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  1. Article ; Online: COVID-19 and Long-COVID Thrombosis: From Clinical and Basic Science to Therapeutics.

    Violi, Francesco / Harenberg, Job / Pignatelli, Pasquale / Cammisotto, Vittoria

    Thrombosis and haemostasis

    2023  Volume 124, Issue 4, Page(s) 286–296

    Abstract: Coronavirus infectious disease-19 (COVID-19) is a pandemic characterized by serious lung disease and thrombotic events in the venous and circulation trees, which represent a harmful clinical sign of poor outcome. Thrombotic events are more frequent in ... ...

    Abstract Coronavirus infectious disease-19 (COVID-19) is a pandemic characterized by serious lung disease and thrombotic events in the venous and circulation trees, which represent a harmful clinical sign of poor outcome. Thrombotic events are more frequent in patients with severe disease requiring intensive care units and are associated with platelet and clotting activation. However, after resolution of acute infection, patients may still have clinical sequelae, the so-called long-COVID-19, including thrombotic events again in the venous and arterial circulation. The mechanisms accounting for thrombosis in acute and long COVID-19 have not been fully clarified; interactions of COVID-19 with angiotensin converting enzyme 2 or toll-like receptor family or infection-induced cytokine storm have been suggested to be implicated in endothelial cells, leucocytes, and platelets to elicit clotting activation in acute as well in chronic phase of the disease. In acute COVID-19, prophylactic or full doses of anticoagulants exert beneficial effects even if the dosage choice is still under investigation; however, a residual risk still remains suggesting a need for a more appropriate therapeutic approach. In long COVID-19 preliminary data provided useful information in terms of antiplatelet treatment but definition of candidates for thrombotic prophylaxis is still undefined.
    MeSH term(s) Humans ; COVID-19 ; Post-Acute COVID-19 Syndrome ; Endothelial Cells ; SARS-CoV-2 ; Anticoagulants/therapeutic use ; Thrombosis/drug therapy ; Communicable Diseases
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2023-11-15
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 518294-3
    ISSN 2567-689X ; 0340-6245
    ISSN (online) 2567-689X
    ISSN 0340-6245
    DOI 10.1055/s-0043-1776713
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Anticoagulant Treatment of COVID-19 as Early as Possible-Sulodexide and Perspectives.

    Schulman, Sam / Harenberg, Job

    Thrombosis and haemostasis

    2021  Volume 121, Issue 7, Page(s) 849–853

    MeSH term(s) Anticoagulants ; COVID-19 ; Glycosaminoglycans ; Humans ; SARS-CoV-2
    Chemical Substances Anticoagulants ; Glycosaminoglycans ; glucuronyl glucosamine glycan sulfate (75HGV0062C)
    Language English
    Publishing date 2021-06-15
    Publishing country Germany
    Document type Editorial ; Comment
    ZDB-ID 518294-3
    ISSN 2567-689X ; 0340-6245
    ISSN (online) 2567-689X
    ISSN 0340-6245
    DOI 10.1055/a-1477-3569
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  3. Article ; Online: Waves of SARS-CoV-2 Infection and Blood Coagulation-A Link and Beyond.

    Harenberg, Job / Violi, Francesco

    Thrombosis and haemostasis

    2021  Volume 121, Issue 1, Page(s) 4–6

    MeSH term(s) Anticoagulants/therapeutic use ; Blood Coagulation/drug effects ; COVID-19/blood ; COVID-19/drug therapy ; COVID-19/mortality ; COVID-19/virology ; Host-Pathogen Interactions ; Humans ; SARS-CoV-2/pathogenicity ; Thromboembolism/blood ; Thromboembolism/mortality ; Thromboembolism/prevention & control ; Thromboembolism/virology
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2021-01-21
    Publishing country Germany
    Document type Editorial
    ZDB-ID 518294-3
    ISSN 2567-689X ; 0340-6245
    ISSN (online) 2567-689X
    ISSN 0340-6245
    DOI 10.1055/s-0040-1721778
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book ; Conference proceedings: Basic and clinical considerations of heparins / 1

    Harenberg, Job

    [5th Glycosaminoglycan Symposium at Villa Vigoni at Lake Como in Italy, held September 16 to 18, 1996]

    (... ; 23,1)

    1997  

    Event/congress Glycosaminoglycan Symposium (5, 1996)
    Author's details Job Harenberg, guest ed
    Series title ... ; 23,1
    Basic and clinical considerations of heparins
    Seminars in thrombosis and hemostasis
    Collection Basic and clinical considerations of heparins
    Seminars in thrombosis and hemostasis
    Language English
    Size S. 1 - 96 : graph. Darst.
    Publisher Thieme
    Publishing place New York u.a.
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT007922245
    Database Catalogue ZB MED Medicine, Health

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    Zs A 1259 -23- not available for loan Zeitschriften-Lesesaal

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  5. Book ; Conference proceedings: Basic and clinical considerations of heparins / 2

    Harenberg, Job

    [5th Glycosaminoglycan Symposium at Villa Vigoni at Lake Como in Italy, held September 16 to 18, 1996]

    (... ; 23,2)

    1997  

    Event/congress Glycosaminoglycan Symposium (5, 1996)
    Author's details Job Harenberg, guest ed
    Series title ... ; 23,2
    Basic and clinical considerations of heparins
    Seminars in thrombosis and hemostasis
    Collection Basic and clinical considerations of heparins
    Seminars in thrombosis and hemostasis
    Language English
    Size S. 97 - 233 : Ill., graph. Darst.
    Publisher Thieme
    Publishing place New York u.a.
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT007960637
    Database Catalogue ZB MED Medicine, Health

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    Zs A 1259 -23- not available for loan Zeitschriften-Lesesaal

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  6. Article ; Online: Laboratory determination of old and new targeted anticoagulant agents for prevention of bleeding and thrombotic events in cancer patients.

    Harenberg, Job

    Thrombosis research

    2016  Volume 140 Suppl 1, Page(s) S165–7

    Abstract: A two-fold prolongation of activated partial thromboplastin time (APTT) is established as therapeutic range for therapy with unfractionated heparin, hirudin and argatroban. The international normalized ratio (INR) of 2 to 3 is required to maintain ... ...

    Abstract A two-fold prolongation of activated partial thromboplastin time (APTT) is established as therapeutic range for therapy with unfractionated heparin, hirudin and argatroban. The international normalized ratio (INR) of 2 to 3 is required to maintain anticoagulation in the therapeutic range of vitamin K antagonists. The therapeutic range of anti-factor Xa activity during therapy with low-molecular weight heparins and danaparoid are less well and of direct oral anticoagulants (DOAC) poorly defined. The relation of aPTT and INR values to thrombotic and bleeding events are well established despite a large variation of values in affected patients. The relation of coagulation values of the other anticoagulants to clinical events is open. The value of determination in cancer patients is higher because of the increased risk for thrombotic and bleeding events of this patient group. Several activities are currently undertaken to certify methods for in vitro diagnostic testing for DAOCs.
    MeSH term(s) Anticoagulants/pharmacology ; Anticoagulants/therapeutic use ; Blood Coagulation Tests ; Dabigatran/pharmacology ; Dabigatran/therapeutic use ; Drug Monitoring ; Factor Xa Inhibitors/pharmacology ; Factor Xa Inhibitors/therapeutic use ; Hemorrhage/chemically induced ; Heparin, Low-Molecular-Weight/pharmacology ; Heparin, Low-Molecular-Weight/therapeutic use ; Humans ; International Normalized Ratio ; Neoplasms/complications ; Partial Thromboplastin Time ; Pyrazoles/pharmacology ; Pyrazoles/therapeutic use ; Pyridones/pharmacology ; Pyridones/therapeutic use ; Rivaroxaban/pharmacology ; Rivaroxaban/therapeutic use ; Thrombosis/etiology ; Thrombosis/prevention & control ; Warfarin/pharmacology ; Warfarin/therapeutic use
    Chemical Substances Anticoagulants ; Factor Xa Inhibitors ; Heparin, Low-Molecular-Weight ; Pyrazoles ; Pyridones ; apixaban (3Z9Y7UWC1J) ; Warfarin (5Q7ZVV76EI) ; Rivaroxaban (9NDF7JZ4M3) ; Dabigatran (I0VM4M70GC)
    Language English
    Publishing date 2016-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 121852-9
    ISSN 1879-2472 ; 0049-3848
    ISSN (online) 1879-2472
    ISSN 0049-3848
    DOI 10.1016/S0049-3848(16)30117-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 863: Show issues Location:
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  7. Article ; Online: Past, present, and future perspectives of heparins in clinical settings and the role of impaired renal function.

    Harenberg, Job

    International journal of cardiology

    2016  Volume 212 Suppl 1, Page(s) S10–3

    Abstract: Heparin, whose discovery goes back one hundred years, was first detected as a thromboplastin from liver tissue, and its anticoagulant action was only identified later. The procoagulant action of heparin, which was later characterized as an immunologic ... ...

    Abstract Heparin, whose discovery goes back one hundred years, was first detected as a thromboplastin from liver tissue, and its anticoagulant action was only identified later. The procoagulant action of heparin, which was later characterized as an immunologic reaction by binding to platelet-factor IV, presenting as heparin-induced thrombocytopenia, remains as a side effect. For more than 60 years heparin has been the immediate anticoagulant of choice in many clinical indications. Further development of heparins resulted in the production of low-molecular weight heparins and Fondaparinux, which substituted heparin for many indications and has received many more new indications, including administration for non-anticoagulant purposes. This development is still ongoing and has resulted in more than 300 registered clinical trials at the end of 2015. All types of heparins are still investigated in patients with impairment of renal function to improve the safety of treatment. New therapeutic strategies for the prevention and treatment of thromboembolism, as well as of the non-anticoagulant actions of natural and modified types of heparins, are studied intensively. The clinical study designs include treatment with vitamin-K and non-vitamin K oral anticoagulants. Consequently, heparins, low-molecular weight heparins and Fondaparinux play an important role in the human health care system.
    MeSH term(s) Anticoagulants/administration & dosage ; Anticoagulants/adverse effects ; Clinical Trials as Topic ; Drug Design ; Heparin/administration & dosage ; Heparin/adverse effects ; Heparin, Low-Molecular-Weight/administration & dosage ; Heparin, Low-Molecular-Weight/adverse effects ; Humans ; Polysaccharides/administration & dosage ; Polysaccharides/adverse effects ; Renal Insufficiency/drug therapy ; Renal Insufficiency/physiopathology ; Thromboembolism/drug therapy ; Thromboembolism/physiopathology ; Vitamin K/administration & dosage
    Chemical Substances Anticoagulants ; Heparin, Low-Molecular-Weight ; Polysaccharides ; Vitamin K (12001-79-5) ; Heparin (9005-49-6) ; fondaparinux (J177FOW5JL)
    Language English
    Publishing date 2016-06
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 779519-1
    ISSN 1874-1754 ; 0167-5273
    ISSN (online) 1874-1754
    ISSN 0167-5273
    DOI 10.1016/S0167-5273(16)12003-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The Dangerous Liaisons between Chronic Obstructive Pulmonary Disease and Venous Thromboembolism.

    Harenberg, Job / Verhamme, Peter

    Thrombosis and haemostasis

    2020  Volume 120, Issue 3, Page(s) 363–365

    MeSH term(s) Humans ; Pulmonary Disease, Chronic Obstructive ; Pulmonary Embolism ; Venous Thromboembolism
    Language English
    Publishing date 2020-01-23
    Publishing country Germany
    Document type Editorial ; Comment
    ZDB-ID 518294-3
    ISSN 2567-689X ; 0340-6245
    ISSN (online) 2567-689X
    ISSN 0340-6245
    DOI 10.1055/s-0039-1701012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Book ; Conference proceedings: Nonanticoagulant actions of glycosaminoglycans

    Harenberg, Job

    [proceedings of the Fourth Symposium on Glycosaminoglycans: Nonanticoagulant Actions of Glycosaminoglycans - Results and Perspectives of the German-Italian Collaboration held October 6 - 8, 1994, in Loveno, Italy]

    1996  

    Institution Symposium on Glycosaminoglycans
    Author's details ed. by Job Harenberg
    Keywords Glycosaminoglycans / pharmacology / congresses ; Glycosaminoglycans / therapeutic use / congresses ; Anticoagulants / pharmacology / congresses ; Glykosaminoglykane ; Arzneimittel ; Antikoagulans ; Pharmakologie ; Thrombose ; Prävention
    Subject Arzneimittellehre ; Arzneimittelwirkung ; Arzneiwirkung ; Experimentelle Pharmakologie ; Anticoagulans ; Gerinnungshemmendes Mittel ; Gerinnungshemmer ; Blutgerinnungshemmendes Mittel ; Thrombininhibitor ; Blutgerinnungshemmer ; Fertigarzneimittel ; Therapeutikum ; Medikament ; Medukamente ; Pharmakon ; Pharmaka ; Arzneistoff ; Arzneimittelwirkstoff ; Arznei ; Pharmazeutikum ; Pharmazeutika ; Pharmazeutischer Wirkstoff ; Arzneidroge ; Glykosaminglykane ; Glycosaminoglycane ; Glycosaminglycane ; Mucopolysaccharide ; Verhütung ; Vorbeugung ; Prophylaxe ; Vorsorge ; Thrombosen
    Language English
    Size VIII, 295 S. : zahlr. graph. Darst.
    Publisher Plenum Press
    Publishing place New York u.a.
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT007467029
    ISBN 0-306-45299-5 ; 978-0-306-45299-4
    Database Catalogue ZB MED Medicine, Health

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  10. Article ; Online: Patients' Plasma Activity of Heparin, low-Molecular-Weight Heparin or no Anticoagulants on Urine Based DOAC Test Strips.

    Harenberg, Job / Hetjens, Svetlana / Weiss, Christel

    Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis

    2022  Volume 28, Page(s) 10760296221083667

    Abstract: DOAC Dipstick determines specifically the presence and absence of direct oral anticoagulants (DOACs) from patients' urine samples and handmade test strips performed as well as the commercial version. To compare plasma activity (chromogenic substrate ... ...

    Abstract DOAC Dipstick determines specifically the presence and absence of direct oral anticoagulants (DOACs) from patients' urine samples and handmade test strips performed as well as the commercial version. To compare plasma activity (chromogenic substrate assays) from plasma samples with results from urine samples (DOAC test strips) of patients treated with heparin, low-molecular weight heparin (LMWH) and without anticoagulation. Plasma anti-factor Xa (aXa) activity was determined by Coamatic chromogenic substrate assay and compared to the presence of anticoagulants in urine by DOAC test strips. Patients were treated for least 5 days and samples were taken 4 hrs after administration in comparison to no treatment with an anticoagulant (n = 42). A total of 100 patients were included treated with heparin (n = 29), LMWH nadroparin (n = 29) or no anticoagulants (n = 42). Plasma aXa levels of patients treated with heparin (2 × 7.500 IU daily subcutaneously, 12 male, age 67.4 ± 11.5 years) were 0,18 IU/ml ± 0,15 IU/ml (mean, standard deviation), with LMWH (1 × 3000 IU daily subcutaneously, 15 male, age 64.2 ± 14.1 years) 0,17 IU/ml ± 0,16 IU/l, and with no anticoagulants (28 male, age 64.2 ± 15.6 years) 0,02 IU/ml ± 0.01 IU/ml. All factor Xa and thrombin inhibitor pad results of test strips were negative. We conclude that DOAC Dipstick has a high probability of not detecting heparin and LMWH in patients on treatment as well as in urine samples of patients not treated with an anticoagulant.
    MeSH term(s) Administration, Oral ; Aged ; Anticoagulants/pharmacology ; Anticoagulants/therapeutic use ; Factor Xa Inhibitors/pharmacology ; Factor Xa Inhibitors/therapeutic use ; Heparin/pharmacology ; Heparin/therapeutic use ; Heparin, Low-Molecular-Weight/pharmacology ; Heparin, Low-Molecular-Weight/therapeutic use ; Humans ; Male ; Middle Aged
    Chemical Substances Anticoagulants ; Factor Xa Inhibitors ; Heparin, Low-Molecular-Weight ; Heparin (9005-49-6)
    Language English
    Publishing date 2022-03-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1237357-6
    ISSN 1938-2723 ; 1076-0296
    ISSN (online) 1938-2723
    ISSN 1076-0296
    DOI 10.1177/10760296221083667
    Database MEDical Literature Analysis and Retrieval System OnLINE

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