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Article: COVID-19: a brief update for radiologists.

2020 Volume 53, Issue 5, Page(s) 320–328

Abstract: Coronavirus disease 2019 (COVID-19), which is caused by a new coronavirus-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-is a pandemic with major impacts on the health care sector, and a broad view of the disease is of fundamental ... ...

Abstract	Coronavirus disease 2019 (COVID-19), which is caused by a new coronavirus-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-is a pandemic with major impacts on the health care sector, and a broad view of the disease is of fundamental importance for any radiologist. The purpose of this review is to address the main clinical and imaging aspects of COVID-19, as well as guidelines for requesting and using imaging methods; measures to protect patients and health care professionals; systems for quantifying pulmonary findings and preparing integrated reports; and the main innovations that have emerged during this pandemic.
Keywords	covid19
Language	English
Publishing date	2020-10-13
Publishing country	Brazil
Document type	Journal Article ; Review
ZDB-ID	2078806-X
ISSN	1678-7099 ; 0100-3984
ISSN (online)	1678-7099
ISSN	0100-3984
DOI	10.1590/0100-3984.2020.0074
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: COVID-19

Gustavo de Souza Portes Meirelles

Radiologia Brasileira, Vol 53, Iss 5, Pp 320-

a brief update for radiologists

2020 Volume 328

Abstract: Abstract Coronavirus disease 2019 (COVID-19), which is caused by a new coronavirus-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-is a pandemic with major impacts on the health care sector, and a broad view of the disease is of fundamental ... ...

Abstract	Abstract Coronavirus disease 2019 (COVID-19), which is caused by a new coronavirus-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-is a pandemic with major impacts on the health care sector, and a broad view of the disease is of fundamental importance for any radiologist. The purpose of this review is to address the main clinical and imaging aspects of COVID-19, as well as guidelines for requesting and using imaging methods; measures to protect patients and health care professionals; systems for quantifying pulmonary findings and preparing integrated reports; and the main innovations that have emerged during this pandemic.
Keywords	Coronavirus infection/diagnostic imaging ; Coronavirus ; Review ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
Language	English
Publishing date	2020-10-01T00:00:00Z
Publisher	Colégio Brasileiro de Radiologia e Diagnóstico por Imagem
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: COVID-19

Meirelles, Gustavo de Souza Portes

Radiologia Brasileira v.53 n.5 2020

a brief update for radiologists

2020

Abstract	Abstract Coronavirus disease 2019 (COVID-19), which is caused by a new coronavirus-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-is a pandemic with major impacts on the health care sector, and a broad view of the disease is of fundamental importance for any radiologist. The purpose of this review is to address the main clinical and imaging aspects of COVID-19, as well as guidelines for requesting and using imaging methods; measures to protect patients and health care professionals; systems for quantifying pulmonary findings and preparing integrated reports; and the main innovations that have emerged during this pandemic.
Keywords	Coronavirus infection/diagnostic imaging ; Coronavirus ; Review ; covid19
Language	English
Publishing date	2020-10-01
Publisher	Publicação do Colégio Brasileiro de Radiologia e Diagnóstico por Imagem
Publishing country	br
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Pitfalls and artifacts in the interpretation of oncologic PET/CT of the chest.

Meirelles, Gustavo de Souza Portes / Capobianco, Julia / de Oliveira, Marco Antônio Condé

Radiologia brasileira

2017 Volume 50, Issue 1, Page(s) 55–59

Abstract: PET/CT is widely used for the evaluation of patients with thoracic malignancies. Although the levels ... ...

Abstract	PET/CT is widely used for the evaluation of patients with thoracic malignancies. Although the levels of
Language	English
Publishing date	2017-02-13
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2078806-X
ISSN	1678-7099 ; 0100-3984
ISSN (online)	1678-7099
ISSN	0100-3984
DOI	10.1590/0100-3984.2015.0194
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Article ; Online: Importance of chest HRCT in the diagnostic evaluation of fibrosing interstitial lung diseases.

Torres, Pedro Paulo Teixeira E Silva / Rabahi, Marcelo Fouad / Moreira, Maria Auxiliadora do Carmo / Escuissato, Dante Luiz / Meirelles, Gustavo de Souza Portes / Marchiori, Edson

Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia

2021 Volume 47, Issue 3, Page(s) e20200096

Abstract: Many conditions result in chronic interstitial lung disease (ILD), being classified as fibrosing ILDs, including idiopathic pulmonary fibrosis, connective tissue diseases, sarcoidosis, and fibrotic hypersensitivity pneumonitis. HRCT plays an important ... ...

Abstract	Many conditions result in chronic interstitial lung disease (ILD), being classified as fibrosing ILDs, including idiopathic pulmonary fibrosis, connective tissue diseases, sarcoidosis, and fibrotic hypersensitivity pneumonitis. HRCT plays an important role in the clinical evaluation of fibrosing ILDs. Current treatment perspectives are encouraging and reinforce the need for HRCT scans of adequate technical quality for early detection of fibrosing ILD. Despite efforts in this regard, the significance and management of imaging findings of early interstitial lung abnormalities have yet to be clarified. After identification of CT findings consistent with fibrosing ILD, radiologists must be able to identify characteristic morphological patterns and, in some cases, features of specific clinical entities. In cases in which HRCT features are not sufficiently specific for a definitive diagnosis, HRCT can aid in selecting the best site for surgical lung biopsy. CT follow-up is useful for identifying progressive fibrosing ILDs and detecting complications unrelated to the underlying disease, including infections, acute exacerbations, and neoplasms. Automated quantification tools have clinical applicability and are likely to be available for use in imaging analysis in the near future. In addition, incorporation of CT evaluation into scoring systems based on clinical and functional parameters for staging fibrosing disease is likely to become valuable in determining prognosis. Knowledge of the clinical applications of CT evaluation is essential for specialists managing patients with fibrosing ILD and can have a positive impact on the clinical course of the disease.
MeSH term(s)	Disease Progression ; Fibrosis ; Humans ; Idiopathic Pulmonary Fibrosis/diagnostic imaging ; Lung/diagnostic imaging ; Lung Diseases, Interstitial/diagnostic imaging
Language	Portuguese
Publishing date	2021-05-31
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2223157-2
ISSN	1806-3756 ; 1806-3713
ISSN (online)	1806-3756
ISSN	1806-3713
DOI	10.36416/1806-3756/e20200096
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Article: Neurofibromatosis type 1: evaluation by chest computed tomography.

Alves Júnior, Sérgio Ferreira / Irion, Klaus Loureiro / de Melo, Alessandro Severo Alves / Meirelles, Gustavo de Souza Portes / Rodrigues, Rosana Souza / Souza, Arthur Soares / Hochhegger, Bruno / Zanetti, Gláucia / Marchiori, Edson

Radiologia brasileira

2021 Volume 54, Issue 6, Page(s) 375–380

Abstract: Objective: The aim of this study was to evaluate chest computed tomography (CT) findings in patients diagnosed with neurofibromatosis type 1 (NF1).: Material and methods: This was a retrospective study in which we reviewed the chest CT scans of 14 ... ...

Abstract	Objective: The aim of this study was to evaluate chest computed tomography (CT) findings in patients diagnosed with neurofibromatosis type 1 (NF1). Material and methods: This was a retrospective study in which we reviewed the chest CT scans of 14 patients diagnosed with NF1 and neurofibromatosis-associated diffuse lung disease (NF-DLD). The sample comprised eight women and six men. The median age was 55 years (range, 11-75 years). The diagnosis of NF1 was made on the basis of the diagnostic criteria established by the U.S. National Institutes of Health. The images were analyzed by two chest radiologists, who reached decisions by consensus. Results: The predominant CT finding of NF-DLD was multiple cysts, which were observed in 13 patients (92.9%), followed by emphysema, in eight (57.1%) and subpleural bullae, in six (42.9%). Other findings included subcutaneous neurofibromas, in 12 patients (85.7%), ground-glass opacities, in one (7.1%), and tracheobronchial neurofibromas, in one (7.1%). The pulmonary abnormalities were bilateral in 12 cases (85.7%). The abnormalities were predominantly in the upper lung fields in eight cases (57.1%), and their distribution was random in 11 (78.6%). Conclusion: Pulmonary cysts, emphysema, and subpleural bullae appear to be the chest CT findings that are most characteristic of NF-DLD.
Language	English
Publishing date	2021-11-27
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2078806-X
ISSN	1678-7099 ; 0100-3984
ISSN (online)	1678-7099
ISSN	0100-3984
DOI	10.1590/0100-3984.2020.0150
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Article ; Online: Neurofibromatosis type 1: State-of-the-art review with emphasis on pulmonary involvement.

Alves Júnior, Sérgio Ferreira / Zanetti, Gláucia / Alves de Melo, Alessandro Severo / Souza, Arthur Soares / Souza, Luciana Soares / de Souza Portes Meirelles, Gustavo / Irion, Klaus Loureiro / Hochhegger, Bruno / Marchiori, Edson

Respiratory medicine

2019 Volume 149, Page(s) 9–15

Abstract: Neurofibromatosis type 1 (NF-1), also known as von Recklinghausen's disease, is an autosomal dominant dysplasia of the ectoderm and mesoderm with a variable clinical expression, but near-complete penetrance before the age of 5 years. The estimated ... ...

Abstract	Neurofibromatosis type 1 (NF-1), also known as von Recklinghausen's disease, is an autosomal dominant dysplasia of the ectoderm and mesoderm with a variable clinical expression, but near-complete penetrance before the age of 5 years. The estimated incidence is 1 in 3000 births. NF-1 is characterized by collections of neurofibromas, café-au-lait spots, axillary and inguinal freckling, and pigmented hamartomas in the iris (Lisch nodules). Pulmonary manifestations of NF-1, which usually include bilateral basal reticulations and apical bullae and cysts, are reported in 10-20% of adult patients. Clinically, neurofibromatosis-associated diffuse lung disease (NF-DLD) usually presents with nonspecific respiratory symptoms, including dyspnea on exertion, shortness of breath, and chronic cough or chest pain, at the time of diagnosis. Computed tomography (CT) is highly accurate for the identification and characterization of NF-DLD; it is the most reliable method for the diagnosis of this lung involvement. Various CT findings of NF-DLD, including cysts, bullae, ground-glass opacities, bibasilar reticular opacities, and emphysema, have been described in patients with NF-1. The typical CT pattern, however, is characterized by upper-lobe cystic and bullous disease, and basilar interstitial lung disease. Currently, the goal of NF-DLD treatment is the earliest possible diagnosis, focusing on symptom relief and interventions that positively alter the course of the disease, such as smoking cessation. The aim of this review is to describe the main clinical, pathological, and imaging aspects of NF-1, with a focus on pulmonary involvement.
MeSH term(s)	Acrylonitrile/analogs & derivatives ; Acrylonitrile/therapeutic use ; Aged ; Aniline Compounds/therapeutic use ; Antineoplastic Agents/therapeutic use ; Benzimidazoles/therapeutic use ; Blister/pathology ; Child ; Female ; Genetic Counseling/methods ; Humans ; Hypertension, Pulmonary/etiology ; Lung Diseases/diagnostic imaging ; Lung Diseases/etiology ; Lung Diseases/pathology ; Lung Diseases, Interstitial/diagnostic imaging ; Lung Diseases, Interstitial/etiology ; Lung Diseases, Interstitial/pathology ; Male ; Middle Aged ; Neurofibromatosis 1/complications ; Neurofibromatosis 1/epidemiology ; Neurofibromatosis 1/pathology ; Neurofibromatosis 1/therapy ; Pulmonary Emphysema/etiology ; Tomography, X-Ray Computed/methods ; Tretinoin/therapeutic use ; Young Adult
Chemical Substances	AZD 6244 ; Aniline Compounds ; Antineoplastic Agents ; Benzimidazoles ; MEK inhibitor I ; Tretinoin (5688UTC01R) ; Acrylonitrile (MP1U0D42PE)
Language	English
Publishing date	2019-01-17
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1003348-8
ISSN	1532-3064 ; 0954-6111
ISSN (online)	1532-3064
ISSN	0954-6111
DOI	10.1016/j.rmed.2019.01.002
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Article ; Online: Clinical diagnosis of patients subjected to surgical lung biopsy with a probable usual interstitial pneumonia pattern on high-resolution computed tomography.

Tibana, Regina Celia Carlos / Soares, Maria Raquel / Storrer, Karin Mueller / de Souza Portes Meirelles, Gustavo / Hidemi Nishiyama, Katia / Missrie, Israel / Coletta, Ester Nei Aparecida Martins / Ferreira, Rimarcs Gomes / de Castro Pereira, Carlos Alberto

BMC pulmonary medicine

2020 Volume 20, Issue 1, Page(s) 299

Abstract: Background: Usual interstitial pneumonia can present with a probable pattern on high-resolution computed tomography (HRCT), but the probability of identifying usual interstitial pneumonia by surgical lung biopsy in such cases remains controversial. We ... ...

Abstract	Background: Usual interstitial pneumonia can present with a probable pattern on high-resolution computed tomography (HRCT), but the probability of identifying usual interstitial pneumonia by surgical lung biopsy in such cases remains controversial. We aimed to determine the final clinical diagnosis in patients with a probable usual interstitial pneumonia pattern on HRCT who were subjected to surgical lung biopsy. Methods: HRCT images were assessed and categorized by three radiologists, and tissue slides were evaluated by two pathologists, all of whom were blinded to the clinical findings. The final clinical diagnosis was accomplished via a multidisciplinary discussion. Patients with a single layer of honeycombing located outside of the lower lobes on HRCT were not excluded. Results: A total of 50 patients were evaluated. The most common final clinical diagnosis was fibrotic hypersensitivity pneumonitis (38.0%) followed by idiopathic pulmonary fibrosis (24.0%), interstitial lung disease ascribed to gastroesophageal reflux disease (12.0%) and familial interstitial lung disease (10.0%). In the group without environmental exposure (n = 22), 10 patients had a final clinical diagnosis of idiopathic pulmonary fibrosis (45.5%). Irrespective of the final clinical diagnosis, by multivariate Cox analysis, patients with honeycombing, dyspnoea and fibroblastic foci on surgical lung biopsy had a high risk of death. Conclusions: The most common disease associated with a probable usual interstitial pneumonia pattern on HRCT is fibrotic hypersensitivity pneumonitis followed by idiopathic pulmonary fibrosis and interstitial lung disease ascribed to gastroesophageal reflux disease. In patients without environmental exposure, the frequencies of usual interstitial pneumonia and a final clinical diagnosis of idiopathic pulmonary fibrosis are not sufficiently high to obviate the indications for surgical lung biopsy.
MeSH term(s)	Aged ; Alveolitis, Extrinsic Allergic/diagnostic imaging ; Alveolitis, Extrinsic Allergic/pathology ; Biopsy/adverse effects ; Diagnosis, Differential ; Female ; Humans ; Idiopathic Pulmonary Fibrosis/diagnostic imaging ; Idiopathic Pulmonary Fibrosis/pathology ; Lung/diagnostic imaging ; Lung/pathology ; Lung Diseases, Interstitial/diagnostic imaging ; Lung Diseases, Interstitial/pathology ; Male ; Middle Aged ; Probability ; Retrospective Studies ; Tomography, X-Ray Computed
Language	English
Publishing date	2020-11-16
Publishing country	England
Document type	Journal Article
ZDB-ID	2059871-3
ISSN	1471-2466 ; 1471-2466
ISSN (online)	1471-2466
ISSN	1471-2466
DOI	10.1186/s12890-020-01339-9
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Influenza

Gustavo de Souza Portes Meirelles

Radiologia Brasileira, Vol 42, Iss 6, Pp V-VI (2009)

o velho inimigo está de volta - e renovado Influenza: the old enemy is back - and renewed

2009

Keywords	Medical physics. Medical radiology. Nuclear medicine ; R895-920
Language	English
Publishing date	2009-12-01T00:00:00Z
Publisher	Colégio Brasileiro de Radiologia e Diagnóstico por Imagem
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Carbohydrate antigen 15-3 as a marker of disease severity in patients with chronic hypersensitivity pneumonitis.

Gomes, Paula Silva / Soares, Maria Raquel / Marchenta, Maria Fernanda Munhoz Lages / Meirelles, Gustavo de Souza Portes / Ferreira, Rimarcs Gomes / Botelho, André Bezerra / Martins, Rafaela Boaventura / Pereira, Carlos Alberto de Castro

Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia

2021 Volume 47, Issue 1, Page(s) e20200589

Abstract: Objective: Biomarkers associated with mucin 1, such as Krebs von den Lungen-6 and carbohydrate antigen (CA) 15-3, are increased in various interstitial lung diseases. Our aim was to determine whether CA 15-3 could be considered a biomarker of disease ... ...

Abstract	Objective: Biomarkers associated with mucin 1, such as Krebs von den Lungen-6 and carbohydrate antigen (CA) 15-3, are increased in various interstitial lung diseases. Our aim was to determine whether CA 15-3 could be considered a biomarker of disease severity in patients with chronic hypersensitivity pneumonitis (cHP). Methods: This was a prospective observational study involving adult patients with cHP. Serum levels of CA 15-3 were measured and were correlated with variables related to disease severity and extension. HRCT scans were quantitatively analyzed using a computational platform and an image analysis tool (Computer Aided Lung Informatics for Pathology Evaluation and Rating). CA 15-3 levels were normalized by logarithmic transformation. Results: The sample comprised 41 patients. The mean age of the patients was 60.1 ± 11.6 years. The mean FVC in % of predicted was 70.3% ± 17.3%, and the median of the serum level of CA 15-3 was 48.1 U/mL. CA 15-3 levels inversely correlated with FVC in % of predicted (r = -0,30; p = 0,05), DLCO in % of predicted (r = -0,54; p < 0,01), and SpO2 at the end of a 4-min step test (r = -0,59; p < 0,01), but they directly correlated with total quantitative HRCT scores (r = 0,47; p = 0,004), especially regarding ground-glass opacities (r = 0.58; p < 0,001). Conclusions: CA 15-3 is likely to be a biomarker of disease severity of patients with cHP, particularly regarding gas exchange abnormalities.
MeSH term(s)	Adult ; Aged ; Alveolitis, Extrinsic Allergic/diagnostic imaging ; Biomarkers ; Carbohydrates ; Humans ; Middle Aged ; Mucin-1 ; Severity of Illness Index ; Tomography, X-Ray Computed
Chemical Substances	Biomarkers ; Carbohydrates ; Mucin-1
Language	Portuguese
Publishing date	2021-03-08
Publishing country	Brazil
Document type	Journal Article ; Observational Study
ZDB-ID	2223157-2
ISSN	1806-3756 ; 1806-3713
ISSN (online)	1806-3756
ISSN	1806-3713
DOI	10.36416/1806-3756/e20200589
Database	MEDical Literature Analysis and Retrieval System OnLINE

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