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  1. Article ; Online: Complement Inhibition for Geographic Atrophy - Will the Years 2023/2024 Mark a Turning Point for Retinology?

    Siedlecki, Jakob

    Klinische Monatsblatter fur Augenheilkunde

    2023  Volume 240, Issue 12, Page(s) 1345–1347

    Title translation Komplementinhibition bei geografischer Atrophie – Werden die Jahre 2023/2024 zum großen Wendepunkt in der Retinologie?
    MeSH term(s) Humans ; Geographic Atrophy ; Macular Degeneration/drug therapy ; Complement C3
    Chemical Substances Complement C3
    Language German
    Publishing date 2023-12-13
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 80175-6
    ISSN 1439-3999 ; 0344-6360 ; 0344-6387 ; 0023-2165
    ISSN (online) 1439-3999
    ISSN 0344-6360 ; 0344-6387 ; 0023-2165
    DOI 10.1055/a-2192-2705
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Komplementinhibition bei geografischer Atrophie – Werden die Jahre 2023/2024 zum großen Wendepunkt in der Retinologie?

    Siedlecki, Jakob

    Klinische Monatsblätter für Augenheilkunde

    2023  Volume 240, Issue 12, Page(s) 1345–1347

    Language German
    Publishing date 2023-12-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 80175-6
    ISSN 1439-3999 ; 0023-2165 ; 0344-6360 ; 0344-6387
    ISSN (online) 1439-3999
    ISSN 0023-2165 ; 0344-6360 ; 0344-6387
    DOI 10.1055/a-2192-2705
    Database Thieme publisher's database

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  3. Article ; Online: Selektive Vitalfarbstoffe in der Makulachirurgie : Erhöhen sie die Wahrscheinlichkeit der intraoperativen ILM-Identifizierung auch bei einem erfahrenen Operateur?

    Mueller, Severin F / Siedlecki, Jakob / Mueller, Arthur J

    Die Ophthalmologie

    2024  Volume 121, Issue 3, Page(s) 207–215

    Abstract: Background: Various vital dyes exist on the market for intraoperative internal limiting membrane (ILM) identification. The aim of this study was to verify the added value of these dyes for ILM identification and in the difficulty of ILM peeling during ... ...

    Title translation Selective vital dyes in macular surgery : Do they increase the probability of intraoperative identification of the internal limiting membrane also for an experienced surgeon?
    Abstract Background: Various vital dyes exist on the market for intraoperative internal limiting membrane (ILM) identification. The aim of this study was to verify the added value of these dyes for ILM identification and in the difficulty of ILM peeling during pars plana vitrectomy (ppV) by a single surgeon highly experienced in this operation.
    Material and methods: In this study 400 ppV surgical reports involving ILM peeling were retrospectively analyzed. Intraoperative assessment of identification or difficulty of intraoperative ILM peeling had to be documented in the surgical report. The total group consisted of 2 cohorts each with 200 surgical reports (first cohort without selective vital dyes, period 2004-2006; second cohort with vital dyes in the majority of ppVs, period 2013-2020).
    Results: The difference between both groups in terms of intraoperative identification of ILM was statistically significant (p < 0.001); however, no statistically significant difference (p = 0.951) was found between the two groups in terms of difficulty of ILM peeling. In logistic regression analysis neither patient gender, age, eye side, lens status nor posterior vitreous limiting membrane status were significantly associated with ILM identification.
    Conclusion: The introduction of intravital dyes represents a decisive advancement in retinal surgery. In the investigated sample this benefit was evident from two precisely defined surgical cohorts of a single highly experienced surgeon. This underlines the additional benefit of using selective vital dyes to identify ILM in macular surgery for less experienced surgeons.
    MeSH term(s) Humans ; Retrospective Studies ; Epiretinal Membrane/surgery ; Coloring Agents ; Vitrectomy/adverse effects ; Probability ; Surgeons
    Chemical Substances Coloring Agents
    Language German
    Publishing date 2024-02-22
    Publishing country Germany
    Document type English Abstract ; Journal Article
    ISSN 2731-7218
    ISSN (online) 2731-7218
    DOI 10.1007/s00347-024-01989-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book ; Online ; Thesis: Primäre und sekundäre Optimierung keratorefraktiver Myopiekorrektur mittels Small-Incision Lenticule Extraction (SMILE)

    Siedlecki, Jakob [Verfasser]

    2021  

    Author's details Jakob Siedlecki
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitätsbibliothek der Ludwig-Maximilians-Universität
    Publishing place München
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  5. Article ; Online: Minimal Residual Disease in Neovascular Age-Related Macular Degeneration.

    Siedlecki, Jakob / Pulido, Jose / Priglinger, Siegfried

    Klinische Monatsblatter fur Augenheilkunde

    2021  Volume 238, Issue 6, Page(s) 700–702

    Abstract: With the advent of long-acting anti-vascular endothelial growth factor substances, "healing of AMD (age-related macular degeneration)" might be easily assumed due to prolonged treatment intervals. Adoption of the oncological concept of minimal residual ... ...

    Title translation Minimal Residual Disease bei altersbedingter Makuladegeneration.
    Abstract With the advent of long-acting anti-vascular endothelial growth factor substances, "healing of AMD (age-related macular degeneration)" might be easily assumed due to prolonged treatment intervals. Adoption of the oncological concept of minimal residual disease for quiescent choroidal neovascularization (CNV) lesions might enhance the importance of continued monitoring, and spur research into the core of the disease, i.e., CNV biology.
    MeSH term(s) Choroidal Neovascularization/diagnosis ; Choroidal Neovascularization/drug therapy ; Humans ; Macular Degeneration ; Neoplasm, Residual
    Language English
    Publishing date 2021-04-14
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 80175-6
    ISSN 1439-3999 ; 0344-6360 ; 0344-6387 ; 0023-2165
    ISSN (online) 1439-3999
    ISSN 0344-6360 ; 0344-6387 ; 0023-2165
    DOI 10.1055/a-1333-3522
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Retinal and choroidal efficacy of switching treatment to faricimab in recalcitrant neovascular age related macular degeneration.

    Eckardt, Franziska / Lorger, Anna / Hafner, Michael / Klaas, Julian Elias / Schworm, Benedikt / Kreutzer, Thomas Christian / Priglinger, Siegfried Georg / Siedlecki, Jakob

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 9600

    Abstract: Aim of this study was to evaluate the efficacy of switching treatment to faricimab in neovascular age-related macular degeneration (nAMD) from other anti-VEGF agents. Fifty-eight eyes of fifty-one patients with nAMD and a full upload series of four ... ...

    Abstract Aim of this study was to evaluate the efficacy of switching treatment to faricimab in neovascular age-related macular degeneration (nAMD) from other anti-VEGF agents. Fifty-eight eyes of fifty-one patients with nAMD and a full upload series of four faricimab injections were included. Demographic data, multimodal imaging and treatment parameters were recorded. The primary outcome measures were changes in central subfield thickness (CST) and subfoveal choroidal thickness (SFCT). A subgroup analysis was performed for eyes with prior ranibizumab (R) or aflibercept (A) treatment. Mean injection intervals before and after switching were comparable (33.8 ± 11.2 vs. 29.3 ± 2.6 days; p = 0.08). Mean CST of 361.4 ± 108.1 µm prior to switching decreased significantly to 318.3 ± 97.7 µm (p < 0.01) after the third faricimab injection, regardless of prior anti-VEGF treatment (p < 0.01). Although SFCT slightly improved for the whole cohort from 165.8 ± 76.8 µm to 161.0 ± 82,8 µm (p = 0.029), subgroup analysis did not confirm this positive effect (subgroup R: p = 0.604; subgroup A: p = 0.306). In patients with a suboptimal response to aflibercept or ranibizumab in nAMD, farcimab can improve CST and slightly improve or maintain SFCT. Further prospective randomized trials are warranted.
    MeSH term(s) Humans ; Male ; Female ; Aged ; Ranibizumab/administration & dosage ; Ranibizumab/therapeutic use ; Recombinant Fusion Proteins/administration & dosage ; Recombinant Fusion Proteins/therapeutic use ; Choroid/drug effects ; Choroid/diagnostic imaging ; Choroid/pathology ; Aged, 80 and over ; Treatment Outcome ; Angiogenesis Inhibitors/therapeutic use ; Angiogenesis Inhibitors/administration & dosage ; Receptors, Vascular Endothelial Growth Factor/therapeutic use ; Receptors, Vascular Endothelial Growth Factor/administration & dosage ; Retina/pathology ; Retina/drug effects ; Retina/diagnostic imaging ; Intravitreal Injections ; Macular Degeneration/drug therapy ; Macular Degeneration/pathology ; Tomography, Optical Coherence ; Visual Acuity/drug effects ; Vascular Endothelial Growth Factor A/antagonists & inhibitors ; Drug Substitution
    Chemical Substances Ranibizumab (ZL1R02VT79) ; Recombinant Fusion Proteins ; aflibercept (15C2VL427D) ; Angiogenesis Inhibitors ; Receptors, Vascular Endothelial Growth Factor (EC 2.7.10.1) ; Vascular Endothelial Growth Factor A
    Language English
    Publishing date 2024-04-26
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-59632-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Assessment of ChatGPT in the Prehospital Management of Ophthalmological Emergencies - An Analysis of 10 Fictional Case Vignettes.

    Knebel, Dominik / Priglinger, Siegfried / Scherer, Nicolas / Klaas, Julian / Siedlecki, Jakob / Schworm, Benedikt

    Klinische Monatsblatter fur Augenheilkunde

    2023  

    Abstract: Background: The artificial intelligence (AI)-based platform ChatGPT (Chat Generative Pre-Trained Transformer, OpenAI LP, San Francisco, CA, USA) has gained impressive popularity in recent months. Its performance on case vignettes of general medical (non- ...

    Title translation ChatGPT in der präklinischen Versorgung augenärztlicher Notfälle – eine Untersuchung von 10 fiktiven Fallvignetten.
    Abstract Background: The artificial intelligence (AI)-based platform ChatGPT (Chat Generative Pre-Trained Transformer, OpenAI LP, San Francisco, CA, USA) has gained impressive popularity in recent months. Its performance on case vignettes of general medical (non-ophthalmological) emergencies has been assessed - with very encouraging results. The purpose of this study was to assess the performance of ChatGPT on ophthalmological emergency case vignettes in terms of the main outcome measures triage accuracy, appropriateness of recommended prehospital measures, and overall potential to inflict harm to the user/patient.
    Methods: We wrote ten short, fictional case vignettes describing different acute ophthalmological symptoms. Each vignette was entered into ChatGPT five times with the same wording and following a standardized interaction pathway. The answers were analyzed following a systematic approach.
    Results: We observed a triage accuracy of 93.6%. Most answers contained only appropriate recommendations for prehospital measures. However, an overall potential to inflict harm to users/patients was present in 32% of answers.
    Conclusion: ChatGPT should presently not be used as a stand-alone primary source of information about acute ophthalmological symptoms. As AI continues to evolve, its safety and efficacy in the prehospital management of ophthalmological emergencies has to be reassessed regularly.
    Language English
    Publishing date 2023-10-27
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 80175-6
    ISSN 1439-3999 ; 0344-6360 ; 0344-6387 ; 0023-2165
    ISSN (online) 1439-3999
    ISSN 0344-6360 ; 0344-6387 ; 0023-2165
    DOI 10.1055/a-2149-0447
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Biomarker in der Therapie venöser retinaler Gefäßverschlüsse.

    Siedlecki, Jakob / Hattenbach, Lars-Olof / Feltgen, Nikolas / Priglinger, Siegfried G

    Die Ophthalmologie

    2022  Volume 119, Issue 11, Page(s) 1111–1120

    Abstract: Background: Retinal vein occlusion, subdivided into central retinal and branch retinal vein occlusion, is one of the most frequent vascular diseases of the retina. Biomarkers of optical coherence tomography (OCT), OCT-angiography and (ultra-widefield) ... ...

    Title translation Biomarkers in the treatment of retinal vein occlusion.
    Abstract Background: Retinal vein occlusion, subdivided into central retinal and branch retinal vein occlusion, is one of the most frequent vascular diseases of the retina. Biomarkers of optical coherence tomography (OCT), OCT-angiography and (ultra-widefield) fluorescein angiography are of exceptional importance in the initial diagnosis and also in the treatment of complications associated with retinal vascular occlusion, particularly macular edema.
    Methods: A systematic literature review was carried out in PubMed with the keywords central retinal vein occlusion, branch retinal vein occlusion, biomarker, OCT, OCT angiography, ultra-widefield fluorescein angiography with prioritization of the most important aspects.
    Results: Relevant biomarkers in OCT include central retinal thickness (CRT), macular fluid, the integrity of the photoreceptor bands (external limiting membrane and ellipsoid zone), disorganization of retinal inner layers (DRIL), hyperreflective foci, choroidal thickness and signs of ischemia, such as a prominent middle limiting membrane (p-MLM), paracentral acute middle maculopathy (PAMM) as well as hyperreflectivity of inner retinal layers (HIRL). The importance of OCT-angiography lies particularly in the assessment of microvascular alterations, especially vessel density in the deep retinal vascular plexus, the foveal avascular zone and of areas with no capillary perfusion. Biomarkers of ultra-widefield angiography, such as peripheral ischemia (ischemic index) and neovascularízation are essential with respect to treatment decisions for retinal laser.
    Conclusion: A multitude of simple and complex biomarkers currently enable an effective individualized evaluation of treatment and prognosis in retinal vein occlusion. A shift from invasive to noninvasive biomarkers can be observed.
    MeSH term(s) Humans ; Retinal Vein Occlusion/diagnosis ; Retinal Vessels ; Visual Acuity ; Tomography, Optical Coherence/adverse effects ; Retinal Diseases/diagnosis ; Ischemia/complications ; Biomarkers
    Chemical Substances Biomarkers
    Language German
    Publishing date 2022-10-06
    Publishing country Germany
    Document type English Abstract ; Journal Article ; Review
    ISSN 2731-7218
    ISSN (online) 2731-7218
    DOI 10.1007/s00347-022-01732-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Questions on a Study on the Effects of Flavanol-Rich Dark Chocolate on Visual Function and Retinal Perfusion-Reply.

    Siedlecki, Jakob / Luft, Nikolaus / Priglinger, Siegfried G

    JAMA ophthalmology

    2020  Volume 138, Issue 7, Page(s) 799–800

    MeSH term(s) Angiography ; Blood Pressure ; Chocolate ; Humans ; Perfusion ; Tomography, Optical Coherence
    Language English
    Publishing date 2020-05-14
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2701705-9
    ISSN 2168-6173 ; 2168-6165
    ISSN (online) 2168-6173
    ISSN 2168-6165
    DOI 10.1001/jamaophthalmol.2020.1493
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  10. Conference proceedings: Ergänzende intravitreale Ranibizumab-Injektionen bei nAMD-Patienten mit dem Port Delivery System mit Ranibizumab (PDS) in der Phase-3-Studie Archway

    Siedlecki, Jakob / Pieramici, Dante / Gune, Shamika / DeGraaf, Stephanie / Barteselli, Giulio / Heinrich, Dominic

    2023  , Page(s) FP 3.5

    Event/congress 35. Internationaler Kongress der Deutschen Ophthalmochirurgie (DOC); Nürnberg; 2023
    Keywords Medizin, Gesundheit
    Publishing date 2023-06-13
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/23doc022
    Database German Medical Science

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