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Article ; Online: Candida auris

Chowdhary, Anuradha / Jain, Kusum / Chauhan, Neeraj

2023 Volume 77, Page(s) 583–602

Abstract: ... Candida ... ...

Abstract	Candida auris
MeSH term(s)	Humans ; Aged ; Candida/genetics ; Candida auris ; Antifungal Agents/pharmacology ; Antifungal Agents/therapeutic use ; Echinocandins ; Amphotericin B
Chemical Substances	Antifungal Agents ; Echinocandins ; Amphotericin B (7XU7A7DROE)
Language	English
Publishing date	2023-07-05
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, N.I.H., Extramural
ZDB-ID	207931-8
ISSN	1545-3251 ; 0066-4227
ISSN (online)	1545-3251
ISSN	0066-4227
DOI	10.1146/annurev-micro-032521-015858
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Article ; Online: Genetic Enhancement of Cereals Using Genomic Resources for Nutritional Food Security.

Chaudhary, Neeraj / Salgotra, Romesh Kumar / Chauhan, Bhagirath Singh

Genes

2023 Volume 14, Issue 9

Abstract: Advances in genomics resources have facilitated the evolution of cereal crops with enhanced yield, improved nutritional values, and heightened resistance to various biotic and abiotic stresses. Genomic approaches present a promising avenue for the ... ...

Abstract	Advances in genomics resources have facilitated the evolution of cereal crops with enhanced yield, improved nutritional values, and heightened resistance to various biotic and abiotic stresses. Genomic approaches present a promising avenue for the development of high-yielding varieties, thereby ensuring food and nutritional security. Significant improvements have been made within the omics domain, specifically in genomics, transcriptomics, and proteomics. The advent of Next-Generation Sequencing (NGS) techniques has yielded an immense volume of data, accompanied by substantial progress in bioinformatic tools for proficient analysis. The synergy between genomics and computational tools has been acknowledged as pivotal for unravelling the intricate mechanisms governing genome-wide gene regulation. Within this review, the essential genomic resources are delineated, and their harmonization in the enhancement of cereal crop varieties is expounded upon, with a paramount focus on fulfilling the nutritional requisites of humankind. Furthermore, an encompassing compendium of the available genomic resources for cereal crops is presented, accompanied by an elucidation of their judicious utilization in the advancement of crop attributes.
MeSH term(s)	Edible Grain/genetics ; Genetic Enhancement ; Genomics ; Proteomics ; Computational Biology ; Crops, Agricultural/genetics
Language	English
Publishing date	2023-09-07
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527218-4
ISSN	2073-4425 ; 2073-4425
ISSN (online)	2073-4425
ISSN	2073-4425
DOI	10.3390/genes14091770
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Article ; Online: Comparison of modified Glasgow-Imrie, Ranson, and Apache II scoring systems in predicting the severity of acute pancreatitis.

Chauhan, Rohit / Saxena, Neeraj / Kapur, Neeti / Kardam, Dinesh

Polski przeglad chirurgiczny

2023 Volume 95, Issue 1, Page(s) 6–12

Abstract: ... Aim: ... The course of acute pancreatitis is variable with patients at risk of poor outcomes. The purpose of this study was to compare Modified Glasgow-Imrie, Ranson, and APACHE II scoring systems in predicting the severity of acute pancreatitis. ... ...

Abstract	Aim: The course of acute pancreatitis is variable with patients at risk of poor outcomes. The purpose of this study was to compare Modified Glasgow-Imrie, Ranson, and APACHE II scoring systems in predicting the severity of acute pancreatitis. Material and Methods: After a brief history, clinical examination and qualifying inclusion criteria, 70 patients (41 women, 29 men) diagnosed with acute pancreatitis were included in the study. The three scores were calculated for each patient and evaluated for their role in the assessment of specific outcomes. Results: 34.3% patients were diagnosed with severe acute pancreatitis, while 65.7% patients had mild acute pancreatitis. A strong positive correlation was found between all the prognostic scores and the severity of disease. In the prediction of the severity of disease according to AUC, it was found that Glasgow-Imrie score had an AUC of 0.864 (0.7560.973), followed very closely by APACHE II score with an AUC of 0.863 (0.7580.968). APACHE II had the highest sensitivity (79.17%) in predicting severity while Glasgow-Imrie score was the most specific (97.83%) of all the scores. Patients with a Glasgow-Imrie score above the cut-off value of 3 had more complications and a longer hospital stay. Conclusion: The Glasgow-Imrie score was comparable to APACHE II score and better than Ranson score statistically in predicting the severity of acute pancreatitis. Its administration in predicting the severity of acute pancreatitis is recommended.
MeSH term(s)	Male ; Humans ; Female ; APACHE ; Acute Disease ; Pancreatitis/diagnosis ; Length of Stay
Language	English
Publishing date	2023-02-18
Publishing country	Poland
Document type	Journal Article
ZDB-ID	128732-1
ISSN	2299-2847 ; 0032-373X
ISSN (online)	2299-2847
ISSN	0032-373X
DOI	10.5604/01.3001.0015.8384
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Article: The Predominance of Tobacco Propensities and Tobacco-Related Oral Lesions in Textile Mill Workers of Bhopal: A Cross-Sectional Study.

Kaur, Arshdeep / Chauhan, Neeraj S / Shivakumar, Sahana

Cureus

2023 Volume 15, Issue 6, Page(s) e41085

Abstract: Introduction: Low wages, long work hours, and stressful working conditions predominantly affect the oral and general health of industrial workers, which in turn result in their tobacco consumption. This cross-sectional study examined the prevalence of ... ...

Abstract	Introduction: Low wages, long work hours, and stressful working conditions predominantly affect the oral and general health of industrial workers, which in turn result in their tobacco consumption. This cross-sectional study examined the prevalence of tobacco use and its associated oral lesions among textile mill workers in Bhopal, India. Oral cancer and premalignant lesions are significantly increased by smoking and chewing tobacco. The study's objective was to assess and record the prevalence of oral mucosal lesions linked to tobacco use in different age groups among Bhopal textile industry workers. Methodology: A cross-sectional study was conducted among 583 textile mill workers. Data were collected using a questionnaire and the WHO Oral Health Assessment Form 2013. IBM SPSS Statistics for Windows, Version 29 (Released 2022; IBM Corp., Armonk, New York, United States) was used for the statistical analysis. Variables were compared using the mean, percentage, and standard deviation. The chi-square test and Fisher's exact test were used to compare the distribution of gender, tobacco habits, and oral mucosal lesions in different age groups. Results: Males made up 69.1% of the workforce. A clear male preference was noted (P ≤ 0.001). About 64.7% of the workers did not have any tobacco-related habits, 20.8% used smokeless tobacco, 7.9% used a smoking form of tobacco, and 6.7% used both. Older age groups, 31-45 and >46 years old, had a higher proportion of users of smokeless tobacco (P ≤ 0.001). The most commonly reported oral mucosal lesions were ulcerative conditions in 6.9%, followed by oral submucous fibrosis (OSMF), keratotic lesions, and leukoplakia in 5.0%, 4.1%, and 3.6% of the study population, respectively. Leukoplakia and OSMF were prevalent in the 31-45-year age group, while ulcerative lesions were more prevalent in the 18-30-year age group (P ≤ 0.001). Conclusion: Workers at textile mills were more likely to use a smokeless form of tobacco. Older age groups had higher rates of smokeless tobacco use as compared to smoking, which was more prevalent in the younger age group. Oral mucosal lesions in older age groups frequently include OSMF and leukoplakia. The main reasons for engaging in the tobacco use habit were stress and a lack of awareness. Oral hygiene was a neglected entity among workers.
Language	English
Publishing date	2023-06-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.41085
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Article ; Online: A hybrid B-spline collocation technique for the Caputo time fractional nonlinear Burgers’ equation

Mohammad Tamsir / Deependra Nigam / Neeraj Dhiman / Anand Chauhan

Beni-Suef University Journal of Basic and Applied Sciences, Vol 12, Iss 1, Pp 1-

2023 Volume 14

Abstract: Abstract Background This study proposes an efficient and stable technique based on new hybrid B-spline (HB-spline) functions for the numerical treatment of the Caputo time fractional nonlinear Burgers’ (TFNB) equation. The time derivative is discretized ... ...

Abstract	Abstract Background This study proposes an efficient and stable technique based on new hybrid B-spline (HB-spline) functions for the numerical treatment of the Caputo time fractional nonlinear Burgers’ (TFNB) equation. The time derivative is discretized using the definition of the Caputo derivative, whereas HB-spline functions are used to discretize the spatial derivatives. The Rubin–Graves technique is used to linearize the nonlinear terms. Results The performance and efficacy of the established method are tested using three examples. The graphical results represent the smoothness between numerical and exact solutions. The absolute errors are very low as $$1{0}^{-4}$$ 1 0 - 4 and $$1{0}^{-5}$$ 1 0 - 5 . The convergence rate shows that the proposed method is second-order accurate in space. Conclusions The proposed method provides better results than the methods available in the literature. The method yields highly accurate results and can handle large-scale problems, which is the novelty of the present work.
Keywords	Caputo TFNB equation ; HB-spline basis functions ; Stability analysis ; Convergence rate ; Medicine (General) ; R5-920 ; Science ; Q
Subject code	518
Language	English
Publishing date	2023-10-01T00:00:00Z
Publisher	SpringerOpen
Document type	Article ; Online
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Article: The

Shivarathri, Raju / Chauhan, Manju / Datta, Abhishek / Das, Diprasom / Karuli, Adela / Jenull, Sabrina / Kuchler, Karl / Thangamani, Shankar / Chowdhary, Anuradha / Desai, Jigar V / Chauhan, Neeraj

bioRxiv : the preprint server for biology

2024

Abstract: Candida auris: Importance: Candida ... ...

Abstract	Candida auris Importance: Candida auris
Language	English
Publishing date	2024-03-18
Publishing country	United States
Document type	Preprint
DOI	10.1101/2024.03.18.585572
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Article ; Online: Comparison of quality of life between pre- and post-operative standard laparoscopic cholecystectomy using Short Form-36

Nikhil Nakhate / Neeraj Kumar Banoria / Pankaj Saunakiya / Nalin Kumar / Jatin Chauhan / Shibin Geroge

Asian Journal of Medical Sciences, Vol 15, Iss 1, Pp 229-

2024 Volume 234

Abstract: Background: Gallstone disease (cholelithiasis) is a wide spectrum of conditions, ranging from asymptomatic cholelithiasis, biliary colic, empyema gallbladder, and gangrene to perforation and peritonitis. Aims and Objectives: The aim of this study was to ... ...

Abstract	Background: Gallstone disease (cholelithiasis) is a wide spectrum of conditions, ranging from asymptomatic cholelithiasis, biliary colic, empyema gallbladder, and gangrene to perforation and peritonitis. Aims and Objectives: The aim of this study was to assess the quality of life before and after a standard laparoscopic cholecystectomy (LC) using the Short Form-36 (SF-36). Materials and Methods: In the study cohort of 100 patients using SF-36 in patients of pre-operative and post-operative standard LC are compared in eight domains of health quality index in Maharani Laxmi Bai Medical College, Jhansi between January 2021 and June 2022. Results: There is finding of significant change in seven domains in mean±1 month, (1) Physical functioning – pre-operative and post-operative, that is, 33.00±31.812 and 88.68±22.40, respectively, (2) Role limitations due to physical health – pre-operative and post-operative, that is, 3.5±18.401 and 98.75±10.546, respectively, (3) Role limitations due to emotional problems – pre-operative and post-operative, that is, 4.67±21.128 and 98.67±11.489, respectively, (4) Energy/fatigue- pre-operative and post-operative, that is, 34.94±16.638 and 83.11±12.456, respectively, (5) Social pre-operative functioning – pre-operative and post-operative, that is, 39.38±20.428 and 98.88±5.196 respectively, (6) Pain – pre-operative and post-operative, that is, 34.73±18.340 and 97.30±15.489, respectively, (7) General health – pre-operative and post-operative, that is, 35.85±35.897 and 67.00±35.511, respectively, and minimal change in one domain (8) Emotional well-being – pre-operative and post-operative, that is, 34.16±15.491 and 39.08±18.694. Conclusion: The pre-operative and post-operative parameters of the SF-36 questionnaire show a significant change in their mean±standard deviation at 1-month postoperatively following standard LC. The maximum significant change occurred in parameters of physical functioning, role emotion, role physical, energy, social functioning, pain, and general health.
Keywords	gallstone disease ; laparoscopic cholecystectomy ; quality of life ; Medicine ; R
Subject code	027
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	Manipal College of Medical Sciences, Pokhara
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: One-step simultaneous liquid phase exfoliation-induced chirality in graphene and their chirality-mediated microRNA delivery.

Pranav / Ghali, Eswara N H K / Chauhan, Neeraj / Tiwari, Rahul / Cabrera, Marco / Chauhan, Subhash C / Yallapu, Murali M

Materials advances

2023 Volume 4, Issue 23, Page(s) 6199–6212

Abstract: Graphene (G) has established itself as an exciting prospect for a broad range of applications owing to its remarkable properties. Recent innovations in chiral nanosystems have led to sensors, drug delivery, catalysis, ...

Abstract	Graphene (G) has established itself as an exciting prospect for a broad range of applications owing to its remarkable properties. Recent innovations in chiral nanosystems have led to sensors, drug delivery, catalysis,
Language	English
Publishing date	2023-10-04
Publishing country	England
Document type	Journal Article
ISSN	2633-5409
ISSN (online)	2633-5409
DOI	10.1039/d3ma00611e
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Article ; Online: Two-component phosphorelays in fungal mitochondria and beyond.

Chauhan, Neeraj

Mitochondrion

2015 Volume 22, Page(s) 60–65

Abstract: Prokaryotes, eukaryotic microorganisms and plants utilize two-component signal transduction pathways to detect and respond to various environmental cues. These signaling cascades were acquired by eukaryotes via horizontal gene transfer events from ... ...

Abstract	Prokaryotes, eukaryotic microorganisms and plants utilize two-component signal transduction pathways to detect and respond to various environmental cues. These signaling cascades were acquired by eukaryotes via horizontal gene transfer events from ancestral bacteria. Recent exciting discoveries have identified two-component signaling systems in mitochondria and chloroplasts of several eukaryotic microorganisms and plants, therefore providing important clues to the evolutionary transition of these signaling cascades from prokaryotes to eukaryotes. This review will focus on the role of two-component signal transduction pathways in fungal pathogenesis and also discuss key new discoveries of presence of proteins participating in these signaling pathways in mitochondrion. Before addressing these issues, I first briefly describe the magnitude and the economic impact of the healthcare problems caused by fungal pathogens.
MeSH term(s)	Fungi/genetics ; Fungi/metabolism ; Fungi/pathogenicity ; Fungi/physiology ; Gene Expression Regulation ; Histidine Kinase ; Mitochondria/genetics ; Mitochondria/metabolism ; Mitochondria/physiology ; Phosphoproteins/metabolism ; Protein Kinases/metabolism ; Signal Transduction ; Virulence ; Virulence Factors/biosynthesis
Chemical Substances	Phosphoproteins ; Virulence Factors ; Protein Kinases (EC 2.7.-) ; Histidine Kinase (EC 2.7.13.1)
Language	English
Publishing date	2015-05
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2056923-3
ISSN	1872-8278 ; 1567-7249
ISSN (online)	1872-8278
ISSN	1567-7249
DOI	10.1016/j.mito.2015.03.003
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Article ; Online: A review of methods for detecting single-nucleotide polymorphisms in the Toll-like receptor gene family.

Chauhan, Alex / Pandey, Nilesh / Jain, Neeraj

Biomarkers in medicine

2021 Volume 15, Issue 13, Page(s) 1187–1198

Abstract: The Toll-like receptors play an essential role in immunity through targeting the pathogen-associated molecular patterns. Nucleotide variations ... ...

Abstract	The Toll-like receptors play an essential role in immunity through targeting the pathogen-associated molecular patterns. Nucleotide variations in
MeSH term(s)	Feasibility Studies ; Genotyping Techniques/methods ; Humans ; Multigene Family ; Polymerase Chain Reaction/methods ; Polymorphism, Restriction Fragment Length ; Polymorphism, Single Nucleotide ; Polymorphism, Single-Stranded Conformational ; Reproducibility of Results ; Sequence Analysis, DNA/methods ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization/methods ; Toll-Like Receptors/genetics
Chemical Substances	Toll-Like Receptors
Language	English
Publishing date	2021-08-17
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2481014-9
ISSN	1752-0371 ; 1752-0363
ISSN (online)	1752-0371
ISSN	1752-0363
DOI	10.2217/bmm-2021-0077
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