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  1. Book: David Paul von Hansemann: Contributions to oncology

    Hansemann, David von / Bignold, Leon P. / Coghlan, Brian L. D. / Jersmann, Hubertus P. A.

    context, comments and translations

    2007  

    Author's details Leon P. Bignold ; Brian L. D. Coghlan ; Hubertus P. A. Jersmann
    Keywords Biomedical Research ; Neoplasms ; Hansemann, David von ; Onkologie
    Subject Geschwulstforschung ; Geschwulstlehre
    Subject code 610.92 ; 616.994
    Language English
    Size XXIV, 371 S. : Ill., 24 cm
    Publisher Birkhäuser
    Publishing place Basel u.a.
    Publishing country Switzerland
    Document type Book
    Note Bibliogr. und Literaturverz. S. 331 - 361
    HBZ-ID HT015000528
    ISBN 978-3-7643-7768-7 ; 3-7643-7768-2
    Database Catalogue ZB MED Medicine, Health

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    2007 A 1467 order for loan Magazin

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  2. Book: David Paul von Hansemann

    Hansemann, David / Bignold, Leon P / Coghlan, Brian L. D / Jersmann, Hubertus P. A

    contributions to oncology : context, comments and translations

    2007  

    Author's details Leon P. Bignold, Brian L.D. Coghlan, Hubertus P.A. Jersmann
    MeSH term(s) Neoplasms/history ; Medical Oncology/history ; History, 19th Century ; History, 20th Century
    Language English
    Size xxiv, 371 p. :, ill., port.
    Publisher Birkhäuser
    Publishing place Basel ; Boston
    Document type Book
    Note Bibliography of David Paul von Hausemann (p.331-346).
    ISBN 9783764377687 ; 3764377682 ; 9783764377694 ; 3764377690
    Database Catalogue of the US National Library of Medicine (NLM)

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  3. Article: A comparison of the AVID and DAVID trials of implantable defibrillators.

    Sharma, Arjun / Epstein, Andrew E / Herre, John M / Klein, Richard C / Platia, Edward V / Wilkoff, Bruce / Ledingham, Robert B / Greene, H Leon / Hallstrom, Alfred P

    The American journal of cardiology

    2005  Volume 95, Issue 12, Page(s) 1431–1435

    Abstract: ... Implantable Defibrillator (DAVID) trial (2000 to 2002) showed that VVI pacing at 40 beats/min in patients with ICDs reduced ... at 70 beats/min. Patients in the AVID trial (631 of 1,016) and the DAVID trial (221 of 506) meeting ... in the AVID and DAVID trials were similar, but more AVID patients had coronary artery disease (p = 0.04 ...

    Abstract We compared 2 studies of implantable cardiac defibrillators (ICDs) to determine the effects of device mode on outcomes. The Antiarrhythmics Versus Implantable Defibrillators (AVID) trial (1993 to 1997) demonstrated improved survival with the ICD compared with antiarrhythmic drug therapy. The Dual-chamber And VVI Implantable Defibrillator (DAVID) trial (2000 to 2002) showed that VVI pacing at 40 beats/min in patients with ICDs reduced the combined end point of death and hospitalization for congestive heart failure compared with DDDR pacing at 70 beats/min. Patients in the AVID trial (631 of 1,016) and the DAVID trial (221 of 506) meeting common inclusion and all exclusion criteria were studied. The major end points were the time to death, and the composite end point of time to death or hospitalization for congestive heart failure. Patients in the AVID and DAVID trials were similar, but more AVID patients had coronary artery disease (p = 0.04), history of myocardial infarction (p = 0.005), and previous ventricular arrhythmias (p = 0.03). DAVID patients underwent more previous revascularization procedures (coronary artery bypass surgery, p = 0.03; percutaneous coronary intervention, p = 0.001), and were more often taking beta-blocking drugs at hospital discharge (p <0.001). The backup VVI ICD groups in both studies had similar outcomes (p = 0.4), even when corrected for the previous demographic differences. The time-to- composite end point was similar in AVID patients treated with antiarrhythmic drugs and DAVID patients treated with DDDR ICDs (p = 0.6). Despite improved pharmacologic therapy and revascularization, outcomes have not improved with backup VVI pacing ICDs. If DDDR ICDs had been used in the AVID trial, benefit from ICDs for patients with serious ventricular arrhythmias could have been missed.
    MeSH term(s) Adrenergic beta-Antagonists/therapeutic use ; Aged ; Amiodarone/therapeutic use ; Anti-Arrhythmia Agents/therapeutic use ; Cardiac Pacing, Artificial/methods ; Defibrillators, Implantable ; Equipment Design ; Female ; Follow-Up Studies ; Heart Failure/etiology ; Heart Failure/mortality ; Hospitalization/statistics & numerical data ; Humans ; Male ; Prospective Studies ; Randomized Controlled Trials as Topic ; Survival Rate ; Tachycardia, Ventricular/complications ; Tachycardia, Ventricular/physiopathology ; Tachycardia, Ventricular/therapy ; Treatment Outcome
    Chemical Substances Adrenergic beta-Antagonists ; Anti-Arrhythmia Agents ; Amiodarone (N3RQ532IUT)
    Language English
    Publishing date 2005-06-15
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80014-4
    ISSN 1879-1913 ; 0002-9149
    ISSN (online) 1879-1913
    ISSN 0002-9149
    DOI 10.1016/j.amjcard.2005.02.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui IV Zs.73: Show issues Location:
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  4. Article ; Online: David Paul Hansemann: chromosomes and the origin of the cancerous features of tumor cells.

    Bignold, Leon P / Coghlan, Brian / Jersmann, Hubertus

    Cellular oncology : the official journal of the International Society for Cellular Oncology

    2008  Volume 31, Issue 1, Page(s) 61

    MeSH term(s) Chromosome Aberrations ; Chromosomes, Human ; History, 19th Century ; History, 20th Century ; Humans ; Neoplasms/genetics ; Neoplasms/history
    Language English
    Publishing date 2008-12-18
    Publishing country Netherlands
    Document type Biography ; Historical Article ; Letter
    ZDB-ID 2157351-7
    ISSN 1875-8606 ; 1570-5870
    ISSN (online) 1875-8606
    ISSN 1570-5870
    DOI 10.3233/clo-2009-0451
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3139: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  5. Book: Gordis epidemiology

    Celentano, David D. / Szklo, Moyses / Farag, Youssef / Gordis, Leon

    2025  

    Title variant Epidemiology
    Author's details David Celentano, Moyses Szklo, Youssef M.K. Farag
    MeSH term(s) Epidemiology ; Epidemiologic Methods
    Keywords Epidemiology ; Epidemiologic Methods ; Textbooks ; Epidemiologie
    Subject Krankheitsverbreitung
    Language English
    Size xi, 432 Seiten, Illustrationen, Diagramme
    Edition Seventh edition
    Publisher Elsevier
    Publishing place Philadelphia, PA
    Publishing country United States
    Document type Book
    Note Zugang zu Enhanced Digital Version über Code
    HBZ-ID HT030709313
    ISBN 978-0-323-87775-6 ; 0-323-87775-3
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2024 A 418 available for loan (reading room) Lesesaal EG
    Zugang zu zusätzlichem Internetmaterial über Code aus lizenzrechtlichen Gründen nicht verfügbar

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  6. Article: Percent right ventricular pacing predicts outcomes in the DAVID trial.

    Sharma, Arjun D / Rizo-Patron, Carlos / Hallstrom, Alfred P / O'Neill, Gearoid P / Rothbart, Stephen / Martins, James B / Roelke, Marc / Steinberg, Jonathan S / Greene, H Leon

    Heart rhythm

    2005  Volume 2, Issue 8, Page(s) 830–834

    Abstract: Background: The Dual-Chamber and VVI Implantable Defibrillator (DAVID) trial demonstrated a worse ... RV) is an independent predictor of outcome in the DAVID trial.: Methods: We evaluated ...

    Abstract Background: The Dual-Chamber and VVI Implantable Defibrillator (DAVID) trial demonstrated a worse outcome in patients with implantable cardioverter-defibrillators (ICDs) programmed to DDDR at 70 bpm compared with patients who had ICDs programmed to VVI backup pacing at 40 bpm. Pacing was more frequent in the DDDR group.
    Objectives: The purpose of this study was to determine whether right ventricular pacing (RV) is an independent predictor of outcome in the DAVID trial.
    Methods: We evaluated the relationship of percent RV pacing to the composite endpoint of death or hospitalization for congestive heart failure. Patients who had a 3-month follow-up and who had not yet reached an endpoint were included in the study. Using Cox regression analysis (VVI group N = 195; DDDR group N = 185), we examined multiple factors, including percent RV pacing at 3-month follow-up, that might be associated with adverse outcomes.
    Results: Percent RV pacing as a continuous variable was correlated with the primary endpoint. As a dichotomous variable, the best separation for predicting endpoints occurred with DDDR RV pacing > 40% vs DDDR RV pacing < or = 40% (P = .025). Patients with DDDR RV pacing < or = 40% had similar or better outcomes to the VVI backup group (P = .07). Correction for baseline variables predictive of the composite outcome in the (nonpaced) VVI group (use of nitrates, increased heart rate, and increased age) did not change the findings for RV pacing (P = .008). In contrast, atrial pacing was not predictive of worse outcomes.
    Conclusion: These results suggest, but do not prove, a causal relationship between frequent RV pacing and adverse outcomes in patients with left ventricular ejection fraction < or = 40%.
    MeSH term(s) Cardiac Pacing, Artificial ; Defibrillators, Implantable ; Heart Failure/physiopathology ; Heart Ventricles/physiopathology ; Hospitalization ; Humans ; Prognosis ; Proportional Hazards Models ; Prospective Studies ; Randomized Controlled Trials as Topic ; Stroke Volume ; Tachycardia/mortality ; Tachycardia/therapy ; Time Factors ; Treatment Outcome
    Language English
    Publishing date 2005-08
    Publishing country United States
    Document type Evaluation Studies ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2229357-7
    ISSN 1556-3871 ; 1547-5271
    ISSN (online) 1556-3871
    ISSN 1547-5271
    DOI 10.1016/j.hrthm.2005.05.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6278: Show issues Location:
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  7. Article ; Online: Deutsche Medizin im neunzehnten Jahrhundert erforschen – das Beispiel des David Paul von Hansemann (1858-1920)

    Peterson, Mary F. / Bignold, Leon P. / Jersmann, Hubertus P.A.

    GMS Medizin - Bibliothek - Information

    2007  Volume 7, Issue 2, Page(s) 22

    Keywords Medizin, Gesundheit ; AGMB-Jahrestagung 2007
    Publishing date 2007-09-21
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Article ; Online
    ISSN 1865-066X
    ISSN (online) 1865-066X
    Database German Medical Science

    Full text online

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  8. Article ; Online: Deutsche Medizin im neunzehnten Jahrhundert erforschen – das Beispiel des David Paul von Hansemann (1858-1920)

    Peterson, Mary F. / Bignold, Leon P. / Jersmann, Hubertus P. A.

    GMS Medizin – Bibliothek – Information, Vol 7, Iss 2, p Doc

    2007  Volume 22

    Keywords Bibliography. Library science. Information resources ; Z ; Medicine (General) ; R5-920
    Language German
    Publishing date 2007-09-01T00:00:00Z
    Publisher German Medical Science GMS Publishing House
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: Dual-chamber pacing or ventricular backup pacing in patients with an implantable defibrillator: the Dual Chamber and VVI Implantable Defibrillator (DAVID) Trial.

    Wilkoff, Bruce L / Cook, James R / Epstein, Andrew E / Greene, H Leon / Hallstrom, Alfred P / Hsia, Henry / Kutalek, Steven P / Sharma, Arjun

    JAMA

    2002  Volume 288, Issue 24, Page(s) 3115–3123

    Abstract: ... but without indications for antibradycardia pacing.: Design: The Dual Chamber and VVI Implantable Defibrillator (DAVID ...

    Abstract Context: Implantable cardioverter defibrillator (ICD) therapy with backup ventricular pacing increases survival in patients with life-threatening ventricular arrhythmias. Most currently implanted ICD devices provide dual-chamber pacing therapy. The most common comorbid cause for mortality in this population is congestive heart failure.
    Objective: To determine the efficacy of dual-chamber pacing compared with backup ventricular pacing in patients with standard indications for ICD implantation but without indications for antibradycardia pacing.
    Design: The Dual Chamber and VVI Implantable Defibrillator (DAVID) Trial, a single-blind, parallel-group, randomized clinical trial.
    Setting and participants: A total of 506 patients with indications for ICD therapy were enrolled between October 2000 and September 2002 at 37 US centers. All patients had a left ventricular ejection fraction (LVEF) of 40% or less, no indication for antibradycardia pacemaker therapy, and no persistent atrial arrhythmias.
    Interventions: All patients had an ICD with dual-chamber, rate-responsive pacing capability implanted. Patients were randomly assigned to have the ICDs programmed to ventricular backup pacing at 40/min (VVI-40; n = 256) or dual-chamber rate-responsive pacing at 70/min (DDDR-70; n = 250). Maximal tolerated medical therapy for left ventricular dysfunction, including angiotensin-converting enzyme inhibitors and beta-blockers, was prescribed to all patients.
    Main outcome measure: Composite end point of time to death or first hospitalization for congestive heart failure.
    Results: One-year survival free of the composite end point was 83.9% for patients treated with VVI-40 compared with 73.3% for patients treated with DDDR-70 (relative hazard, 1.61; 95% confidence interval [CI], 1.06-2.44). The components of the composite end point, mortality of 6.5% for VVI-40 vs 10.1% for DDDR-70 (relative hazard, 1.61; 95% CI, 0.84-3.09) and hospitalization for congestive heart failure of 13.3% for VVI-40 vs 22.6% for DDDR-70 (relative hazard, 1.54; 95% CI, 0.97-2.46), also trended in favor of VVI-40 programming.
    Conclusion: For patients with standard indications for ICD therapy, no indication for cardiac pacing, and an LVEF of 40% or less, dual-chamber pacing offers no clinical advantage over ventricular backup pacing and may be detrimental by increasing the combined end point of death or hospitalization for heart failure.
    MeSH term(s) Adrenergic beta-Antagonists/therapeutic use ; Aged ; Amiodarone/therapeutic use ; Angiotensin-Converting Enzyme Inhibitors/therapeutic use ; Anti-Arrhythmia Agents/therapeutic use ; Anticoagulants/therapeutic use ; Arrhythmias, Cardiac/complications ; Arrhythmias, Cardiac/therapy ; Cardiac Pacing, Artificial ; Cardiovascular Agents/therapeutic use ; Catheter Ablation ; Defibrillators, Implantable ; Digoxin/therapeutic use ; Diuretics/therapeutic use ; Female ; Heart Failure/epidemiology ; Humans ; Male ; Middle Aged ; Pacemaker, Artificial ; Single-Blind Method ; Survival Analysis ; Tachycardia, Ventricular/therapy ; Ventricular Dysfunction, Left/complications ; Ventricular Dysfunction, Left/therapy ; Warfarin/therapeutic use
    Chemical Substances Adrenergic beta-Antagonists ; Angiotensin-Converting Enzyme Inhibitors ; Anti-Arrhythmia Agents ; Anticoagulants ; Cardiovascular Agents ; Diuretics ; Warfarin (5Q7ZVV76EI) ; Digoxin (73K4184T59) ; Amiodarone (N3RQ532IUT)
    Language English
    Publishing date 2002-08-23
    Publishing country United States
    Document type Clinical Trial ; Comparative Study ; Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0098-7484 ; 0254-9077 ; 0002-9955
    ISSN (online) 1538-3598
    ISSN 0098-7484 ; 0254-9077 ; 0002-9955
    DOI 10.1001/jama.288.24.3115
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.88: Show issues Location:
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  10. Article ; Online: Reseña de "El México olvidado. La historia del pueblo chicano" de David R. Maciel

    Ricardo León

    Araucaria, Vol 2, Iss 4, Pp 195-

    2000  Volume 199

    Keywords History of scholarship and learning. The humanities ; AZ20-999 ; Political science ; J ; Philosophy (General) ; B1-5802
    Language English
    Publishing date 2000-01-01T00:00:00Z
    Publisher Universidad de Sevilla
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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