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  1. Article ; Online: Trailblazing women immunologists of Australia and New Zealand.

    Borger, Jessica Geraldine / Nguyen-Robertson, Catriona Vi / Harris, James

    Immunology and cell biology

    2021  Volume 99, Issue 4, Page(s) 338–343

    MeSH term(s) Allergy and Immunology ; Australia ; Female ; Humans ; New Zealand ; Physicians, Women
    Language English
    Publishing date 2021-04-15
    Publishing country United States
    Document type Editorial
    ZDB-ID 284057-1
    ISSN 1440-1711 ; 0818-9641
    ISSN (online) 1440-1711
    ISSN 0818-9641
    DOI 10.1111/imcb.12454
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: COVID-19: searching for clues among other respiratory viruses.

    Nguyen-Robertson, Catriona / Haque, Ashraful / Mintern, Justine / La Flamme, Anne C

    Immunology and cell biology

    2020  Volume 98, Issue 4, Page(s) 247–250

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Internet ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-05-17
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 284057-1
    ISSN 1440-1711 ; 0818-9641
    ISSN (online) 1440-1711
    ISSN 0818-9641
    DOI 10.1111/imcb.12336
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  4. Article ; Online: COVID‐19

    Nguyen‐Robertson, Catriona / Haque, Ashraful / Mintern, Justine / La Flamme, Anne C

    Immunology & Cell Biology

    searching for clues among other respiratory viruses

    2020  Volume 98, Issue 4, Page(s) 247–250

    Keywords Immunology ; Cell Biology ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    ZDB-ID 284057-1
    ISSN 1440-1711 ; 0818-9641
    ISSN (online) 1440-1711
    ISSN 0818-9641
    DOI 10.1111/imcb.12336
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  5. Article ; Online: COVID‐19

    Nguyen‐Robertson, Catriona / Haque, Ashraful / Mintern, Justine / La Flamme, Anne C.

    searching for clues among other respiratory viruses

    2020  

    Keywords Immunology ; Cell Biology ; 1307 Cell Biology ; 2403 Immunology ; 2723 Immunology and Allergy ; covid19
    Language English
    Publishing date 2020-04-01
    Publisher John Wiley & Sons
    Publishing country au
    Document type Article ; Online
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  6. Article ; Online: High CD26 and Low CD94 Expression Identifies an IL-23 Responsive Vδ2

    Wragg, Kathleen M / Tan, Hyon-Xhi / Kristensen, Anne B / Nguyen-Robertson, Catriona V / Kelleher, Anthony D / Parsons, Matthew S / Wheatley, Adam K / Berzins, Stuart P / Pellicci, Daniel G / Kent, Stephen J / Juno, Jennifer A

    Cell reports

    2020  Volume 31, Issue 11, Page(s) 107773

    Abstract: ... ...

    Abstract Vδ2
    MeSH term(s) Dipeptidyl Peptidase 4/metabolism ; Humans ; Interleukin-23/metabolism ; Lymphocyte Activation/immunology ; NK Cell Lectin-Like Receptor Subfamily D/metabolism ; Receptors, Antigen, T-Cell, gamma-delta/metabolism ; T-Lymphocyte Subsets/metabolism
    Chemical Substances Interleukin-23 ; KLRD1 protein, human ; NK Cell Lectin-Like Receptor Subfamily D ; Receptors, Antigen, T-Cell, gamma-delta ; DPP4 protein, human (EC 3.4.14.5) ; Dipeptidyl Peptidase 4 (EC 3.4.14.5)
    Language English
    Publishing date 2020-06-17
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2020.107773
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  7. Article ; Online: Blister fluid as a cellular input for

    Awad, Andrew / Mouhtouris, Effie / Nguyen-Robertson, Catriona Vi / Holmes, Natasha / Chua, Kyra Y L / Copaescu, Ana / James, Fiona / Goh, Michelle S / Aung, Ar Kar / Godfrey, Dale I / Philips, Elizabeth J / Gibson, Andrew / Almeida, Catarina F / Trubiano, Jason A

    The journal of allergy and clinical immunology. Global

    2021  Volume 1, Issue 1, Page(s) 16–21

    Abstract: Background: Drug-induced severe cutaneous adverse reactions (SCARs) are presumed T-cell-mediated hypersensitivities associated with significant morbidity and mortality. Traditional : Objective: We sought to improve : Methods: ELISpot and flow ... ...

    Abstract Background: Drug-induced severe cutaneous adverse reactions (SCARs) are presumed T-cell-mediated hypersensitivities associated with significant morbidity and mortality. Traditional
    Objective: We sought to improve
    Methods: ELISpot and flow cytometry analyses of IFN-γ release were performed on donor-matched PBMC and BFC samples from 4 patients with SCARs with distinct drug hypersensitivity.
    Results: Immune responses to suspected drugs were detected in both the PBMC and BFC samples of 2 donors (donor patient 1 in response to ceftriaxone and case patient 4 in response to oxypurinol), with BFCs eliciting stronger responses. For the other 2 donors, only BFC samples showed a response to meloxicam (case patient 2) or sulfamethoxazole and its 4-nitro metabolite (case patient 3). Consistently, flow cytometry revealed a greater proportion of IFN-γ-secreting cells in the BFCs than in the PBMCs. The BFCs from case patient 3 were also enriched for memory, activation, and/or tissue recruitment markers over the PBMCs.
    Conclusion: Analysis of BFC samples for drug hypersensitivity diagnostics offers a higher sensitivity for detecting positive responses than does analysis of PBMC samples. This is consistent with recruitment (and enrichment) of cytokine-secreting cells with a memory/activated phenotype into blisters.
    Language English
    Publishing date 2021-11-30
    Publishing country United States
    Document type Journal Article
    ISSN 2772-8293
    ISSN (online) 2772-8293
    DOI 10.1016/j.jacig.2021.11.001
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  8. Article ; Online: Maximal exercise increases mucosal associated invariant T cell frequency and number in healthy young men.

    Hanson, Erik D / Danson, Eli / Nguyen-Robertson, Catriona V / Fyfe, Jackson J / Stepto, Nigel K / Bartlett, David B / Sakkal, Samy

    European journal of applied physiology

    2017  Volume 117, Issue 11, Page(s) 2159–2169

    Abstract: Purpose: Mucosal associated invariant T (MAIT) cells have properties of the innate and acquired immune systems. While the response to vigorous exercise has been established for most leukocytes, MAIT cells have not been investigated. Therefore, the ... ...

    Abstract Purpose: Mucosal associated invariant T (MAIT) cells have properties of the innate and acquired immune systems. While the response to vigorous exercise has been established for most leukocytes, MAIT cells have not been investigated. Therefore, the purpose was to determine if MAIT cell lymphocytosis occurs with acute maximal aerobic exercise and if this response is influenced by exercise duration, cardiovascular fitness, or body composition.
    Methods: Twenty healthy young males with moderate fitness levels performed an extended graded exercise test until volitional fatigue. Peripheral blood mononuclear cells were isolated from venous blood obtained prior and immediately after exercise and were labeled to identify specific T cell populations using flow cytometry.
    Results: The percentage of MAIT cells relative to total T cells significantly increased from 3.0 to 3.8% and absolute MAIT cell counts increased by 2.2-fold following maximal exercise. MAIT cell subpopulation proportions were unchanged with exercise. Within cytotoxic T lymphocytes (CTL), MAIT cells consisted of 8% of these cells and this remained constant after exercise. MAIT cell counts and changes with exercise were not affected by body composition, VO
    Conclusions: Maximal exercise doubled MAIT cell numbers and showed preferential mobilization within total T cells but the response was not influenced by fitness levels, exercise duration, or body composition. These results suggest that acute exercise could be used to offset MAIT cell deficiencies observed with certain pathologies. MAIT cells also make up a substantial proportion of CTLs, which may have implications for cytotoxicity assays using these cells.
    Language English
    Publishing date 2017-11
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 124793-1
    ISSN 1439-6327 ; 1432-1025 ; 0301-5548 ; 1439-6319
    ISSN (online) 1439-6327 ; 1432-1025
    ISSN 0301-5548 ; 1439-6319
    DOI 10.1007/s00421-017-3704-z
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    Uc I Zs.195: Show issues Location:
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  9. Article ; Online: Benzofuran sulfonates and small self-lipid antigens activate type II NKT cells via CD1d.

    Almeida, Catarina F / Smith, Dylan G M / Cheng, Tan-Yun / Harpur, Chris M / Batleska, Elena / Nguyen-Robertson, Catriona V / Nguyen, Tram / Thelemann, Tamara / Reddiex, Scott J J / Li, Shihan / Eckle, Sidonia B G / Van Rhijn, Ildiko / Rossjohn, Jamie / Uldrich, Adam P / Moody, D Branch / Williams, Spencer J / Pellicci, Daniel G / Godfrey, Dale I

    Proceedings of the National Academy of Sciences of the United States of America

    2021  Volume 118, Issue 34

    Abstract: Natural killer T (NKT) cells detect lipids presented by CD1d. Most studies focus on type I NKT cells that express semi-invariant αβ T cell receptors (TCR) and recognize α-galactosylceramides. However, CD1d also presents structurally distinct lipids to ... ...

    Abstract Natural killer T (NKT) cells detect lipids presented by CD1d. Most studies focus on type I NKT cells that express semi-invariant αβ T cell receptors (TCR) and recognize α-galactosylceramides. However, CD1d also presents structurally distinct lipids to NKT cells expressing diverse TCRs (type II NKT cells), but our knowledge of the antigens for type II NKT cells is limited. An early study identified a nonlipidic NKT cell agonist, phenyl pentamethyldihydrobenzofuransulfonate (PPBF), which is notable for its similarity to common sulfa drugs, but its mechanism of NKT cell activation remained unknown. Here, we demonstrate that a range of pentamethylbenzofuransulfonates (PBFs), including PPBF, activate polyclonal type II NKT cells from human donors. Whereas these sulfa drug-like molecules might have acted pharmacologically on cells, here we demonstrate direct contact between TCRs and PBF-treated CD1d complexes. Further, PBF-treated CD1d tetramers identified type II NKT cell populations expressing αβTCRs and γδTCRs, including those with variable and joining region gene usage (TRAV12-1-TRAJ6) that was conserved across donors. By trapping a CD1d-type II NKT TCR complex for direct mass-spectrometric analysis, we detected molecules that allow the binding of CD1d to TCRs, finding that both selected PBF family members and short-chain sphingomyelin lipids are present in these complexes. Furthermore, the combination of PPBF and short-chain sphingomyelin enhances CD1d tetramer staining of PPBF-reactive T cell lines over either molecule alone. This study demonstrates that nonlipidic small molecules, which resemble sulfa drugs implicated in systemic hypersensitivity and drug allergy reactions, are targeted by a polyclonal population of type II NKT cells in a CD1d-restricted manner.
    MeSH term(s) Antigen Presentation/immunology ; Antigens, CD1d/immunology ; Antigens, CD1d/metabolism ; Arylsulfonates/immunology ; Autoantigens/immunology ; Autoantigens/metabolism ; Benzofurans/immunology ; Humans ; Lipids/immunology ; Lymphocyte Activation/immunology ; Natural Killer T-Cells/immunology ; Receptors, Antigen, T-Cell/immunology ; Receptors, Antigen, T-Cell/metabolism ; T-Lymphocyte Subsets/immunology
    Chemical Substances Antigens, CD1d ; Arylsulfonates ; Autoantigens ; Benzofurans ; CD1D protein, human ; Lipids ; Receptors, Antigen, T-Cell ; phenyl 2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonate
    Language English
    Publishing date 2021-08-20
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2104420118
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  10. Article ; Online: CD36 family members are TCR-independent ligands for CD1 antigen-presenting molecules.

    Gherardin, Nicholas A / Redmond, Samuel J / McWilliam, Hamish E G / Almeida, Catarina F / Gourley, Katherine H A / Seneviratna, Rebecca / Li, Shihan / De Rose, Robert / Ross, Fiona J / Nguyen-Robertson, Catriona V / Su, Shian / Ritchie, Matthew E / Villadangos, Jose A / Moody, D Branch / Pellicci, Daniel G / Uldrich, Adam P / Godfrey, Dale I

    Science immunology

    2021  Volume 6, Issue 60

    Abstract: CD1c presents lipid-based antigens to CD1c-restricted T cells, which are thought to be a major component of the human T cell pool. However, the study of CD1c-restricted T cells is hampered by the presence of an abundantly expressed, non-T cell receptor ( ... ...

    Abstract CD1c presents lipid-based antigens to CD1c-restricted T cells, which are thought to be a major component of the human T cell pool. However, the study of CD1c-restricted T cells is hampered by the presence of an abundantly expressed, non-T cell receptor (TCR) ligand for CD1c on blood cells, confounding analysis of TCR-mediated CD1c tetramer staining. Here, we identified the CD36 family (CD36, SR-B1, and LIMP-2) as ligands for CD1c, CD1b, and CD1d proteins and showed that CD36 is the receptor responsible for non-TCR-mediated CD1c tetramer staining of blood cells. Moreover, CD36 blockade clarified tetramer-based identification of CD1c-restricted T cells and improved identification of CD1b- and CD1d-restricted T cells. We used this technique to characterize CD1c-restricted T cells ex vivo and showed diverse phenotypic features, TCR repertoire, and antigen-specific subsets. Accordingly, this work will enable further studies into the biology of CD1 and human CD1-restricted T cells.
    MeSH term(s) Antigen Presentation ; Antigens, CD1/metabolism ; Blood Buffy Coat ; CD36 Antigens/antagonists & inhibitors ; CD36 Antigens/metabolism ; Glycoproteins/metabolism ; Healthy Volunteers ; Humans ; Jurkat Cells ; Ligands ; Lipids/immunology ; Primary Cell Culture ; Protein Multimerization ; Receptors, Antigen, T-Cell/metabolism ; T-Lymphocyte Subsets/immunology ; T-Lymphocyte Subsets/metabolism
    Chemical Substances Antigens, CD1 ; CD1C protein, human ; CD36 Antigens ; Glycoproteins ; Ligands ; Lipids ; Receptors, Antigen, T-Cell
    Language English
    Publishing date 2021-05-26
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2470-9468
    ISSN (online) 2470-9468
    DOI 10.1126/sciimmunol.abg4176
    Database MEDical Literature Analysis and Retrieval System OnLINE

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