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Article ; Online: Hepatitis C virus viral load distribution in the era of extended access to direct acting antivirals treatment: a real-life single center study.

Basso, Monica / Zago, Daniela / Pozzetto, Irene / Parisi, Saverio G

European journal of gastroenterology & hepatology

2022 Volume 33, Issue 1S Suppl 1, Page(s) e1076–e1077

MeSH term(s)	Antiviral Agents/therapeutic use ; Hepacivirus/genetics ; Hepatitis C/diagnosis ; Hepatitis C/drug therapy ; Hepatitis C, Chronic/drug therapy ; Humans ; Viral Load
Chemical Substances	Antiviral Agents
Language	English
Publishing date	2022-01-28
Publishing country	England
Document type	Letter
ZDB-ID	1034239-4
ISSN	1473-5687 ; 0954-691X
ISSN (online)	1473-5687
ISSN	0954-691X
DOI	10.1097/MEG.0000000000002088
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Dolutegravir based antiretroviral therapy compared to other combined antiretroviral regimens for the treatment of HIV-infected naive patients: A systematic review and meta-analysis.

Cruciani, Mario / Parisi, Saverio G

PloS one

2019 Volume 14, Issue 9, Page(s) e0222229

Abstract: Background: Numerous randomized clinical trials (RCTs) were conducted to evaluate dolutegravir based triple antiretroviral therapy (ART) compared to other triple antiretroviral regimens in naïve patients, and a summary of the available evidence is ... ...

Abstract	Background: Numerous randomized clinical trials (RCTs) were conducted to evaluate dolutegravir based triple antiretroviral therapy (ART) compared to other triple antiretroviral regimens in naïve patients, and a summary of the available evidence is required to shed more light on safety and effectiveness issues. Methods: Systematic review and meta-analysis of RCTs comparing dolutegravir-containing ART to non-dolutegravir containing ART in HIV-infected naive patients. Primary outcomes: % of patients with viral load<50 copies/mL at 48 weeks, stratified according to baseline viral load levels (< or >100.000 copies/mL); overall rate of discontinuation and/or switching for any cause (virologic failure, clinical failure, adverse events). Measure of treatment effect: Risk Difference (RD) with 95% confidence intervals (CIs). The GRADE system was used to assess the certainty of the body of evidence. Results: We included 7 RCTs (13 reports, 6407patients) comparing dolutegravir containing to non-dolutegravir containing ART, both in combination with 2 NRTIs. Controls were raltegravir or bictegravir (3 RCTs), boosted atazanavir or darunavir (2 RCTs) or efavirenz (2 RCTs). Rates of patients with VL <50 copies/ml were higher in dolutegravir recipients compared to controls at 48 weeks (RD, 0.05; 95% CIs, 0.03/0.08, p = 0.0002) and 96 weeks (RD, 0.06; 95% CIs, 0.03/0.10, p<0.0001); the average benefit of using dolutegravir was particularly evident at 48 weeks in the subgroup of patients with high baseline viral load (RD, 0.10; 95% CIs, 0.05/0.15; p< 0.0001; GRADE assessment: "high certainty of evidence"). Overall rate of discontinuation were lower in dolutegravir compared to controls (RD,-0.03, 95% CIs -0.05/-0.01; p = 0.007). No significant differences were observed in rates of discontinuation due to adverse events (RD, -0.02; 95% CIs, -0.05/0.00), virologic failure (RD, -0.01; 95% CIs, -0.02/0.01), and most common adverse events (GRADE assessment: from "very-low" to "moderate certainty of evidence"). Conclusion: Starting treatment in naive patients with dolutegravir containing ART has an increased likelihood of achieving viral suppression in the comparison with non-dolutegravir containing ART. The average benefit is particularly evident in those with high baseline viral load.
MeSH term(s)	HIV Infections/drug therapy ; HIV Integrase Inhibitors/therapeutic use ; Heterocyclic Compounds, 3-Ring/therapeutic use ; Humans
Chemical Substances	HIV Integrase Inhibitors ; Heterocyclic Compounds, 3-Ring ; dolutegravir (DKO1W9H7M1)
Language	English
Publishing date	2019-09-10
Publishing country	United States
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0222229
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Dolutegravir based antiretroviral therapy compared to other combined antiretroviral regimens for the treatment of HIV-infected naive patients

Mario Cruciani / Saverio G Parisi

PLoS ONE, Vol 14, Iss 9, p e

A systematic review and meta-analysis.

2019 Volume 0222229

Abstract: Background Numerous randomized clinical trials (RCTs) were conducted to evaluate dolutegravir based triple antiretroviral therapy (ART) compared to other triple antiretroviral regimens in naïve patients, and a summary of the available evidence is ... ...

Abstract	Background Numerous randomized clinical trials (RCTs) were conducted to evaluate dolutegravir based triple antiretroviral therapy (ART) compared to other triple antiretroviral regimens in naïve patients, and a summary of the available evidence is required to shed more light on safety and effectiveness issues. Methods Systematic review and meta-analysis of RCTs comparing dolutegravir-containing ART to non-dolutegravir containing ART in HIV-infected naive patients. Primary outcomes: % of patients with viral load<50 copies/mL at 48 weeks, stratified according to baseline viral load levels (< or >100.000 copies/mL); overall rate of discontinuation and/or switching for any cause (virologic failure, clinical failure, adverse events). Measure of treatment effect: Risk Difference (RD) with 95% confidence intervals (CIs). The GRADE system was used to assess the certainty of the body of evidence. Results We included 7 RCTs (13 reports, 6407patients) comparing dolutegravir containing to non-dolutegravir containing ART, both in combination with 2 NRTIs. Controls were raltegravir or bictegravir (3 RCTs), boosted atazanavir or darunavir (2 RCTs) or efavirenz (2 RCTs). Rates of patients with VL <50 copies/ml were higher in dolutegravir recipients compared to controls at 48 weeks (RD, 0.05; 95% CIs, 0.03/0.08, p = 0.0002) and 96 weeks (RD, 0.06; 95% CIs, 0.03/0.10, p<0.0001); the average benefit of using dolutegravir was particularly evident at 48 weeks in the subgroup of patients with high baseline viral load (RD, 0.10; 95% CIs, 0.05/0.15; p< 0.0001; GRADE assessment: "high certainty of evidence"). Overall rate of discontinuation were lower in dolutegravir compared to controls (RD,-0.03, 95% CIs -0.05/-0.01; p = 0.007). No significant differences were observed in rates of discontinuation due to adverse events (RD, -0.02; 95% CIs, -0.05/0.00), virologic failure (RD, -0.01; 95% CIs, -0.02/0.01), and most common adverse events (GRADE assessment: from "very-low" to "moderate certainty of evidence"). Conclusion ...
Keywords	Medicine ; R ; Science ; Q
Subject code	610
Language	English
Publishing date	2019-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: COVID-19: The wrong target for healthcare liability claims.

Parisi, Saverio G / Viel, Guido / Cecchi, Rossana / Montisci, Massimo

Legal medicine (Tokyo, Japan)

2020 Volume 46, Page(s) 101718

Abstract: Regrettably, after a first moment of appreciation and praise of the citizens for healthcare personnel facing COVID 19 pandemia, numerous episodes of actions taken against them on the issue of their legal liability followed. Impelling is to start an ... ...

Abstract	Regrettably, after a first moment of appreciation and praise of the citizens for healthcare personnel facing COVID 19 pandemia, numerous episodes of actions taken against them on the issue of their legal liability followed. Impelling is to start an argumentation on this problem that aims to establish a shared conduct in dealing with them. The authors propose a basis for discussion on which to begin a constructive debate.
MeSH term(s)	Betacoronavirus ; COVID-19 ; Coronavirus Infections/therapy ; Humans ; Liability, Legal ; Malpractice/legislation & jurisprudence ; Pandemics ; Pneumonia, Viral/therapy ; SARS-CoV-2
Keywords	covid19
Language	English
Publishing date	2020-05-16
Publishing country	Ireland
Document type	Editorial
ZDB-ID	2019555-2
ISSN	1873-4162 ; 1344-6223
ISSN (online)	1873-4162
ISSN	1344-6223
DOI	10.1016/j.legalmed.2020.101718
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Article: Comparable Post-Vaccination Decay of Neutralizing Antibody Response to Wild-Type and Delta SARS-CoV-2 Variant in Healthcare Workers Recovered from Mild or Asymptomatic Infection.

Vicenti, Ilaria / Basso, Monica / Dragoni, Filippo / Gatti, Francesca / Scaggiante, Renzo / Fiaschi, Lia / Parisi, Saverio G / Zazzi, Maurizio

Vaccines

2022 Volume 10, Issue 4

Abstract: We described the long-term decay of neutralizing antibody (NtAb) to the wild-type and Delta SARS-CoV-2 variant after three antigen stimulations (mild or asymptomatic natural infection followed by two doses of the BNT162b2 mRNA vaccine after a median of ... ...

Abstract	We described the long-term decay of neutralizing antibody (NtAb) to the wild-type and Delta SARS-CoV-2 variant after three antigen stimulations (mild or asymptomatic natural infection followed by two doses of the BNT162b2 mRNA vaccine after a median of 296 days) in immunocompetent healthcare workers (HCWs). Live virus microneutralization against the B.1 and Delta SARS-CoV-2 variants was performed in VERO E6 cell cultures. The median NtAb titers for B.1 and Delta were comparable and highly correlated at both 20 and 200 days after the second vaccine dose in the 23 HCWs enrolled (median age, 46 years). A small group of naturally infected unvaccinated HCWs had comparable NtAb titers for the two strains after a median follow-up of 522 days from infection diagnosis. The NtAb response to the Delta VoC appears to follow the same long-term dynamics as the wild-type response regardless of the vaccinal boost; data collected after three antigen stimulations (natural infection followed by two doses of the BNT162b2 mRNA vaccine) may be helpful for tailoring the continuous monitoring of vaccine protection against SARS-CoV-2 variants over time.
Language	English
Publishing date	2022-04-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2703319-3
ISSN	2076-393X
ISSN	2076-393X
DOI	10.3390/vaccines10040580
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Article ; Online: COVID-19

Parisi, Saverio G. / Viel, Guido / Cecchi, Rossana / Montisci, Massimo

Legal Medicine

The wrong target for healthcare liability claims

2020 Volume 46, Page(s) 101718

Keywords	Pathology and Forensic Medicine ; Issues, ethics and legal aspects ; covid19
Language	English
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
ZDB-ID	2019555-2
ISSN	1344-6223
ISSN	1344-6223
DOI	10.1016/j.legalmed.2020.101718
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Comparable Post-Vaccination Decay of Neutralizing Antibody Response to Wild-Type and Delta SARS-CoV-2 Variant in Healthcare Workers Recovered from Mild or Asymptomatic Infection

Ilaria Vicenti / Monica Basso / Filippo Dragoni / Francesca Gatti / Renzo Scaggiante / Lia Fiaschi / Saverio G. Parisi / Maurizio Zazzi

Vaccines, Vol 10, Iss 580, p

2022 Volume 580

Abstract	We described the long-term decay of neutralizing antibody (NtAb) to the wild-type and Delta SARS-CoV-2 variant after three antigen stimulations (mild or asymptomatic natural infection followed by two doses of the BNT162b2 mRNA vaccine after a median of 296 days) in immunocompetent healthcare workers (HCWs). Live virus microneutralization against the B.1 and Delta SARS-CoV-2 variants was performed in VERO E6 cell cultures. The median NtAb titers for B.1 and Delta were comparable and highly correlated at both 20 and 200 days after the second vaccine dose in the 23 HCWs enrolled (median age, 46 years). A small group of naturally infected unvaccinated HCWs had comparable NtAb titers for the two strains after a median follow-up of 522 days from infection diagnosis. The NtAb response to the Delta VoC appears to follow the same long-term dynamics as the wild-type response regardless of the vaccinal boost; data collected after three antigen stimulations (natural infection followed by two doses of the BNT162b2 mRNA vaccine) may be helpful for tailoring the continuous monitoring of vaccine protection against SARS-CoV-2 variants over time.
Keywords	COVID-19 ; vaccination ; Delta ; BNT162b2 vaccine ; neutralizing antibody ; Medicine ; R
Language	English
Publishing date	2022-04-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: An open and georeferenced dataset of forest structural attributes and microhabitats in central and southern Apennines (Italy).

Parisi, Francesco / Francini, Saverio / Borghi, Costanza / Chirici, Gherardo

Data in brief

2022 Volume 43, Page(s) 108445

Abstract: Forests cover 30% of the Earth's landmass, host 80% of the biodiversity on land, and represent one of the main sinks of carbon. Studying forest ecosystems and dynamics is more crucial than ever now that the climate is changing. On the other hand, forest ... ...

Abstract	Forests cover 30% of the Earth's landmass, host 80% of the biodiversity on land, and represent one of the main sinks of carbon. Studying forest ecosystems and dynamics is more crucial than ever now that the climate is changing. On the other hand, forest structural attributes and microhabitats data acquisition is challenging, and require huge efforts. Here we provide a georeferenced dataset of living trees, deadwood, and microhabitats referring to 199 plots (13 m radius), collected between 2012 and 2018, and located over six Apennine mountainous forest types across Italy. The dataset we provide promotes collaboration among researchers and improves the possibilities to analyze the evolution of forest ecosystems.
Language	English
Publishing date	2022-07-08
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2786545-9
ISSN	2352-3409 ; 2352-3409
ISSN (online)	2352-3409
ISSN	2352-3409
DOI	10.1016/j.dib.2022.108445
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Article: COVID-19: The wrong target for healthcare liability claims

Parisi, Saverio G / Viel, Guido / Cecchi, Rossana / Montisci, Massimo

Leg Med (Tokyo)

Abstract	Regrettably, after a first moment of appreciation and praise of the citizens for healthcare personnel facing COVID 19 pandemia, numerous episodes of actions taken against them on the issue of their legal liability followed. Impelling is to start an argumentation on this problem that aims to establish a shared conduct in dealing with them. The authors propose a basis for discussion on which to begin a constructive debate.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #276848
Database	COVID19

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Article ; Online: Latent Tuberculosis Infection in Haematopoietic Stem Cell Transplant Recipients: A Retrospective Italian Cohort Study in Tor Vergata University Hospital, Rome.

Compagno, Mirko / Navarra, Assunta / Campogiani, Laura / Coppola, Luigi / Rossi, Benedetta / Iannetta, Marco / Malagnino, Vincenzo / Parisi, Saverio G / Mariotti, Benedetta / Cerretti, Raffaella / Arcese, William / Goletti, Delia / Andreoni, Massimo / Sarmati, Loredana

International journal of environmental research and public health

2022 Volume 19, Issue 17

Abstract: The results of tuberculosis (TB) screening and reactivation in a cohort of 323 adult patients undergoing haematopoietic stem cell transplantation (HSCT) from 2015 to 2019 at the University Hospital of Tor Vergata, Rome, Italy, were reported. A total of ... ...

Abstract	The results of tuberculosis (TB) screening and reactivation in a cohort of 323 adult patients undergoing haematopoietic stem cell transplantation (HSCT) from 2015 to 2019 at the University Hospital of Tor Vergata, Rome, Italy, were reported. A total of 260 patients, 59 (18.3%) autologous and 264 (81.7%) allogeneic transplants, underwent Interferon Release (IFN)-γ (IGRA) test screening: 228 (87.7%) were negative, 11 (4.2%) indeterminate and 21 (8.1%) positive. Most of the IGRA-positive patients were of Italian origin (95.2%) and significantly older than the IGRA-negative (
MeSH term(s)	Adult ; Cohort Studies ; Hematopoietic Stem Cell Transplantation/adverse effects ; Hospitals ; Humans ; Interferon-gamma Release Tests/methods ; Latent Tuberculosis/diagnosis ; Latent Tuberculosis/epidemiology ; Retrospective Studies ; Rome/epidemiology ; Tuberculin Test/methods ; Tuberculosis/diagnosis ; Tuberculosis/epidemiology
Language	English
Publishing date	2022-08-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph191710693
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