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  1. Article ; Online: Response to: Comment on: Ten-year outcomes of antivascular endothelial growth factor therapy in neovascular age-related macular degeneration.

    Chandra, Shruti

    Eye (London, England)

    2021  Volume 36, Issue 2, Page(s) 474

    MeSH term(s) Endothelial Growth Factors/therapeutic use ; Humans ; Intravitreal Injections ; Macular Degeneration/drug therapy ; Ranibizumab/therapeutic use
    Chemical Substances Endothelial Growth Factors ; Ranibizumab (ZL1R02VT79)
    Language English
    Publishing date 2021-01-29
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 91001-6
    ISSN 1476-5454 ; 0950-222X
    ISSN (online) 1476-5454
    ISSN 0950-222X
    DOI 10.1038/s41433-020-01386-w
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  2. Article ; Online: Role of nursing in telehealth.

    Lebar, Kiersten / Chandra, Shruti / Hollander, Judd E

    Nursing

    2022  Volume 52, Issue 6, Page(s) 42–46

    Abstract: Abstract: This article explores the types, features, and benefits of telehealth-including a sample telehealth program-and discusses the role of nurses in the efficient delivery and improvement of telehealth systems. ...

    Abstract Abstract: This article explores the types, features, and benefits of telehealth-including a sample telehealth program-and discusses the role of nurses in the efficient delivery and improvement of telehealth systems.
    MeSH term(s) Humans ; Nurse's Role ; Telemedicine
    Language English
    Publishing date 2022-05-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 197895-0
    ISSN 1538-8689 ; 0360-4039
    ISSN (online) 1538-8689
    ISSN 0360-4039
    DOI 10.1097/01.NURSE.0000829908.44004.9a
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  3. Article: Not Only WEIRD but "Uncanny"? A Systematic Review of Diversity in Human-Robot Interaction Research.

    Seaborn, Katie / Barbareschi, Giulia / Chandra, Shruti

    International journal of social robotics

    2023  , Page(s) 1–30

    Abstract: Critical voices within and beyond the scientific community have pointed to a grave matter of concern regarding who is included in research and who is not. Subsequent investigations have revealed an extensive form of sampling bias across a broad range of ... ...

    Abstract Critical voices within and beyond the scientific community have pointed to a grave matter of concern regarding who is included in research and who is not. Subsequent investigations have revealed an extensive form of sampling bias across a broad range of disciplines that conduct human subjects research called "WEIRD": Western, Educated, Industrial, Rich, and Democratic. Recent work has indicated that this pattern exists within human-computer interaction (HCI) research, as well. How then does human-robot interaction (HRI) fare? And could there be other patterns of sampling bias at play, perhaps those especially relevant to this field of study? We conducted a systematic review of the premier ACM/IEEE International Conference on Human-Robot Interaction (2006-2022) to discover whether and how WEIRD HRI research is. Importantly, we expanded our purview to other factors of representation highlighted by critical work on inclusion and intersectionality as potentially underreported, overlooked, and even marginalized factors of human diversity. Findings from 827 studies across 749 papers confirm that participants in HRI research also tend to be drawn from WEIRD populations. Moreover, we find evidence of limited, obscured, and possible misrepresentation in participant sampling and reporting along key axes of diversity: sex and gender, race and ethnicity, age, sexuality and family configuration, disability, body type, ideology, and domain expertise. We discuss methodological and ethical implications for recruitment, analysis, and reporting, as well as the significance for HRI as a base of knowledge.
    Language English
    Publishing date 2023-03-08
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2486751-2
    ISSN 1875-4805 ; 1875-4791
    ISSN (online) 1875-4805
    ISSN 1875-4791
    DOI 10.1007/s12369-023-00968-4
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  4. Article ; Online: Tyrosine Kinase Inhibitors and their role in treating neovascular age-related macular degeneration and diabetic macular oedema.

    Chandra, Shruti / Tan, Emanuel Yuquan / Empeslidis, Theo / Sivaprasad, Sobha

    Eye (London, England)

    2023  Volume 37, Issue 18, Page(s) 3725–3733

    Abstract: The advent of intravitreal anti-VEGF injections has revolutionised the treatment of both neovascular age-related macular degeneration (nAMD or wet AMD) and diabetic macular oedema (DMO). Despite their efficacy, anti-VEGF injections precipitate ... ...

    Abstract The advent of intravitreal anti-VEGF injections has revolutionised the treatment of both neovascular age-related macular degeneration (nAMD or wet AMD) and diabetic macular oedema (DMO). Despite their efficacy, anti-VEGF injections precipitate significant treatment burden for patients, caregivers and healthcare systems due to the high frequency of injections required to sustain treatment benefit. Therefore, there remains an unmet need for lower-burden therapies. Tyrosine kinase inhibitors (TKI) are a novel class of drugs that may have considerable potential in addressing this issue. This review will summarise and discuss the results of various pilot studies and clinical trials exploring the role of TKIs in treatment of nAMD and DMO, highlighting promising candidates and possible challenges in developments.
    MeSH term(s) Humans ; Macular Edema/drug therapy ; Ranibizumab/therapeutic use ; Angiogenesis Inhibitors/therapeutic use ; Tyrosine Kinase Inhibitors ; Vascular Endothelial Growth Factor A ; Wet Macular Degeneration/drug therapy ; Diabetic Retinopathy/complications ; Diabetic Retinopathy/drug therapy ; Intravitreal Injections ; Diabetes Mellitus
    Chemical Substances Ranibizumab (ZL1R02VT79) ; Angiogenesis Inhibitors ; Tyrosine Kinase Inhibitors ; Vascular Endothelial Growth Factor A
    Language English
    Publishing date 2023-06-07
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 91001-6
    ISSN 1476-5454 ; 0950-222X
    ISSN (online) 1476-5454
    ISSN 0950-222X
    DOI 10.1038/s41433-023-02610-z
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  5. Article ; Online: Mucinous adenocarcinoma of renal pelvis in a young male: a diagnostic challenge.

    Gupta, Pooja / Agarwal, Deepti / Shruti, Sharma / Chandra, Mithlesh

    German medical science : GMS e-journal

    2020  Volume 18, Page(s) Doc11

    Abstract: Primary mucinous adenocarcinoma of the renal pelvis is an extremely rare tumor with only a handful of cases reported to date. Clinical and radiological features are not specific, and hence, histopathological examination holds the key for definitive ... ...

    Abstract Primary mucinous adenocarcinoma of the renal pelvis is an extremely rare tumor with only a handful of cases reported to date. Clinical and radiological features are not specific, and hence, histopathological examination holds the key for definitive diagnosis. This tumor has mainly been described in the elderly population, with less than five cases reported in individuals aged <35 years. Here, we report a case of primary mucinous adenocarcinoma of the renal pelvis in a young male. A 31-year-old male presented with a history of right-sided flank pain for the past year. On examination, he had right-sided costovertebral tenderness. Computed tomography (CT) scan revealed the presence of a hyperdense mass lesion in the right renal pelvis with severe hydronephrosis and cortical thinning. Because of the non-functioning status, right nephrectomy was performed. To our surprise, histopathology showed the presence of mucinous adenocarcinoma of the renal pelvis with carcinoma in situ of the ureter. This case describes a rare presentation of primary mucinous adenocarcinoma of the renal pelvis, and highlights the importance of histopathological examination in reaching the correct diagnosis.
    MeSH term(s) Adenocarcinoma, Mucinous/pathology ; Adenocarcinoma, Mucinous/physiopathology ; Adenocarcinoma, Mucinous/surgery ; Adult ; Carcinoma in Situ/pathology ; Carcinoma in Situ/surgery ; Flank Pain/diagnosis ; Flank Pain/etiology ; Humans ; Hydronephrosis/diagnosis ; Hydronephrosis/etiology ; Kidney Neoplasms/pathology ; Kidney Neoplasms/physiopathology ; Kidney Neoplasms/surgery ; Kidney Pelvis/diagnostic imaging ; Kidney Pelvis/pathology ; Male ; Nephrectomy/methods ; Tomography, X-Ray Computed/methods ; Treatment Outcome ; Ultrasonography/methods ; Ureter/diagnostic imaging ; Ureter/pathology ; Ureteral Neoplasms/pathology ; Ureteral Neoplasms/surgery
    Language English
    Publishing date 2020-11-25
    Publishing country Germany
    Document type Case Reports
    ISSN 1612-3174
    ISSN (online) 1612-3174
    DOI 10.3205/000287
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  6. Article: Endoscopic ultrasound-guided gastroenterostomy versus surgical gastrojejunostomy in treatment of malignant gastric outlet obstruction: Systematic review and meta-analysis.

    Bomman, Shivanand / Ghafoor, Adil / Sanders, David J / Jayaraj, Mahendran / Chandra, Shruti / Krishnamoorthi, Rajesh

    Endoscopy international open

    2022  Volume 10, Issue 4, Page(s) E361–E368

    Abstract: Background and study ... ...

    Abstract Background and study aims
    Language English
    Publishing date 2022-04-14
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2761052-4
    ISSN 2196-9736 ; 2364-3722
    ISSN (online) 2196-9736
    ISSN 2364-3722
    DOI 10.1055/a-1783-8949
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  7. Article ; Online: The Royal College of Ophthalmologists Commissioning guidelines on age macular degeneration: executive summary.

    Chandra, Shruti / McKibbin, Martin / Mahmood, Sajjad / Downey, Louise / Barnes, Beth / Sivaprasad, Sobha

    Eye (London, England)

    2022  Volume 36, Issue 11, Page(s) 2078–2083

    MeSH term(s) Humans ; Ophthalmologists ; Macular Degeneration/diagnosis ; Macular Degeneration/therapy ; Ophthalmology
    Language English
    Publishing date 2022-05-27
    Publishing country England
    Document type Editorial
    ZDB-ID 91001-6
    ISSN 1476-5454 ; 0950-222X
    ISSN (online) 1476-5454
    ISSN 0950-222X
    DOI 10.1038/s41433-022-02095-2
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  8. Article ; Online: Are Fungi Becoming the Most Common Organisms in Primary Infected Pancreatic Necrosis?

    Horibe, Masayasu / Sannapaneni, Shilpa / Chandra, Shruti / Sharma, Ayush / Vege, Santhi Swaroop

    Pancreas

    2022  Volume 51, Issue 1, Page(s) e6–e7

    MeSH term(s) Bacterial Infections ; Fungi/isolation & purification ; Humans ; Pancreatitis, Acute Necrotizing/etiology ; Pancreatitis, Acute Necrotizing/microbiology
    Language English
    Publishing date 2022-02-16
    Publishing country United States
    Document type Letter
    ZDB-ID 632831-3
    ISSN 1536-4828 ; 0885-3177
    ISSN (online) 1536-4828
    ISSN 0885-3177
    DOI 10.1097/MPA.0000000000001943
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  9. Book ; Online: Transcending the "Male Code"

    Seaborn, Katie / Chandra, Shruti / Fabre, Thibault

    Implicit Masculine Biases in NLP Contexts

    2023  

    Abstract: Critical scholarship has elevated the problem of gender bias in data sets used to train virtual assistants (VAs). Most work has focused on explicit biases in language, especially against women, girls, femme-identifying people, and genderqueer folk; ... ...

    Abstract Critical scholarship has elevated the problem of gender bias in data sets used to train virtual assistants (VAs). Most work has focused on explicit biases in language, especially against women, girls, femme-identifying people, and genderqueer folk; implicit associations through word embeddings; and limited models of gender and masculinities, especially toxic masculinities, conflation of sex and gender, and a sex/gender binary framing of the masculine as diametric to the feminine. Yet, we must also interrogate how masculinities are "coded" into language and the assumption of "male" as the linguistic default: implicit masculine biases. To this end, we examined two natural language processing (NLP) data sets. We found that when gendered language was present, so were gender biases and especially masculine biases. Moreover, these biases related in nuanced ways to the NLP context. We offer a new dictionary called AVA that covers ambiguous associations between gendered language and the language of VAs.

    Comment: 19 pages
    Keywords Computer Science - Computation and Language ; Computer Science - Computers and Society ; Computer Science - Human-Computer Interaction ; Computer Science - Machine Learning
    Subject code 121
    Publishing date 2023-04-21
    Publishing country us
    Document type Book ; Online
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  10. Article ; Online: Perspectives from clinical trials: is geographic atrophy one disease?

    Sivaprasad, Sobha / Chandra, Shruti / Kwon, Jeha / Khalid, Noorulain / Chong, Victor

    Eye (London, England)

    2022  Volume 37, Issue 3, Page(s) 402–407

    Abstract: Geographic atrophy (GA) is currently an untreatable condition. Emerging evidence from recent clinical trials show that anti-complement therapy may be a successful treatment option. However, several trials in this therapy area have failed as well. This ... ...

    Abstract Geographic atrophy (GA) is currently an untreatable condition. Emerging evidence from recent clinical trials show that anti-complement therapy may be a successful treatment option. However, several trials in this therapy area have failed as well. This raises several questions. Firstly, does complement therapy work for all patients with GA? Secondly, is GA one disease? Can we assume that these failed clinical trials are due to ineffective interventions or are they due to flawed clinical trial designs, heterogeneity in GA progression rates or differences in study cohorts? In this article we try to answer these questions by providing an overview of the challenges of designing and interpreting outcomes of randomised controlled trials (RCTs) in GA. These include differing inclusion-exclusion criteria, heterogeneous progression rates of the disease, outcome choices and confounders.
    MeSH term(s) Humans ; Geographic Atrophy ; Disease Progression
    Language English
    Publishing date 2022-05-31
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 91001-6
    ISSN 1476-5454 ; 0950-222X
    ISSN (online) 1476-5454
    ISSN 0950-222X
    DOI 10.1038/s41433-022-02115-1
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