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  1. Article: Divine grace, human care, and the limits of morality

    McKenny, Gerald P

    Considering religious traditions in bioethics : Christian and Jewish voices

    physician-assisted suicide from a Protestant perspective

    2001  

    Author's details Gerald P. McKenny
    MeSH term(s) Christianity ; Protestantism ; Suicide, Assisted ; Personal Autonomy ; Spirituality ; Suicide/psychology
    Keywords Death and Euthanasia ; Religious Approach
    Language English
    Size p. 107-117.
    Document type Article
    Note Book compiler: Mary Jo Iozzio.
    ISBN 0940866986 ; 9780940866980
    Database Catalogue of the US National Library of Medicine (NLM)

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  2. Article: Is simulation useful in preparing doctors-to-be for patient death: A narrative review.

    Wong, Grace / Kenny, Ross / Hannam, Matthew / Colucci, Gianluca

    Journal of education and health promotion

    2023  Volume 12, Page(s) 240

    Abstract: Clinical and communication skills involved in managing patient death are essential for medical practitioners, yet these skills are often neglected in undergraduate medical education. We aim to review current reported evidence of simulation-based ... ...

    Abstract Clinical and communication skills involved in managing patient death are essential for medical practitioners, yet these skills are often neglected in undergraduate medical education. We aim to review current reported evidence of simulation-based education on medical students' preparedness and performance toward patient death. A narrative review of the literature on simulation-based education for medical students on patient death was conducted. Data on study design, simulation dimension, evaluation tool, and outcome were collected and summarized. Eleven prospective studies were included for narrative review. Simulation modalities included mannequins, standardized patients, and online virtual reality. Heterogeneity in the evaluation tool of simulation-based education was demonstrated. Ninety percent of studies concluded positive outcome of simulation on improving medical students' preparedness in patient death. No negative or adverse learner reaction was reported. Simulation-based education may safely improve medical students' competence in handling patient death. Current data and evaluation tools of education outcomes are sparse and heterogeneous. Future research is encouraged to explore this under-researched topic, amid increasing interest in the use of simulation in medical education.
    Language English
    Publishing date 2023-07-29
    Publishing country India
    Document type Journal Article ; Review
    ZDB-ID 2715449-X
    ISSN 2319-6440 ; 2277-9531
    ISSN (online) 2319-6440
    ISSN 2277-9531
    DOI 10.4103/jehp.jehp_1559_22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Tocilizumab for the treatment of non-critical COVID-19 pneumonia: an overview of the rationale and clinical evidence to date.

    Kenny, Grace / Mallon, Patrick W G

    Expert review of clinical pharmacology

    2021  Volume 14, Issue 10, Page(s) 1279–1287

    Abstract: ... ...

    Abstract Introduction
    MeSH term(s) Antibodies, Monoclonal, Humanized/therapeutic use ; Antiviral Agents/therapeutic use ; COVID-19/physiopathology ; Humans ; Interleukin-6/physiology ; SARS-CoV-2 ; COVID-19 Drug Treatment
    Chemical Substances Antibodies, Monoclonal, Humanized ; Antiviral Agents ; Interleukin-6 ; tocilizumab (I031V2H011)
    Language English
    Publishing date 2021-07-26
    Publishing country England
    Document type Journal Article ; Review
    ISSN 1751-2441
    ISSN (online) 1751-2441
    DOI 10.1080/17512433.2021.1949286
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Long COVID: Clinical characteristics, proposed pathogenesis and potential therapeutic targets.

    Kenny, Grace / Townsend, Liam / Savinelli, Stefano / Mallon, Patrick W G

    Frontiers in molecular biosciences

    2023  Volume 10, Page(s) 1157651

    Abstract: The emergence of persistent ill-health in the aftermath of SARS-CoV-2 infection has presented significant challenges to patients, healthcare workers and researchers. Termed long COVID, or post-acute sequelae of COVID-19 (PASC), the symptoms of this ... ...

    Abstract The emergence of persistent ill-health in the aftermath of SARS-CoV-2 infection has presented significant challenges to patients, healthcare workers and researchers. Termed long COVID, or post-acute sequelae of COVID-19 (PASC), the symptoms of this condition are highly variable and span multiple body systems. The underlying pathophysiology remains poorly understood, with no therapeutic agents proven to be effective. This narrative review describes predominant clinical features and phenotypes of long COVID alongside the data supporting potential pathogenesis of these phenotypes including ongoing immune dysregulation, viral persistence, endotheliopathy, gastrointestinal microbiome disturbance, autoimmunity, and dysautonomia. Finally, we describe current potential therapies under investigation, as well as future potential therapeutic options based on the proposed pathogenesis research.
    Language English
    Publishing date 2023-04-26
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2814330-9
    ISSN 2296-889X
    ISSN 2296-889X
    DOI 10.3389/fmolb.2023.1157651
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: A molecular perspective of obesity-mediated incisional hernia

    Mary Grace Kenny / Swati Agrawal / Christine Crigler / Robert J. Fitzgibbons

    Health Sciences Review, Vol 6, Iss , Pp 100080- (2023)

    2023  

    Abstract: Background: Incisional hernia is a common complication following laparotomy. Obesity increases the incidence of incisional hernia by about three-fold. However, the pathophysiology behind the formation of incisional hernia is not well described. Methods: ... ...

    Abstract Background: Incisional hernia is a common complication following laparotomy. Obesity increases the incidence of incisional hernia by about three-fold. However, the pathophysiology behind the formation of incisional hernia is not well described. Methods: The current literature was reviewed, investigating the effect of the pro-inflammatory state of adipose tissue in obesity on post-operative wound healing and subsequent incisional hernia formation. Results: The increase in leptin, M1 macrophages, and pro-inflammatory cytokines and concomitant decrease in adiponectin, M2 macrophages, and anti-inflammatory cytokines seen with the hypertrophy of adipocytes in obesity creates a chronic inflammatory state that impacts wound healing. Prolonged inflammation disrupts the interaction of endothelial tip cells and formation of vessel lumens during angiogenesis and decreases ratio of type I to type III collagen and number of cross-links, resulting in decreased tensile strength of the ECM and association with incisional hernia formation. Conclusion: Obesity has impacts on the inflammatory, fibroproliferative, and wound remodeling stages of wound healing that are suggested to contribute to incisional hernia formation. Further studies are needed to investigate the pathophysiology of incisional hernia formation in the setting of obesity to decrease the incidence of incisional hernias and identify possible treatments.
    Keywords Incisional hernia ; Obesity ; Adipokine ; Macrophage phenotype ; Collagen homeostasis ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: COVID19- clinical presentation and therapeutic considerations.

    Kenny, Grace / Mallon, Patrick W

    Biochemical and biophysical research communications

    2020  Volume 538, Page(s) 125–131

    Abstract: The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) as a pandemic infection in 2020 has presented many therapeutic challenges. Not least among these is the importance of abnormal host response to infection that is one of the ... ...

    Abstract The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) as a pandemic infection in 2020 has presented many therapeutic challenges. Not least among these is the importance of abnormal host response to infection that is one of the main drivers of more severe disease. Despite significant research endeavours, very few effective therapies have been identified, in part related to the different pathogenic mechanisms underlying different stages of clinical COVID-19. This mini review summarises data related to current and potential future therapies for COVID-19 and highlights the many challenges inherent in developing effective therapeutic options for new pandemic infection.
    MeSH term(s) Antiviral Agents/therapeutic use ; Humans ; Pandemics ; SARS-CoV-2 ; COVID-19 Drug Treatment
    Chemical Substances Antiviral Agents
    Keywords covid19
    Language English
    Publishing date 2020-11-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 205723-2
    ISSN 1090-2104 ; 0006-291X ; 0006-291X
    ISSN (online) 1090-2104 ; 0006-291X
    ISSN 0006-291X
    DOI 10.1016/j.bbrc.2020.11.021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 116: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Professional responsibility, nurses, and conscientious objection: A framework for ethical evaluation.

    Grace, Pamela J / Peter, Elizabeth / Lachman, Vicki D / Johnson, Norah L / Kenny, Deborah J / Wocial, Lucia D

    Nursing ethics

    2023  , Page(s) 9697330231180749

    Abstract: Conscientious objections (CO) can be disruptive in a variety of ways and may disadvantage patients and colleagues who must step-in to assume care. Nevertheless, nurses have a right and responsibility to object to participation in interventions that would ...

    Abstract Conscientious objections (CO) can be disruptive in a variety of ways and may disadvantage patients and colleagues who must step-in to assume care. Nevertheless, nurses have a right and responsibility to object to participation in interventions that would seriously harm their sense of integrity. This is an ethical problem of balancing risks and responsibilities related to patient care. Here we explore the problem and propose a nonlinear framework for exploring the authenticity of a claim of CO from the perspective of the nurse and of those who must evaluate such claims. We synthesized the framework using Rest's Four Component Model of moral reasoning along with tenets of the International Council of Nursing's (ICN) Code of Ethics for Nurses and insights from relevant ethics and nursing ethics literature. The resulting framework facilitates evaluating potential consequences of a given CO for all involved. We propose that the framework can also serve as an aid for nurse educators as they prepare students for practice. Gaining clarity about the sense in which the concept of conscience provides a defensible foundation for objecting to legally, or otherwise ethically, permissible actions, in any given case is critical to arriving at an ethical and reasonable plan of action.
    Language English
    Publishing date 2023-07-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 1200467-4
    ISSN 1477-0989 ; 0969-7330
    ISSN (online) 1477-0989
    ISSN 0969-7330
    DOI 10.1177/09697330231180749
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4041: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Melanoma Mimicker: Pigmented Mammary Paget Disease in a Man.

    Kenny, Mary Grace / Nguyen, Mai / Modi, Mitul / Eilers, David / Souchik, Adam

    The American Journal of dermatopathology

    2023  Volume 46, Issue 1, Page(s) 46–49

    Abstract: Abstract: Male breast cancer comprises less than 1% of all breast cancer cases. Mammary Paget disease (MPD) represents a subset of breast cancer that presents with skin changes of the nipple and areola, and is frequently misdiagnosed clinically due to ... ...

    Abstract Abstract: Male breast cancer comprises less than 1% of all breast cancer cases. Mammary Paget disease (MPD) represents a subset of breast cancer that presents with skin changes of the nipple and areola, and is frequently misdiagnosed clinically due to similarities with other disease states, leading to an average delay in diagnosis of 1 month to 2 years. Pigmented mammary Paget disease (PMPD) is an uncommon variant of MPD that clinically and histologically resembles malignant melanoma. Due to variable immunohistochemical staining patterns, analysis can be challenging and often requires interpretation of panels for accurate diagnosis. We present a rare case of PMPD in a male, originally diagnosed both clinically and histologically as malignant melanoma, to highlight the diagnostic challenges that this entity presents, and to review staining patterns which may be useful in its diagnosis.
    MeSH term(s) Humans ; Male ; Breast Neoplasms/pathology ; Breast Neoplasms, Male/diagnosis ; Breast Neoplasms, Male/pathology ; Diagnosis, Differential ; Melanoma/diagnosis ; Melanoma/pathology ; Nipples/pathology ; Paget's Disease, Mammary/diagnosis ; Paget's Disease, Mammary/pathology ; Skin Neoplasms/diagnosis ; Skin Neoplasms/pathology
    Language English
    Publishing date 2023-11-20
    Publishing country United States
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 448469-1
    ISSN 1533-0311 ; 0193-1091
    ISSN (online) 1533-0311
    ISSN 0193-1091
    DOI 10.1097/DAD.0000000000002588
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1518: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: COVID19- clinical presentation and therapeutic considerations

    Kenny, Grace / Mallon, Patrick W.

    Biochemical and Biophysical Research Communications ; ISSN 0006-291X

    2020  

    Keywords Biophysics ; Cell Biology ; Biochemistry ; Molecular Biology ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    DOI 10.1016/j.bbrc.2020.11.021
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: A qualitative study of perceived barriers and facilitators to sustainable parasite control on thoroughbred studs in Ireland.

    Walshe, Nicola / Burrell, Alison / Kenny, Ursula / Mulcahy, Grace / Duggan, Vivienne / Regan, Aine

    Veterinary parasitology

    2023  Volume 317, Page(s) 109904

    Abstract: In view of the rising threat of anthelmintic resistance in parasite populations and the planned change of classification of anthelmintics in Ireland for food animals to prescription-only medicines, there is a need for increased focus on parasite control ... ...

    Abstract In view of the rising threat of anthelmintic resistance in parasite populations and the planned change of classification of anthelmintics in Ireland for food animals to prescription-only medicines, there is a need for increased focus on parasite control strategies for horses. Effective parasite control programs (PCPs) are complex, necessitating the application of risk-assessment based on host immune status, infection pressure, type of parasite and seasonality to determine the requirement for anthelmintic administration and an understanding of parasite biology to employ effective, non- therapeutic, parasite control measures. The aim of this study was to explore horse breeders' attitudes and behaviours towards general parasite control practices and anthelmintic use on thoroughbred studs in Ireland using qualitative research methods, in order to help identify barriers to the implementation of sustainable equine PCPs supported by veterinary involvement. One-to-one, qualitative, semi-structured interviews were conducted with 16 breeders, using an interview topic guide that allowed for an open questioning style. The topic guide facilitated discussion around the following areas: (i) parasite control measures (general approach, (ii) veterinary involvement, (iii) use of anthelmintics, (iv) use of diagnostics, pasture management), (v) recording of anthelmintic use and (vi) anthelmintic resistance. Convenience, purposive (subjective selection) sampling was used to select a small group of participants that reflected the characteristics of current thoroughbred breeders in Ireland taking into account farm type, farm size, geographical location. The interviews were transcribed, and a method of inductive thematic analysis (a data driven identification and analysis of themes) was performed. Assessment of current behaviours by these participants found that PCPs were primarily based on the prophylactic use of anthelmintics without a strategic rationale. A key driver of behaviour regarding parasite prevention practices was localised routine, dictated by tradition, that gave breeders a sense of confidence and protection regarding parasite control. The perceptions of the benefits of parasitology diagnostics were varied and their application to control was poorly understood. Anthelmintic resistance was recognised as an industry threat but not an issue for individual farms. By using a qualitative approach, this study offers insights into the possible barriers to the adoption of sustainable PCPs on Irish thoroughbred farms and highlights the need for end-user involvement in the preparation of future guidelines.
    MeSH term(s) Animals ; Horses ; Surveys and Questionnaires ; Horse Diseases/epidemiology ; Horse Diseases/prevention & control ; Horse Diseases/drug therapy ; Ireland/epidemiology ; Animal Husbandry/methods ; Anthelmintics/therapeutic use ; Anthelmintics/pharmacology ; Parasites ; Communicable Disease Control ; Qualitative Research ; Drug Resistance ; Parasite Egg Count/veterinary
    Chemical Substances Anthelmintics
    Language English
    Publishing date 2023-03-05
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 196831-2
    ISSN 1873-2550 ; 0304-4017
    ISSN (online) 1873-2550
    ISSN 0304-4017
    DOI 10.1016/j.vetpar.2023.109904
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4380: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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