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  1. Article ; Online: Successful One-Lung Ventilation With a Double Bronchial Blocker Technique in a Patient With Bronchial Anomaly and Tracheal Stenosis Caused by Kommerell Diverticulum.

    Suzuki, Hiroaki / Fujishiro, Asuka / Arai, Takero

    Journal of cardiothoracic and vascular anesthesia

    2023  Volume 37, Issue 12, Page(s) 2607–2610

    MeSH term(s) Humans ; One-Lung Ventilation/methods ; Tracheal Stenosis/complications ; Tracheal Stenosis/diagnostic imaging ; Bronchi/diagnostic imaging ; Bronchi/surgery ; Bronchoscopy ; Diverticulum/complications ; Diverticulum/diagnostic imaging ; Diverticulum/surgery ; Intubation, Intratracheal/methods ; Respiration, Artificial
    Language English
    Publishing date 2023-09-09
    Publishing country United States
    Document type Case Reports
    ZDB-ID 1067317-9
    ISSN 1532-8422 ; 1053-0770
    ISSN (online) 1532-8422
    ISSN 1053-0770
    DOI 10.1053/j.jvca.2023.09.007
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    Zs.A 2203: Show issues Location:
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  2. Article ; Online: Aerosol extractor for airway management of COVID-19 patients.

    Saito, Tomoyuki / Fujishiro, Asuka / Asai, Takashi

    Journal of anesthesia

    2021  Volume 35, Issue 2, Page(s) 323

    Language English
    Publishing date 2021-03-07
    Publishing country Japan
    Document type Letter
    ZDB-ID 1107821-2
    ISSN 1438-8359 ; 0913-8668
    ISSN (online) 1438-8359
    ISSN 0913-8668
    DOI 10.1007/s00540-021-02916-w
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    Zs.A 3408: Show issues Location:
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  3. Article ; Online: Efficacy of an aerosol suction device Free-100 M in removing aerosols produced by coughing to minimize COVID-19 infection.

    Fujishiro, Asuka / Asai, Takashi / Saito, Tomoyuki / Okuda, Yasuhisa

    Journal of anesthesia

    2022  Volume 37, Issue 2, Page(s) 196–200

    Abstract: Purpose: The healthcare workers are at the greatest risk of being exposed to viral infection during airway management of a patient with coronavirus disease 2019 (COVID-19). An air extractor which suctions air around the patient's face would reduce the ... ...

    Abstract Purpose: The healthcare workers are at the greatest risk of being exposed to viral infection during airway management of a patient with coronavirus disease 2019 (COVID-19). An air extractor which suctions air around the patient's face would reduce the spread of viral aerosols during coughing, but no study has confirmed this. We assessed whether or not an air extractor reduces the amount of aerosols spreading toward the operator's face, during coughing of simulated patients.
    Methods: After obtained approval of the study by a research ethics committee and written informed consent from 20 volunteers (and additional 20 volunteers), we asked each volunteer to lie supine on a table in a positive-pressure management operating room. As a cross-over design, we used an airborne particle counter (Handheld 3016, SGY company, Tokyo) to measure the aerosols approximately 30 cm above the participant's mouth, while the volunteer was coughing, with and without the use of an air extractor Free-100 M (Forest-one, Funabashi), facing the participant's mouth. In another 20 volunteers, the aerosols were measured, while each volunteer was lying supine, without coughing, and without the use of the air extractor.
    Results: The aerosol count during coughing was significantly lower when the air extractor was used [median: 55 (interquartile range: 15-128)] than when it was not used [73 (44-201)] [p = 0.001, difference: 19 (95%CI: 4-70)].
    Conclusions: The Free-100 M air extractor would reduce, but do not remove all, aerosols produced by coughing of a patient, and thus may reduce the risk of infection of COVID-19.
    MeSH term(s) Humans ; Airway Management ; COVID-19 ; Respiratory Aerosols and Droplets ; Suction ; Cross-Over Studies
    Language English
    Publishing date 2022-11-30
    Publishing country Japan
    Document type Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1107821-2
    ISSN 1438-8359 ; 0913-8668
    ISSN (online) 1438-8359
    ISSN 0913-8668
    DOI 10.1007/s00540-022-03144-6
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  4. Article ; Online: High-flow extractor with ULPA filter to minimize viral aerosols in patients with COVID-19.

    Saito, Tomoyuki / Fujishiro, Asuka / Ugajin, Wakana / Okuda, Yasuhisa

    Minerva anestesiologica

    2021  Volume 87, Issue 9, Page(s) 1051–1053

    MeSH term(s) Aerosols ; COVID-19 ; Humans ; SARS-CoV-2
    Chemical Substances Aerosols
    Language English
    Publishing date 2021-05-13
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 123584-9
    ISSN 1827-1596 ; 0026-4717 ; 0375-9393
    ISSN (online) 1827-1596
    ISSN 0026-4717 ; 0375-9393
    DOI 10.23736/S0375-9393.21.15685-8
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    Zs.MO 192: Show issues

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  5. Article ; Online: COVID-19: be aware of contaminated airway devices.

    Fujishiro, Asuka / Saito, Tomoyuki / Asai, Takashi

    Journal of anesthesia

    2020  Volume 34, Issue 6, Page(s) 960–961

    Keywords covid19
    Language English
    Publishing date 2020-09-11
    Publishing country Japan
    Document type Letter
    ZDB-ID 1107821-2
    ISSN 1438-8359 ; 0913-8668
    ISSN (online) 1438-8359
    ISSN 0913-8668
    DOI 10.1007/s00540-020-02854-z
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  7. Article ; Online: COVID-19

    Fujishiro, Asuka / Saito, Tomoyuki / Asai, Takashi

    Journal of Anesthesia ; ISSN 0913-8668 1438-8359

    be aware of contaminated airway devices

    2020  

    Keywords Anesthesiology and Pain Medicine ; covid19
    Language English
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    DOI 10.1007/s00540-020-02854-z
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Impact of elobixibat on liver tumors, microbiome, and bile acid levels in a mouse model of nonalcoholic steatohepatitis.

    Sugiyama, Yoshiaki / Yamamoto, Kenta / Honda, Takashi / Kato, Asuka / Muto, Hisanori / Yokoyama, Shinya / Ito, Takanori / Imai, Norihiro / Ishizu, Yoji / Nakamura, Masanao / Asano, Tomomi / Enomoto, Atsushi / Zaitsu, Kei / Ishigami, Masatoshi / Fujishiro, Mitsuhiro / Kawashima, Hiroki

    Hepatology international

    2023  Volume 17, Issue 6, Page(s) 1378–1392

    Abstract: Background: Elevated bile acid levels have been associated with liver tumors in fatty liver. Ileal bile acid transporter inhibitors may inhibit bile acid absorption in the distal ileum and increase bile acid levels in the colon, potentially decreasing ... ...

    Abstract Background: Elevated bile acid levels have been associated with liver tumors in fatty liver. Ileal bile acid transporter inhibitors may inhibit bile acid absorption in the distal ileum and increase bile acid levels in the colon, potentially decreasing the serum and hepatic bile acid levels. This study aimed to investigate the impact of these factors on liver tumor.
    Methods: C57BL/6J mice received a one-time intraperitoneal injection of 25-mg/kg diethylnitrosamine. They were fed a choline-deficient high-fat diet for 20 weeks starting from 8 weeks of age, with or without elobixibat (EA Pharma, Tokyo, Japan).
    Results: Both groups showed liver fat accumulation and fibrosis, with no significant differences between the two groups. However, mice with elobixibat showed fewer liver tumors. The total serum bile acid levels, including free, tauro-conjugated, glyco-conjugated, and tauro-α/β-muricholic acids in the liver, were noticeably reduced following elobixibat treatment. The proportion of gram-positive bacteria in feces was significantly lower in the group treated with elobixibat (5.4%) than in the group without elobixibat (33.7%).
    Conclusion: Elobixibat suppressed tumor growth by inhibiting bile acid reabsorption, and decreasing total bile acid and primary bile acid levels in the serum and liver. Additionally, the presence of bile acids in the colon may have led to a significant reduction in the proportion of gram-positive bacteria, potentially resulting in decreased secondary bile acid synthesis.
    MeSH term(s) Mice ; Animals ; Bile Acids and Salts ; Non-alcoholic Fatty Liver Disease/drug therapy ; Non-alcoholic Fatty Liver Disease/pathology ; Mice, Inbred C57BL ; Liver/pathology ; Liver Neoplasms ; Microbiota
    Chemical Substances Bile Acids and Salts ; elobixibat (865UEK4EJC)
    Language English
    Publishing date 2023-09-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2270316-0
    ISSN 1936-0541 ; 1936-0533
    ISSN (online) 1936-0541
    ISSN 1936-0533
    DOI 10.1007/s12072-023-10581-2
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  9. Article ; Online: Astaxanthin Attenuates Nonalcoholic Steatohepatitis with Downregulation of Osteoprotegerin in Ovariectomized Mice Fed Choline-Deficient High-Fat Diet.

    Zhao, Meng / Ma, Lingyun / Honda, Takashi / Kato, Asuka / Ohshiro, Taichi / Yokoyama, Shinya / Yamamoto, Kenta / Ito, Takanori / Imai, Norihiro / Ishizu, Yoji / Nakamura, Masanao / Kawashima, Hiroki / Tsuji, Noriko M / Ishigami, Masatoshi / Fujishiro, Mitsuhiro

    Digestive diseases and sciences

    2022  Volume 68, Issue 1, Page(s) 155–163

    Abstract: Background: Postmenopausal estrogen decline increases the risk of developing nonalcoholic steatohepatitis (NASH), and it might accelerate progression to cirrhosis and hepatocellular carcinoma.: Aims: This study aimed to investigate a novel therapy ... ...

    Abstract Background: Postmenopausal estrogen decline increases the risk of developing nonalcoholic steatohepatitis (NASH), and it might accelerate progression to cirrhosis and hepatocellular carcinoma.
    Aims: This study aimed to investigate a novel therapy for postmenopausal women who are diagnosed with NASH.
    Methods: Seven-week-old female C57BL/6 J mice were divided into three experimental groups as follows: (1) sham operation (SHAM group), (2) ovariectomy (OVX group), and (3) ovariectomy + 0.02% astaxanthin (OVX + ASTX group). These three groups of mice were fed a choline-deficient high-fat (CDHF) diet for 8 weeks. Blood serum and liver tissues were collected to examine liver injury, histological changes, and hepatic genes associated with NASH. An in vitro study was performed with the hepatic stellate cell line LX-2.
    Results: The administration of ASTX significantly improved pathological NASH with suppressed steatosis, inflammation, and fibrosis, in comparison with those in the OVX-induced estrogen deficiency group. As a result, liver injury was also attenuated with reduced levels of alanine aminotransferase and aspartate transaminase. In addition, our study found that ASTX supplementation decreased hepatic osteoprotegerin (OPG) in vivo, a possible factor that contributes to NASH development. In vitro, this study further confirmed that ASTX has an inhibitory effect on the secretion of OPG in LX-2 human hepatic stellate cells.
    Conclusions: Our findings suggest that ASTX alleviates CDHF-OVX-induced pathohistological NASH with downregulated OPG, possibly via suppression of the transforming growth factor beta pathway. ASTX could has promise for use in postmenopausal women diagnosed with NASH.
    MeSH term(s) Female ; Humans ; Mice ; Animals ; Non-alcoholic Fatty Liver Disease/drug therapy ; Non-alcoholic Fatty Liver Disease/etiology ; Non-alcoholic Fatty Liver Disease/metabolism ; Choline ; Diet, High-Fat/adverse effects ; Down-Regulation ; Osteoprotegerin/genetics ; Osteoprotegerin/metabolism ; Osteoprotegerin/pharmacology ; Mice, Inbred C57BL ; Liver/pathology ; Liver Cirrhosis/pathology ; Fibrosis ; Estrogens/pharmacology ; Diet
    Chemical Substances Choline (N91BDP6H0X) ; astaxanthine (8XPW32PR7I) ; Osteoprotegerin ; Estrogens
    Language English
    Publishing date 2022-04-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 304250-9
    ISSN 1573-2568 ; 0163-2116
    ISSN (online) 1573-2568
    ISSN 0163-2116
    DOI 10.1007/s10620-022-07489-6
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  10. Article ; Online: Microbiome, fibrosis and tumor networks in a non-alcoholic steatohepatitis model of a choline-deficient high-fat diet using diethylnitrosamine.

    Yamamoto, Kenta / Honda, Takashi / Yokoyama, Shinya / Ma, Lingyun / Kato, Asuka / Ito, Takanori / Ishizu, Yoji / Kuzuya, Teiji / Nakamura, Masanao / Kawashima, Hiroki / Ishigami, Masatoshi / Tsuji, Noriko M / Fujishiro, Mitsuhiro

    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver

    2021  Volume 53, Issue 11, Page(s) 1443–1450

    Abstract: Background & aims: Hepatocellular carcinoma in nonalcoholic steatohepatitis is caused by the complex factors of inflammation, fibrosis and microbiomes. We used network analysis to examine the interrelationships of these factors.: Methods: C57Bl/6 ... ...

    Abstract Background & aims: Hepatocellular carcinoma in nonalcoholic steatohepatitis is caused by the complex factors of inflammation, fibrosis and microbiomes. We used network analysis to examine the interrelationships of these factors.
    Methods: C57Bl/6 mice were categorized into groups: choline-sufficient high-fat (CSHF, n = 8), choline-deficient high-fat (CDHF, n = 9), and CDHF+ diethylnitrosamine (DEN, n = 8). All mice were fed CSHF or CDHF for 20 weeks starting at week 8, and mice in the CDHF + DEN group received one injection of DEN at 3 weeks of age. Bacterial gene was isolated from feces and analyzed using Miseq.
    Results: The CSHF group had less fibrosis than the other groups. Tumors were found in 22.2% and 87.5% of the CDHF group and CDHF + DEN groups, respectively. Gene expression in the liver of Cdkn1a (p21: tumor-suppressor) and c-jun was highest in the CDHF group. Bacteroides, Roseburia, Odoribacter, and Clostridium correlated with fibrosis. Streptococcus and Dorea correlated with inflammation and tumors. Akkermansia and Bilophila were inversely correlated with fibrosis and Bifidobacterium was inversely correlated with tumors.
    Conclusions: DEN suppressed the overexpression of p21 caused by CDHF. Some bacteria formed a relationship networking associated with their progression and inhibition for tumors and fibrosis.
    MeSH term(s) Alkylating Agents/metabolism ; Animals ; Carcinogenesis/metabolism ; Carcinoma, Hepatocellular/microbiology ; Carcinoma, Hepatocellular/pathology ; Choline Deficiency/metabolism ; Cyclin-Dependent Kinase Inhibitor p21 ; Diethylnitrosamine/metabolism ; Humans ; Liver Neoplasms/microbiology ; Liver Neoplasms/pathology ; Mice ; Mice, Inbred C57BL ; Microbiota ; Non-alcoholic Fatty Liver Disease/complications ; Random Allocation
    Chemical Substances Alkylating Agents ; Cdkn1a protein, mouse ; Cyclin-Dependent Kinase Inhibitor p21 ; Diethylnitrosamine (3IQ78TTX1A)
    Language English
    Publishing date 2021-03-13
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1459373-7
    ISSN 1878-3562 ; 1125-8055
    ISSN (online) 1878-3562
    ISSN 1125-8055
    DOI 10.1016/j.dld.2021.02.013
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