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Book ; Thesis: Die Wertigkeit des klinischen Talusvorschub im Vergleich zur indirekten Stresssonografie und Arthrometeruntersuchung bei Außenbandrupturen im oberen Sprunggelenk

Pacha, Tarek Omar

2013

Author's details	vorgelegt von Tarek Omar Pacha
Language	German
Size	113 Bl. : Ill., graph. Darst.
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Hannover, Med. Hochsch., Diss., 2013
HBZ-ID	HT018581089
Database	Catalogue ZB MED Medicine, Health

In stock of ZB MED Cologne/Königswinter

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2015 E 484	order for loan	Magazin

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Article ; Online: Extremitätenerhaltende Resektion von Weichteilsarkomen in der Regio axillaris.

Stauss, Ricarda / Graulich, Tilman / Omar Pacha, Tarek / Omar, Mohamed

Operative Orthopadie und Traumatologie

2023 Volume 35, Issue 6, Page(s) 377–389

Abstract: Objective: For patients with soft tissue sarcoma, surgical resection is a key element of curative therapy. Surgery is performed as a wide resection with microscopically negative margins (R0 resection) and as limb-sparing procedure whenever possible to ... ...

Title translation	Limb-sparing resection of axillary soft tissue sarcomas.
Abstract	Objective: For patients with soft tissue sarcoma, surgical resection is a key element of curative therapy. Surgery is performed as a wide resection with microscopically negative margins (R0 resection) and as limb-sparing procedure whenever possible to preserve maximum function. Indications: Soft tissue sarcoma, metastases. Contraindications: Extensive disease with major neurovascular involvement, placement of biopsy tract necessitates extensive resection, palliative care. Surgical technique: Extended deltopectoral approach. Release of pectoralis major and minor tendons. Vascular and neurologic exploration, identification of the axillary vessels and brachial plexus, placing of loops around major structures. Mobilization of these structures to achieve adequate exposure. Clipping of vessels entering the tumor. Tumor resection, suture marking for histological analysis. Soft tissue reconstruction by transosseous reinsertion of the pectoralis minor to the coracoid process. Drill channel placement, transosseous refixation of the pectoralis major to the humerus. Postoperative management: Shoulder abduction brace for 6 weeks, passive mobilization for 6-12 weeks followed by active mobilization. Compression sleeve. Oncological follow-up. Results: Between 2017 and 2022, wide resection was performed in 6 consecutive cases including 4 primary soft tissue sarcomas and 2 metastases. Primary R0 resection was achieved in 100%. Mean follow-up was 22.5 months (3-60 months). There were no local recurrences. Mean active shoulder abduction was 135.0 ± 41.4° (90-180°). Neurological deficits were not observed. Mean subjective shoulder function was 80.0 ± 21.0% (50-100%). The mean Musculoskeletal Tumor Society (MSTS) score was 89.5% (32-100%), indicating good functional outcome in the study cohort.
MeSH term(s)	Humans ; Plastic Surgery Procedures ; Treatment Outcome ; Sarcoma/surgery ; Sarcoma/pathology ; Limb Salvage/methods ; Shoulder/pathology ; Shoulder/surgery ; Soft Tissue Neoplasms/surgery ; Soft Tissue Neoplasms/pathology ; Retrospective Studies
Language	German
Publishing date	2023-07-18
Publishing country	Germany
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	1007514-8
ISSN	1439-0981 ; 0934-6694
ISSN (online)	1439-0981
ISSN	0934-6694
DOI	10.1007/s00064-023-00824-8
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 2846: Show issues

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Article: Skin Reactions to Immune Checkpoint Inhibitors.

Patel, Anisha B / Pacha, Omar

Advances in experimental medicine and biology

2022 Volume 1342, Page(s) 319–330

Abstract: Due to the novelty of immune checkpoint inhibitors, their cutaneous adverse events (AEs) have only been recently characterized. This, along with the substantial rate of cutaneous reactions, has left many clinicians without sufficient familiarity to ... ...

Abstract	Due to the novelty of immune checkpoint inhibitors, their cutaneous adverse events (AEs) have only been recently characterized. This, along with the substantial rate of cutaneous reactions, has left many clinicians without sufficient familiarity to diagnose and treat cutaneous AEs. Pruritus and rash are among the top five immune-related AEs reported in clinical trials for this class of therapy. Incidence varies between 35 and 60% for cutaneous AEs among the seven FDA-approved drugs used as monotherapy or combination therapy. Although only 2% are reported as grade 3 or 4 events with monotherapy, the incidence can be as high as 6-9% for combination therapy and the impact on quality of life can be significant for these patients. Of ipilimumab patients, 43.5% have a cutaneous AE, and, at our institution, 20% of them had a dose interruption as a result. This means potentially 9% of patients have dose interruption of ipilimumab because of their cutaneous AEs. In the following chapter, we review the categories of these drugs, common cutaneous effects, their grading, and management options.
MeSH term(s)	Exanthema/chemically induced ; Humans ; Immune Checkpoint Inhibitors/adverse effects ; Ipilimumab/adverse effects ; Quality of Life
Chemical Substances	Immune Checkpoint Inhibitors ; Ipilimumab
Language	English
Publishing date	2022-01-01
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2214-8019 ; 0065-2598
ISSN (online)	2214-8019
ISSN	0065-2598
DOI	10.1007/978-3-030-79308-1_11
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The effect of biologic therapy for immune-mediated inflammatory diseases on clinical outcomes of COVID-19 in the greater Houston area: A retrospective chart review.

Lee, Kevin P / Koshelev, Misha V / Pacha, Omar

Journal of the American Academy of Dermatology

2022 Volume 87, Issue 3, Page(s) 658–660

MeSH term(s)	Antirheumatic Agents/therapeutic use ; Biological Therapy ; COVID-19 ; Humans ; Retrospective Studies
Chemical Substances	Antirheumatic Agents
Language	English
Publishing date	2022-01-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	603641-7
ISSN	1097-6787 ; 0190-9622
ISSN (online)	1097-6787
ISSN	0190-9622
DOI	10.1016/j.jaad.2021.12.054
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Zs.A 1540: Show issues

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Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article: Reconstruction of an Extensive Segmental Radial Shaft Bone Defect by Vascularized 3D-Printed Graft Cage.

Mommsen, Philipp / März, Vincent / Krezdorn, Nicco / Aktas, Gökmen / Sehmisch, Stephan / Vogt, Peter Maria / Großner, Tobias / Omar Pacha, Tarek

Journal of personalized medicine

2024 Volume 14, Issue 2

Abstract: We report here a 46-year-old male patient with a 14 cm segmental bone defect of the radial shaft after third degree open infected fracture caused by a shrapnel injury. The patient underwent fixed-angle plate osteosynthesis and bone reconstruction of the ... ...

Abstract	We report here a 46-year-old male patient with a 14 cm segmental bone defect of the radial shaft after third degree open infected fracture caused by a shrapnel injury. The patient underwent fixed-angle plate osteosynthesis and bone reconstruction of the radial shaft by a vascularized 3D-printed graft cage, including plastic coverage with a latissimus dorsi flap and an additional central vascular pedicle. Bony reconstruction of segmental defects still represents a major challenge in musculo-skeletal surgery. Thereby, 3D-printed scaffolds or graft cages display a new treatment option for bone restoration. As missing vascularization sets the limits for the treatment of large-volume bone defects by 3D-printed scaffolds, in the present case, we firstly describe the reconstruction of an extensive radial shaft bone defect by using a graft cage with additional vascularization.
Language	English
Publishing date	2024-02-04
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2662248-8
ISSN	2075-4426
ISSN	2075-4426
DOI	10.3390/jpm14020178
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Article ; Online: Predictive factors for docking site procedure in bone transport for large lower extremity segmental defects.

Omar Pacha, T / Aktas, G / Graulich, T / Stübig, T / Clausen, J D / Liodakis, E / Omar, M / Sehmisch, S / Mommsen, P

BMC musculoskeletal disorders

2023 Volume 24, Issue 1, Page(s) 500

Abstract: Background: Segmental bone transport is a common technique for treating large segmental bone defects. However, a docking site procedure is often necessary in segmental bone transport. To date, no prognostic factors for the need of docking site procedure ...

Abstract	Background: Segmental bone transport is a common technique for treating large segmental bone defects. However, a docking site procedure is often necessary in segmental bone transport. To date, no prognostic factors for the need of docking site procedure have been reported. Thus, the decision is often made at random, based on the surgeon's subjective judgment and experience. The aim of this study was to identify prognostic factors for the need of docking site operation. Methods: Patients with segmental bone transport in lower extremity bone defects were included regardless of age, aetiology, and defect size. We excluded patients undergoing treatments that were not yet completed, and those who discontinued therapy by any reason. The need for docking site operation was modelled with logistical and linear regression as well as univariate analysis of variances (ANOVA). Receiver operating characteristics (ROC) curve analysis was also performed. Results: Twenty-seven patients from age 12 to 74 years (mean age: 39.07 ± 18.20 years) were included. The mean defect size was 76.39 ± 41.10 mm. The duration of transport (days) showed a significant influence (p = 0.049, 95%CI: 1.00-1.02) on the need for docking site operation. No other significant influences were detected. Conclusion: A link between the duration of transport and the need for docking site operation was detected. Our data showed that if a threshold of about 188 days is exceeded, docking surgery should be considered.
MeSH term(s)	Humans ; Young Adult ; Adult ; Middle Aged ; Child ; Adolescent ; Aged ; Osteogenesis, Distraction/methods ; Treatment Outcome ; Lower Extremity/surgery ; Retrospective Studies ; Tibia/surgery ; Tibial Fractures/surgery
Language	English
Publishing date	2023-06-17
Publishing country	England
Document type	Journal Article
ZDB-ID	2041355-5
ISSN	1471-2474 ; 1471-2474
ISSN (online)	1471-2474
ISSN	1471-2474
DOI	10.1186/s12891-023-06593-6
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Article ; Online: Do admission glucose levels independently predict coagulopathy in multiple trauma patients? A retrospective cohort analysis.

Mayor, Jorge / Gräff, Pascal / Birgel, Vera / Clausen, Jan-Dierk / Omar-Pacha, Tarek / Aktas, Gökmen / Sehmisch, Stephan / Mommsen, Philipp

European journal of trauma and emergency surgery : official publication of the European Trauma Society

2024

Abstract: Background: Coagulopathy is prevalent in multiple trauma patients and worsens bleeding complications, leading to higher morbidity and mortality rates. Hyperglycemia upon admission predicts hemorrhagic shock and mortality in severely injured patients. ... ...

Abstract	Background: Coagulopathy is prevalent in multiple trauma patients and worsens bleeding complications, leading to higher morbidity and mortality rates. Hyperglycemia upon admission predicts hemorrhagic shock and mortality in severely injured patients. This study aimed to assess admission glucose levels as an independent prognostic factor for coagulopathy in multiply injured patients. Methods: This retrospective cohort study observed multiple trauma patients treated at a level I trauma center between January 1, 2005, and December 31, 2020. Coagulopathy was defined as an international normalized ratio (INR) > 1.4 and/or activated thromboplastin time (APTT) > 40 s. Analysis of variance compared clinical and laboratory parameters of patients with and without coagulopathy. Receiver-operating-characteristic (ROC) and multivariate logistic regression analyses identified risk factors associated with coagulopathy. Results: The study included 913 patients, of whom 188 (20%) had coagulopathy at admission. Coagulopathy patients had higher mortality than those without (26% vs. 5.0%, p < 0.001). Mean glucose level in coagulopathy patients was 10.09 mmol/L, significantly higher than 7.97 mmol/L in non-coagulopathy patients (p < 0.001). Admission glucose showed an area under the curve (AUC) of 0.64 (95% CI [0.59-0.69], p < 0.001) with an optimal cut-off point of 12.35 mmol/L. After adjusting for other factors, patients with high admission glucose had a 1.99-fold risk of developing coagulopathy (95% CI 1.07-3.60). Other laboratory parameters associated with coagulopathy included haemoglobin, bicarbonate (HCO3), and lactate levels. Conclusion: This study emphasizes the significance of admission blood glucose as an independent predictor of coagulopathy. Monitoring hyperglycemia can aid in identifying high-risk patients.
Language	English
Publishing date	2024-02-14
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2275480-5
ISSN	1863-9941 ; 1863-9933
ISSN (online)	1863-9941
ISSN	1863-9933
DOI	10.1007/s00068-023-02405-7
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Zs.A 1221: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Skin Reactions to Immune Checkpoint Inhibitors.

Patel, Anisha B / Pacha, Omar

Advances in experimental medicine and biology

2020 Volume 1244, Page(s) 235–246

Abstract	Due to the novelty of immune checkpoint inhibitors, their cutaneous adverse events (AEs) have only been recently characterized. This, along with the substantial rate of cutaneous reactions, has left many clinicians without sufficient familiarity to diagnose and treat cutaneous AEs. Pruritus and rash are among the top five immune-related AEs reported in clinical trials for this class of therapy. Incidence varies between 35 and 50% for cutaneous AEs among the eight FDA-approved drugs. Although only 2% are reported as grade 3 or 4 events, the impact on quality of life can be significant for these patients and is best described and most severe in ipilimumab trials. Of ipilimumab patients, 43.5% have a cutaneous AE and, at our institution, 20% of them had a dose interruption as a result. This means potentially 9% of patients have dose interruption of ipilimumab because of their cutaneous AEs. In the following chapter, we review the categories of these drugs, common cutaneous effects, their grading, and management options.
MeSH term(s)	Antineoplastic Agents, Immunological/adverse effects ; Exanthema/chemically induced ; Exanthema/diagnosis ; Exanthema/therapy ; Humans ; Immunotherapy/adverse effects ; Ipilimumab/adverse effects ; Neoplasms/immunology ; Neoplasms/therapy ; Pruritus/chemically induced ; Pruritus/diagnosis ; Pruritus/therapy ; Quality of Life
Chemical Substances	Antineoplastic Agents, Immunological ; Ipilimumab
Language	English
Publishing date	2020-04-16
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2214-8019 ; 0065-2598
ISSN (online)	2214-8019
ISSN	0065-2598
DOI	10.1007/978-3-030-41008-7_11
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Conference proceedings: Prädiktive Faktoren für Dockingsite-Operationen beim Segmenttransport zur Behandlung großer Knochendefekte der unteren Extremität

Omar Pacha, Tarek / Aktas, Gökmen / Graulich, Tilman / Stübig, Timo / Clausen, Jan-Dierk / Liodakis, Emmanouil / Omar, Mohamed / Sehmisch, Stephan / Mommsen, Philipp

2023 , Page(s) AB44–3342

Event/congress	Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2023); Berlin; ; Berufsverband für Orthopädie und Unfallchirurgie; 2023
Keywords	Medizin, Gesundheit ; Segmentdefekt ; Transport ; Pseudarthrose ; Knochendefekt
Publishing date	2023-10-23
Publisher	German Medical Science GMS Publishing House; Düsseldorf
Document type	Conference proceedings
DOI	10.3205/23dkou200
Database	German Medical Science

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Article ; Online: Management von frakturassoziierten Infektionen.

Clausen, Jan-Dierk / Mommsen, Philipp / Omar Pacha, Tarek / Winkelmann, Marcel / Krettek, Christian / Omar, Mohamed

Der Unfallchirurg

2021 Volume 125, Issue 1, Page(s) 41–49

Abstract: Fracture-related infections (FRI) are a major challenge in orthopedic trauma surgery. The problems in the treatment of such infections are manifold. Especially in cases with insufficient fracture consolidation the treatment not only focusses on the ... ...

Title translation	Management of fracture-related infections.
Abstract	Fracture-related infections (FRI) are a major challenge in orthopedic trauma surgery. The problems in the treatment of such infections are manifold. Especially in cases with insufficient fracture consolidation the treatment not only focusses on the eradication of the infection but also on the restoration of the osseous continuity. The extent of the accompanying soft tissue damage is of particular importance as reduced vascularization leads to impairments in fracture healing. Although acute infections are frequently easy to recognize, the symptoms of chronic infections can be unspecific and evade the diagnostic procedures. This fact makes the treatment of such infections complicated and sometimes necessitates an interdisciplinary approach. For this reason, the Fracture-related Infection Consensus Group developed an algorithm, which was first published in 2017 and revised in 2018 and 2020. The FRIs are biofilm-associated infections, so that the current guidelines follow the previously established treatment algorithms for periprosthetic infections. Despite the analogies to periprosthetic infections there are also differences in the treatment as the aspects of fracture healing and bone defect restoration represent determining factors in the treatment of FRI. This article presents the special features of FRI and the classification and guidelines for the treatment are discussed.
MeSH term(s)	Fracture Healing ; Fractures, Bone/surgery ; Humans ; Orthopedics ; Persistent Infection ; Surgical Wound Infection/diagnosis ; Surgical Wound Infection/therapy
Language	German
Publishing date	2021-12-21
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	605965-x
ISSN	1433-044X ; 0177-5537
ISSN (online)	1433-044X
ISSN	0177-5537
DOI	10.1007/s00113-021-01116-1
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