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  1. Book: Forschungsnetze in Deutschland

    Schett, Georg

    neue Einblicke in das Wechselspiel von Entzündung und Knochen

    (Zeitschrift für Rheumatologie ; Band 77, Supplement 1 (Mai 2018))

    2018  

    Author's details Herausgeber: Prof. Dr. Georg Schett
    Series title Zeitschrift für Rheumatologie ; Band 77, Supplement 1 (Mai 2018)
    Collection
    Language German
    Size S33 Seiten, Illustrationen
    Publisher Springer Medizin
    Publishing place Heidelberg
    Publishing country Germany
    Document type Book
    HBZ-ID HT019695952
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Uh III Zs 128 -77,Suppl.1- verfügbar in Königswinter Königswinter

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  2. Article ; Online: Difficult-to-Treat Psoriatic Arthritis: A Conceptual Approach.

    Fagni, Filippo / Motta, Francesca / Schett, Georg / Selmi, Carlo

    Arthritis & rheumatology (Hoboken, N.J.)

    2024  Volume 76, Issue 5, Page(s) 670–674

    MeSH term(s) Humans ; Arthritis, Psoriatic/drug therapy ; Antirheumatic Agents/therapeutic use
    Chemical Substances Antirheumatic Agents
    Language English
    Publishing date 2024-01-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2756371-6
    ISSN 2326-5205 ; 2326-5191
    ISSN (online) 2326-5205
    ISSN 2326-5191
    DOI 10.1002/art.42780
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 24: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Entwicklungen in der gezielten Behandlung immun-mediierter Erkrankungen

    Schett, Georg

    Immunologie

    2021  Volume 5, Issue 4, Page(s) 226

    Language German
    Document type Article
    ZDB-ID 2935137-6
    ISSN 2625-3585 ; 2513-1583
    Database Current Contents Medicine

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 7237: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  4. Book ; Online ; Thesis: Der Zusammenhang der Expressionsstärke von Siglec-7 und Siglec-9 mit der Krankheitsaktivität in Patienten mit Rheumatoider Arthritis

    Zapf, Johanna [Verfasser] / Schett, Georg [Akademischer Betreuer] / Schett, Georg [Gutachter]

    2023  

    Author's details Johanna Zapf ; Gutachter:  Georg Schett ; Betreuer:  Georg Schett
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU)
    Publishing place Erlangen
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  5. Article ; Online: Editorial overview: Osteoimmunology.

    Schett, Georg / Takayanagi, Hiroshi

    Bone

    2022  Volume 162, Page(s) 116466

    MeSH term(s) Bone and Bones ; Osteoclasts
    Language English
    Publishing date 2022-06-08
    Publishing country United States
    Document type Editorial
    ZDB-ID 632515-4
    ISSN 1873-2763 ; 8756-3282
    ISSN (online) 1873-2763
    ISSN 8756-3282
    DOI 10.1016/j.bone.2022.116466
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 332: Show issues

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  6. Article ; Online: Resolution of inflammation in arthritis.

    Schett, Georg

    Seminars in immunopathology

    2019  Volume 41, Issue 6, Page(s) 675–679

    Abstract: Rheumatoid arthritis is among the most frequent and severe chronic inflammatory diseases. The disease is characterized by ongoing synovial inflammation, which leads to the destruction of cartilage and bone. In RA, the mechanisms of resolution of ... ...

    Abstract Rheumatoid arthritis is among the most frequent and severe chronic inflammatory diseases. The disease is characterized by ongoing synovial inflammation, which leads to the destruction of cartilage and bone. In RA, the mechanisms of resolution of inflammation, which are normally intact in the joints, are either suppressed or overruled. Little efforts have been undertaken to understand the mechanisms of resolution of arthritis until recently, when several molecular mechanisms have been identified that determine the chronicity and resolution of inflammation in the joints, respectively. This review describes the key concepts of resolution of arthritis mentioning the key mechanisms involved, such as regulatory macrophages, pro-resolving lipid, fatty acid and cytokine mediators, aggregated neutrophil extracellular trap formation, antibody glycosylation changes, and stromal cell alterations that are involved in determining the decision between chronicity and resolution of arthritis. Each of these mechanisms represents a potential therapeutic approach that allows skewing the balance of the inflammatory processes towards resolution.
    MeSH term(s) Animals ; Arthritis/diagnosis ; Arthritis/etiology ; Arthritis/metabolism ; Arthritis/therapy ; Cell Membrane/metabolism ; Cytokines/metabolism ; Disease Susceptibility ; Extracellular Traps/immunology ; Extracellular Traps/metabolism ; Humans ; Inflammation Mediators/metabolism ; Lipid Metabolism ; Macrophages/immunology ; Macrophages/metabolism ; Macrophages/pathology ; Stromal Cells/immunology ; Stromal Cells/metabolism
    Chemical Substances Cytokines ; Inflammation Mediators
    Language English
    Publishing date 2019-11-12
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2316828-6
    ISSN 1863-2300 ; 1863-2297
    ISSN (online) 1863-2300
    ISSN 1863-2297
    DOI 10.1007/s00281-019-00768-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1425: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Towards preventive treatment of rheumatoid arthritis.

    Rech, Jürgen / Schett, Georg

    Lancet (London, England)

    2022  Volume 400, Issue 10348, Page(s) 253–255

    MeSH term(s) Arthritis, Rheumatoid/drug therapy ; Arthritis, Rheumatoid/prevention & control ; Humans
    Language English
    Publishing date 2022-06-25
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(22)01327-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.5: Show issues Location:
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    Zs.MG 94: Show issues

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  8. Book ; Online ; Thesis: Der Zusammenhang von Knorpelmarkerkinetik und subjektiver Bewegungseinschränkung mit körperlicher Aktivität in prä-RA und RA-Patienten.

    Bleckwedel-Rolack, Lisa Lena Kathrein [Verfasser] / Schett, Georg [Akademischer Betreuer] / Schett, Georg [Gutachter]

    2023  

    Author's details Lisa Lena Kathrein Bleckwedel-Rolack ; Gutachter: Georg Schett ; Betreuer: Georg Schett
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU)
    Publishing place Erlangen
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

    Full text online

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    Inter-library loan at ZB MED

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  9. Book ; Online ; Thesis: Molecular involvement of HIF1α and HIF2α expression in the pathogenesis of rheumatoid arthritis

    Wen, Jinming [Verfasser] / Schett, Georg [Akademischer Betreuer] / Schett, Georg [Gutachter] / Bozec, Georg [Gutachter]

    2023  

    Author's details Jinming Wen ; Gutachter:  Georg Schett,  Georg Bozec ; Betreuer:  Georg Schett
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language English
    Publisher Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU)
    Publishing place Erlangen
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

    Full text online

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  10. Article ; Online: Physiological effects of modulating the interleukin-6 axis.

    Schett, Georg

    Rheumatology (Oxford, England)

    2018  Volume 57, Issue suppl_2, Page(s) ii43–ii50

    Abstract: IL-6 is a pleiotropic cytokine involved in many biological functions that affect tissues beyond the immune system and the vasculature. This multifunctional cytokine exerts its actions via the classic signalling pathway when it binds to the transmembrane ... ...

    Abstract IL-6 is a pleiotropic cytokine involved in many biological functions that affect tissues beyond the immune system and the vasculature. This multifunctional cytokine exerts its actions via the classic signalling pathway when it binds to the transmembrane IL-6 receptor (IL-6R) or via the trans-signalling pathway upon binding to the soluble form of IL-6R (sIL-6R). In general, classic IL-6 signalling is responsible for the anti-inflammatory properties of IL-6, whereas trans-signalling is responsible for the pro-inflammatory actions of IL-6. As a result, dysregulation of the IL-6 axis can lead to the onset or development of several disease states, particularly autoimmune and inflammatory disorders, including RA and GCA. This pathological role of IL-6 means that pharmacologic modulation of the IL-6 axis is a rational therapeutic approach; however, multiple predictable, but often underappreciated, effects on tissues and organs beyond the blood vessels may also occur.
    MeSH term(s) Arthritis, Rheumatoid/physiopathology ; Autoimmune Diseases/physiopathology ; Giant Cell Arteritis/physiopathology ; Humans ; Interleukin-6/physiology ; Receptors, Interleukin-6/physiology ; Signal Transduction/physiology
    Chemical Substances IL6 protein, human ; IL6R protein, human ; Interleukin-6 ; Receptors, Interleukin-6
    Language English
    Publishing date 2018--01
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1464822-2
    ISSN 1462-0332 ; 1462-0324
    ISSN (online) 1462-0332
    ISSN 1462-0324
    DOI 10.1093/rheumatology/kex513
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 240: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Zs.MO 497: Show issues

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