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Article ; Online: Correction: Electroacupuncture Promotes Nerve Regeneration and Functional Recovery Through Regulating lncRNA GAS5 Targeting miR-21 After Sciatic Nerve Injury.

Tian, Ming-Yue / Yang, Yi-Duo / Qin, Wan-Ting / Liu, Bao-Nian / Mou, Fang-Fang / Zhu, Jing / Guo, Hai-Dong / Shao, Shui-Jin

Molecular neurobiology

2024 Volume 61, Issue 2, Page(s) 950–952

Language	English
Publishing date	2024-01-24
Publishing country	United States
Document type	Published Erratum
ZDB-ID	645020-9
ISSN	1559-1182 ; 0893-7648
ISSN (online)	1559-1182
ISSN	0893-7648
DOI	10.1007/s12035-024-03932-z
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Zs.A 2411: Show issues

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Article ; Online: Clinical characteristics and prognosis of pregnancy-related acute kidney injury: a case series study.

Lu, Wei / Hu, Min-Jie / Zhu, Dong-Dong / Lin, Fu-Jun / Huang, Hai-Dong

International urology and nephrology

2023 Volume 55, Issue 9, Page(s) 2249–2255

Abstract: Objective: Acute kidney injury (AKI) seriously affects the health of both pregnant women and fetuses. This study aimed to investigate the clinical characteristics and prognosis of pregnancy-related AKI (PR-AKI).: Methods: This case series study ... ...

Abstract	Objective: Acute kidney injury (AKI) seriously affects the health of both pregnant women and fetuses. This study aimed to investigate the clinical characteristics and prognosis of pregnancy-related AKI (PR-AKI). Methods: This case series study enrolled pregnant women with PR-AKI admitted to the surgical intensive care unit of Xinhua Hospital affiliated to Shanghai Jiaotong University School of Medicine between January 2010 and December 2020. Results: Thirty-one PR-AKI patients were enrolled with a mean age of 29.16 ± 4.97 years. Seventeen pregnant women (54.84%) had complete recovery of renal function, 5 (16.13%) had partial recovery of renal function, 2 (6.45%) patients had no renal function improvement, and 7 (22.58%) died. Among the 31 patients with 35 fetuses, 25 (80.6%) pregnant women had poor fetal outcomes, including 5 cases of stillbirths, 5 neonatal asphyxia, 18 premature births, 10 low birth weight, and 8 deficient birth weight infants. Compared to cases with good fetal outcomes, cases with poor fetal outcomes had significantly shorter gestational weeks (39.26 ± 1.53 vs. 31.62 ± 5.50, P = 0.002), lower platelet count (217.13 ± 122.87 vs. 90.24 ± 84.88, P = 0.005), lower hemoglobin (94.19 ± 13.21 vs. 74.48 ± 20.78, P = 0.036), higher blood urea nitrogen (11.87 ± 4.28 vs. 19.47 ± 10.98, P = 0.013), and higher uric acid (262.41 ± 167.00 vs. 586.87 ± 144.52, P < 0.001). Conclusions: The maternal renal function of women with PR-AKI might improve after treatment, but occurrence rates of adverse fetal outcomes were still high.
MeSH term(s)	Infant, Newborn ; Infant ; Pregnancy ; Female ; Humans ; Young Adult ; Adult ; Pregnancy Outcome/epidemiology ; China/epidemiology ; Prognosis ; Acute Kidney Injury/diagnosis ; Acute Kidney Injury/etiology ; Acute Kidney Injury/epidemiology ; Kidney ; Retrospective Studies
Language	English
Publishing date	2023-02-28
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	204048-7
ISSN	1573-2584 ; 0301-1623 ; 0042-1162
ISSN (online)	1573-2584
ISSN	0301-1623 ; 0042-1162
DOI	10.1007/s11255-023-03484-6
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Zs.A 733: Show issues

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Article: [Effects of TUG1 on hepatic fibrosis and its mechanism].

Zhu, Hai-Dong / Lyu, Chang-Kun / Ma, Fei-Fei

Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology

2021 Volume 37, Issue 6, Page(s) 616–621

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Animals ; Hepatic Stellate Cells ; Liver Cirrhosis/pathology ; RNA, Long Noncoding/genetics ; Rats
Chemical Substances	RNA, Long Noncoding ; TUG1 long noncoding RNA, rat
Language	Chinese
Publishing date	2021-11-24
Publishing country	China
Document type	Journal Article
ISSN	1000-6834
ISSN	1000-6834
DOI	10.12047/j.cjap.6139.2021.094
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Article ; Online: Locoregional therapies for hepatocellular carcinoma: The current status and future perspectives.

Chen, Jian-Jian / Jin, Zhi-Cheng / Zhong, Bin-Yan / Fan, Wenzhe / Zhang, Wei-Hua / Luo, Biao / Wang, Yu-Qing / Teng, Gao-Jun / Zhu, Hai-Dong

United European gastroenterology journal

2024 Volume 12, Issue 2, Page(s) 226–239

Abstract: Hepatocellular carcinoma (HCC) is one of the most common cancers and a leading cause of cancer-related mortality. Locoregional therapies (LRTs) play a crucial role in HCC management and are selectively adopted in real-world practice across various stages. ...

Abstract	Hepatocellular carcinoma (HCC) is one of the most common cancers and a leading cause of cancer-related mortality. Locoregional therapies (LRTs) play a crucial role in HCC management and are selectively adopted in real-world practice across various stages. Choosing the best form of LRTs depends on technical aspects, patient clinical status and tumour characteristics. Previous studies have consistently highlighted the efficacy of combining LRTs with molecular targeted agents in HCC treatment. Recent studies propose that integrating LRTs with immune checkpoint inhibitors and molecular targeted agents could provide substantial therapeutic benefits, a notion underpinned by both basic and clinical evidence. This review summarised the current landscape of LRTs in HCC and discussed the anticipated outcomes of combinations with immunotherapy regimens.
MeSH term(s)	Humans ; Carcinoma, Hepatocellular ; Liver Neoplasms ; Treatment Outcome ; Immunotherapy ; Antineoplastic Agents/therapeutic use
Chemical Substances	Antineoplastic Agents
Language	English
Publishing date	2024-02-19
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2728585-6
ISSN	2050-6414 ; 2050-6406
ISSN (online)	2050-6414
ISSN	2050-6406
DOI	10.1002/ueg2.12554
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Article ; Online: Benchmark Status of Women Interventional Radiologists in China.

Zeng, Chu-Hui / Lu, Jian / Zhu, Hai-Dong / Teng, Gao-Jun

Journal of vascular and interventional radiology : JVIR

2021 Volume 32, Issue 7, Page(s) 974–982

Abstract: Purpose: To evaluate the current status of women interventional radiologists in China and discuss possible measures to boost their representation in this male-dominated field for a more diverse workplace environment in the future.: Materials and ... ...

Abstract	Purpose: To evaluate the current status of women interventional radiologists in China and discuss possible measures to boost their representation in this male-dominated field for a more diverse workplace environment in the future. Materials and methods: The list of Chinese interventional radiologists obtained from the Chinese College of Interventionalists was retrospectively reviewed. Key information was extracted from the database, including sex, chronologic trends of representation of women interventional radiologists, position, education level, geographic distribution, interventional radiology (IR) practice time, departmental affiliation, and hospital classification. Results: Of the 13,855 entries, 7,324 (52.9%) were interventional radiologists having valid information. Among them, 684 (9.3%) were identified as women. The number of women interventional radiologists has continued to increase since the first woman registered in 1992. The average age of women interventional radiologists was 39.1 years ± 5.7 (range, 26-50). The majority of them were attending physicians (n = 280; 40.9%) with a bachelor's degree (n = 363; 53.1%). Most women interventional radiologists (n = 215, 31.4%) joined this specialty 5-9 years after becoming physicians, whereas 128 (18.7%) started practicing IR from the very beginning. A total of 42.4% of women interventional radiologists were from the departments of IR and cardiology. Conclusions: Although the total number shows an upward trend, women interventional radiologists are still underrepresented. Education level, geographic areas, and other socioeconomic factors may simultaneously influence the population size of women interventional radiologists in China.
MeSH term(s)	Adult ; Benchmarking ; China ; Female ; Humans ; Male ; Middle Aged ; Radiologists ; Radiology, Interventional ; Retrospective Studies
Language	English
Publishing date	2021-04-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	1137756-2
ISSN	1535-7732 ; 1051-0443
ISSN (online)	1535-7732
ISSN	1051-0443
DOI	10.1016/j.jvir.2021.02.026
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Zs.A 3720: Show issues

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ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Electroacupuncture Promotes Nerve Regeneration and Functional Recovery Through Regulating lncRNA GAS5 Targeting miR-21 After Sciatic Nerve Injury.

Tian, Ming-Yue / Yang, Yi-Duo / Qin, Wan-Ting / Liu, Bao-Nian / Mou, Fang-Fang / Zhu, Jing / Guo, Hai-Dong / Shao, Shui-Jin

Molecular neurobiology

2023 Volume 61, Issue 2, Page(s) 935–949

Abstract: Although the benefits of electroacupuncture (EA) for peripheral nerve injury (PNI) are well accepted in clinical practice, the underlying mechanism remains incompletely elucidated. In our study, we observed that EA intervention led to a reduction in the ... ...

Abstract	Although the benefits of electroacupuncture (EA) for peripheral nerve injury (PNI) are well accepted in clinical practice, the underlying mechanism remains incompletely elucidated. In our study, we observed that EA intervention led to a reduction in the expression of the long non-coding RNA growth-arrest-specific transcript 5 (GAS5) and an increased in miR-21 levels within the injured nerve, effectively promoting functional recovery and nerve regeneration following sciatic nerve injury (SNI). In contrast, administration of adeno-associated virus expressing GAS5 (AAV-GAS5) weakened the therapeutic effect of EA. On the other hand, both silencing GAS5 and introducing a miR-21 mimic prominently enhanced the proliferation activity and migration ability of Schwann cells (SCs), while also inhibiting SCs apoptosis. On the contrary, inhibition of SCs apoptosis was found to be mediated by miR-21. Additionally, overexpression of GAS5 counteracted the effects of the miR-21 mimic on SCs. Moreover, SCs that transfected with the miR-21 mimic promoted neurite growth in hypoxia/reoxygenation-induced neurons, which might be prevented by overexpressing GAS5. Furthermore, GAS5 was found to be widely distributed in the cytoplasm and was negatively regulated by miR-21. Consequently, the targeting of GAS5 by miR-21 represents a potential mechanism through which EA enhances reinnervation and functional restoration following SNI. Mechanistically, the GAS5/miR-21 axis can modulate the proliferation, migration, and apoptosis of SCs while potentially influencing the neurite growth of neurons.
MeSH term(s)	Humans ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Peripheral Nerve Injuries/therapy ; Peripheral Nerve Injuries/metabolism ; Electroacupuncture ; Sciatic Neuropathy/metabolism ; Nerve Regeneration/physiology ; Sciatic Nerve/metabolism
Chemical Substances	RNA, Long Noncoding ; MicroRNAs ; MIRN21 microRNA, human
Language	English
Publishing date	2023-09-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	645020-9
ISSN	1559-1182 ; 0893-7648
ISSN (online)	1559-1182
ISSN	0893-7648
DOI	10.1007/s12035-023-03613-3
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Zs.A 2411: Show issues

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Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Correlation of CT-derived pectoralis muscle status and COVID-19 induced lung injury in elderly patients.

Ying-Hao, Pei / Hai-Dong, Zhang / Yuan, Fang / Yong-Kang, Liu / Sen, Liang / Wei-Long, Xu / Yu-Shan, Yang / Jun-Feng, Zhu / Hai-Qi, Zhou / Hua, Jiang

BMC medical imaging

2022 Volume 22, Issue 1, Page(s) 144

Abstract: Objectives: To explore the association between CT-derived pectoralis muscle index (PMI) and COVID-19 induced lung injury.: Methods: We enrolled 116 elderly COVID-19 patients linked to the COVID-19 outbreak in Nanjing Lukou international airport. We ... ...

Abstract	Objectives: To explore the association between CT-derived pectoralis muscle index (PMI) and COVID-19 induced lung injury. Methods: We enrolled 116 elderly COVID-19 patients linked to the COVID-19 outbreak in Nanjing Lukou international airport. We extracted three sessions of their CT data, including one upon admission (T1), one during the first 2 weeks when lung injury peaked (T2) and one on day 14 ± 2 (T3). Lung injury was assessed by CT severity score (CTSS) and pulmonary opacity score (POS). Pneumonia evolution was evaluated by changes of CT scores at T2 from T1(Δ). Results: The maximum CT scores in low PMI patients were higher than those of normal PMI patients, including CTSS1 (7, IQR 6-10 vs. 5, IQR 3-6, p < 0.001), CTSS2 (8, IQR 7-11 vs. 5, IQR 4-7, p < 0.001) and POS (2, IQR 1-2.5 vs. 1, IQR 1-2, p < 0.001). Comorbidity (OR = 6.15, p = 0.023) and the presence of low PMI (OR = 5.43, p = 0.001) were predictors of lung injury aggravation with ΔCTSS1 > 4. The presence of low PMI (OR = 5.98, p < 0.001) was the predictor of lung injury aggravation with ΔCTSS2 > 4. Meanwhile, presence of low PMI (OR = 2.82, p = 0.042) and incrementally increasing D-dimer (OR = 0.088, p = 0.024) were predictors of lung injury aggravation with ΔPOS = 2. Conclusions: PMI can be easily assessed on chest CT images and can potentially be used as one of the markers to predict the severity of lung injury in elderly COVID-19 patients.
MeSH term(s)	Aged ; COVID-19 ; Humans ; Lung/diagnostic imaging ; Lung Injury/diagnostic imaging ; Pectoralis Muscles ; Retrospective Studies ; Thorax ; Tomography, X-Ray Computed/methods
Language	English
Publishing date	2022-08-12
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2061975-3
ISSN	1471-2342 ; 1471-2342
ISSN (online)	1471-2342
ISSN	1471-2342
DOI	10.1186/s12880-022-00872-9
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Article ; Online: The Exploration of a Novel Biodegradable Drug-Eluting Biliary Stent: Preliminary Work.

Zeng, Chu-Hui / Liu, Lin-Lin / Zhu, Hai-Dong / Teng, Gao-Jun

Cardiovascular and interventional radiology

2021 Volume 44, Issue 10, Page(s) 1633–1642

Abstract: Purpose: To explore the degradation, drug release, and mechanical properties of drug-incorporated films made of different ratios of poly(lactic-co-glycolic acid) (PLGA) and different amounts of paclitaxel (PTX), which may serve as the material platform ... ...

Abstract	Purpose: To explore the degradation, drug release, and mechanical properties of drug-incorporated films made of different ratios of poly(lactic-co-glycolic acid) (PLGA) and different amounts of paclitaxel (PTX), which may serve as the material platform for the manufacturing of biodegradable drug-eluting biliary stents. Materials and methods: PLGA of different lactic acid/glycolic acid ratios (50/50, 70/30, and 80/20) and 0%, 10, 20, and 30% weight by weight (w/w) PTX was mixed to make PLGA films, which were then cut into small pieces for further testing. Films were immersed in phosphate-buffered saline (pH 7.4) for a maximum of 11 weeks. Samples were taken randomly at Day 2, 4, 6, 8, 10, 12, 14, and weekly thereafter until Week 11 to test tensile strength, weight loss, pH value of the soaking solution, and drug release. The morphology of films was observed using scanning electron microscope (SEM). Results: At Week 10 of degradation, PLGA 80/20 still withstood a tensile strength of 9.7 newton (N), while PLGA 50/50 and 70/30 cracked spontaneously since Day 4. At Week 11, weight loss of PLGA 50/50, 70/30, and 80/20 was 95.15, 82.32, and 16.17%, respectively; and the lowest pH value of soaking solution was 1.87, 1.95, and 6.58, respectively. Drug release of 10, 20, and 30% PTX groups was 3.52-4.48%, 1.90-2.26%, and 1.44-2.06%, respectively. SEM proved smooth films before degradation; however, after the tensile strength was lost, cracks could be seen. Conclusion: The degradation rate of PLGA can be controlled by altering lactic acid/glycolic acid ratio. Overall, PLGA 50/50 and 70/30 degrade significantly faster than 80/20. PLGA can serve as an effective drug carrier for PTX while being the stent strut, and PTX can be slowly released as PLGA degrades.
MeSH term(s)	Drug Carriers ; Humans ; Lactic Acid ; Polyglycolic Acid ; Polylactic Acid-Polyglycolic Acid Copolymer ; Stents
Chemical Substances	Drug Carriers ; Polylactic Acid-Polyglycolic Acid Copolymer (1SIA8062RS) ; Polyglycolic Acid (26009-03-0) ; Lactic Acid (33X04XA5AT)
Language	English
Publishing date	2021-07-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	603082-8
ISSN	1432-086X ; 0342-7196 ; 0174-1551
ISSN (online)	1432-086X
ISSN	0342-7196 ; 0174-1551
DOI	10.1007/s00270-021-02892-4
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Zs.A 1378: Show issues

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Article ; Online: New First-line Immunotherapy-based Therapies for Unresectable Hepatocellular Carcinoma: A Living Network Meta-analysis.

Chen, Jian-Jian / Jin, Zhi-Cheng / Luo, Biao / Wang, Yu-Qing / Li, Rui / Zhu, Hai-Dong / Teng, Gao-Jun

Journal of clinical and translational hepatology

2023 Volume 12, Issue 1, Page(s) 15–24

Abstract: Background and aims: Several first-line immune checkpoint inhibitor (ICI)-based combination therapies have been identified for unresectable hepatocellular carcinoma (uHCC). This network meta-analysis (NMA) aimed to provide the most updated evidence ... ...

Abstract	Background and aims: Several first-line immune checkpoint inhibitor (ICI)-based combination therapies have been identified for unresectable hepatocellular carcinoma (uHCC). This network meta-analysis (NMA) aimed to provide the most updated evidence about the preferred first-line ICI-based regimens for uHCC. Methods: A comprehensive literature search was performed in various databases from database inception to May 2022. The phase 3 trials evaluating first-line single-agent ICIs, molecular-target agents (MTAs), or their combinations in uHCC were included. The main endpoints were overall survival (OS) and progression-free survival (PFS). Pooled effect estimates were calculated using a random effects model within the frequentist framework. Subgroup analyses based on etiology were also conducted. Results: Twelve trials at low risk of bias with 8,275 patients comparing 13 treatments were included. OS with atezolizumab plus bevacizumab was comparable to sintilimab plus IBI305 [hazard ratio (HR): 1.16; 95% confidence interval (CI): 0.80-1.68] and camrelizumab plus apatinib (HR: 1.06; 95% CI: 0.75-1.51). The combination therapies, apart from atezolizumab plus cabozantinib in OS and durvalumab plus tremelimumab in PFS, had higher P-score than single-agent MTAs or ICIs. The survival benefits were associated with a high risk of adverse events leading to treatment discontinuation. The proportion of patients with hepatitis B virus-related HCC receiving ICIs combinations might positively correlate with survival advantages ( Conclusion: This NMA demonstrated that atezolizumab plus bevacizumab remains the stand of care and confers comparable survival benefits to sintilimab plus IBI305 and camrelizumab plus apatinib in first-line therapy for uHCC. The optimal treatment algorithms should consider efficacy, safety, and etiology.
Language	English
Publishing date	2023-09-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	3019822-7
ISSN	2310-8819 ; 2225-0719
ISSN (online)	2310-8819
ISSN	2225-0719
DOI	10.14218/JCTH.2023.00188
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Article ; Online: Reply to: "Potential limitations of irradiation stent implantation in unresectable malignant biliary obstruction".

Zhu, Hai-Dong / Lu, Jian / Teng, Gao-Jun

Journal of hepatology

2018 Volume 69, Issue 2, Page(s) 557–558

MeSH term(s)	Bile Duct Neoplasms ; Cholestasis ; Humans ; Stents
Language	English
Publishing date	2018-05-09
Publishing country	Netherlands
Document type	Letter ; Comment
ZDB-ID	605953-3
ISSN	1600-0641 ; 0168-8278
ISSN (online)	1600-0641
ISSN	0168-8278
DOI	10.1016/j.jhep.2018.05.003
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Zs.A 2027: Show issues

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