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Article ; Online: Alcohol-induced hormonal and metabolic alterations in plasma and erythrocytes-a gender-based study.

Lonappan, Daisy Kunnathuparambil / Kuruvalli, Gouthami / Shaik, Althaf Hussain / Hebbani, Ananda Vardhan / Reddyvari, Hymavathi / Damodara Reddy, Vaddi / Vadamalai, Veeraraghavan

Toxicology mechanisms and methods

2023 , Page(s) 1–9

Abstract: Purpose: ...

Abstract	Purpose:
Language	English
Publishing date	2023-11-29
Publishing country	England
Document type	Journal Article
ZDB-ID	2081252-8
ISSN	1537-6524 ; 1537-6516 ; 1051-7235
ISSN (online)	1537-6524
ISSN	1537-6516 ; 1051-7235
DOI	10.1080/15376516.2023.2290071
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Article ; Online: Bioremediation of greywater using a novel bacterial-fungal consortium: optimization and validation of the operating parameters

Rajpal, Nikita / Ratan, Jatinder K / Divya, Neetu / Hebbani, Ananda Vardhan

Environmental technology

2021 Volume 43, Issue 16, Page(s) 2430–2442

Abstract: In the present study, removal of pollutants in greywater was investigated using a novel bacterial-fungal consortium. Response surface methodology was used for the optimization of process variables like pH, temperature, inoculum size, and Carbon/Nitrogen ( ...

Abstract	In the present study, removal of pollutants in greywater was investigated using a novel bacterial-fungal consortium. Response surface methodology was used for the optimization of process variables like pH, temperature, inoculum size, and Carbon/Nitrogen (C/N ratio) for degradation of pollutants. Experiments were based on Box Behnken statistical design and the results show a good fit with the quadratic model, coefficient of determination (
MeSH term(s)	Biodegradation, Environmental ; Biological Oxygen Demand Analysis ; Environmental Pollutants ; Reproducibility of Results ; Sulfates ; Water Pollutants, Chemical
Chemical Substances	Environmental Pollutants ; Sulfates ; Water Pollutants, Chemical
Language	English
Publishing date	2021-02-11
Publishing country	England
Document type	Journal Article
ISSN	1479-487X
ISSN (online)	1479-487X
DOI	10.1080/09593330.2021.1882582
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Article: Protective effect of Terminalia arjuna against alcohol induced oxidative damage of rat erythrocyte membranes.

Hebbani, Ananda Vardhan / Vaddi, Damodara Reddy / Dd, Padma Priya / NCh, Varadacharyulu

Journal of Ayurveda and integrative medicine

2021 Volume 12, Issue 2, Page(s) 330–339

Abstract: Background: Alcohol is a widely abused drug with many health implications, mainly caused by the oxidative and nitrosative stress on different body parts. Ayurvedic herbalism authenticates the multiple therapeutic applications of Terminalia arjuna bark ... ...

Abstract	Background: Alcohol is a widely abused drug with many health implications, mainly caused by the oxidative and nitrosative stress on different body parts. Ayurvedic herbalism authenticates the multiple therapeutic applications of Terminalia arjuna bark due to its rich phytochemical repertoire. Objective: To observe the extent of oxidative damage caused to erythrocytes by alcohol and assess the protective ability of T. arjuna bark powder aqueous extract (AETA) against the damage. Materials and methods: Wister albino rats were categorized into four groups of eight rats per group; first group (control) was fed with glucose, second group was given alcohol at a dose of 20% v/v; 5g alcohol/kg b. wt/day, third group was co-administered with AETA (0.5 g/kg b. wt/day) and alcohol and the fourth group was kept on bark extract alone. Blood samples were collected and evaluated for different biochemical parameters after the completion of the treatment period. Results: Alcohol significantly increased the erythrocyte membrane protein carbonyl and malondialdehyde (MDA) contents, along with a concomitant decrease in the membrane antioxidant status, when compared to the control group. Chromatographic analysis of the alcohol-treated rat erythrocyte membranes revealed altered membrane individual phospholipid contents and fluidity properties. Alcohol-induced morphological changes in the erythrocytes and its effect on decreasing the resistance of hypotonic shock induced by NaCl are evident from the hemolysis curves. However, AETA administration to alcoholic rats beneficially modulated the membrane properties anvd protected erythrocytes from damage. Conclusion: Results suggest that AETA protects erythrocytes from alcohol-induced oxidative stress, biophysical, and biochemical changes very effectively.
Language	English
Publishing date	2021-03-14
Publishing country	United States
Document type	Journal Article
ISSN	0975-9476
ISSN	0975-9476
DOI	10.1016/j.jaim.2021.02.001
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Article ; Online: Targeting cytokine storm as the potential anti-viral therapy: Implications in regulating SARS-CoV-2 pathogenicity.

Maity, Subhasish / Santra, Ayantika / Hebbani, Ananda Vardhan / Pulakuntla, Swetha / Chatterjee, Ankita / Badri, Kameswara Rao / Damodara Reddy, Vaddi

Gene

2023 Volume 881, Page(s) 147612

Abstract: The latest global pandemic corona virus disease - 2019 (COVID-19) caused by the virus SARS-CoV-2 is still a matter of worrying concern both for the scientific communities and health care organizations. COVID-19 disease is proved to be a highly contagious ...

Abstract	The latest global pandemic corona virus disease - 2019 (COVID-19) caused by the virus SARS-CoV-2 is still a matter of worrying concern both for the scientific communities and health care organizations. COVID-19 disease is proved to be a highly contagious disease transmitted through respiratory droplets and even close contact with affected individuals. COVID-19 disease is also understood to exhibit diverse symptoms of ranging severities i.e., from mild fatigue to death. Affected individuals' susceptibility to induce immunologic dysregulation phenomena termed 'cytokine storm' seems to be playing the damaging role of escalating the disease manifestation from mild to severe. Cytokine storm in patients with severe symptoms is understood to be characterized by enhanced serum levels of many cytokines including interleukin-1β, interleukin-6, IP-10/CXCL10, TNF, interferon-γ, MIP-1α, MIP-1β and VEGF. Since cytokine production in general is the most important antiviral defense response, understanding the COVID-19 associated cytokine storm in particular and differentiating it from the regular cytokine production response becomes crucial in developing an effective therapeutic strategy.This review focuses on the potential targeting of COVID-19 associated cytokine storm and its challenges.
MeSH term(s)	Humans ; SARS-CoV-2 ; COVID-19 ; Virulence ; Cytokines ; Antiviral Agents/therapeutic use
Chemical Substances	Cytokines ; Antiviral Agents
Language	English
Publishing date	2023-07-08
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	391792-7
ISSN	1879-0038 ; 0378-1119
ISSN (online)	1879-0038
ISSN	0378-1119
DOI	10.1016/j.gene.2023.147612
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Article ; Online: Targeting cytokine storm as the potential anti-viral therapy: Implications in regulating SARS-CoV-2 pathogenicity

Maity, Subashish / Santra, Ayantika / Vardhan Hebbani, Ananda / Pulakuntla, Swetha / Chatterjee, Ankita / Rao Badri, Kameswara / Damodara Reddy, Vaddi

Gene. 2023 July 08, p.147612-

2023 , Page(s) 147612–

Abstract	The latest global pandemic corona virus disease - 2019 (COVID-19) caused by the virus SARS-CoV-2 is still a matter of worrying concern both for the scientific communities and health care organizations. COVID-19 disease is proved to be a highly contagious disease transmitted through respiratory droplets and even close contact with affected individuals. COVID-19 disease is also understood to exhibit diverse symptoms of ranging severities i.e., from mild fatigue to death. Affected individuals' susceptibility to induce immunologic dysregulation phenomena termed ‘cytokine storm’ seems to be playing the damaging role of escalating the disease manifestation from mild to severe. Cytokine storm in patients with severe symptoms is understood to be characterized by enhanced serum levels of many cytokines including interleukin-1β, interleukin-6, IL-10, TNF, interferon-γ, MIP-1α, MIP-1β and VEGF. Since cytokine production in general is the most important antiviral defense response, understanding the COVID-19 associated cytokine storm in particular and differentiating it from the regular cytokine production response becomes crucial in developing an effective therapeutic strategy.This review focuses on the potential targeting of COVID-19 associated cytokine storm and its challenges.
Keywords	COVID-19 infection ; Severe acute respiratory syndrome coronavirus 2 ; blood serum ; death ; genes ; health services ; interleukin-10 ; interleukin-6 ; pandemic ; pathogenicity ; therapeutics ; viruses ; COVID-19 Disease ; SARS-CoV-2 ; cytokine storm ; COVID-19 ; IL ; TNF ; MIP ; INF ; WHO ; MERS-CoV ; ACE2 ; TMPRSS ; ARDS ; CRS ; CRP ; HSPCs ; TLRs
Language	English
Dates of publication	2023-0708
Publishing place	Elsevier B.V.
Document type	Article ; Online
Note	Pre-press version
ZDB-ID	391792-7
ISSN	1879-0038 ; 0378-1119
ISSN (online)	1879-0038
ISSN	0378-1119
DOI	10.1016/j.gene.2023.147612
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Article: Bioremediation of greywater using a novel bacterial–fungal consortium: optimization and validation of the operating parameters in vitro

Rajpal, Nikita / Ratan, Jatinder K. / Divya, Neetu / Hebbani, Ananda Vardhan

Environmental technology. 2022 July 16, v. 43, no. 16

2022

Abstract: In the present study, removal of pollutants in greywater was investigated using a novel bacterial–fungal consortium. Response surface methodology was used for the optimization of process variables like pH, temperature, inoculum size, and Carbon/Nitrogen ( ...

Abstract	In the present study, removal of pollutants in greywater was investigated using a novel bacterial–fungal consortium. Response surface methodology was used for the optimization of process variables like pH, temperature, inoculum size, and Carbon/Nitrogen (C/N ratio) for degradation of pollutants. Experiments were based on Box Behnken statistical design and the results show a good fit with the quadratic model, coefficient of determination (R ²) value of 0.9499. The reliability of the model was established by various statistical parameters like lack of fit, pure error, and residual sum of squares. The optimized conditions for maximum reduction in chemical oxygen demand, oil & grease and sulphate were found to be 78.7%, 82.6% and 89.7%, respectively after 96 h of incubation of the reaction mixture at pH 7; temperature 35°C; inoculum size 150 µl and C/N ratio of 1:2. Our results clearly demonstrate that the developed novel bacterial–fungal consortium can be a cost-effective, safe, and environment-friendly alternative for remediation of greywater.
Keywords	bioremediation ; carbon ; chemical oxygen demand ; cost effectiveness ; environmental technology ; greywater ; inoculum ; models ; nitrogen ; oils ; pH ; response surface methodology ; sulfates ; temperature
Language	English
Dates of publication	2022-0716
Size	p. 2430-2442.
Publishing place	Taylor & Francis
Document type	Article
ISSN	1479-487X
DOI	10.1080/09593330.2021.1882582
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: COVID-19: comprehensive review on mutations and current vaccines

Hebbani, Ananda Vardhan / Pulakuntla, Swetha / Pannuru, Padmavathi / Aramgam, Sreelatha / Badri, Kameswara Rao / Reddy, Vaddi Damodara

Arch Microbiol. 2022 Jan., v. 204, no. 1 p.8-8

2022

Abstract: Viral outbreaks had been a threat for the human race for a long time. Several epidemics and pandemics have been reported in the past with serious consequences on human health and subsequent social and economic aspects. According to WHO, viral infections ... ...

Abstract	Viral outbreaks had been a threat for the human race for a long time. Several epidemics and pandemics have been reported in the past with serious consequences on human health and subsequent social and economic aspects. According to WHO, viral infections continue to be a major health concern globally. Novel coronavirus, SARS-CoV-2 (Severe acute respiratory syndrome coronavirus-2) causes the most recent infectious pandemic disease, COVID-19 (Coronavirus disease-19). As of now, there were 249 million infections of COVID-19 worldwide with a high mortality of more than 5 million deaths reported; and the number of new additional cases is drastically increasing. Development of therapies to treat the infected cases and prophylactic agents including vaccines that are effective towards different variants are crucial to curtail the COVID-19 pandemic. Owing to the fact that there is a high mortality and morbidity rate along with the risk of virus causing further epidemic outbursts, development of additional effective therapeutic and preventive strategies are highly warranted. Prevention, early detection and treatment will reduce the spread of COVID-19 pandemic. The present review highlights the novel mutations and therapeutic updates associated with coronaviruses along with the clinical manifestations—diagnosis, clinical management and, prophylactic and therapeutic strategies of COVID-19 infection.
Keywords	COVID-19 infection ; Severe acute respiratory syndrome coronavirus 2 ; human health ; humans ; morbidity ; mortality ; pandemic ; risk ; therapeutics ; viruses
Language	English
Dates of publication	2022-01
Size	p. 8.
Publishing place	Springer Berlin Heidelberg
Document type	Article ; Online
Note	Review
ZDB-ID	124824-8
ISSN	1432-072X ; 0302-8933
ISSN (online)	1432-072X
ISSN	0302-8933
DOI	10.1007/s00203-021-02606-x
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Article: Evaluation of cadmium biosorption property of de-oiled palm kernel cake

Hebbani, Ananda Vardhan / Anantha, Ratnakumari / Kasaba Manjunath, Gowrang / Kulkarni, Ashwini / Sam, Ria / Mishra, Anshu

International journal of phytoremediation. 2021 Apr. 16, v. 23, no. 5

2021

Abstract: Cadmium contamination is a global concern because of its widespread nature of polluting both biotic and abiotic components of ecosystem. Though many natural, chemical/synthetic components have been researched for remediation of cadmium, development of an ...

Abstract	Cadmium contamination is a global concern because of its widespread nature of polluting both biotic and abiotic components of ecosystem. Though many natural, chemical/synthetic components have been researched for remediation of cadmium, development of an eco-friendly, economic biosorbent still remains a challenge. Deoiled palm kernel cake (DOPC), a byproduct from palm-oil mills was investigated in the present study for its cadmium remediating capacity. DOPC was immobilized using sodium alginate polymer and biosorption studies were carried out using DOPC as adsorbent for removal of cadmium. Research revealed biosorption potential of DOPC and the optimum conditions for maximum biosorption of cadmium have been identified as 120 min of contact time, 150 rpm of agitation speed, pH 6 and 15 mg/L of initial cadmium concentration. Maximum percentage of adsorption was 99% by using 1.5 g/100 ml of adsorbent. The adsorption equilibrium data Biosorbent was characterized before and after adsorption by FTIR which showed the involvement of carboxyl, hydroxyl and amino-groups. Statement of novelty Cadmium pollution and the leading environmental problems is a global concern. Despite various attempts for development of different matrices for remediation of cadmium from contaminated samples, application of deoiled palm kernel cake (DOPC) as a biosorbent is not being explored. Present study provides quantitative data relating the richness of phytochemical repertoire DOPC possess, its resulting radical scavenging potential and its applications as an efficient, eco-friendly and economic alternative as a biosorbent matrix material for cadmium bio-remediation.
Keywords	adsorbents ; adsorption ; agitation ; biosorbents ; biosorption ; byproducts ; cadmium ; ecosystems ; pH ; palm kernel cake ; phytochemicals ; phytoremediation ; pollution ; polymers ; sodium alginate
Language	English
Dates of publication	2021-0416
Size	p. 522-529.
Publishing place	Taylor & Francis
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	2055357-2
ISSN	1549-7879 ; 1522-6514
ISSN (online)	1549-7879
ISSN	1522-6514
DOI	10.1080/15226514.2020.1829544
Database	NAL-Catalogue (AGRICOLA)

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Article: Protective effect of Terminalia arjuna against alcohol induced oxidative damage of rat erythrocyte membranes

Hebbani, Ananda Vardhan / Vaddi, Damodara Reddy / DD, Padma Priya / NCh, Varadacharyulu

Journal of Ayurveda and integrative medicine. 2021 Feb. 11,

2021

Abstract: Alcohol is a widely abused drug with many health implications, mainly caused by the oxidative and nitrosative stress on different body parts. Ayurvedic herbalism authenticates the multiple therapeutic applications of Terminalia arjuna bark due to its ... ...

Abstract	Alcohol is a widely abused drug with many health implications, mainly caused by the oxidative and nitrosative stress on different body parts. Ayurvedic herbalism authenticates the multiple therapeutic applications of Terminalia arjuna bark due to its rich phytochemical repertoire.To observe the extent of oxidative damage caused to erythrocytes by alcohol and assess the protective ability of T. arjuna bark powder aqueous extract (AETA) against the damage.Wister albino rats were categorized into four groups of eight rats per group; first group (control) was fed with glucose, second group was given alcohol at a dose of 20% v/v; 5g alcohol/kg b. wt/day, third group was co-administered with AETA (0.5 g/kg b. wt/day) and alcohol and the fourth group was kept on bark extract alone. Blood samples were collected and evaluated for different biochemical parameters after the completion of the treatment period.Alcohol significantly increased the erythrocyte membrane protein carbonyl and malondialdehyde (MDA) contents, along with a concomitant decrease in the membrane antioxidant status, when compared to the control group. Chromatographic analysis of the alcohol-treated rat erythrocyte membranes revealed altered membrane individual phospholipid contents and fluidity properties. Alcohol-induced morphological changes in the erythrocytes and its effect on decreasing the resistance of hypotonic shock induced by NaCl are evident from the hemolysis curves. However, AETA administration to alcoholic rats beneficially modulated the membrane properties anvd protected erythrocytes from damage.Results suggest that AETA protects erythrocytes from alcohol-induced oxidative stress, biophysical, and biochemical changes very effectively.
Keywords	Ayurvedic medicine ; Terminalia arjuna ; albino ; alcohols ; antioxidants ; bark ; bark extracts ; chromatography ; erythrocyte membrane ; erythrocytes ; glucose ; hemolysis ; illicit drugs ; malondialdehyde ; membrane proteins ; oxidative stress ; phospholipids ; phytochemicals ; protective effect ; rats ; therapeutics
Language	English
Dates of publication	2021-0211
Publishing place	Elsevier B.V.
Document type	Article
Note	NAL-light ; Pre-press version
ISSN	0975-9476
DOI	10.1016/j.jaim.2021.02.001
Database	NAL-Catalogue (AGRICOLA)

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Article: In

Prabhakaran, Prejwal / Hebbani, Ananda Vardhan / Menon, Soumya V / Paital, Biswaranjan / Murmu, Sneha / Kumar, Sunil / Singh, Mahender Kumar / Sahoo, Dipak Kumar / Desai, Padma Priya Dharmavaram

Frontiers in microbiology

2023 Volume 14, Page(s) 1194794

Abstract: The recent emergence of novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing the coronavirus disease (COVID-19) has become a global public health crisis, and a crucial need exists for rapid identification and development of novel ... ...

Abstract	The recent emergence of novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing the coronavirus disease (COVID-19) has become a global public health crisis, and a crucial need exists for rapid identification and development of novel therapeutic interventions. In this study, a recurrent neural network (RNN) is trained and optimized to produce novel ligands that could serve as potential inhibitors to the SARS-CoV-2 viral protease: 3 chymotrypsin-like protease (3CL
Language	English
Publishing date	2023-06-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2023.1194794
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