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Article: [Acute toxicity test of the Li-Dan-He-Ji granules].

Su, Mengjie / Qin, Huan / Yi, Wei / Zhou, Lishan / Yan, Suqi

Zhonghua wei zhong bing ji jiu yi xue

2023 Volume 35, Issue 12, Page(s) 1316–1320

Abstract: Objective: To observe the acute toxic reaction of the Li-Dan-He-Ji granules, and to evaluate ... was used to intragastric administration of Li-Dan-He-Ji granules 0.04 mL/g (42.8 g/kg), three times ... Conclusions: The Li-Dan-He-Ji granules have low oral toxicity, combined with clinical observation, can be ...

Abstract	Objective: To observe the acute toxic reaction of the Li-Dan-He-Ji granules, and to evaluate its safety. Methods: Sixty C57BL6/J mice were randomly divided into normal control group, vehicle group and drug treatment group, with 10 females and 10 males in each group. According to the Technical guidelines for the study of toxicity of single drug administration, the maximum administration dosage (MAD) was used to intragastric administration of Li-Dan-He-Ji granules 0.04 mL/g (42.8 g/kg), three times within 24 hours, with an interval of 6 hours. The vehicle group was fed with the same pure water. The normal control group received no treatment. The mice were observed continuously for 14 days, and the appearance characteristics, behavioral activities, body weight changes and the number of deaths in each group were recorded. At the 14 days, blood samples were collected from the eyeballs, and routine blood tests such as white blood cell count (WBC), lymphocyte count (LYM), neutrophil count (NEU), lymphocyte percentage (LYM%), neutrophil percentage (NEU%), red blood cell count (RBC), hemoglobin (Hb), and platelet count (PLT) were performed. And alanine aminotransferase (ALT), aspartate aminotransferase (AST), blood urea nitrogen (BUN), creatinine (Cr) and other biochemical indicators. The mice were then sacrificed, and the histopathological changes of liver and kidney were observed by hematoxylin-eosin (HE) staining. The organ indexes of heart, liver, spleen, lung, kidney and thymus were calculated. Results: The median lethal dose (LD Conclusions: The Li-Dan-He-Ji granules have low oral toxicity, combined with clinical observation, can be safely used in infants.
MeSH term(s)	Animals ; Female ; Humans ; Male ; Mice ; Body Weight ; Kidney ; Leukocyte Count ; Liver ; Toxicity Tests, Acute
Language	Chinese
Publishing date	2023-12-19
Publishing country	China
Document type	English Abstract ; Journal Article
ISSN	2095-4352
ISSN	2095-4352
DOI	10.3760/cma.j.cn121430-20230812-00617
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Wang, Tao / Xia, Wenjun / Huang, Yongqiang / Sun, Huaiqiang / Liu, Yan / Chen, Hu / Zhou, Jiliu / Zhang, Yi

Dual-Domain Adaptive-Scaling Non-local Network for CT Metal Artifact Reduction

2021

Abstract: ... performance. In this paper, a novel Dual-domain Adaptive-scaling Non-local network (DAN-Net) for MAR ... module are leveraged in the proposed network model. In the experiments, the proposed DAN-Net demonstrates ...

Abstract	Metal implants can heavily attenuate X-rays in computed tomography (CT) scans, leading to severe artifacts in reconstructed images, which significantly jeopardize image quality and negatively impact subsequent diagnoses and treatment planning. With the rapid development of deep learning in the field of medical imaging, several network models have been proposed for metal artifact reduction (MAR) in CT. Despite the encouraging results achieved by these methods, there is still much room to further improve performance. In this paper, a novel Dual-domain Adaptive-scaling Non-local network (DAN-Net) for MAR. We correct the corrupted sinogram using adaptive scaling first to preserve more tissue and bone details as a more informative input. Then, an end-to-end dual-domain network is adopted to successively process the sinogram and its corresponding reconstructed image generated by the analytical reconstruction layer. In addition, to better suppress the existing artifacts and restrain the potential secondary artifacts caused by inaccurate results of the sinogram-domain network, a novel residual sinogram learning strategy and nonlocal module are leveraged in the proposed network model. In the experiments, the proposed DAN-Net demonstrates performance competitive with several state-of-the-art MAR methods in both qualitative and quantitative aspects. Comment: 29 pages, 11 figures
Keywords	Physics - Medical Physics ; Computer Science - Computer Vision and Pattern Recognition
Subject code	006
Publishing date	2021-02-16
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Qi-dan-dihuang decoction ameliorates renal fibrosis in diabetic rats via p38MAPK/AKT/mTOR signaling pathway.

Kuang, Liuyan / You, Yanting / Qi, Jieying / Chen, Jieyu / Zhou, Xinghong / Ji, Shuai / Cheng, Jingru / Kwan, Hiu Yee / Jiang, Pingping / Sun, Xiaomin / Su, Mengting / Wang, Ming / Chen, Wenxiao / Luo, Ren / Zhao, Xiaoshan / Zhou, Lin

Environmental toxicology

2024

Abstract: Context: Qi-dan-dihuang decoction (QDD) has been used to treat diabetic kidney disease (DKD ...

Abstract	Context: Qi-dan-dihuang decoction (QDD) has been used to treat diabetic kidney disease (DKD), but the underlying mechanisms are poorly understood. Objective: This study reveals the mechanism by which QDD ameliorates DKD. Materials and methods: The compounds in QDD were identified by high-performance liquid chromatography and quadrupole-time-of-flight tandem mass spectrometry (HPLC-Q-TOF-MS). Key targets and signaling pathways were screened through bioinformatics. Nondiabetic Lepr db/m mice were used as control group, while Lepr db/db mice were divided into model group, dapagliflozin group, 1% QDD-low (QDD-L), and 2% QDD-high (QDD-H) group. After 12 weeks of administration, 24 h urinary protein, serum creatinine, and blood urea nitrogen levels were detected. Kidney tissues damage and fibrosis were evaluated by pathological staining. In addition, 30 mmol/L glucose-treated HK-2 and NRK-52E cells to induce DKD model. Cell activity and migration capacity as well as protein expression levels were evaluated. Results: A total of 46 key target genes were identified. Functional enrichment analyses showed that key target genes were significantly enriched in the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) and mitogen-activated protein kinase (MAPK) signaling pathways. In addition, in vivo and in vitro experiments confirmed that QDD ameliorated renal fibrosis in diabetic mice by resolving inflammation and inhibiting the epithelial-mesenchymal transition (EMT) via the p38MAPK and AKT-mammalian target of rapamycin (mTOR) pathways. Discussion and conclusion: QDD inhibits EMT and the inflammatory response through the p38MAPK and AKT/mTOR signaling pathways, thereby playing a protective role in renal fibrosis in DKD.
Language	English
Publishing date	2024-03-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	1463449-1
ISSN	1522-7278 ; 1520-4081
ISSN (online)	1522-7278
ISSN	1520-4081
DOI	10.1002/tox.24179
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Article ; Online: A newly-discovered tea population variety processed Bai Mu Dan white tea: Flavor characteristics and chemical basis.

Lin, Yanping / Huang, Yibiao / Zhou, Su / Li, Xiaolan / Tao, Yike / Pan, Yani / Feng, Xinyu / Guo, Haowei / Chen, Ping / Chu, Qiang

Food chemistry

2024 Volume 446, Page(s) 138851

Abstract: The quality of white tea (WT) is impacted by selected tea cultivars. To explore the organoleptic quality of a recently-discovered WT ("Caicha", CC), HS-SPME/GC-MS and UPLC were employed to identify volatile and non-volatile compounds in tea samples. ... ...

Abstract	The quality of white tea (WT) is impacted by selected tea cultivars. To explore the organoleptic quality of a recently-discovered WT ("Caicha", CC), HS-SPME/GC-MS and UPLC were employed to identify volatile and non-volatile compounds in tea samples. Multiple statistical methods demonstrated the distinctions between CC and four mainstream WT varieties from main producing areas. CC exhibited abundant volatile alcohol, terpenoids, ketone, aldehyde and ester, as well as non-volatile lignans and coumarins, phenolic acids and low-molecular carbohydrates. These substances combinedly contributed to the flavor attributes of CC, characterized by an intense herbal/citrus-like cleanness and flower/fruit-like sweetness, scarce in existing commercial WT varieties. Sensory evaluation corroborated these findings. In conclusion, we have processed a new tea variety (CC) with WT manufacturing technology, and discovered the unique cleanness and sweetness of it. This study enriches the raw material database for WT production and blending, and boosts the development of more premium WT varieties.
MeSH term(s)	Tea/chemistry ; Camellia sinensis/chemistry ; Volatile Organic Compounds/analysis ; Gas Chromatography-Mass Spectrometry/methods ; Lignans
Chemical Substances	Tea ; Volatile Organic Compounds ; Lignans
Language	English
Publishing date	2024-02-28
Publishing country	England
Document type	Journal Article
ZDB-ID	243123-3
ISSN	1873-7072 ; 0308-8146
ISSN (online)	1873-7072
ISSN	0308-8146
DOI	10.1016/j.foodchem.2024.138851
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Article ; Online: Dan-Deng-Tong-Nao softgel capsule promotes angiogenesis of cerebral microvasculature to protect cerebral ischemia reperfusion injury via activating HIF-1α-VEGFA-Notch1 signaling pathway.

Wang, Lei / Li, Jiacheng / Wang, Yang / Ge, Chaowen / Huang, Qi / Li, Lili / Wang, Ning / Chen, Yuang / Zhou, Xian / Chang, Dennis / Li, Dan / Hou, Jincai

Phytomedicine : international journal of phytotherapy and phytopharmacology

2023 Volume 118, Page(s) 154966

Abstract: Background: A proprietary Chinese herbal product called Dan-Deng-Tong-Nao softgel capsule (DDTNC ...

Abstract	Background: A proprietary Chinese herbal product called Dan-Deng-Tong-Nao softgel capsule (DDTNC) is used to treat ischemic stroke. However, the preventive mechanisms of DDTNC against cerebral ischemia reperfusion injury (CIRI) haven not been characterized. Objective: To explore the mechanisms of protective effects of DDTNC against CIRI from both internal and external levels. Methods: Chemical characterization was performed using UPLC. The potential protective mechanisms of DDTNC against CIRI were predicted using network pharmacology. Model of middle cerebral artery occlusion/reperfusion (MCAO/R) was established in rats. An model of brain microvascular endothelial cells (BMECs) induced by oxygen-glucose deprivation/reoxygenation (OGD/R) was also established. We evaluated neurological deficits, cerebral infarct volume, cortical neuron damage, and mitochondrial swelling in vivo. We evaluated the expression of VEGFR2, VEGFA, HIF-1α, CD31, and CD34 in ischemic cortex, and VEGF, bFGF, BDNF, angiostatin, and endostatin in serum of rats and in BMEC supernatants. We also evaluated cell viability, cytotoxicity, intracellular ROS, apoptosis, and migration ability in vitro. Results: Seven components were detected in DDTNC. KEGG enrichment analysis showed that DDTNC may modulate angiogenesis via the HIF-1 signaling pathway. DDTNC treatment reduced neurological score and infarct volume, and improved cell morphology of damaged neurons. Transmission electron microscopy showed that DDTNC reduced mitochondria swelling in cortical neurons. Furthermore, DDTNC reduced intracellular ROS and inhibited apoptosis. DDTNC boosted the expression of CD31, CD34, VEGFR2, VEGFA and HIF-1α, highlighting its involvement in angiogenesis, according to immunofluorescence studies. Furthermore, DDTNC enhanced tube formation and migration of BMECs in vitro. ELISA and western blotting indicated that DDTNCCSF induced the expression of VEGF, BDNF and bFGF, reduced the level of angiostatin and endostatin, increased the protein expression of VEGFA, Notch1 and HIF-1α in vitro and in vivo. Conclusions: DDTNC promoted angiogenesis to protect brain tissue against MCAO/R, and exerted protective effects against OGD/R in BMECs via activating HIF-1α-VEGFA-NOTCH1 signal transduction pathway.
MeSH term(s)	Rats ; Animals ; Endothelial Cells ; Vascular Endothelial Growth Factor A/metabolism ; Angiostatins/metabolism ; Angiostatins/pharmacology ; Angiostatins/therapeutic use ; Brain-Derived Neurotrophic Factor/metabolism ; Endostatins/metabolism ; Endostatins/pharmacology ; Endostatins/therapeutic use ; Reactive Oxygen Species/metabolism ; Signal Transduction ; Brain Ischemia/drug therapy ; Brain Ischemia/metabolism ; Infarction, Middle Cerebral Artery/drug therapy ; Infarction, Middle Cerebral Artery/metabolism ; Reperfusion Injury/drug therapy ; Reperfusion Injury/metabolism ; Microvessels/metabolism ; Receptor, Notch1/metabolism
Chemical Substances	Vascular Endothelial Growth Factor A ; Angiostatins (86090-08-6) ; Brain-Derived Neurotrophic Factor ; Endostatins ; Reactive Oxygen Species ; Notch1 protein, rat ; Receptor, Notch1
Language	English
Publishing date	2023-07-13
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1205240-1
ISSN	1618-095X ; 0944-7113
ISSN (online)	1618-095X
ISSN	0944-7113
DOI	10.1016/j.phymed.2023.154966
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Article: Protective effects of Shen Yuan Dan on myocardial ischemia-reperfusion injury via the regulation of mitochondrial quality control.

Zhang, Zhuhua / Zhou, Mingxue / Liu, Hongxu / Liu, Wei / Chen, Jiaping

Cardiovascular diagnosis and therapy

2023 Volume 13, Issue 2, Page(s) 395–407

Abstract: ... of Shen Yuan Dan (SYD) on cardiomyocytes hypoxia-reoxygenation (H/R) injury via the regulation ...

Abstract	Background: Myocardial cell death resulting from ischemia-reperfusion (I/R) injury has been a predominant contributor to morbidity and mortality globally. The mitochondria-centered mechanism plays an important role in the formation of I/R injury. This study intended to discuss the protective mechanism of Shen Yuan Dan (SYD) on cardiomyocytes hypoxia-reoxygenation (H/R) injury via the regulation of mitochondrial quality control (MQC). Additionally, this study clarified the mechanism by which SYD suppressed mitophagy activity through the suppression of the PTEN-induced kinase 1 (PINK1)/Parkin pathway. Methods: To induce cellular injury, H9c2 cardiomyocytes were exposed to H/R stimulation. Following the pretreatment with SYD, cardiomyocytes were subjected to H/R stimulation. Mitochondrial membrane potential (MMP), adenosine triphosphate (ATP), superoxide dismutase (SOD), and methane dicarboxylic aldehyde (MDA) were detected to evaluate the degree of cardiomyocyte mitochondrial damage. Laser confocal microscopy was applied to observe the mitochondrial quality, and the messenger (mRNA) levels of mitofusin 1 (Mfn1), mitofusin 2 (Mfn2), optic atrophy protein 1 (Opa1), dynamin-related protein 1 (Drp1), fission 1 (Fis1), and peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α) in cardiomyocytes were assessed using reverse transcription-quantitative polymerase chain reaction (RT-qPCR). Western blotting was employed for the estimation of light chain 3 (LC3)-I, LC3-II, PINK1, and Parkin in cardiomyocytes. Results: It was discovered that SYD pretreatment elevated MMP in H/R injury cardiomyocytes, enhanced ATP content, activated SOD activity, and reduced MDA level. SYD treatment increased the mRNA levels of Mfn1, Mfn2, Opa1 and PGC-1α decreased the mRNA levels of Drp1 and Fis1, and reduced the protein levels of LC3, PINK1, and Parkin. Conclusions: SYD plays a protective role in H/R injury to cardiomyocytes by regulating mitochondrial quality. Meanwhile, SYD may inhibit mitophagy activity through inhibiting the PINK1/Parkin pathway. This study provides insights into the underlying mechanism of SYD in alleviating myocardial I/R injury.
Language	English
Publishing date	2023-04-24
Publishing country	China
Document type	Journal Article
ZDB-ID	2685043-6
ISSN	2223-3660 ; 2223-3652
ISSN (online)	2223-3660
ISSN	2223-3652
DOI	10.21037/cdt-23-86
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Article ; Online: Neuroprotective potential of phytochemicals isolated from Paeonia ostii ‘Feng Dan’ stamen

Peng, Xiao-Na / Zhou, Yang / Liu, Yan-Xiang / Huo, Yi-Lin / Ren, Jie-Yi / Bai, Zhang-Zhen / Zhang, Yan-Long / Tang, Jiang-Jiang

Industrial Crops & Products. 2023 Sept., v. 200 p.116808-

2023

Abstract: Paeonia ostii ‘Feng Dan’, traditionally known as an important medicinal and ornamental plant, is ...

Abstract	Paeonia ostii ‘Feng Dan’, traditionally known as an important medicinal and ornamental plant, is an emerging oilseed crop widely cultivated in China. As a byproduct, its stamens showed promising anti-neuroinflammation potential in our previous study. In this work, an in-depth phytochemical investigation was firstly conducted through comprehensive spectra to elucidate the neuroprotective components. Two new compounds (+)-oxylactiflorin (1), (+)-3′′-methoxy-oxylactiflorin (2), and twenty-two known compounds were isolated and identified. In lipopolysaccharides-induced BV-2 cells, compound 2 exhibited excellent inhibitory property in inhibiting nitric oxide (NO) production with the lowest EC₅₀ value of 3.02 ± 1.60 µM among all tested compounds. Western blotting and molecular docking results demonstrated the feasible mechanism that 2 exerted anti-inflammatory activity mainly by binding with the key protein cyclooxygenase-2 (COX-2). Additionally, compound 2 showed potent protective effects on the oxidative damages of H₂O₂ or 6-Hydroxydopamine (6-OHDA)-treated PC12 cells. This work provides a theoretical basis of P. ostii stamens for developing into a promising functional tea or neuroprotective drug.
Keywords	Paeonia ostii ; anti-inflammatory activity ; byproducts ; drugs ; neuroprotective effect ; nitric oxide ; oilseed crops ; ornamental plants ; phytochemicals ; prostaglandin synthase ; tea ; China ; Paeonia ostii stamen ; Anti-neuroinflammation ; Cyclooxygenase-2 ; Neuroprotection
Language	English
Dates of publication	2023-09
Publishing place	Elsevier B.V.
Document type	Article ; Online
ZDB-ID	1132158-1
ISSN	1872-633X ; 0926-6690
ISSN (online)	1872-633X
ISSN	0926-6690
DOI	10.1016/j.indcrop.2023.116808
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Dan-Deng-Tong-Nao Softgel Capsule Promotes Angiogenesis of Cerebral Microvasculature to Protect Cerebral Ischemia Reperfusion Injury via Activating HIF-1a-VEGFA-Notch1 Signaling Pathway

Wang, Lei / Li, Jiacheng / Wang, Yang / Ge, Chaowen / Huang, Qi / Li, Lili / Wang, Ning / Chen, Yuang / Zhou, Xian / Chang, Dennis / Li, Dan / Hou, Jincai

Phytomedicine. 2023 July 13, p.154966-

2023 , Page(s) 154966–

Abstract: A proprietary Chinese herbal product called Dan-Deng-Tong-Nao softgel capsule (DDTNC) is used ...

Abstract	A proprietary Chinese herbal product called Dan-Deng-Tong-Nao softgel capsule (DDTNC) is used to treat ischemic stroke. However, the preventive mechanisms of DDTNC against cerebral ischemia reperfusion injury (CIRI) haven not been characterized. To explore the mechanisms of protective effects of DDTNC against CIRI from both internal and external levels. Chemical characterization was performed using UPLC. The potential protective mechanisms of DDTNC against CIRI were predicted using network pharmacology. Model of middle cerebral artery occlusion/reperfusion (MCAO/R) was established in rats. An model of brain microvascular endothelial cells (BMECs) induced by oxygen-glucose deprivation/reoxygenation (OGD/R) was also established. We evaluated neurological deficits, cerebral infarct volume, cortical neuron damage, and mitochondrial swelling in vivo. We evaluated the expression of VEGFR2, VEGFA, HIF-1α, CD31, and CD34 in ischemic cortex, and VEGF, bFGF, BDNF, angiostatin, and endostatin in serum of rats and in BMEC supernatants. We also evaluated cell viability, cytotoxicity, intracellular ROS, apoptosis, and migration ability in vitro. Seven components were detected in DDTNC. KEGG enrichment analysis showed that DDTNC may modulate angiogenesis via the HIF-1 signaling pathway. DDTNC treatment reduced neurological score and infarct volume, and improved cell morphology of damaged neurons. Transmission electron microscopy showed that DDTNC reduced mitochondria swelling in cortical neurons. Furthermore, DDTNC reduced intracellular ROS and inhibited apoptosis. DDTNC boosted the expression of CD31, CD34, VEGFR2, VEGFA and HIF-1α, highlighting its involvement in angiogenesis, according to immunofluorescence studies. Furthermore, DDTNC enhanced tube formation and migration of BMECs in vitro. ELISA and western blotting indicated that DDTNC-CSF induced the expression of VEGF, BDNF and bFGF, reduced the level of angiostatin and endostatin, increased the protein expression of VEGFA, Notch1 and HIF-1α in vitro and in vivo. DDTNC promoted angiogenesis to protect brain tissue against MCAO/R, and exerted protective effects against OGD/R in BMECs via activating HIF-1α-VEGFA-Notch1 signal transduction pathway.
Keywords	angiogenesis ; apoptosis ; blood serum ; brain ; cell viability ; cortex ; cytotoxicity ; fluorescent antibody technique ; infarction ; ischemia ; mitochondria ; models ; neurons ; pharmacology ; protein synthesis ; reperfusion injury ; signal transduction ; stroke ; transmission electron microscopy ; vascular endothelial growth factor receptor-2 ; DDTNC ; Network pharmacology ; HIF-1α-VEGFA-Notch1 ; CIRI ; Dll4 ; UPLC
Language	English
Dates of publication	2023-0713
Publishing place	Elsevier GmbH
Document type	Article ; Online
Note	Pre-press version
ZDB-ID	1205240-1
ISSN	1618-095X ; 0944-7113
ISSN (online)	1618-095X
ISSN	0944-7113
DOI	10.1016/j.phymed.2023.154966
Database	NAL-Catalogue (AGRICOLA)

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Article: Traditional Chinese Medicine Shen-Yuan-Dan (SYD) Improves Hypoxia-Induced Cardiomyocyte Apoptosis in Neonatal Rats by Upregulating miR-24/Bim Pathway.

Chu, Fuyong / Yan, Xue / Xiong, Xingjiang / Zhou, Mingxue / Tan, Yupei / Li, Yixuan / Liu, Wei / Liu, Hongxu

Evidence-based complementary and alternative medicine : eCAM

2022 Volume 2022, Page(s) 5804187

Abstract: ... ...

Abstract	Background
Language	English
Publishing date	2022-02-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2022/5804187
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Article ; Online: DAN-Net: Dual-domain adaptive-scaling non-local network for CT metal artifact reduction.

Wang, Tao / Xia, Wenjun / Huang, Yongqiang / Sun, Huaiqiang / Liu, Yan / Chen, Hu / Zhou, Jiliu / Zhang, Yi

Physics in medicine and biology

2021 Volume 66, Issue 15

Abstract: ... performance. In this paper, a novel dual-domain adaptive-scaling non-local network (DAN-Net) is proposed ... in the proposed network model. Experiments demonstrate the performance of the proposed DAN-Net is competitive ...

Abstract	Metallic implants can heavily attenuate x-rays in computed tomography (CT) scans, leading to severe artifacts in reconstructed images, which significantly jeopardize image quality and negatively impact subsequent diagnoses and treatment planning. With the rapid development of deep learning in the field of medical imaging, several network models have been proposed for metal artifact reduction (MAR) in CT. Despite the encouraging results achieved by these methods, there is still much room to further improve performance. In this paper, a novel dual-domain adaptive-scaling non-local network (DAN-Net) is proposed for MAR. We correct the corrupted sinogram using adaptive scaling first to preserve more tissue and bone details. Then, an end-to-end dual-domain network is adopted to successively process the sinogram and its corresponding reconstructed image is generated by the analytical reconstruction layer. In addition, to better suppress the existing artifacts and restrain the potential secondary artifacts caused by inaccurate results of the sinogram-domain network, a novel residual sinogram learning strategy and non-local module are leveraged in the proposed network model. Experiments demonstrate the performance of the proposed DAN-Net is competitive with several state-of-the-art MAR methods in both qualitative and quantitative aspects.
MeSH term(s)	Algorithms ; Artifacts ; Image Processing, Computer-Assisted ; Metals ; Phantoms, Imaging ; Tomography, X-Ray Computed
Chemical Substances	Metals
Language	English
Publishing date	2021-07-22
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	208857-5
ISSN	1361-6560 ; 0031-9155
ISSN (online)	1361-6560
ISSN	0031-9155
DOI	10.1088/1361-6560/ac1156
Database	MEDical Literature Analysis and Retrieval System OnLINE

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