN 88-323-3111-X ; 978-88-323-3111-0
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2003 A 3996 order for loan Magazin

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  4. Article: Correction to: COVID­19: The crucial role of blood coagulation and fibrinolysis

    Coccheri, Sergio

    Intern. emerg. med

    Abstract: The original article can be found online. ...

    Abstract The original article can be found online.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #888277
    Database COVID19

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  5. Article ; Online: COVID-19

    Coccheri, Sergio

    Internal and Emergency Medicine ; ISSN 1828-0447 1970-9366

    The crucial role of blood coagulation and fibrinolysis

    2020  

    Keywords Internal Medicine ; Emergency Medicine ; covid19
    Language English
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    DOI 10.1007/s11739-020-02443-8
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  6. Book ; Conference proceedings: 17th International Congress on Thrombosis

    Coccheri, Sergio

    Bologna, Italy, October 26 - 30, 2002

    (Pathophysiology of haemostasis and thrombosis ; 32, Suppl. 2)

    2002  

    Event/congress International Congress on Thrombosis (17, 2002, Bologna)
    Author's details guest ed. Sergio Coccheri
    Series title Pathophysiology of haemostasis and thrombosis ; 32, Suppl. 2
    Collection
    Keywords Gerinnungsfaktor VII ; Rekombinantes Protein
    Subject Rekombinante Substanz ; Hybrid-Protein ; Rekombiniertes Protein ; Fusionsprotein ; Blutgerinnungsfaktor VII ; Faktor VII ; NovoSeven ; CAS 9001-25-6
    Language English
    Size XXIII, 150 S.
    Publisher Karger
    Publishing place Basel u.a.
    Publishing country Switzerland
    Document type Book ; Conference proceedings
    HBZ-ID HT013564664
    ISBN 3-8055-7498-3 ; 978-3-8055-7498-3
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 896 -32,Suppl.2- not available for loan Zeitschriften-Lesesaal

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  7. Article: COVID-19: The crucial role of blood coagulation and fibrinolysis

    Coccheri, Sergio

    Intern Emerg Med

    Abstract: The overflow of studies in the recent literature on COVID-19 often gives provisional or contradictory results and therefore deserves pauses of reflection and reconsideration. In fact, knowledges of pathophysiology of this new disease are still in ... ...

    Abstract The overflow of studies in the recent literature on COVID-19 often gives provisional or contradictory results and therefore deserves pauses of reflection and reconsideration. In fact, knowledges of pathophysiology of this new disease are still in development and hence originate discussions and interpretations. Regarding the role of blood coagulation and fibrinolysis, these mechanisms should be considered as crucial especially in severe cases. It is proposed to consider two distinct phenotypes of thrombotic manifestations: the current "thromboembolic type" also occurring in other kinds of sepsis, and the diffuse micro-thrombotic type, prevailing in the lungs but sometimes extending to other organs. Both types can induce severe disease and are potentially lethal. The micro-thrombotic pattern, more specific for COVID-19, results from a massive activation of coagulation strictly coupled with a hyper-intense inflammatory and immune reaction. This results in widespread occlusive thrombotic micro-angiopathy with destruction of alveoli and obstructive neoangiogenesis. The involvement of fibrinolysis, often neglected, confers a double faceted process of activation/inhibition, finally conducive to a fibrinolytic shutdown that reinforces persistence of micro-thrombi. Considering these peculiar mechanisms, it seems evident that both prophylactic and therapeutic effects of current anti-thrombotic drugs cannot be taken for granted and need therefore new specific and rigorous controlled trials.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #691858
    Database COVID19

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  8. Article ; Online: Error, contradiction and reversal in science and medicine.

    Coccheri, Sergio

    European journal of internal medicine

    2017  Volume 41, Page(s) 28–29

    Abstract: Error and contradictions are not "per se" detrimental in science and medicine. Going back to the history of philosophy, Sir Francis Bacon stated that "truth emerges more readily from error than from confusion", and recently Popper introduced the concept ... ...

    Abstract Error and contradictions are not "per se" detrimental in science and medicine. Going back to the history of philosophy, Sir Francis Bacon stated that "truth emerges more readily from error than from confusion", and recently Popper introduced the concept of an approximate temporary truth that constitutes the engine of scientific progress. In biomedical research and in clinical practice we assisted during the last decades to many overturnings or reversals of concepts and practices. This phenomenon may discourage patients from accepting ordinary medical care and may favour the choice of alternative medicine. The media often enhance the disappointment for these discrepancies. In this note I recommend to transfer to patients the concept of a confirmed and dependable knowledge at the present time. However, physicians should tolerate uncertainty and accept the idea that medical concepts and applications are subjected to continuous progression, change and displacement.
    Language English
    Publishing date 2017-06
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1038679-8
    ISSN 1879-0828 ; 0953-6205
    ISSN (online) 1879-0828
    ISSN 0953-6205
    DOI 10.1016/j.ejim.2017.03.026
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2608: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article: Use and Misuse of Aspirin in Primary Cardiovascular Prevention.

    Coccheri, Sergio

    Clinical Medicine Insights. Cardiology

    2017  Volume 11, Page(s) 1179546817702149

    Abstract: The use of low-dose aspirin in primary prevention of cardiovascular (CV) events in healthy or apparently healthy people is a widely debated topic. Many arguments indicate that "primary prevention" is only a conventional definition and that the transition ...

    Abstract The use of low-dose aspirin in primary prevention of cardiovascular (CV) events in healthy or apparently healthy people is a widely debated topic. Many arguments indicate that "primary prevention" is only a conventional definition and that the transition from primary to secondary prevention represents a continuum of increasing levels of CV risk. Although there are no direct proofs of a different efficacy of aspirin at different CV risk levels, in low-risk populations aspirin will appear to be less efficient. In fact, the lower number of events occurring in patients at low risk yields lower absolute numbers of events prevented. As many as 6 meta-analyses of trials of primary CV prevention with aspirin versus placebo, performed between 2009 and 2016, confirmed the above concepts and showed a concordant, significant reduction in nonfatal myocardial infarction, with no significant effects on stroke, as well as on CV and all-cause mortality. The recent demonstration of a moderate protective effect of aspirin on cancer (especially colorectal) confers, however, additional value to the use of aspirin, although unusually long durations of treatment and optimal daily compliance seem to be necessary. Because aspirin increases the bleeding risk, the evaluation of its net clinical benefit is an important point of debate. Thus, it is justified to search for a cutoff level of global CV risk above which the net clinical benefit of aspirin becomes evident. Such a threshold value has been calculated considering the data of 9 primary prevention trials, by the Thrombosis Group of the European Society of Cardiology, and has been indicated as a risk value of 2 or more major CV events per 100 persons per year. Also, in the recent 2016 US Guidelines, the main criterion adopted for the indication of aspirin is the level of global CV risk (suggested cutoff is 1 or more major CV events per 100 persons per year). Beyond the different values selected, it is seems very important to introduce to clinical practice and future trials a new criterion based on the level of global CV risk.
    Language English
    Publishing date 2017-04-21
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2575256-X
    ISSN 1179-5468
    ISSN 1179-5468
    DOI 10.1177/1179546817702149
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Book: A guide to oral anticoagulant therapy

    Coccheri, Sergio

    14 tables

    (Haemostasis ; 28, Suppl. 1)

    1998  

    Institution Federazione Centri Sorveglianza Anticoagulanti
    Author's details Federazione Centri Sorveglianza Anticoagulanti (FSCA), Italian Federation of Anticoagulation Clinics. Ed. by Sergio Coccheri
    Series title Haemostasis ; 28, Suppl. 1
    Collection
    Keywords Antikoagulans
    Subject Anticoagulans ; Gerinnungshemmendes Mittel ; Gerinnungshemmer ; Blutgerinnungshemmendes Mittel ; Thrombininhibitor ; Blutgerinnungshemmer
    Language English
    Size 46 S.
    Publisher Karger
    Publishing place Basel u.a.
    Publishing country Switzerland
    Document type Book
    HBZ-ID HT009413874
    ISBN 3-8055-6777-4 ; 978-3-8055-6777-0
    Database Catalogue ZB MED Medicine, Health

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    Zs A 896 -28,Suppl.1- not available for loan Zeitschriften-Lesesaal

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