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  1. Article ; Online: Welcoming the Era of Gene Editing in Medicine.

    Daley, George Q

    The New England journal of medicine

    2024  

    Language English
    Publishing date 2024-04-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMp2314279
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  2. Article ; Online: Introduction to the Special Issue on CRISPR.

    Daley, George Q

    Perspectives in biology and medicine

    2020  Volume 63, Issue 1, Page(s) 1–13

    MeSH term(s) Clustered Regularly Interspaced Short Palindromic Repeats/physiology ; DNA, Recombinant ; Gene Editing ; Humans
    Chemical Substances DNA, Recombinant
    Language English
    Publishing date 2020-02-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80373-x
    ISSN 1529-8795 ; 0031-5982
    ISSN (online) 1529-8795
    ISSN 0031-5982
    DOI 10.1353/pbm.2020.0000
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Dipping a toe in the fountain of youth.

    Markel, Arianna / Daley, George Q

    Nature aging

    2022  Volume 2, Issue 3, Page(s) 192–194

    MeSH term(s) Humans ; Adolescent ; Palpation ; Toes
    Language English
    Publishing date 2022-11-10
    Publishing country United States
    Document type Journal Article ; Comment
    ISSN 2662-8465
    ISSN (online) 2662-8465
    DOI 10.1038/s43587-022-00188-x
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  4. Article ; Online: Polar Extremes in the Clinical Use of Stem Cells.

    Daley, George Q

    The New England journal of medicine

    2017  Volume 376, Issue 11, Page(s) 1075–1077

    Language English
    Publishing date 2017--16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMe1701379
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  5. Article ; Online: Oral health care in the 21st century: It is time for the integration of dental and medical education.

    Donoff, R Bruce / Daley, George Q

    Journal of dental education

    2020  Volume 84, Issue 9, Page(s) 999–1002

    Abstract: Major issues exist in the provision of oral health care in America, especially to underserved populations. Access to care, health disparities, an aging population with higher chronic disease burden, and rising healthcare costs continue to impact health ... ...

    Abstract Major issues exist in the provision of oral health care in America, especially to underserved populations. Access to care, health disparities, an aging population with higher chronic disease burden, and rising healthcare costs continue to impact health outcomes for millions. The marginalization of oral health care, like that of behavioral health care, is a contributor. This perspective presents an idea whose time has come: putting the mouth back in the body. Several national reports stress the imperative to better integrate the practice of medicine and dentistry, including the first-ever Surgeon General's Report on Oral Health in 2000. A plan to lead a multifaceted integration of oral health into overall health is proposed. Leaders will come from new educational and practice models stressing teamwork, interprofessional education, innovative residency training programs and even dual degree options.
    MeSH term(s) Education, Medical ; Health Care Costs ; Medically Underserved Area ; Oral Health ; United States
    Language English
    Publishing date 2020-05-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 410579-5
    ISSN 1930-7837 ; 0022-0337
    ISSN (online) 1930-7837
    ISSN 0022-0337
    DOI 10.1002/jdd.12191
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  6. Article ; Online: Stem Cells in the Treatment of Disease.

    Blau, Helen M / Daley, George Q

    The New England journal of medicine

    2019  Volume 380, Issue 18, Page(s) 1748–1760

    MeSH term(s) Animals ; Cardiomyopathies/therapy ; Combined Modality Therapy ; Epidermolysis Bullosa/therapy ; Genetic Therapy ; Humans ; Induced Pluripotent Stem Cells/transplantation ; Macular Degeneration/therapy ; Muscular Dystrophy, Duchenne/therapy ; Stem Cell Transplantation ; Stem Cells
    Language English
    Publishing date 2019-05-01
    Publishing country United States
    Document type Journal Article ; Review ; Video-Audio Media
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMra1716145
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  7. Article ; Online: Induced pluripotent stem cells in disease modelling and drug discovery.

    Rowe, R Grant / Daley, George Q

    Nature reviews. Genetics

    2019  Volume 20, Issue 7, Page(s) 377–388

    Abstract: The derivation of induced pluripotent stem cells (iPSCs) over a decade ago sparked widespread enthusiasm for the development of new models of human disease, enhanced platforms for drug discovery and more widespread use of autologous cell-based therapy. ... ...

    Abstract The derivation of induced pluripotent stem cells (iPSCs) over a decade ago sparked widespread enthusiasm for the development of new models of human disease, enhanced platforms for drug discovery and more widespread use of autologous cell-based therapy. Early studies using directed differentiation of iPSCs frequently uncovered cell-level phenotypes in monogenic diseases, but translation to tissue-level and organ-level diseases has required development of more complex, 3D, multicellular systems. Organoids and human-rodent chimaeras more accurately mirror the diverse cellular ecosystems of complex tissues and are being applied to iPSC disease models to recapitulate the pathobiology of a broad spectrum of human maladies, including infectious diseases, genetic disorders and cancer.
    MeSH term(s) Animals ; Cell Differentiation ; Cell Lineage/genetics ; Cell Lineage/immunology ; Chimera/genetics ; Chimera/immunology ; Communicable Diseases/genetics ; Communicable Diseases/immunology ; Communicable Diseases/pathology ; Communicable Diseases/therapy ; Drug Discovery/methods ; Genetic Diseases, Inborn/genetics ; Genetic Diseases, Inborn/immunology ; Genetic Diseases, Inborn/pathology ; Genetic Diseases, Inborn/therapy ; Genetic Therapy/methods ; Humans ; Induced Pluripotent Stem Cells/cytology ; Induced Pluripotent Stem Cells/immunology ; Induced Pluripotent Stem Cells/transplantation ; Models, Animal ; Models, Biological ; Neoplasms/genetics ; Neoplasms/immunology ; Neoplasms/pathology ; Neoplasms/therapy ; Organoids/cytology ; Organoids/drug effects ; Organoids/immunology ; Tissue Engineering/methods ; Tissue Transplantation/methods ; Transplantation, Heterologous
    Language English
    Publishing date 2019-02-04
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2035157-4
    ISSN 1471-0064 ; 1471-0056
    ISSN (online) 1471-0064
    ISSN 1471-0056
    DOI 10.1038/s41576-019-0100-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Anniversary reflections: ISSCR presidents on 20 years of progress.

    Little, Melissa / Morrison, Sean J / Rossant, Janet / Srivastava, Deepak / Daley, George Q

    Cell stem cell

    2022  Volume 29, Issue 6, Page(s) 876–878

    Abstract: This year, Cell Stem Cell and the International Society for Stem Cell Research (ISSCR) are celebrating their ... ...

    Abstract This year, Cell Stem Cell and the International Society for Stem Cell Research (ISSCR) are celebrating their 15
    MeSH term(s) Anniversaries and Special Events ; Policy ; Societies, Scientific ; Stem Cell Research
    Language English
    Publishing date 2022-05-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2375354-7
    ISSN 1875-9777 ; 1934-5909
    ISSN (online) 1875-9777
    ISSN 1934-5909
    DOI 10.1016/j.stem.2022.05.003
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  9. Article ; Online: Stem cells and the evolving notion of cellular identity.

    Daley, George Q

    Philosophical transactions of the Royal Society of London. Series B, Biological sciences

    2015  Volume 370, Issue 1680, Page(s) 20140376

    Abstract: Stem cells are but one class of the myriad types of cells within an organism. With potential to self-renew and capacity to differentiate, stem cells play essential roles at multiple stages of development. In the early embryo, pluripotent stem cells ... ...

    Abstract Stem cells are but one class of the myriad types of cells within an organism. With potential to self-renew and capacity to differentiate, stem cells play essential roles at multiple stages of development. In the early embryo, pluripotent stem cells represent progenitors for all tissues while later in development, tissue-restricted stem cells give rise to cells with highly specialized functions. As best understood in the blood, skin and gut, stem cells are the seeds that sustain tissue homeostasis and regeneration, while in other tissues like the muscle, liver, kidney and lung, various stem or progenitor cells play facultative roles in tissue repair and response to injury. Here, I will provide a brief perspective on the evolving notion of cellular identity and how reprogramming and transcription factor-mediated conversions of one cell type into another have fundamentally altered our assumptions about the stability of cell identity, with profound long-term implications for biomedical research and regenerative medicine.
    MeSH term(s) Animals ; Cell Dedifferentiation ; Cell Differentiation ; Cell Engineering ; Cell Transdifferentiation ; Cellular Reprogramming ; Humans ; Induced Pluripotent Stem Cells/cytology ; Multipotent Stem Cells/cytology ; Pluripotent Stem Cells/cytology ; Software ; Stem Cells/cytology ; Stem Cells/physiology
    Language English
    Publishing date 2015-09-25
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 208382-6
    ISSN 1471-2970 ; 0080-4622 ; 0264-3839 ; 0962-8436
    ISSN (online) 1471-2970
    ISSN 0080-4622 ; 0264-3839 ; 0962-8436
    DOI 10.1098/rstb.2014.0376
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Einzelsignatur: Show issues

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  10. Article ; Online: The Toughest Triage - Allocating Ventilators in a Pandemic.

    Truog, Robert D / Mitchell, Christine / Daley, George Q

    The New England journal of medicine

    2020  Volume 382, Issue 21, Page(s) 1973–1975

    MeSH term(s) COVID-19 ; Coronavirus Infections/epidemiology ; Coronavirus Infections/therapy ; Ethics Committees, Clinical ; Health Care Rationing/ethics ; Health Care Rationing/methods ; Humans ; Pandemics ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/therapy ; Resource Allocation/ethics ; Triage/ethics ; Triage/methods ; United States/epidemiology ; Ventilators, Mechanical/supply & distribution ; Withholding Treatment/ethics
    Keywords covid19
    Language English
    Publishing date 2020-03-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMp2005689
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