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  1. Article ; Online: COVID-19: The personal and professional impact of one case.

    Bortnick, Anna E

    Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions

    2020  Volume 97, Issue 3, Page(s) E352–E353

    MeSH term(s) COVID-19/complications ; COVID-19/diagnosis ; COVID-19/transmission ; Humans ; Infection Control/organization & administration ; Infectious Disease Transmission, Patient-to-Professional ; Male ; Middle Aged ; Quarantine/psychology ; ST Elevation Myocardial Infarction/diagnosis ; ST Elevation Myocardial Infarction/therapy ; ST Elevation Myocardial Infarction/virology
    Keywords covid19
    Language English
    Publishing date 2020-05-21
    Publishing country United States
    Document type Case Reports ; Editorial ; Personal Narrative ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1459995-8
    ISSN 1522-726X ; 1522-1946
    ISSN (online) 1522-726X
    ISSN 1522-1946
    DOI 10.1002/ccd.28987
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    Zs.A 1226: Show issues Location:
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  3. Article ; Online: Women's Cardiovascular Health: Prioritizing the Majority Minority.

    Bortnick, Anna E / Pllana, Edita / Wolfe, Diana S / Taub, Cynthia C

    Journal of cardiovascular development and disease

    2023  Volume 10, Issue 3

    Abstract: Women make up the majority of the global population, and [ ... ]. ...

    Abstract Women make up the majority of the global population, and [...].
    Language English
    Publishing date 2023-03-17
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2777082-5
    ISSN 2308-3425 ; 2308-3425
    ISSN (online) 2308-3425
    ISSN 2308-3425
    DOI 10.3390/jcdd10030128
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  4. Article ; Online: COVID ‐19

    Bortnick, Anna E.

    Catheterization and Cardiovascular Interventions ; ISSN 1522-1946 1522-726X

    The personal and professional impact of one case

    2020  

    Keywords Radiology Nuclear Medicine and imaging ; Cardiology and Cardiovascular Medicine ; General Medicine ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    DOI 10.1002/ccd.28987
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Measures of high-density lipoprotein function in men and women with severe aortic stenosis.

    Hafiane, Anouar / Favari, Elda / Bortnick, Anna E

    Lipids in health and disease

    2022  Volume 21, Issue 1, Page(s) 48

    Abstract: Background: Calcification of the aortic valve is a common heart valve disorder, in some cases leading to clinically impactful severe aortic stenosis (AS). Sex-specific differences in aortic valve calcification (ACV) exist, with women having a lower ... ...

    Abstract Background: Calcification of the aortic valve is a common heart valve disorder, in some cases leading to clinically impactful severe aortic stenosis (AS). Sex-specific differences in aortic valve calcification (ACV) exist, with women having a lower burden of calcification than men as measured by computed tomography; however, the pathophysiological mechanism that leads to these differences remains unclear.
    Methods: Using cultured human Tamm-Horsfall protein 1 (THP-1) macrophages and human aortic valve interstitial cells, the effects of high-density lipoprotein (HDL) particles isolated from the plasma of men and women with severe AS were studied for cholesterol efflux capacity (CEC).
    Results: HDL-CEC was assessed in 46 patients with severe AS, n = 30 men, n = 16 women. ATP-Binding Cassette A1 (ABCA1)-mediated HDL-CEC was measured from human cultured THP-1 macrophages to plasma HDL samples. Women with severe AS had more ABCA1-mediated HDL-CEC, as compared to men (8.50 ± 3.90% cpm vs. 6.80 ± 1.50% cpm, P = 0.04). HDL pre-β1 and α-particles were higher in woman than in men by spectral density, (pre-β1 HDL, 20298.29 ± 1076.15 vs. 15,661.74 ± 789.00, P = 0.002, and α-HDL, 63006.35 ± 756.81 vs. 50,447.00 ± 546.52, P = 0.03). Lecithin-cholesterol acyltransferase conversion of free cholesterol into cholesteryl esters was higher in women than men (16.44 ± 9.11%/h vs. 12.00 ± 8.07%/h, P = 0.03).
    Conclusions: Sex-specific changes in various parameters of HDL-CEC were found in patients with severe AS. Sex-based modifications in HDL functionality by HDL-CEC might account for the reduced burden of calcification in women vs. men with severe AS. Therefore, future studies should target sex-related pathways in AS to help to improve understanding and treatment of AS. Sex specifc differences in AVC and differences associated with HDL function in men and women with severe AS. When compared to men, women had higher preβ-HDL and α-HDL migrating particles, higher cholesterol efflux to HDL, and higher lecithin cholesterol acyl transferase (LCAT) activity, possibly indicating that improved reverse cholesterol transport may be protective against worsened calcification.
    MeSH term(s) Aortic Valve Stenosis/genetics ; Cholesterol/metabolism ; Female ; High-Density Lipoproteins, Pre-beta ; Humans ; Lecithins ; Lipoproteins, HDL ; Male
    Chemical Substances High-Density Lipoproteins, Pre-beta ; Lecithins ; Lipoproteins, HDL ; Cholesterol (97C5T2UQ7J)
    Language English
    Publishing date 2022-05-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 2091381-3
    ISSN 1476-511X ; 1476-511X
    ISSN (online) 1476-511X
    ISSN 1476-511X
    DOI 10.1186/s12944-022-01653-7
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  6. Article ; Online: Valvular Heart Disease in Pregnancy.

    Bortnick, Anna E / Levine, Lisa D

    Clinical obstetrics and gynecology

    2020  Volume 63, Issue 4, Page(s) 910–922

    Abstract: The number of reproductive age women with valvular heart disease is rising and accounts for one third of all heart disease among pregnant women. Severe, symptomatic left-sided cardiac lesions, particularly mitral and aortic stenosis, and mechanical heart ...

    Abstract The number of reproductive age women with valvular heart disease is rising and accounts for one third of all heart disease among pregnant women. Severe, symptomatic left-sided cardiac lesions, particularly mitral and aortic stenosis, and mechanical heart valves, are associated with adverse maternal and fetal outcomes. Decreasing maternal and fetal risk requires shared decision-making among patients and the heart team, consisting of obstetricians, maternal-fetal medicine subspecialists, and cardiologists.
    MeSH term(s) Female ; Heart Diseases ; Heart Valve Diseases/diagnostic imaging ; Heart Valve Diseases/therapy ; Heart Valve Prosthesis ; Humans ; Pregnancy ; Pregnancy Complications, Cardiovascular/therapy ; Pregnancy Outcome ; Prenatal Care
    Language English
    Publishing date 2020-10-01
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 391207-3
    ISSN 1532-5520 ; 0009-9201
    ISSN (online) 1532-5520
    ISSN 0009-9201
    DOI 10.1097/GRF.0000000000000570
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  7. Article: Extracardiac Prothrombotic Effects of COVID-19.

    Kankaria, Rohan / Sanina, Cristina / Gabr, Mohamed / Wiley, Jose / Bortnick, Anna E

    Heart failure clinics

    2023  Volume 19, Issue 2, Page(s) 213–220

    Abstract: COVID-19 infection triggers a heightened inflammatory response which in turn, increases thrombosis and thromboembolism. Microvascular thrombosis has been detected in various tissue beds which may account for some of the multi-system organ dysfunction ... ...

    Abstract COVID-19 infection triggers a heightened inflammatory response which in turn, increases thrombosis and thromboembolism. Microvascular thrombosis has been detected in various tissue beds which may account for some of the multi-system organ dysfunction associated with COVID-19. Additional research is needed to understand which prophylactic and therapeutic drug regimens are best for the prevention and treatment of thrombotic complications of COVID-19.
    MeSH term(s) Humans ; COVID-19/complications ; Thrombosis/drug therapy ; Thrombosis/virology ; Thromboembolism/drug therapy ; Thromboembolism/virology
    Language English
    Publishing date 2023-02-10
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2212019-1
    ISSN 1551-7136
    ISSN 1551-7136
    DOI 10.1016/j.hfc.2022.08.008
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    Zs.A 6554: Show issues Location:
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  8. Article ; Online: Management of Ischemic Heart Disease in Pregnancy.

    Chavez, Patricia / Wolfe, Diana / Bortnick, Anna E

    Current atherosclerosis reports

    2021  Volume 23, Issue 9, Page(s) 52

    Abstract: Purpose of review: Cardiovascular disease is an escalating cause of maternal morbidity and mortality. Women are at risk for acute myocardial infarction (MI), and more are living with risk factors for ischemic heart disease (IHD). The purpose of this ... ...

    Abstract Purpose of review: Cardiovascular disease is an escalating cause of maternal morbidity and mortality. Women are at risk for acute myocardial infarction (MI), and more are living with risk factors for ischemic heart disease (IHD). The purpose of this review is to describe the evaluation and management of women at risk for and diagnosed with IHD in pregnancy.
    Recent findings: Pregnancy can provoke MI which has been estimated as occurring in 1.5-10/100, 000 deliveries or 1/12,400 hospitalizations, with a high inpatient mortality rate of approximately 5-7%. An invasive strategy may or may not be preferred, but fetal radiation exposure is less of a concern in comparison to maternal mortality. Common medications used to treat IHD may be continued successfully during pregnancy and lactation, including aspirin, which has an emerging role in pregnancy to prevent preeclampsia, preterm labor, and maternal mortality. Hemodynamics can be modulated during pregnancy, labor, and postpartum to mitigate risk for acute decompensation in women with IHD. Cardiologists can successfully manage IHD in pregnancy with obstetric partners and should engage women in a lifetime of cardiovascular care.
    MeSH term(s) Female ; Humans ; Infant, Newborn ; Maternal Mortality ; Myocardial Infarction ; Myocardial Ischemia/epidemiology ; Myocardial Ischemia/therapy ; Pre-Eclampsia ; Pregnancy ; Risk Factors
    Language English
    Publishing date 2021-07-16
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2057369-8
    ISSN 1534-6242 ; 1523-3804
    ISSN (online) 1534-6242
    ISSN 1523-3804
    DOI 10.1007/s11883-021-00944-1
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    Zs.A 5534: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Extracardiac Prothrombotic Effects of COVID-19.

    Kankaria, Rohan / Sanina, Cristina / Gabr, Mohamed / Wiley, Jose / Bortnick, Anna E

    Cardiology clinics

    2022  Volume 40, Issue 3, Page(s) 337–344

    Abstract: COVID-19 infection triggers a heightened inflammatory response which in turn, increases thrombosis and thromboembolism. Microvascular thrombosis has been detected in various tissue beds which may account for some of the multi-system organ dysfunction ... ...

    Abstract COVID-19 infection triggers a heightened inflammatory response which in turn, increases thrombosis and thromboembolism. Microvascular thrombosis has been detected in various tissue beds which may account for some of the multi-system organ dysfunction associated with COVID-19. Additional research is needed to understand which prophylactic and therapeutic drug regimens are best for the prevention and treatment of thrombotic complications of COVID-19.
    MeSH term(s) Anticoagulants/therapeutic use ; COVID-19/complications ; Humans ; SARS-CoV-2 ; Thrombosis/etiology ; Thrombosis/prevention & control
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2022-03-29
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 1196385-2
    ISSN 1558-2264 ; 0733-8651
    ISSN (online) 1558-2264
    ISSN 0733-8651
    DOI 10.1016/j.ccl.2022.03.008
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    Se 853: Show issues Location:
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  10. Article ; Online: Characteristics and outcomes of socioeconomically disadvantaged pregnant individuals with adult congenital heart disease presenting to a Cardio-Obstetrics Program.

    Yellin, Shira / Wiener, Sara / Kankaria, Rohan / Vorawandthanachai, Thammatat / Hsu, Daphne / Haberer, Kim / Bortnick, Anna E / Diana, Wolfe S

    American journal of obstetrics & gynecology MFM

    2023  Volume 5, Issue 11, Page(s) 101146

    Abstract: Background: Outcomes of individuals with adult congenital heart disease who are socioeconomically disadvantaged and cared for in cardio-obstetrical programs, are lacking.: Objective: This study aimed to describe the clinical characteristics, maternal ...

    Abstract Background: Outcomes of individuals with adult congenital heart disease who are socioeconomically disadvantaged and cared for in cardio-obstetrical programs, are lacking.
    Objective: This study aimed to describe the clinical characteristics, maternal pregnancy outcomes, and contraceptive uptake in individuals with adult congenital heart disease in an urban cardio-obstetrical program.
    Study design: Retrospective data were collected for individuals with adult congenital heart disease seen in the Maternal Fetal Medicine-Cardiology Joint Program at Montefiore Health System between 2015 and 2021 and compared using modified World Health Organization class I, II vs the modified World Health Organization class ≥II/III.
    Results: Over 90% of individuals with adult congenital heart disease were pregnant at the time of referral. Modified World Health Organization class I, II (n=77, 62.4% Black or Hispanic/Latina) had a total of 94 pregnancies and modified World Health Organization class ≥II/III (n=49, 49.0% Black or Hispanic/Latina) had a total of 56 pregnancies. Over 25% of individuals in each group had a body mass index ≥30 (P=.78), and very low summary socioeconomic scores. Modified World Health Organization class ≥II/III were more likely to be anticoagulated in the first trimester than modified World Health Organization class I, II (10.7% vs 0.0%, P=.002) and throughout pregnancy (14.3% vs 3.2% P=.02). Modified World Health Organization class ≥II/III were more likely to require arterial monitoring during delivery than modified World Health Organization class I, II (14.3% vs 0.0%, P=.001) or delivery under general anesthesia (8.9% vs 1.1%, P=.03) but had a comparable frequency of cesarean delivery (35.8% vs 41.3%, P=.68). There were no in-hospital maternal deaths. There was no difference in the type of contraception recommended by modified World Health Organization class, however, modified World Health Organization class ≥II/III were more likely to receive long-acting types or permanent sterilization (35.6% vs 54.6%, P=.045).
    Conclusion: In a socioeconomically disadvantaged cohort with adult congenital heart disease from a historically marginalized community, those with modified World Health Organization class ≥II/III had more complex antepartum and intrapartum needs but similar maternal and obstetrical outcomes as modified World Health Organization class I, II. The multidisciplinary approach offered by a cardio-obstetrics program may contribute to successful outcomes in this high-risk cohort, and these data are hypothesis-generating.
    MeSH term(s) Pregnancy ; Female ; Humans ; Adult ; Heart Defects, Congenital/diagnosis ; Heart Defects, Congenital/epidemiology ; Heart Defects, Congenital/therapy ; Retrospective Studies ; Pregnancy Outcome/epidemiology ; Cesarean Section
    Language English
    Publishing date 2023-09-01
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 2589-9333
    ISSN (online) 2589-9333
    DOI 10.1016/j.ajogmf.2023.101146
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