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Article ; Online: Interesting case from Argentina: Kidney transplant recipient with skin lesions-A Latin American perspective.

Radisic, Marcelo Víctor / Santoro Lopes, Guilherme / Hasslocher-Moreno, Alejandro Marcel / Eichenberger, Emily M / Hall, Victoria G / Pujato, Natalia Rosana / Clemente, Wanessa Trindade

Transplant infectious disease : an official journal of the Transplantation Society

2024 Volume 26, Issue 2, Page(s) e14243

Abstract: This is a case of a kidney transplant recipient who presented with skin lesions, low-grade fevers, and pancytopenia 2 months after his transplant. ...

Abstract	This is a case of a kidney transplant recipient who presented with skin lesions, low-grade fevers, and pancytopenia 2 months after his transplant.
MeSH term(s)	Humans ; Trypanosoma cruzi ; Chagas Disease/pathology ; Kidney Transplantation/adverse effects ; Argentina ; Latin America
Language	English
Publishing date	2024-02-26
Publishing country	Denmark
Document type	Case Reports ; Journal Article
ZDB-ID	1476094-0
ISSN	1399-3062 ; 1398-2273
ISSN (online)	1399-3062
ISSN	1398-2273
DOI	10.1111/tid.14243
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Zs.A 5100: Show issues

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Article ; Online: Purification and use of crude green glycerol from the transesterification of triglycerides in the formulation of an alcohol gel hand sanitizer.

Trindade Mazala, Tassio / Costa Viana, Mateus / Carneiro, Guilherme / Lee Nelson, David / de Freitas-Marques, Maria B / De Martinis, Bruno Spinosa / Florêncio, Jacques / Mazzé, Fernanda Marur / da Silva, Severino G Domingos / Barbosa, Sandro L

Scientific reports

2024 Volume 14, Issue 1, Page(s) 5510

Abstract: ... glycerol was purified using chemical and physical treatments. The sanitizer was prepared using 71.100 g ... of 99.3° GL ethanol, 28.0 g H ...

Abstract	The aim of this study was to produce an alcohol gel hand sanitizer containing green glycerol. Crude glycerol was purified using chemical and physical treatments. The sanitizer was prepared using 71.100 g of 99.3° GL ethanol, 28.0 g H
MeSH term(s)	Glycerol ; Hand Sanitizers ; Triglycerides ; Ethanol ; Gels ; Ethanolamines
Chemical Substances	Glycerol (PDC6A3C0OX) ; triethanolamine (9O3K93S3TK) ; Hand Sanitizers ; Triglycerides ; Ethanol (3K9958V90M) ; Gels ; Ethanolamines
Language	English
Publishing date	2024-03-06
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-49422-5
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Article ; Online: Microsurgical Resection of Giant Petroclival Meningioma via the Posterior Petrosal Approach: 2-Dimensional Operative Video.

Ceccato, Guilherme H W / da Trindade, Érico S G G / Foltran, Rodrigo S / Pereira, Rodrigo V / Borba, Luis A B

World neurosurgery

2022 Volume 166, Page(s) 191

Abstract: Petroclival meningiomas are challenging deep-seated lesions related to many critical neurovascular structures of the skull base. ...

Abstract	Petroclival meningiomas are challenging deep-seated lesions related to many critical neurovascular structures of the skull base.
MeSH term(s)	Humans ; Male ; Meningeal Neoplasms/diagnostic imaging ; Meningeal Neoplasms/surgery ; Meningioma/diagnostic imaging ; Meningioma/surgery ; Middle Aged ; Neurosurgical Procedures/methods ; Petrous Bone/diagnostic imaging ; Petrous Bone/pathology ; Petrous Bone/surgery ; Skull Base Neoplasms/diagnostic imaging ; Skull Base Neoplasms/pathology ; Skull Base Neoplasms/surgery
Language	English
Publishing date	2022-08-11
Publishing country	United States
Document type	Case Reports ; Video-Audio Media
ZDB-ID	2534351-8
ISSN	1878-8769 ; 1878-8750
ISSN (online)	1878-8769
ISSN	1878-8750
DOI	10.1016/j.wneu.2022.08.008
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Article ; Online: Multimodal treatment of a pediatric posterior fossa arteriovenous malformation employing endovascular and microsurgical techniques.

Demartini, Zeferino / Ceccato, Guilherme H W / da Trindade, Érico S G G / Borba, Luis A B

Neurosurgical focus: Video

2021 Volume 4, Issue 1, Page(s) V17

Abstract: Intracranial hemorrhage is the most common presentation of posterior fossa arteriovenous malformations (AVMs) and may have serious consequences. The authors present a case of a 7-year-old girl with headache, vomiting, dysmetria, and ataxia due to a ... ...

Abstract	Intracranial hemorrhage is the most common presentation of posterior fossa arteriovenous malformations (AVMs) and may have serious consequences. The authors present a case of a 7-year-old girl with headache, vomiting, dysmetria, and ataxia due to a ruptured cerebellar grade III AVM. After two sessions of embolization, the patient underwent total microsurgical resection through a suboccipital craniotomy. There were no additional postoperative deficits, and the patient improved progressively during 6 months of rehabilitation. These challenging lesions should be removed after rupture, especially in children with long-term cumulative risk of rebleeding. Multimodal treatment reduces the perioperative bleeding, allowing better outcomes for pediatric AVM. The video can be found here: https://youtu.be/HQWnjD8ENZQ.
Language	English
Publishing date	2021-01-01
Publishing country	United States
Document type	Journal Article
ISSN	2643-5217
ISSN (online)	2643-5217
DOI	10.3171/2020.10.FOCVID2064
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Article ; Online: DENTAL INTRAORAL EXPOSURES IN PORTUGAL: FROM 1990 TO 2018.

Trindade, Hugo / Coutinho, Guilherme

Radiation protection dosimetry

2019 Volume 185, Issue 4, Page(s) 452–455

Abstract: Data from dental intraoral radiography quality controls was gathered from 1201 units (22% of the licensed X-ray units existing in Portugal), using film and digital image systems, between 2016 and 2018. The median incident air KERMA for standard superior ... ...

Abstract	Data from dental intraoral radiography quality controls was gathered from 1201 units (22% of the licensed X-ray units existing in Portugal), using film and digital image systems, between 2016 and 2018. The median incident air KERMA for standard superior molar tooth was evaluated in 0.9 mGy with the value of 1.3 mGy as the upper quartile. Comparisons with a 1990 published survey from dental exposures in Portugal were made. A 85% reduction for incident air KERMA per exposure was observed (6.0 mGy for the 1990 survey), which can be attributed to technical advances in the X-ray image receptors, as well as the implementation of legal requirements for technical acceptability of radiological units. It was also observed an increase of X-ray exams, which is related to an increase of dental practitioners, available radiological equipment and the level of dental healthcare.
MeSH term(s)	Humans ; Portugal ; Quality Control ; Radiation Dosage ; Radiography, Dental/methods ; Radiography, Dental/statistics & numerical data ; Radiography, Dental, Digital/methods ; Radiography, Dental, Digital/statistics & numerical data ; Radiology ; Radiometry ; Surveys and Questionnaires ; X-Ray Intensifying Screens ; X-Rays
Language	English
Publishing date	2019-09-06
Publishing country	England
Document type	Journal Article
ZDB-ID	225912-6
ISSN	1742-3406 ; 0144-8420
ISSN (online)	1742-3406
ISSN	0144-8420
DOI	10.1093/rpd/ncz033
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Article: Facial Expressions of Horses Using Weighted Multivariate Statistics for Assessment of Subtle Local Pain Induced by Polylactide-Based Polymers Implanted Subcutaneously.

Carvalho, Júlia R G / Trindade, Pedro H E / Conde, Gabriel / Antonioli, Marina L / Funnicelli, Michelli I G / Dias, Paula P / Canola, Paulo A / Chinelatto, Marcelo A / Ferraz, Guilherme C

Animals : an open access journal from MDPI

2022 Volume 12, Issue 18

Abstract: Facial-expression-based analysis has been widely applied as a pain coding system in horses. Herein, we aimed to identify pain in horses undergoing subcutaneously polylactide-based polymer implantation. The sham group was submitted only to surgical ... ...

Abstract	Facial-expression-based analysis has been widely applied as a pain coding system in horses. Herein, we aimed to identify pain in horses undergoing subcutaneously polylactide-based polymer implantation. The sham group was submitted only to surgical incision. The horses were filmed before and 24 and 48 h after implantation. Five statistical methods for evaluating their facial expressions (FEs) were tested. Primarily, three levels of scores (0, 1, and 2) were applied to the seven FEs (ear movements, eyebrow tension, orbicularis tension, dilated nostrils, eye opening, muzzle tension, and masticatory muscles tension). Subsequently, the scores of the seven FEs were added (SUM). Afterwards, principal component analysis (PCoA) was performed using the scores of the seven FEs obtained using the first method. Subsequently, weights were created for each FE, based on each variable's contribution variability obtained from the PCoA (SUM.W). Lastly, we applied a general score (GFS) to the animal's face (0 = without pain; 1 = moderate pain; 2 = severe pain). The mechanical nociceptive threshold (MNT) and cutaneous temperature (CT) values were collected at the same moments. The results show no intra- or intergroup differences, when evaluating each FE separately or in the GFS. In the intragroup comparison and 48 h after implantation, the control group showed higher values for SUM, PCoA, and SUM.W, although the horses implanted with polymers displayed more obvious alterations in the CT and MNT. Our findings show that the five statistical strategies used to analyze the faces of the horses were not able to detect low-grade inflammatory pain.
Language	English
Publishing date	2022-09-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606558-7
ISSN	2076-2615
ISSN	2076-2615
DOI	10.3390/ani12182400
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Article ; Online: COVID-19: therapeutic approaches description and discussion.

Trindade, Guilherme G / Caxito, Samyra M C / Xavier, Alessandra Rejane E O / Xavier, Mauro A S / BrandÃo, Fabiana

Anais da Academia Brasileira de Ciencias

2020 Volume 92, Issue 2, Page(s) e20200466

Abstract: COVID-19 emerged in December 2019 in China, and since then, has disrupted global public health and changed economic paradigms. In dealing with the new Coronavirus, SARS-CoV-2, the world has not faced such extreme global fragility since the "Spanish flu" ... ...

Abstract	COVID-19 emerged in December 2019 in China, and since then, has disrupted global public health and changed economic paradigms. In dealing with the new Coronavirus, SARS-CoV-2, the world has not faced such extreme global fragility since the "Spanish flu" pandemic in 1918. Researchers globally are dedicating efforts to the search for an effective treatment for COVID-19. Drugs already used in a clinical setting for other pathologies have been tested as a new therapeutic approach against SARS-CoV-2, setting off a frenzy over the preliminary data of different studies. This work aims to compile and discuss the data published thus far. Despite the potential effects of some antivirals and antiparasitic against COVID-19, clinical studies must confirm real effectiveness. However, non-pharmacological approaches have proven to be the most efficient strategy to date.
MeSH term(s)	Anti-Bacterial Agents/administration & dosage ; Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Antiparasitic Agents/administration & dosage ; Antiparasitic Agents/chemistry ; Antiparasitic Agents/pharmacology ; Antiviral Agents/administration & dosage ; Antiviral Agents/chemistry ; Antiviral Agents/pharmacology ; Betacoronavirus/drug effects ; COVID-19 ; Coronavirus Infections/drug therapy ; Humans ; Macrolides/administration & dosage ; Macrolides/chemistry ; Macrolides/pharmacology ; Pandemics ; Pneumonia, Viral/drug therapy ; SARS-CoV-2 ; Serine Proteinase Inhibitors/administration & dosage ; Serine Proteinase Inhibitors/chemistry ; Serine Proteinase Inhibitors/pharmacology
Chemical Substances	Anti-Bacterial Agents ; Antiparasitic Agents ; Antiviral Agents ; Macrolides ; Serine Proteinase Inhibitors
Keywords	covid19
Language	English
Publishing date	2020-06-15
Publishing country	Brazil
Document type	Journal Article ; Review
ZDB-ID	2046885-4
ISSN	1678-2690 ; 0001-3765
ISSN (online)	1678-2690
ISSN	0001-3765
DOI	10.1590/0001-3765202020200466
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Article ; Online: COVID-19

TRINDADE, GUILHERME G. / CAXITO, SAMYRA M.C. / XAVIER, ALESSANDRA REJANE E.O. / XAVIER, MAURO A.S. / BRANDÃO, FABIANA

Anais da Academia Brasileira de Ciências v.92 n.2 2020

therapeutic approaches description and discussion

2020

Abstract: Abstract Abstract: COVID-19 emerged in December 2019 in China, and since then, has disrupted global public health and changed economic paradigms. In dealing with the new Coronavirus, SARS-CoV-2, the world has not faced such extreme global fragility since ...

Abstract	Abstract Abstract: COVID-19 emerged in December 2019 in China, and since then, has disrupted global public health and changed economic paradigms. In dealing with the new Coronavirus, SARS-CoV-2, the world has not faced such extreme global fragility since the “Spanish flu” pandemic in 1918. Researchers globally are dedicating efforts to the search for an effective treatment for COVID-19. Drugs already used in a clinical setting for other pathologies have been tested as a new therapeutic approach against SARS-CoV-2, setting off a frenzy over the preliminary data of different studies. This work aims to compile and discuss the data published thus far. Despite the potential effects of some antivirals and antiparasitic against COVID-19, clinical studies must confirm real effectiveness. However, non-pharmacological approaches have proven to be the most efficient strategy to date.
Keywords	antivirals ; antiparasitic ; COVID-19 ; SARS-CoV-2 ; therapeutic approaches ; covid19
Language	English
Publishing date	2020-01-01
Publisher	Academia Brasileira de Ciências
Publishing country	br
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Facial Expressions of Horses Using Weighted Multivariate Statistics for Assessment of Subtle Local Pain Induced by Polylactide-Based Polymers Implanted Subcutaneously

Carvalho, Júlia R. G. / Trindade, Pedro H. E. / Conde, Gabriel / Antonioli, Marina L. / Funnicelli, Michelli I. G. / Dias, Paula P. / Canola, Paulo A. / Chinelatto, Marcelo A. / Ferraz, Guilherme C.

Animals. 2022 Sept. 13, v. 12, no. 18

2022

Abstract	Facial-expression-based analysis has been widely applied as a pain coding system in horses. Herein, we aimed to identify pain in horses undergoing subcutaneously polylactide-based polymer implantation. The sham group was submitted only to surgical incision. The horses were filmed before and 24 and 48 h after implantation. Five statistical methods for evaluating their facial expressions (FEs) were tested. Primarily, three levels of scores (0, 1, and 2) were applied to the seven FEs (ear movements, eyebrow tension, orbicularis tension, dilated nostrils, eye opening, muzzle tension, and masticatory muscles tension). Subsequently, the scores of the seven FEs were added (SUM). Afterwards, principal component analysis (PCoA) was performed using the scores of the seven FEs obtained using the first method. Subsequently, weights were created for each FE, based on each variable’s contribution variability obtained from the PCoA (SUM.W). Lastly, we applied a general score (GFS) to the animal’s face (0 = without pain; 1 = moderate pain; 2 = severe pain). The mechanical nociceptive threshold (MNT) and cutaneous temperature (CT) values were collected at the same moments. The results show no intra- or intergroup differences, when evaluating each FE separately or in the GFS. In the intragroup comparison and 48 h after implantation, the control group showed higher values for SUM, PCoA, and SUM.W, although the horses implanted with polymers displayed more obvious alterations in the CT and MNT. Our findings show that the five statistical strategies used to analyze the faces of the horses were not able to detect low-grade inflammatory pain.
Keywords	animals ; ears ; face ; multivariate analysis ; pain ; polymers ; principal component analysis ; temperature
Language	English
Dates of publication	2022-0913
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2606558-7
ISSN	2076-2615
ISSN	2076-2615
DOI	10.3390/ani12182400
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Praziquantel pharmacotherapy reduces systemic osteopontin levels and liver collagen content in murine schistosomiasis mansoni.

Pereira, Thiago A / Vaz de Melo Trindade, Guilherme / Trindade Santos, Elisangela / Pereira, Fausto E L / Souza, Márcia Maria de

International journal for parasitology

2021 Volume 51, Issue 6, Page(s) 437–440

Abstract: The pathogenesis of schistosomiasis and the mechanism of disease regression after Praziquantel pharmacotherapy are not fully elucidated. Schistosoma mansoni egg antigens directly stimulate the expression of the profibrogenic molecule osteopontin (OPN), ... ...

Abstract	The pathogenesis of schistosomiasis and the mechanism of disease regression after Praziquantel pharmacotherapy are not fully elucidated. Schistosoma mansoni egg antigens directly stimulate the expression of the profibrogenic molecule osteopontin (OPN), and systemic OPN levels strongly correlate with disease severity, suggesting its use as a potential morbidity biomarker. In this study, we investigated the impact of Praziquantel use on systemic OPN levels and on liver collagen deposition in chronic murine schistosomiasis. Praziquantel treatment significantly reduced systemic OPN levels and liver collagen deposition, indicating that OPN could be a reliable tool for monitoring PZQ efficacy and fibrosis regression in murine schistosomiasis.
MeSH term(s)	Animals ; Anthelmintics/therapeutic use ; Collagen/therapeutic use ; Liver ; Mice ; Osteopontin ; Praziquantel/therapeutic use ; Schistosoma mansoni ; Schistosomiasis mansoni/drug therapy
Chemical Substances	Anthelmintics ; Osteopontin (106441-73-0) ; Praziquantel (6490C9U457) ; Collagen (9007-34-5)
Language	English
Publishing date	2021-01-23
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	120518-3
ISSN	1879-0135 ; 0020-7519
ISSN (online)	1879-0135
ISSN	0020-7519
DOI	10.1016/j.ijpara.2020.11.002
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