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  1. Article ; Online: Monitoring CO2 kinetics as a marker of cardiopulmonary efficiency.

    Sipmann, Fernando Suarez / Giralt, Juan Antonio Sanchez / Tusman, Gerardo

    Current opinion in critical care

    2024  Volume 30, Issue 3, Page(s) 251–259

    Abstract: Purpose of review: To describe current and near future developments and applications of CO2 kinetics in clinical respiratory and cardiovascular monitoring.: Recent findings: In the last years, we have witnessed a renewed interest in CO2 kinetics in ... ...

    Abstract Purpose of review: To describe current and near future developments and applications of CO2 kinetics in clinical respiratory and cardiovascular monitoring.
    Recent findings: In the last years, we have witnessed a renewed interest in CO2 kinetics in relation with a better understanding of volumetric capnography and its derived parameters. This together with technological advances and improved measurement systems have expanded the monitoring potential of CO2 kinetics including breath by breath continuous end-expiratory lung volume and continuous noninvasive cardiac output. Dead space has slowly been gaining relevance in clinical monitoring and prognostic evaluation. Easy to measure dead space surrogates such as the ventilatory ratio have demonstrated a strong prognostic value in patients with acute respiratory failure.
    Summary: The kinetics of carbon dioxide describe many relevant physiological processes. The clinical introduction of new ways of assessing respiratory and circulatory efficiency based on advanced analysis of CO2 kinetics are paving the road to a long-desired goal in clinical monitoring of critically ill patients: the integration of respiratory and circulatory monitoring during mechanical ventilation.
    MeSH term(s) Humans ; Carbon Dioxide/analysis ; Capnography/methods ; Monitoring, Physiologic/methods ; Respiration, Artificial/methods ; Kinetics ; Cardiac Output/physiology ; Biomarkers ; Respiratory Dead Space/physiology
    Chemical Substances Carbon Dioxide (142M471B3J) ; Biomarkers
    Language English
    Publishing date 2024-03-28
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1235629-3
    ISSN 1531-7072 ; 1070-5295
    ISSN (online) 1531-7072
    ISSN 1070-5295
    DOI 10.1097/MCC.0000000000001156
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A skeptical look about the existence of the veno-arteriolar reflex.

    Tusman, Gerardo / Sipmann, Fernando Suarez / Böhm, Stephan H

    The Journal of physiology

    2024  Volume 602, Issue 9, Page(s) 1855–1861

    MeSH term(s) Reflex/physiology ; Humans ; Animals
    Language English
    Publishing date 2024-04-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 3115-x
    ISSN 1469-7793 ; 0022-3751
    ISSN (online) 1469-7793
    ISSN 0022-3751
    DOI 10.1113/JP286490
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Ultrasound-guided brachiocephalic vein access in neonates and pediatric patients.

    Acosta, C M / Tusman, G

    Revista espanola de anestesiologia y reanimacion

    2021  

    Abstract: Central venous accesses in neonates and pediatric patients represent a common and important procedure for both, intraoperative and postoperative care. Point-of-care ultrasound-guided technique has been proposed to increased success rate and efficiency, ... ...

    Title translation Accesos vasculares ecoguiados de la vena braquiocefálica en neonatos y pacientes pediátricos.
    Abstract Central venous accesses in neonates and pediatric patients represent a common and important procedure for both, intraoperative and postoperative care. Point-of-care ultrasound-guided technique has been proposed to increased success rate and efficiency, as well as to decrease the number of complications. Ultrasound-guided internal jugular vein cannulation is considering the "gold standard" in children. Another central venous cannulation option in neonates and children has been supraclavicular ultrasound-guided cannulation of the brachiocephalic vein using the in-plane approach. This article gives a review of the current evidence, the basic knowledge of the technique and the structured approach to follow for supraclavicular ultrasound-guided brachiocephalic vein access in children and neonates.
    Language Spanish
    Publishing date 2021-04-27
    Publishing country Spain
    Document type Journal Article
    ISSN 2341-1929
    ISSN (online) 2341-1929
    DOI 10.1016/j.redar.2020.10.016
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  4. Article ; Online: Ultrasound-guided brachiocephalic vein access in neonates and pediatric patients.

    Acosta, C M / Tusman, G

    Revista espanola de anestesiologia y reanimacion

    2021  Volume 68, Issue 10, Page(s) 584–591

    Abstract: Central venous accesses in neonates and pediatric patients represent a common and important procedure for both, intraoperative and postoperative care. Point-of-care ultrasound-guided technique has been proposed to increased success rate and efficiency, ... ...

    Abstract Central venous accesses in neonates and pediatric patients represent a common and important procedure for both, intraoperative and postoperative care. Point-of-care ultrasound-guided technique has been proposed to increased success rate and efficiency, as well as to decrease the number of complications. Ultrasound-guided internal jugular vein cannulation is considering the "gold standard" in children. Another central venous cannulation option in neonates and children has been supraclavicular ultrasound-guided cannulation of the brachiocephalic vein using the in-plane approach. This article gives a review of the current evidence, the basic knowledge of the technique and the structured approach to follow for supraclavicular ultrasound-guided brachiocephalic vein access in children and neonates.
    MeSH term(s) Brachiocephalic Veins/diagnostic imaging ; Catheterization, Central Venous ; Child ; Humans ; Infant, Newborn ; Jugular Veins/diagnostic imaging ; Ultrasonography ; Ultrasonography, Interventional
    Language English
    Publishing date 2021-11-25
    Publishing country Spain
    Document type Journal Article ; Review
    ISSN 2341-1929
    ISSN (online) 2341-1929
    DOI 10.1016/j.redare.2020.10.011
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  5. Article ; Online: Effects of apparatus dead space on volumetric capnograms in neonates with healthy lungs: a simulation study.

    Campos, Marcelo D / Palazzi, Lucio H / Böhm, Stephan H / Tusman, Gerardo

    Paediatric anaesthesia

    2023  Volume 33, Issue 11, Page(s) 973–982

    Abstract: Background: Volumetric capnography in healthy ventilated neonates showed deformed waveforms, which are supposedly due to technological limitations of flow and carbon dioxide sensors.: Aims: This bench study analyzed the role of apparatus dead space ... ...

    Abstract Background: Volumetric capnography in healthy ventilated neonates showed deformed waveforms, which are supposedly due to technological limitations of flow and carbon dioxide sensors.
    Aims: This bench study analyzed the role of apparatus dead space on the shape of capnograms in simulated neonates with healthy lungs.
    Methods: We simulated mechanical breaths in neonates of 2, 2.5, and 3 kg of body weight using a neonatal volumetric capnography simulator. The simulator was fed by a fixed amount of carbon dioxide of 6 mL/kg/min. Such simulator was ventilated in a volume control mode using fixed ventilatory settings with a tidal volume of 8 mL/kg and respiratory rates of 40, 35, and 30 breaths per minute for the 2, 2.5 and 3 kg neonates, respectively. We tested the above baseline ventilation with and without an additional apparatus dead space of 4 mL.
    Results: Simulations showed that adding the apparatus dead space to baseline ventilation increased the amount of re-inhaled carbon dioxide in all neonates: 0.16 ± 0.01 to 0.32 ± 0.03 mL (2 kg), 0.14 ± 0.02 to 0.39 ± 0.05 mL (2.5 kg), and 0.13 ± 0.01 to 0.36 ± 0.05 mL (3 kg); (p < .001). Apparatus dead space was computed as part of the airway dead space, and therefore, the ratio of airway dead space to tidal volume increased from 0.51 ± 0.04 to 0.68 ± 0.06, from 0.43 ± 0.04 to 0.62 ± 0.01 and from 0.38 ± 0.01 to 0.60 ± 0.02 in the 2, 2.5 and 3 kg simulated neonates, respectively (p < .001). Compared to baseline ventilation, adding apparatus dead space decreased the ratio of the volume of phase III to V
    Conclusions: The addition of a small apparatus dead space artificially deformed the volumetric capnograms in simulated neonates with healthy lungs.
    MeSH term(s) Infant, Newborn ; Humans ; Carbon Dioxide ; Respiration, Artificial ; Respiratory Dead Space ; Lung ; Tidal Volume ; Capnography
    Chemical Substances Carbon Dioxide (142M471B3J)
    Language English
    Publishing date 2023-07-04
    Publishing country France
    Document type Journal Article
    ZDB-ID 1086049-6
    ISSN 1460-9592 ; 1155-5645
    ISSN (online) 1460-9592
    ISSN 1155-5645
    DOI 10.1111/pan.14724
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  6. Article: Impact of respiratory cycle during mechanical ventilation on beat-to-beat right ventricle stroke volume estimation by pulmonary artery pulse wave analysis.

    Santos, Arnoldo / Monge-García, M Ignacio / Borges, João Batista / Retamal, Jaime / Tusman, Gerardo / Larsson, Anders / Suarez-Sipmann, Fernando

    Intensive care medicine experimental

    2024  Volume 12, Issue 1, Page(s) 34

    Abstract: Background: The same principle behind pulse wave analysis can be applied on the pulmonary artery (PA) pressure waveform to estimate right ventricle stroke volume (RVSV). However, the PA pressure waveform might be influenced by the direct transmission of ...

    Abstract Background: The same principle behind pulse wave analysis can be applied on the pulmonary artery (PA) pressure waveform to estimate right ventricle stroke volume (RVSV). However, the PA pressure waveform might be influenced by the direct transmission of the intrathoracic pressure changes throughout the respiratory cycle caused by mechanical ventilation (MV), potentially impacting the reliability of PA pulse wave analysis (PA
    Methods: Continuous PA pressure and flow were simultaneously measured for 2-3 min in 5 pigs using a high-fidelity micro-tip catheter and a transonic flow sensor around the PA trunk, both pre and post an experimental ARDS model. RVSV was estimated by PA
    Results: The reliability of PA
    Conclusions: In our experimental model, we confirmed that correcting for mechanical ventilation induced changes during the respiratory cycle improves the performance of PA
    Language English
    Publishing date 2024-04-09
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2740385-3
    ISSN 2197-425X
    ISSN 2197-425X
    DOI 10.1186/s40635-024-00618-7
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  7. Article ; Online: Development of a Novel Infant Volumetric Capnography Simulator: Making the Invisible Visible Improves Understanding and Safety.

    Campos, Marcelo D / Bonardi, Ariel / Palazzi, Lucio H / Madorno, Matías / Böhm, Stephan H / Tusman, Gerardo

    Simulation in healthcare : journal of the Society for Simulation in Healthcare

    2023  

    Abstract: Methods: An infant lung simulator was fed with CO2 supplied by a mass flow controller (VCO2-IN) and ventilated using standard settings. A volumetric capnograph was placed between the endotracheal tube and the ventilatory circuit. We simulated ventilated ...

    Abstract Methods: An infant lung simulator was fed with CO2 supplied by a mass flow controller (VCO2-IN) and ventilated using standard settings. A volumetric capnograph was placed between the endotracheal tube and the ventilatory circuit. We simulated ventilated babies of different body weights (2, 2.5, 3, and 5 kg) with a VCO2 ranging from 12 to 30 mL/min. The correlation coefficient (r2), bias, coefficient of variation (CV = SD/x × 100), and precision (2 × CV) between the VCO2-IN and the elimination of CO2 recorded by the capnograph (VCO2-OUT) were calculated. The quality of the capnogram's waveforms was compared with real ones belonging to anesthetized infants using an 8-point scoring system, where 6 points or greater meant that the simulated capnogram showed good, 5 to 3 points acceptable, and less than 3 points an unacceptable shape.
    Results: The correlation between VCO2-IN and VCO2-OUT was r2 = 0.9953 (P < 0.001), with a bias of 0.16 (95% confidence intervals from 0.12 to 0.20) mL/min. The CV was 5% or less and the precision was 10% or less. All simulated capnograms showed similar shapes compared with real babies, scoring 6 points for 3 kg and 6.5 points for 2-, 2.5-, and 5-kg babies.
    Conclusions: The simulator of volumetric capnograms was reliable, accurate, and precise for simulating the CO2 kinetics of ventilated infants.
    Language English
    Publishing date 2023-02-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2223429-9
    ISSN 1559-713X ; 1559-2332
    ISSN (online) 1559-713X
    ISSN 1559-2332
    DOI 10.1097/SIH.0000000000000717
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  8. Article ; Online: Mechanical ventilation in lung injury caused by SARS-CoV-2: What can contribute volumetric capnography?

    Turchetto, E S / Tusman, G / Makinistian, R L

    Revista espanola de anestesiologia y reanimacion

    2020  Volume 68, Issue 2, Page(s) 116–118

    Title translation Ventilación mecánica en daño pulmonar por SARS-CoV-2: ¿qué puede aportar la capnografía volumétrica?
    MeSH term(s) COVID-19 ; Capnography ; Humans ; Lung Injury ; Phenotype ; Respiration, Artificial ; SARS-CoV-2
    Language Spanish
    Publishing date 2020-05-23
    Document type Letter ; Comment
    ISSN 2341-1929
    ISSN (online) 2341-1929
    DOI 10.1016/j.redar.2020.05.008
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  9. Article ; Online: COVID-19: cómo transformar un ventilador de no invasiva en un ventilador de críticos.

    Tusman, G / Campos, M / Gogniat, E

    Revista espanola de anestesiologia y reanimacion

    2020  Volume 67, Issue 7, Page(s) 367–373

    Abstract: COVID-19 pandemic caused not only many deaths around the world but also made evident technical limitations of hospital and intensive care units (ICU). The growing demand of ICU ventilators in a short lapse of time constitutes one of the main community ... ...

    Title translation COVID-19: how to transform a noninvasive ventilation device in a critical care ventilator.
    Abstract COVID-19 pandemic caused not only many deaths around the world but also made evident technical limitations of hospital and intensive care units (ICU). The growing demand of ICU ventilators in a short lapse of time constitutes one of the main community concerns. The main goal of this communication is to give simple solutions to transform a noninvasive ventilator in an invasive one for intubated patients. The proposal can be applied in two well defined strategies for the COVID-19 pandemic: To replace anesthesia workstations, leaving those machines to be used in patients. To apply this option in COVID-19 patients by way of a therapeutic "bridge", waiting for the release of a ventilator in the ICU.
    MeSH term(s) Betacoronavirus ; COVID-19 ; Carbon Dioxide/metabolism ; Coronavirus Infections/therapy ; Critical Care ; Equipment Design/methods ; Filtration/instrumentation ; Humans ; Inhalation ; Noninvasive Ventilation/instrumentation ; Pandemics ; Pneumonia, Viral/therapy ; Respiration, Artificial/instrumentation ; SARS-CoV-2 ; Simulation Training ; Ventilators, Mechanical/supply & distribution
    Chemical Substances Carbon Dioxide (142M471B3J)
    Keywords covid19
    Language Spanish
    Publishing date 2020-05-15
    Document type Journal Article
    ISSN 2341-1929
    ISSN (online) 2341-1929
    DOI 10.1016/j.redar.2020.05.002
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  10. Article ; Online: Photoplethysmography waveform analysis for classification of vascular tone and arterial blood pressure: Study based on neural networks.

    Echeverría, N I / Scandurra, A G / Acosta, C M / Meschino, G J / Suarez Sipmann, F / Tusman, G

    Revista espanola de anestesiologia y reanimacion

    2023  Volume 70, Issue 4, Page(s) 209–217

    Abstract: Background: To test whether a Shallow Neural Network (S-NN) can detect and classify vascular tone dependent changes in arterial blood pressure (ABP) by advanced photopletysmographic (PPG) waveform analysis.: Methods: PPG and invasive ABP signals were ...

    Abstract Background: To test whether a Shallow Neural Network (S-NN) can detect and classify vascular tone dependent changes in arterial blood pressure (ABP) by advanced photopletysmographic (PPG) waveform analysis.
    Methods: PPG and invasive ABP signals were recorded in 26 patients undergoing scheduled general surgery. We studied the occurrence of episodes of hypertension (systolic arterial pressure (SAP) >140 mmHg), normotension and hypotension (SAP < 90 mmHg). Vascular tone according to PPG was classified in two ways: 1) By visual inspection of changes in PPG waveform amplitude and dichrotic notch position; where Classes I-II represent vasoconstriction (notch placed >50% of PPG amplitude in small amplitude waves), Class III normal vascular tone (notch placed between 20-50% of PPG amplitude in normal waves) and Classes IV-V-VI vasodilation (notch <20% of PPG amplitude in large waves). 2) By an automated analysis, using S-NN trained and validated system that combines seven PPG derived parameters.
    Results: The visual assessment was precise in detecting hypotension (sensitivity 91%, specificity 86% and accuracy 88%) and hypertension (sensitivity 93%, specificity 88% and accuracy 90%). Normotension presented as a visual Class III (III-III) (median and 1st-3rd quartiles), hypotension as a Class V (IV-VI) and hypertension as a Class II (I-III); all p < .0001. The automated S-NN performed well in classifying ABP conditions. The percentage of data with correct classification by S-ANN was 83% for normotension, 94% for hypotension, and 90% for hypertension.
    Conclusions: Changes in ABP were correctly classified automatically by S-NN analysis of the PPG waveform contour.
    MeSH term(s) Humans ; Arterial Pressure ; Photoplethysmography ; Hypertension/diagnosis ; Hypotension/diagnosis ; Neural Networks, Computer
    Language English
    Publishing date 2023-02-27
    Publishing country Spain
    Document type Journal Article
    ISSN 2341-1929
    ISSN (online) 2341-1929
    DOI 10.1016/j.redare.2022.01.010
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