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  1. Article ; Online: Inquilinus limosus, an atypical Gram-negative rod from lung transplant recipients and cystic fibrosis patients.

    Farfour, Eric / Corvec, Stéphane / Guillard, Thomas / Revillet, Hélène

    Annales de biologie clinique

    2024  Volume 82, Issue 2, Page(s) 1–2

    Language English
    Publishing date 2024-04-01
    Publishing country France
    Document type Journal Article
    ZDB-ID 418098-7
    ISSN 1950-6112 ; 0003-3898
    ISSN (online) 1950-6112
    ISSN 0003-3898
    DOI 10.1684/abc.2024.1876
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  2. Article ; Online: Mollicutes-related infections in thoracic surgery including lung and heart transplantation: A systematic review.

    Farfour, Eric / Vasse, Marc / Vallée, Alexandre

    The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation

    2023  Volume 43, Issue 1, Page(s) 169–180

    Abstract: Background: Urogenital Mollicutes, that is, Mycoplasma hominis and Ureaplasma spp., can colonize the urogenital tract. While urogenital colonization is frequent, infections are rare but should not be missed. Furthermore, extragenital infections are even ...

    Abstract Background: Urogenital Mollicutes, that is, Mycoplasma hominis and Ureaplasma spp., can colonize the urogenital tract. While urogenital colonization is frequent, infections are rare but should not be missed. Furthermore, extragenital infections are even rarer. Over the past years, they have been increasingly documented as a cause of hyperammonemia syndrome (HS) and post-surgical infections. We review the literature on studies focused on post-surgical infections and HS involving urogenital Mollicutes after thoracic surgery including lung (LTR) and heart (HTR) transplantation.
    Methods: A systematic review was performed by searching PubMed/Medline case reports, case series, cohort studies, and clinical trials. Cases of infections and HS by urogenital Mollicutes after HTR and LTR transplantations were reported.
    Results: Overall, urogenital Mollicutes were associated with 15 HS, 31 infections in HTR and LTR, and 18 post-thoracic surgical infections in another context. Post-surgical infections were reported in all contexts. They were mainly due to M hominis, the only species that could cultivate on standard enriched agar forming pinpoint colonies after 3-5 days of incubation. Microbiologists should be prompted to pinpoint colonies even if the examination of Gram-staining is negative. The patients' management required surgical treatment and antimicrobials, almost always tetracyclines and/or fluoroquinolones. Conversely, HS occurred almost exclusively in bilateral LTR and is more likely due to Ureaplasma spp. As Ureaplasma spp. do not cultivate on standard media, the microbiological diagnosis was performed using molecular methods.
    Conclusions: Infections involving urogenital Mollicute should be considered in LTR with HS. The overall rate of mortality is high and might be due in part to delay in etiologic diagnosis. Post-surgical infections were reported in all contexts. The route of contamination with Mollicutes remains unknown in HTR and non-transplant surgery, but evidence of transmission from donors has been documented for LTR.
    MeSH term(s) Humans ; Thoracic Surgery ; Tenericutes ; Ureaplasma ; Heart Transplantation/adverse effects ; Lung
    Language English
    Publishing date 2023-10-03
    Publishing country United States
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 1062522-7
    ISSN 1557-3117 ; 1053-2498
    ISSN (online) 1557-3117
    ISSN 1053-2498
    DOI 10.1016/j.healun.2023.09.023
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    Zs.A 2056: Show issues Location:
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  3. Article: Plaques en prairie fauchée.

    Farfour, Eric / Zucman, David

    IDCases

    2021  Volume 24, Page(s) e01080

    Abstract: We report a clinical picture of a mowed meadow pattern of the tongue in a 29-year-old sexually active man who has sex with men. The painful lesions also called "Plaques en prairie fauchée", occur in the context of the discovery of a postive HIV serology. ...

    Abstract We report a clinical picture of a mowed meadow pattern of the tongue in a 29-year-old sexually active man who has sex with men. The painful lesions also called "Plaques en prairie fauchée", occur in the context of the discovery of a postive HIV serology. The diagnosis of secondary syphilis was confirmed by a positive syphilis serology (nontreponemal RPR test title of 64) and a positive
    Language English
    Publishing date 2021-03-23
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2745454-X
    ISSN 2214-2509
    ISSN 2214-2509
    DOI 10.1016/j.idcr.2021.e01080
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  4. Article ; Online: Comparison of the Alinity M STI with the GeneXpert CT/NG for the detection of sexually transmitted microorganisms.

    Farfour, Eric / Kitous, Cyril / Zucman, David / Touche, Pauline / Panel, Kewin / Fourn, Erwan / Vasse, Marc

    Diagnostic microbiology and infectious disease

    2024  Volume 108, Issue 3, Page(s) 116179

    Abstract: We assess the performances of the Alinity M STI assay (Abbott Molecular) in comparison to the Xpert CT/NG assay (Cepheid). We first retrospectively used a collection of 70 frozen samples of which 33, 31, and 6 were positives for Chlamydia trachomatis (CT) ...

    Abstract We assess the performances of the Alinity M STI assay (Abbott Molecular) in comparison to the Xpert CT/NG assay (Cepheid). We first retrospectively used a collection of 70 frozen samples of which 33, 31, and 6 were positives for Chlamydia trachomatis (CT), Neisseria gonorrhoea (NG), and both micro-organisms respectively. The Alinity M STI and the Xpert CT/NG results were in accordance for all. The mean difference in cycle threshold values between the Xpert CT/NG and the Alinity M STI were -1.6 and 0.0 for CT and NG respectively. Then 214 fresh samples collected from 121 patients were prospectively tested with both instruments. Anal swabs, throat swabs, vaginal swabs, and urines accounted each for about 25%. Seven (3.2%) samples of which 5 anal swabs, provided inconclusive results with the Alinity M STI. In conclusion, the Alinity M STI is an accurate device for the microbiological diagnosis of NG and CT infections.
    MeSH term(s) Female ; Humans ; Chlamydia trachomatis/genetics ; Gonorrhea/diagnosis ; Gonorrhea/microbiology ; Retrospective Studies ; Neisseria gonorrhoeae/genetics ; Chlamydia Infections/diagnosis ; Tomography, X-Ray Computed ; Sexually Transmitted Diseases/diagnosis ; Sexually Transmitted Diseases/microbiology ; Trichomonas vaginalis ; Prevalence
    Language English
    Publishing date 2024-01-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604920-5
    ISSN 1879-0070 ; 0732-8893
    ISSN (online) 1879-0070
    ISSN 0732-8893
    DOI 10.1016/j.diagmicrobio.2024.116179
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    Zs.A 1845: Show issues Location:
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  5. Article: Evaluation of Four Fully Integrated Molecular Assays for the Detection of Respiratory Viruses during the Co-Circulation of SARS-CoV-2, Influenza and RSV.

    Farfour, Eric / Yung, Thomas / Baudoin, Robin / Vasse, Marc

    Journal of clinical medicine

    2022  Volume 11, Issue 14

    Abstract: ... ...

    Abstract Background
    Language English
    Publishing date 2022-07-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11143942
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  6. Article ; Online: Monkeypox virus: A novel sexually transmitted disease? A case report from France.

    Vallée, Alexandre / Farfour, Eric / Zucman, David

    Travel medicine and infectious disease

    2022  Volume 49, Page(s) 102394

    MeSH term(s) Disease Outbreaks ; France ; Humans ; Monkeypox virus ; Sexually Transmitted Diseases/diagnosis
    Language English
    Publishing date 2022-06-28
    Publishing country Netherlands
    Document type Case Reports ; Letter
    ZDB-ID 2170891-5
    ISSN 1873-0442 ; 1477-8939
    ISSN (online) 1873-0442
    ISSN 1477-8939
    DOI 10.1016/j.tmaid.2022.102394
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  7. Article ; Online: Reply to comments on "Impact of EUCAST rapid Antimicrobial Susceptibility testing (RAST) on management of Gram-negative bloodstream infection".

    Cardot-Martin, E / Colombier, M A / Limousin, L / Farfour, E / Lesprit, P / Vasse, M

    Infectious diseases now

    2023  Volume 53, Issue 2, Page(s) 104667

    MeSH term(s) Humans ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Sepsis/drug therapy
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2023-02-02
    Publishing country France
    Document type Letter ; Comment
    ISSN 2666-9919
    ISSN (online) 2666-9919
    DOI 10.1016/j.idnow.2023.104667
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  8. Article: Rarely Encountered Gram-Negative Rods and Lung Transplant Recipients: A Narrative Review.

    Farfour, Eric / Roux, Antoine / Sage, Edouard / Revillet, Hélène / Vasse, Marc / Vallée, Alexandre

    Microorganisms

    2023  Volume 11, Issue 6

    Abstract: The respiratory tract of lung transplant recipients (LTR) is likely to be colonized with non-fermentative Gram-negative rods. As a consequence of the improvements in molecular sequencing and taxonomy, an increasing number of bacterial species have been ... ...

    Abstract The respiratory tract of lung transplant recipients (LTR) is likely to be colonized with non-fermentative Gram-negative rods. As a consequence of the improvements in molecular sequencing and taxonomy, an increasing number of bacterial species have been described. We performed a review of the literature of bacterial infections in LTR involving non-fermentative Gram-negative rods with exclusion of
    Language English
    Publishing date 2023-05-31
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms11061468
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  9. Article ; Online: Impact of COVID-19 pandemic on blood culture practices and bacteremia epidemiology.

    Farfour, Eric / Clichet, Valentin / Péan de Ponfilly, Gauthier / Carbonnelle, Etienne / Vasse, Marc

    Diagnostic microbiology and infectious disease

    2023  Volume 107, Issue 1, Page(s) 116002

    Abstract: The COVID-19 pandemic has strongly impacted healthcare settings. We assess changes in blood culture practices and results during the COVID-19 era. All blood culture vials processed between January 1, 2017, and December 31, 2020, by 3 clinical ... ...

    Abstract The COVID-19 pandemic has strongly impacted healthcare settings. We assess changes in blood culture practices and results during the COVID-19 era. All blood culture vials processed between January 1, 2017, and December 31, 2020, by 3 clinical laboratories were included. A baseline period from January 1, 2017 to December 31, 2019, was compared to the year 2020. COVID-19 "waves" were defined as follows: "wave 1" from March 16 to May 10, 2020, and "wave 2" from October 29 to December 14, 2020. A mean of 143.5 and 158.6 vials per day were processed in 2019 and 2020 respectively. Up to 300 and 220 vials per day were processed during waves 1 and 2. Among positive vials, a higher rate of contaminant was noticed during wave 1 (55.9% vs 45.0%; P < 0.0001) and interwave (46.0% vs 38.6%; P < 0.0001) in comparison to previous years. The prevalence of contaminants returned to the baseline level during wave 2. Streptococcus pneumonia prevalence fell in 2020 in comparison to the baseline (0.4% vs 1.4%; P < 0.0001). The COVID-19 pandemic was associated with an increase in the number of blood culture vials processed, the rate of contaminants, and a fall in the number of pneumococcal bloodstream infections.
    MeSH term(s) Humans ; COVID-19/epidemiology ; Blood Culture ; Pandemics ; Bacteremia/epidemiology ; Pneumococcal Infections/epidemiology
    Language English
    Publishing date 2023-06-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604920-5
    ISSN 1879-0070 ; 0732-8893
    ISSN (online) 1879-0070
    ISSN 0732-8893
    DOI 10.1016/j.diagmicrobio.2023.116002
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    Zs.A 1845: Show issues Location:
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  10. Article ; Online: Evaluation of the MTS™ aztreonam-avibactam strip (Liofilchem) on New Delhi metallo-β-lactamase-producing Enterobacterales.

    Emilie, Cardot Martin / Alice, Colombier Marie / Marine, Gougeon / Farfour, Eric / Pourbaix, Annabelle / Dortet, Laurent / Lucie, Limousin / Marc, Vasse

    European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology

    2024  Volume 43, Issue 4, Page(s) 777–784

    Abstract: The combination of ceftazidime-avibactam (CAZ-AVI) and aztreonam (ATM) is used to treat MBL-producing Enterobacterales-related infections. The new combination aztreonam-avibactam (AZA) is currently in development. We compared results obtained with the ... ...

    Abstract The combination of ceftazidime-avibactam (CAZ-AVI) and aztreonam (ATM) is used to treat MBL-producing Enterobacterales-related infections. The new combination aztreonam-avibactam (AZA) is currently in development. We compared results obtained with the new MIC test strip (MTS) AZA (Liofilchem) with broth microdilution method (BMD) on 41 MBL-producing Enterobacterales from 41 clinical samples. The MTS AZA was also compared to combination testing method using CAZ-AVI and ATM strips. Compared to BMD, categorical agreement (CA) was 100%. Compared with combination testing method, CA was 97.6%. The MTS AZA can be used to determine MICs levels of AZA or CAZ-AVI/ATM combinations.
    MeSH term(s) Humans ; Aztreonam/pharmacology ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Ceftazidime/therapeutic use ; beta-Lactamases ; Drug Combinations ; Microbial Sensitivity Tests ; Azabicyclo Compounds
    Chemical Substances Aztreonam (G2B4VE5GH8) ; Anti-Bacterial Agents ; beta-lactamase NDM-1 (EC 3.5.2.6) ; avibactam (7352665165) ; Ceftazidime (9M416Z9QNR) ; beta-Lactamases (EC 3.5.2.6) ; Drug Combinations ; Azabicyclo Compounds
    Language English
    Publishing date 2024-01-26
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 603155-9
    ISSN 1435-4373 ; 0934-9723 ; 0722-2211
    ISSN (online) 1435-4373
    ISSN 0934-9723 ; 0722-2211
    DOI 10.1007/s10096-024-04766-2
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