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  1. Article ; Online: Their health is our wealth: lay perceptions on the health impacts of blood donation.

    Fogarty, Helen / McSweeney, Ellen / Hervig, Tor

    Blood transfusion = Trasfusione del sangue

    2023  Volume 22, Issue 1, Page(s) 1–3

    MeSH term(s) Humans ; Blood Donation
    Language English
    Publishing date 2023-09-22
    Publishing country Italy
    Document type Editorial
    ZDB-ID 2135732-8
    ISSN 2385-2070 ; 0041-1787 ; 1723-2007
    ISSN (online) 2385-2070
    ISSN 0041-1787 ; 1723-2007
    DOI 10.2450/BloodTransfus.625
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 798: Show issues Location:
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  2. Article: Liver Disease and Sickle Cell Disease: Auto-Immune Hepatitis more than a Coincidence; A Systematic Review of the Literature.

    Lynch, Kelvin / Mega, Andrea / Daves, Massimo / Sadiq, Asma / Fogarty, Helen / Piccin, Andrea

    Mediterranean journal of hematology and infectious diseases

    2023  Volume 15, Issue 1, Page(s) e2023060

    Abstract: In patients with SCD, chronic liver damage is a common manifestation. More than 50% of SCD patients have elevated liver enzymes. Common underlying aetiologies include sickle cell hepatic crisis, viral hepatitis, sickle cell intrahepatic cholestasis and ... ...

    Abstract In patients with SCD, chronic liver damage is a common manifestation. More than 50% of SCD patients have elevated liver enzymes. Common underlying aetiologies include sickle cell hepatic crisis, viral hepatitis, sickle cell intrahepatic cholestasis and hepatic sequestration in the acute setting, and cholelithiasis and iron overload in the chronic setting. Autoimmune hepatitis (AIH) is a rare disease that appears to occur more commonly in the sickle cell disease (SCD) population than in the general population. There are many schools of thought as to why this is the case, including the phosphatidylserine hypothesis, the heme inflammatory hypothesis, the complement generation hypothesis, and the transfusion alloimmunization hypothesis. Due to the natural history of the two illnesses, SCD is almost always diagnosed first in cases of dual pathology. Symptoms such as jaundice, fatigue, and abdominal pain are common in SCD, as are abnormal liver function tests (LFTs). These abnormalities, attributed to the other more frequent liver involvements in SCD, can lead to delays in AIH diagnosis in this population. Corticosteroids, sometimes with other immunosuppressive agents, such as azathioprine, are the cornerstone of acute AIH treatment. However, corticosteroid use in the SCD population has been shown to carry an increased risk of vaso-occlusive crises, providing a treatment dilemma. The following is a review of AIH in the SCD population, where we explore the pathophysiology behind the association between the two disorders, discuss an approach to investigating abnormal LFTs in SCD, and examine treatment options in this population with co-existing diseases.
    Language English
    Publishing date 2023-11-01
    Publishing country Italy
    Document type Journal Article ; Review
    ZDB-ID 2674750-9
    ISSN 2035-3006
    ISSN 2035-3006
    DOI 10.4084/MJHID.2023.060
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Enhanced thrombin generation potential and endothelial dysfunction in chronic spontaneous urticaria.

    Ridge, Katie / Fogarty, Helen / Doherty, Dearbhla / Byrne, Mary / O'Farrelly, Cliona / O'Donnell, James S / Conlon, Niall

    Clinical and translational allergy

    2023  Volume 13, Issue 7, Page(s) e12285

    Language English
    Publishing date 2023-07-24
    Publishing country England
    Document type Letter
    ZDB-ID 2630865-4
    ISSN 2045-7022
    ISSN 2045-7022
    DOI 10.1002/clt2.12285
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  4. Article ; Online: Australian massage therapists' views and practices related to preconception, pregnancy and the early postpartum period.

    Fogarty, Sarah / Steel, Amie / Hall, Helen / Hay, Phillipa

    Complementary therapies in clinical practice

    2020  Volume 40, Page(s) 101222

    Abstract: Background and purpose: Massage is commonly used by the Australian public and is often sought by expectant mothers. Despite its popularity there is no regulatory body to enforce minimum educational standards, guidelines or evidence-based best practice ... ...

    Abstract Background and purpose: Massage is commonly used by the Australian public and is often sought by expectant mothers. Despite its popularity there is no regulatory body to enforce minimum educational standards, guidelines or evidence-based best practice for massage therapists. The aim of this paper is to critically examine the views and practices of massage therapists who offer preconception, antenatal or postnatal massage.
    Materials and methods: An online survey was administered to Australian massage therapists who provide massage in the preconception, antenatal or postnatal periods.
    Results: Ninety-nine therapists completed the survey. The majority of respondents had received training in pregnancy massage (n = 72; 72.7%) only. The most confident respondents were those that had both training and experience.
    Conclusion: There are potential gaps in training for massage therapists including up-to-date curriculum and a fragmentation around industry training requirements for pregnancy massage, which may impact on the safety and benefits of pregnancy massage.
    MeSH term(s) Adult ; Australia ; Female ; Humans ; Massage/statistics & numerical data ; Middle Aged ; Postpartum Period ; Pregnancy ; Surveys and Questionnaires
    Language English
    Publishing date 2020-07-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2182834-9
    ISSN 1873-6947 ; 1744-3881
    ISSN (online) 1873-6947
    ISSN 1744-3881
    DOI 10.1016/j.ctcp.2020.101222
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    Zs.A 4912: Show issues Location:
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  5. Article ; Online: New developments in von Willebrand disease.

    Fogarty, Helen / Doherty, Dearbhla / O'Donnell, James S

    British journal of haematology

    2020  Volume 191, Issue 3, Page(s) 329–339

    Abstract: Von Willebrand disease (VWD) constitutes the most common inherited human bleeding disorder. It is associated with a mucocutaneous bleeding phenotype that can significantly impact upon quality of life. Despite its prevalence and associated morbidity, the ... ...

    Abstract Von Willebrand disease (VWD) constitutes the most common inherited human bleeding disorder. It is associated with a mucocutaneous bleeding phenotype that can significantly impact upon quality of life. Despite its prevalence and associated morbidity, the diagnosis and subclassification of VWD continue to pose significant clinical challenges. This is in part attributable to the fact that plasma von Willebrand factor (VWF) levels vary over a wide range in the normal population, together with the multiple different physiological functions played by VWF in vivo. Over recent years, substantial progress has been achieved in elucidating the biological roles of VWF. Significant advances have also been made into defining the pathophysiological mechanisms underpinning both quantitative and qualitative VWD. In particular, several new laboratory assays have been developed that enable more precise assessment of specific aspects of VWF activity. In the present review, we discuss these recent developments in the field of VWD diagnosis, and consider how these advances can impact upon clinical diagnostic algorithms for use in routine clinical practice. In addition, we review some important recent advances pertaining to the various treatment options available for managing patients with VWD.
    MeSH term(s) Biomarkers ; Clinical Decision-Making ; Combined Modality Therapy ; Disease Management ; Disease Susceptibility ; Genetic Association Studies/methods ; Genetic Association Studies/standards ; Genetic Predisposition to Disease ; Genotype ; Humans ; Molecular Diagnostic Techniques/methods ; Molecular Diagnostic Techniques/standards ; Phenotype ; Treatment Outcome ; von Willebrand Diseases/diagnosis ; von Willebrand Diseases/etiology ; von Willebrand Diseases/therapy
    Chemical Substances Biomarkers
    Language English
    Publishing date 2020-05-12
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.16681
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  6. Article ; Online: Partner delivered relaxation massage to support mild antenatal anxiety; views of participants.

    Hall, Helen / Lauche, Romy / Fogarty, Sarah / Kloester, Joy / Carr, Bethany / Munk, Niki

    Midwifery

    2021  Volume 105, Page(s) 103229

    Abstract: Background: Approximately one-fifth of pregnant women suffer from anxiety and/or depression. These mental health conditions are associated with increased infant and maternal morbidity. Relaxation massage has the potential to improve mental health and ... ...

    Abstract Background: Approximately one-fifth of pregnant women suffer from anxiety and/or depression. These mental health conditions are associated with increased infant and maternal morbidity. Relaxation massage has the potential to improve mental health and may provide a vaulable option for pregnant women. This paper reports on participants' experiences of partner delivered massage as a technique to manage mild antenatal anxiety.
    Methods: We conducted a feasibility study with 44 pregnant women who self-assessed as mildly anxious. The women were randomised into massage therapy (14 women/partner dyads) or to an active control group (13 women). 4-6 weeks after the birth of their baby, massage group participants were invited to be interviewed about their experiences; twelve women and four partners agreed. The qualitative data was analysed using reflective thematic analysis.
    Results: Four themes emerged from the data; Supporting mental health, Connecting, Useful and adaptable and Making it happen. Partner delivered massage was an accessible and practical method to manage mild anxiety for pregnant women in this study. The massage program also provided useful skills for participants to apply in their lives after the birth of their child, which has the potential to continue to support maternal mental health as well as partner connection.
    Conclusion: Partner delivered massage offers low-cost, accessible option for pregnant women to manage their mild anxiety. These findings have particular relevance in the context of the COVID-19 pandemic, where anecdotal reports indicate that antenatal stress is increasing and women may have limited access to healthcare services.
    MeSH term(s) Anxiety/prevention & control ; COVID-19 ; Depression ; Female ; Humans ; Male ; Massage ; Pandemics ; Parturition ; Pregnancy ; SARS-CoV-2
    Language English
    Publishing date 2021-12-20
    Publishing country Scotland
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 1036567-9
    ISSN 1532-3099 ; 0266-6138
    ISSN (online) 1532-3099
    ISSN 0266-6138
    DOI 10.1016/j.midw.2021.103229
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2662: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Motivators and barriers to blood donation among potential donors of African and Caucasian ethnicity.

    Fogarty, Helen / Sardana, Muskan / Sheridan, Luke / Chieng, Phoebe / Kelly, Sarah / Ngwenya, Noel / Sheehan, Ciara / Morris, Kieran / Tuohy, Emma

    Blood transfusion = Trasfusione del sangue

    2022  Volume 21, Issue 1, Page(s) 13–23

    Abstract: Background: Minority blood donation, especially from individuals of African ethnicity, is a focus for many countries with diverse populations. As the need for antigen-negative RBC transfusions for patients with Sickle Cell Disease (SCD) continues to ... ...

    Abstract Background: Minority blood donation, especially from individuals of African ethnicity, is a focus for many countries with diverse populations. As the need for antigen-negative RBC transfusions for patients with Sickle Cell Disease (SCD) continues to grow, inclusion of more African blood donors is essential to ensure this demand is met.
    Materials and methods: This study aims to explore barriers and motivators to blood donation and awareness of SCD among potential donors of diverse ethnic backgrounds in Ireland. Following ethical approval, patients attending the National Sickle Cell Disease and Thalassemia service at St James's Hospital were invited to share an online anonymous survey within their local communities to achieve snowball-sampling.
    Results: 387 respondents completed the survey, including 311 non-donors (median age 25 years, 67% female). Ethnic backgrounds included: African or African-Irish (59%), White or Caucasian (25%), Asian (8%), Hispanic or Latino (3%), Middle Eastern (3%), Multiracial or Biracial (2%). The most commonly identified barrier overall was lack of information on blood donation. African respondents were significantly more likely to report lack of information and malaria-related barriers than Caucasians. Motivators also varied across ethnic groups, with African respondents more likely to donate to help someone within their own community or for religious motivators. Awareness of SCD was higher among African respondents.
    Discussion: While some barriers to blood donation are shared across all ethnic groups including lack of information, notable differences exist between Caucasian and African respondents. Specific actions to recruit and retain African blood donors should focus on these key areas.
    MeSH term(s) Adult ; Female ; Humans ; Male ; Anemia, Sickle Cell ; Blood Donation ; Blood Donors ; Ethnicity ; Tissue Donors ; Black People ; White People ; Motivation
    Language English
    Publishing date 2022-06-12
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2135732-8
    ISSN 2385-2070 ; 0041-1787 ; 1723-2007
    ISSN (online) 2385-2070
    ISSN 0041-1787 ; 1723-2007
    DOI 10.2450/2022.0014-22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 798: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  8. Article ; Online: Proposing a health promotion framework to address gambling problems in Australian Indigenous communities.

    Fogarty, Marisa / Coalter, Nicola / Gordon, Ashley / Breen, Helen

    Health promotion international

    2017  Volume 33, Issue 2, Page(s) 367

    Language English
    Publishing date 2017-05-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 1027448-0
    ISSN 1460-2245 ; 0957-4824
    ISSN (online) 1460-2245
    ISSN 0957-4824
    DOI 10.1093/heapro/dax018
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    Zs.A 2178: Show issues Location:
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  9. Article ; Online: More on 'Association between ABO blood groups and risk of SARS-CoV-2 pneumonia'.

    O'Sullivan, Jamie M / Ward, Soracha / Fogarty, Helen / O'Donnell, James S

    British journal of haematology

    2020  Volume 190, Issue 1, Page(s) 27–28

    MeSH term(s) Betacoronavirus ; Blood Group Antigens ; COVID-19 ; Coronavirus Infections ; Humans ; Pandemics ; Pneumonia, Viral ; SARS Virus ; SARS-CoV-2
    Chemical Substances Blood Group Antigens
    Keywords covid19
    Language English
    Publishing date 2020-06-01
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.16845
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  10. Article: Immunogenicity and Efficacy of TNX-1800, A Live Virus Recombinant Poxvirus Vaccine Candidate, against SARS-CoV-2 Challenge in Nonhuman Primates.

    Awasthi, Mayanka / Macaluso, Anthony / Myscofski, Dawn / Prigge, Jon / Koide, Fusataka / Noyce, Ryan S / Fogarty, Siobhan / Stillwell, Helen / Goebel, Scott J / Daugherty, Bruce / Nasar, Farooq / Bavari, Sina / Lederman, Seth

    Vaccines

    2023  Volume 11, Issue 11

    Abstract: TNX-1800 is a synthetically derived live recombinant chimeric horsepox virus (rcHPXV) vaccine candidate expressing Wuhan SARS-CoV-2 spike (S) protein. The primary objective of this study was to evaluate the immunogenicity and efficacy of TNX-1800 in two ... ...

    Abstract TNX-1800 is a synthetically derived live recombinant chimeric horsepox virus (rcHPXV) vaccine candidate expressing Wuhan SARS-CoV-2 spike (S) protein. The primary objective of this study was to evaluate the immunogenicity and efficacy of TNX-1800 in two nonhuman primate species challenged with USA-WA1/2020 SARS-CoV-2. TNX-1800 vaccination was well tolerated with no serious adverse events or significant changes in clinical parameters. A single dose of TNX-1800 generated humoral responses in African Green Monkeys and Cynomolgus Macaques, as measured by the total binding of anti-SARS-CoV-2 S IgG and neutralizing antibody titers against the USA-WA1/2020 strain. In addition, a single dose of TNX-1800 induced an interferon-gamma (IFN-γ)-mediated T-cell response in Cynomolgus Macaques. Following challenge with SARS-CoV-2, African Green and Cynomolgus Macaques exhibited rapid clearance of virus in the upper and lower respiratory tract. Future studies will assess the efficacy of TNX-1800 against newly emerging variants and demonstrate its safety in humans.
    Language English
    Publishing date 2023-11-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines11111682
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