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  1. Article ; Online: Post-COVID mRNA-vaccine IgG4 shift: worrisome?

    Kadkhoda, Kamran

    mSphere

    2023  Volume 8, Issue 4, Page(s) e0008523

    Abstract: COVID-19 vaccines play a key role in ending the pandemic. Unraveling the immunological phenomena involved in offering protective immunity is the cornerstone of achieving such success. This perspective evaluates the possible mechanisms and implications of ...

    Abstract COVID-19 vaccines play a key role in ending the pandemic. Unraveling the immunological phenomena involved in offering protective immunity is the cornerstone of achieving such success. This perspective evaluates the possible mechanisms and implications of IgG4 production in response to mRNA-based COVID-19 vaccines.
    MeSH term(s) Humans ; COVID-19/prevention & control ; COVID-19 Vaccines ; Immunoglobulin G ; Pandemics ; RNA, Messenger/genetics
    Chemical Substances COVID-19 Vaccines ; Immunoglobulin G ; RNA, Messenger
    Language English
    Publishing date 2023-05-16
    Publishing country United States
    Document type Journal Article
    ISSN 2379-5042
    ISSN (online) 2379-5042
    DOI 10.1128/msphere.00085-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Update to COVID-19 serologic testing : FAQs and caveats.

    Kadkhoda, Kamran

    Cleveland Clinic journal of medicine

    2022  

    Language English
    Publishing date 2022-01-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639116-3
    ISSN 1939-2869 ; 0891-1150
    ISSN (online) 1939-2869
    ISSN 0891-1150
    DOI 10.3949/ccjm.87a.20054-up
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    Ua VI Zs.212: Show issues Location:
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  3. Article ; Online: Post-adenoviral-based vaccines Guillain-Barre Syndrome: A proposed mechanism.

    Kadkhoda, Kamran

    Medical hypotheses

    2022  Volume 160, Page(s) 110792

    Abstract: Despite great public health advances achieved by COVID-19 vaccines, rare side effects may impact the public acceptance. Guillain-Barre Syndrome has increasingly been reported with adenoviral-based vaccines. This perspective proposes a possible mechanism ... ...

    Abstract Despite great public health advances achieved by COVID-19 vaccines, rare side effects may impact the public acceptance. Guillain-Barre Syndrome has increasingly been reported with adenoviral-based vaccines. This perspective proposes a possible mechanism underlying this rare but clinically significant side effect thereby providing insights for improving our current vaccines against COVID-19.
    Language English
    Publishing date 2022-02-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 193145-3
    ISSN 1532-2777 ; 0306-9877
    ISSN (online) 1532-2777
    ISSN 0306-9877
    DOI 10.1016/j.mehy.2022.110792
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    Zs.A 1132: Show issues Location:
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  4. Article ; Online: Post RNA-based COVID vaccines myocarditis: Proposed mechanisms.

    Kadkhoda, Kamran

    Vaccine

    2021  Volume 40, Issue 3, Page(s) 406–407

    MeSH term(s) COVID-19 ; COVID-19 Vaccines ; Humans ; Myocarditis ; RNA ; SARS-CoV-2 ; mRNA Vaccines
    Chemical Substances COVID-19 Vaccines ; mRNA Vaccines ; RNA (63231-63-0)
    Language English
    Publishing date 2021-12-09
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 605674-x
    ISSN 1873-2518 ; 0264-410X
    ISSN (online) 1873-2518
    ISSN 0264-410X
    DOI 10.1016/j.vaccine.2021.11.093
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    Zs.MO 458: Show issues

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  5. Article ; Online: Herd Immunity to COVID-19.

    Kadkhoda, Kamran

    American journal of clinical pathology

    2021  Volume 155, Issue 4, Page(s) 471–472

    MeSH term(s) COVID-19/epidemiology ; COVID-19/immunology ; COVID-19/prevention & control ; COVID-19/transmission ; COVID-19 Vaccines/immunology ; Global Health ; Humans ; Immunity, Herd/immunology
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2021-03-17
    Publishing country England
    Document type Editorial
    ZDB-ID 2944-0
    ISSN 1943-7722 ; 0002-9173
    ISSN (online) 1943-7722
    ISSN 0002-9173
    DOI 10.1093/ajcp/aqaa272
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    Ud II Zs.91: Show issues Location:
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  6. Article ; Online: Post-adenoviral-based COVID-19 vaccines thrombosis: A proposed mechanism.

    Kadkhoda, Kamran

    Journal of thrombosis and haemostasis : JTH

    2021  Volume 19, Issue 7, Page(s) 1831–1832

    MeSH term(s) COVID-19 ; COVID-19 Vaccines ; Humans ; SARS-CoV-2 ; Thrombosis/prevention & control
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2021-05-05
    Publishing country England
    Document type Letter
    ZDB-ID 2112661-6
    ISSN 1538-7836 ; 1538-7933
    ISSN (online) 1538-7836
    ISSN 1538-7933
    DOI 10.1111/jth.15348
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    Zs.A 5805: Show issues Location:
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    Zs.MO 295: Show issues

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  7. Article ; Online: COVID-19: are neutralizing antibodies neutralizing enough?

    Kadkhoda, Kamran

    Transfusion

    2020  Volume 60, Issue 7, Page(s) 1602–1603

    MeSH term(s) Antibodies, Neutralizing ; Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Critical Illness ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Chemical Substances Antibodies, Neutralizing
    Keywords covid19
    Language English
    Publishing date 2020-06-03
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 208417-x
    ISSN 1537-2995 ; 0041-1132
    ISSN (online) 1537-2995
    ISSN 0041-1132
    DOI 10.1111/trf.15897
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    Zs.A 284: Show issues Location:
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  8. Article ; Online: COVID-19 serologic testing: FAQs and caveats.

    Kadkhoda, Kamran

    Cleveland Clinic journal of medicine

    2020  Volume 87, Issue 6, Page(s) 329–333

    MeSH term(s) Betacoronavirus/immunology ; Betacoronavirus/isolation & purification ; COVID-19 ; COVID-19 Testing ; Clinical Laboratory Techniques/methods ; Coronavirus Infections/diagnosis ; Coronavirus Infections/immunology ; Coronavirus Infections/virology ; Humans ; Immunity/immunology ; Mass Screening ; Pandemics ; Pneumonia, Viral/immunology ; Pneumonia, Viral/virology ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-05-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639116-3
    ISSN 1939-2869 ; 0891-1150
    ISSN (online) 1939-2869
    ISSN 0891-1150
    DOI 10.3949/ccjm.87a.20054
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  9. Article ; Online: COVID-19: an Immunopathological View.

    Kadkhoda, Kamran

    mSphere

    2020  Volume 5, Issue 2

    Abstract: Since its emergence in December 2019, it took only a couple of months for an outbreak of the novel coronavirus disease 2019 (COVID-19) to be declared a pandemic by the World Health Organization (WHO). This along with the highly infectious nature of the ... ...

    Abstract Since its emergence in December 2019, it took only a couple of months for an outbreak of the novel coronavirus disease 2019 (COVID-19) to be declared a pandemic by the World Health Organization (WHO). This along with the highly infectious nature of the disease and the associated mortality call for particular attention to the underlying (immuno)pathomechanism(s). The latter will inform case management and vaccine design. Unravelling these mechanisms can assist basic scientists, laboratory medicine practitioners, clinicians, public health practitioners, funding agencies, and health care policymakers in responding to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic.
    MeSH term(s) Betacoronavirus/immunology ; Coronavirus Infections/immunology ; Coronavirus Infections/physiopathology ; Coronavirus Infections/prevention & control ; Coronavirus Infections/therapy ; Coronavirus Infections/virology ; Humans ; Immunization, Passive ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/immunology ; Pneumonia, Viral/physiopathology ; Pneumonia, Viral/therapy ; Pneumonia, Viral/virology ; Public Health ; Viral Vaccines ; World Health Organization
    Chemical Substances COVID-19 vaccine ; Viral Vaccines
    Keywords covid19
    Language English
    Publishing date 2020-04-22
    Publishing country United States
    Document type Case Reports ; Journal Article ; Review
    ISSN 2379-5042
    ISSN (online) 2379-5042
    DOI 10.1128/mSphere.00344-20
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Severe acute respiratory syndrome coronavirus 2, original antigenic sin, and antibody-dependent enhancement: ménage à trois.

    Kadkhoda, Kamran

    Current opinion in rheumatology

    2020  Volume 32, Issue 5, Page(s) 458–461

    Abstract: Background: Shortly after its emergence in December 2019, the coronavirus disease 2019 (COVID-19) was declared as a pandemic by the World Health Organization. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is the seventh member of the ... ...

    Abstract Background: Shortly after its emergence in December 2019, the coronavirus disease 2019 (COVID-19) was declared as a pandemic by the World Health Organization. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is the seventh member of the Coronaviridae family of viruses that causes disease in humans.
    The problem: Despite the established role of molecular diagnostics, COVID-19 serodiagnosis remains a poorly discovered and enigmatic area. Although there are numerous commercial serological products available globally, there is a severe paucity of high-quality peer-reviewed literature on their true performance characteristics. That being said, publications including in-house developed serological tests started to shed light on the kinetics of the humoral response.
    Summary: In spite of intense focus of assessing the performance characteristics of the commercially-available kits, the main issue remains rather invisible, that is, lack of solid science behind COVID-19 serology its clinical usefulness thereof. This short review summarizes the key points as to why COVID-19 is not jest ready to fly.
    Purpose of review: Despite having been mentioned as a testing option, COVID-19 serology has significant shortcomings that needs discussing. This short review is meant to shed light on one of those aspects.
    MeSH term(s) Antibody-Dependent Enhancement ; Antigens, Viral/immunology ; Betacoronavirus/immunology ; COVID-19 ; Coronavirus Infections/immunology ; Humans ; Pandemics ; Pneumonia, Viral/immunology ; SARS-CoV-2 ; Serologic Tests
    Chemical Substances Antigens, Viral
    Keywords covid19
    Language English
    Publishing date 2020-07-10
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1045317-9
    ISSN 1531-6963 ; 1040-8711
    ISSN (online) 1531-6963
    ISSN 1040-8711
    DOI 10.1097/BOR.0000000000000728
    Database MEDical Literature Analysis and Retrieval System OnLINE

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