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  1. Article ; Online: COVID-19: unanswered questions and work for a better knowledge.

    Cusato, Jessica

    Minerva medica

    2020  Volume 112, Issue 1, Page(s) 111–113

    MeSH term(s) COVID-19 ; Humans
    Language English
    Publishing date 2020-11-18
    Publishing country Italy
    Document type Editorial
    ZDB-ID 123586-2
    ISSN 1827-1669 ; 0026-4806
    ISSN (online) 1827-1669
    ISSN 0026-4806
    DOI 10.23736/S0026-4806.20.07153-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.132: Show issues Location:
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  2. Article ; Online: Therapeutic drug monitoring of TNFα inhibitors: a spotlight on novel techniques and assays.

    Cattaneo, Dario / Cusato, Jessica

    Expert opinion on drug metabolism & toxicology

    2022  Volume 18, Issue 10, Page(s) 615–618

    MeSH term(s) Humans ; Tumor Necrosis Factor-alpha ; Drug Monitoring/methods
    Chemical Substances Tumor Necrosis Factor-alpha
    Language English
    Publishing date 2022-10-12
    Publishing country England
    Document type Editorial
    ZDB-ID 2214462-6
    ISSN 1744-7607 ; 1742-5255
    ISSN (online) 1744-7607
    ISSN 1742-5255
    DOI 10.1080/17425255.2022.2134775
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6264: Show issues Location:
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  3. Article: Editorial: Bench Research Behind Lung Cancer Surgery.

    Bertolaccini, Luca / Spaggiari, Lorenzo / Cusato, Jessica

    Frontiers in surgery

    2022  Volume 9, Page(s) 936922

    Language English
    Publishing date 2022-06-21
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2773823-1
    ISSN 2296-875X
    ISSN 2296-875X
    DOI 10.3389/fsurg.2022.936922
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  4. Article ; Online: Pharmacokinetics and pharmacogenetics of high-dosage tedizolid for disseminated nocardiosis in a lung transplant patient.

    Corcione, Silvia / Vita, Davide / De Nicolò, Amedeo / Scabini, Silvia / Mornese Pinna, Simone / Cusato, Jessica / Mangiapia, Mauro / D'Avolio, Antonio / De Rosa, Francesco Giuseppe

    The Journal of antimicrobial chemotherapy

    2024  Volume 78, Issue 12, Page(s) 3003–3004

    MeSH term(s) Humans ; Pharmacogenetics ; Nocardia Infections/diagnosis ; Nocardia Infections/drug therapy ; Oxazolidinones ; Lung Transplantation/adverse effects ; Anti-Bacterial Agents/therapeutic use ; Anti-Bacterial Agents/pharmacokinetics
    Chemical Substances tedizolid (97HLQ82NGL) ; Oxazolidinones ; Anti-Bacterial Agents
    Language English
    Publishing date 2024-01-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 191709-2
    ISSN 1460-2091 ; 0305-7453
    ISSN (online) 1460-2091
    ISSN 0305-7453
    DOI 10.1093/jac/dkad299
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1197: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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    Zs.MO 124: Show issues

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  5. Article: Stability Study of Fosfomycin in Elastomeric Pumps at 4 °C and 34 °C: Technical Bases for a Continuous Infusion Use for Outpatient Parenteral Antibiotic Therapy.

    Manca, Alessandra / Palermiti, Alice / Mula, Jacopo / Cusato, Jessica / Maiese, Domenico / Simiele, Marco / De Nicolò, Amedeo / D'Avolio, Antonio

    Pharmaceutics

    2023  Volume 15, Issue 9

    Abstract: Background: Fosfomycin acts against aerobic Gram-/+ bacteria by blocking the synthesis of peptidoglycan. Its use has been currently re-evaluated for intravenous administration for the treatment of systemic infections by multidrug-resistant bacteria. ... ...

    Abstract Background: Fosfomycin acts against aerobic Gram-/+ bacteria by blocking the synthesis of peptidoglycan. Its use has been currently re-evaluated for intravenous administration for the treatment of systemic infections by multidrug-resistant bacteria. Concentration-/time-dependent activity has been suggested, with potential clinical advantages from prolonged or continuous infusion. Nevertheless, little is known about Fosfomycin stability in elastomeric pumps. The aim of the present work was stability investigation before administration at 4 °C and during administration at 34 °C.
    Methods: InfectoFos
    Results: Fosfomycin in elastomeric preparation is stable for at least 5 days at a storage temperature of 4 °C and 34 °C.
    Conclusions: The results suggest Fosfomycin eligibility for continuous infusion even in the context of outpatient parenteral antibiotic therapy. Therefore, this approach should be tested in clinical and pharmacokinetic studies, in order to evaluate the possible gains in the pharmacokinetic profile and the clinical effectiveness.
    Language English
    Publishing date 2023-09-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics15092347
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  6. Article: Correlation between Polymorphisms of Vitamin D Metabolism Genes and Perianal Disease in Crohn's Disease.

    Cusato, Jessica / Cafasso, Carla / Antonucci, Miriam / Palermiti, Alice / Manca, Alessandra / Caviglia, Gian Paolo / Vernero, Marta / Armandi, Angelo / Saracco, Giorgio Maria / D'Avolio, Antonio / Ribaldone, Davide Giuseppe

    Biomedicines

    2024  Volume 12, Issue 2

    Abstract: Although the role of vitamin D (VD) in the pathogenesis and progression of Crohn's disease (CD) is known, the association between single-nucleotide polymorphisms (SNPs) of genes linked to vitamin D pathway and CD risk is still under study. Furthermore, ... ...

    Abstract Although the role of vitamin D (VD) in the pathogenesis and progression of Crohn's disease (CD) is known, the association between single-nucleotide polymorphisms (SNPs) of genes linked to vitamin D pathway and CD risk is still under study. Furthermore, no significant association has been previously found between these SNPs and perianal CD (pCD), a severe phenotypic manifestation of CD that may present as perianal fistula, abscess, and recto-vaginal fistula. Among the mechanisms involved in its pathogenesis, local inflammation and intestinal microbiota alteration are recognized. VD seems to act on these elements. The aim of this study was to evaluate the presence of an association between SNPs of genes coding for enzymes, transporters, and receptors involved in the VD pathway and the occurrence of pCD. Blood samples of 206 patients with CD, including 34 with pCD, were analyzed for
    Language English
    Publishing date 2024-01-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines12020320
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  7. Article: Therapeutic Drug Monitoring as a Tool for the Clinical Outcome Prediction in Vedolizumab-Treated Patients: An Italian Pilot Study.

    Cusato, Jessica / Ribaldone, Davide Giuseppe / Falzone, Michela Helga / Manca, Alessandra / Antonucci, Miriam / Palermiti, Alice / Saracco, Giorgio Maria / Ceccarelli, Linda / Costa, Francesco / Bottari, Andrea / Fornaroli, Ginevra / Caviglia, Gian Paolo / D'Avolio, Antonio / Bertani, Lorenzo

    Biomedicines

    2024  Volume 12, Issue 4

    Abstract: Over the years, vedolizumab (VDZ) has emerged as a more effective target therapy for inflammatory bowel disease. The aim of this work was to analyze a cohort of inflammatory bowel disease patients, evaluating the association between VDZ serum ... ...

    Abstract Over the years, vedolizumab (VDZ) has emerged as a more effective target therapy for inflammatory bowel disease. The aim of this work was to analyze a cohort of inflammatory bowel disease patients, evaluating the association between VDZ serum concentrations at 6 months from starting therapy and their clinical and biochemical indexes within one year of treatment, correlating drug levels with response and clinical remission. Forty patients treated with VDZ were enrolled. Drug concentrations were quantified through ELISA methods. VDZ levels correlated with hemoglobin levels at twelve months of therapy (
    Language English
    Publishing date 2024-04-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines12040824
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  8. Article ; Online: Host Single Nucleotide Polymorphisms and Biomarkers of Neuronal Damage and Inflammation in People Living with HIV.

    Cusato, Jessica / Manca, Alessandra / Palermiti, Alice / Mula, Jacopo / Avataneo, Valeria / Antonucci, Miriam / Marinaro, Letizia / Bonora, Stefano / Trunfio, Mattia / Perri, Giovanni Di / D'Avolio, Antonio / Calcagno, Andrea

    International journal of antimicrobial agents

    2024  , Page(s) 107137

    Abstract: Background: Blood brain barrier impairment is frequent in people living with HIV (PLWH), affecting the penetration of target cells and antiretrovirals into the central nervous system, through transporters (e.g. ABCB1), leading to neuroinflammation.: ... ...

    Abstract Background: Blood brain barrier impairment is frequent in people living with HIV (PLWH), affecting the penetration of target cells and antiretrovirals into the central nervous system, through transporters (e.g. ABCB1), leading to neuroinflammation.
    Objectives: The aim of this study was to identify variants of genes encoding transporters able to predict neuroinflammation biomarker levels.
    Materials and methods: Cerebrospinal fluid (CSF) and plasma samples were obtained from PLWH. CSF biomarkers were quantified by commercial assays. Genetic variants were evaluated through real-time polymerase chain reaction (PCR).
    Results: 107 PLWH (163 samples) were included in the study: 79% were male, median age was 48.5 years, CD4% was 25%, HIV-associated neurolocognitive disorder (HAND) was observed in 17.8% of patients. ABCB1 2677G>T genetic variant showed a different allelic distribution according to the clinical group (p=0.026). In linear regression analyses, HIV-related central nervous system disorders, ABCG2 1194+928CC genotype, log viral load, CSAR, β-1,42 levels and CSF proteins were retained in the final model as factors independently associated with CSF neopterin levels; CSF proteins and integrase inhibitors use were associated with CSF tau level in the multivariate model. Phospho-tau regression analysis reported ABCB1 2677GT/TT genotype and CSF proteins as predictors in the final model; gender and protease inhibitors, neopterin, ABCB1 2677 GT/ TT genotype resulted predictors in the multivariate regression for β-1,42.
    Conclusions: For the first time, pharmacogenetic and clinical features were predictors of neuro-inflammation biomarkers.
    Language English
    Publishing date 2024-03-18
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1093977-5
    ISSN 1872-7913 ; 0924-8579
    ISSN (online) 1872-7913
    ISSN 0924-8579
    DOI 10.1016/j.ijantimicag.2024.107137
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    Zs.A 3368: Show issues Location:
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    Zs.MO 500: Show issues

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  9. Article ; Online: Serological and virological response in patients with hepatitis B virus genotype E treated with entecavir or tenofovir: a prospective study.

    Boglione, Lucio / De Benedetto, Ilaria / Lupia, Tommaso / Cusato, Jessica / Cariti, Giuseppe / Di Perri, Giovanni

    Archives of virology

    2021  Volume 166, Issue 4, Page(s) 1125–1131

    Abstract: European clinical practice guidelines (EASL) on chronic hepatitis B (CHB) recently recognized the importance of migration flows in the changing hepatitis B virus (HBV) epidemiology in low-endemic European countries. The role of different genotypes in ... ...

    Abstract European clinical practice guidelines (EASL) on chronic hepatitis B (CHB) recently recognized the importance of migration flows in the changing hepatitis B virus (HBV) epidemiology in low-endemic European countries. The role of different genotypes in nucleos(t)ide analogue (NA) treatment is still unknown. In the case of genotype E, which is mainly circulating in West Africa, a quantitative decrease in the level of HBsAg (qHBsAg) during treatment with entecavir (ETV) predicts a longer time to HBsAg loss when compared to genotypes A and D. We prospectively evaluated qHBsAg decline in HBeAg-negative CHB patients infected with HBV genotype E who were treated with tenofovir 245 mg (TDF) or ETV 0.5 mg from 2008 to 2014. Sixty-five West African patients (58; 89.2% males) were enrolled. The median age was 29 years, and the most prevalent route of transmission was familial (25; 38.5%). Median liver stiffness was 7.4 kPa, HBV-DNA was 4.7 Log IU/ml, and qHBsAg was 3.4 Log UI/ml. According to clinical evaluation, 40 patients (61.5%) started ETV treatment, whereas 25 patients (38.5%) started TDF treatment. The decline of qHBsAg in ETV patients was significantly lower than in TDF patients after 5 years of treatment (0.31 vs. 0.68 LogIU/mL, p < 0.001). At the same time points, a significantly higher virological non-response rate was observed in ETV patients (p < 0.001). Despite the partial and non-response rates observed in the ETV group, no mutations associated with drug resistance were detected in these subjects. In genotype E infections, ETV treatment results in a significantly lower decline in qHBsAg and higher rates of virological non-response after 5 years. TDF could represent the optimal choice.
    MeSH term(s) Adult ; Antiviral Agents/therapeutic use ; Female ; Genotype ; Guanine/analogs & derivatives ; Guanine/therapeutic use ; Hepatitis B Surface Antigens/blood ; Hepatitis B virus/drug effects ; Hepatitis B virus/genetics ; Hepatitis B, Chronic/drug therapy ; Hepatitis B, Chronic/virology ; Humans ; Male ; Prospective Studies ; Tenofovir/therapeutic use ; Treatment Outcome ; Viral Load/drug effects ; Young Adult
    Chemical Substances Antiviral Agents ; Hepatitis B Surface Antigens ; entecavir (5968Y6H45M) ; Guanine (5Z93L87A1R) ; Tenofovir (99YXE507IL)
    Language English
    Publishing date 2021-02-12
    Publishing country Austria
    Document type Comparative Study ; Journal Article
    ZDB-ID 7491-3
    ISSN 1432-8798 ; 0304-8608
    ISSN (online) 1432-8798
    ISSN 0304-8608
    DOI 10.1007/s00705-021-04992-5
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    Ud II Zs.110: Show issues Location:
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  10. Article ; Online: Monthly Increase in Vitamin D Levels upon Supplementation with 2000 IU/Day in Healthy Volunteers: Result from "Integriamoci", a Pilot Pharmacokinetic Study.

    Avataneo, Valeria / Palermiti, Alice / De Nicolò, Amedeo / Cusato, Jessica / Giussani, Gloria / Calcagno, Andrea / D'Avolio, Antonio

    Molecules (Basel, Switzerland)

    2022  Volume 27, Issue 3

    Abstract: Vitamin D (VD) is a calcium- and phosphate-controlling hormone used to treat bone disorders; yet, several other effects are progressively emerging. VD deficiency is highly prevalent worldwide, with suboptimal exposure to sunlight listed among the leading ...

    Abstract Vitamin D (VD) is a calcium- and phosphate-controlling hormone used to treat bone disorders; yet, several other effects are progressively emerging. VD deficiency is highly prevalent worldwide, with suboptimal exposure to sunlight listed among the leading causes: oral supplementation with either cholecalciferol or calcitriol is used. However, there is a scarcity of clinical studies investigating how quickly VD concentrations can increase after supplementation. In this pilot study, the commercial supplement ImmuD3 (by
    MeSH term(s) Adult ; Aged ; Bone Density Conservation Agents/administration & dosage ; Bone Density Conservation Agents/blood ; Bone Density Conservation Agents/therapeutic use ; Cholecalciferol/administration & dosage ; Cholecalciferol/blood ; Cholecalciferol/therapeutic use ; Dietary Supplements/analysis ; Female ; Humans ; Male ; Middle Aged ; Pilot Projects ; Vitamin D Deficiency/blood ; Vitamin D Deficiency/therapy ; Vitamins/administration & dosage ; Vitamins/blood ; Vitamins/therapeutic use ; Young Adult
    Chemical Substances Bone Density Conservation Agents ; Vitamins ; Cholecalciferol (1C6V77QF41)
    Language English
    Publishing date 2022-02-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules27031042
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