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Article ; Online: Association of the rs1126616 and rs9138 Variants in the

Rivera-Cameras, Alicia / Gallegos-Arreola, Martha Patricia / Morán-Moguel, María Cristina / Salazar-Páramo, Mario / Alcaraz-López, Miriam Fabiola / Echeverría-González, Gustavo / Topete-Reyes, Jorge Fernando / Franco-Chávez, Sergio Adalberto / Dávalos-Rodríguez, Ingrid Patricia

International journal of molecular sciences

2024 Volume 25, Issue 2

Abstract: Systemic lupus erythematosus (SLE) is a multisystem disease considered a prototype of the main autoimmune disease and presents serious complications, such as lupus nephritis (LN), which generates a significant impact on morbidity and mortality. ... ...

Abstract	Systemic lupus erythematosus (SLE) is a multisystem disease considered a prototype of the main autoimmune disease and presents serious complications, such as lupus nephritis (LN), which generates a significant impact on morbidity and mortality. The
MeSH term(s)	Humans ; Lupus Nephritis/genetics ; Cross-Sectional Studies ; Lupus Erythematosus, Systemic/genetics ; Alleles ; Genotype ; Osteopontin
Chemical Substances	SPP1 protein, human ; Osteopontin (106441-73-0)
Language	English
Publishing date	2024-01-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25021000
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Article ; Online: Neutralizing antibodies from naturally infected individuals against SARS-CoV-2 Gamma and Delta variants in the Paraguayan population.

Samudio, Angélica / Sotelo, Pablo H / González-Maldonado, Pamela / Alfonso, Laura / Valiente-Echeverría, Fernando / Soto-Rifo, Ricardo / Langjahr, Patricia

Journal of infection in developing countries

2023 Volume 17, Issue 10, Page(s) 1407–1412

Abstract: Introduction: Severe Acute Respiratory Syndrome-Coronavirus-2 Virus (SARS-CoV-2) is responsible for Coronavirus Disease 2019 (COVID-19). A substantial number of SARS-CoV-2 infection cases have been reported during the pandemic, and vaccination coverage ... ...

Abstract	Introduction: Severe Acute Respiratory Syndrome-Coronavirus-2 Virus (SARS-CoV-2) is responsible for Coronavirus Disease 2019 (COVID-19). A substantial number of SARS-CoV-2 infection cases have been reported during the pandemic, and vaccination coverage in some regions, particularly in developing countries, remains very low. SARS-CoV-2 variants of concern (VOCs) have also emerged as some of the most pressing public health issues. In this scenario, it is crucial to know whether COVID-19 convalescent antibodies have cross-neutralizing action against VOCs to contribute to the analysis of the future progress of the pandemic. Methodology: The plasma of individuals infected with SARS-CoV-2 from June to November 2020 in Paraguay (before the first recorded infections associated with VOCs in the country) was selected. Anti-spike antibodies were determined in plasma samples (n = 626) obtained from this convalescent and unvaccinated group. Using a pseudotyped virus neutralization assay, we then investigated the neutralizing response against D614G variant and Gamma, and Delta VOCs. Results: IgG antibodies against spike were detected in 85.6% of convalescent individuals. Samples from individuals previously infected by a non-VOC showed a 6.6- and 8.1-fold reduction in neutralizing capacity to the Gamma and Delta variants, respectively, when compared to the D614G variant. Conclusions: Our findings show that antibodies generated by non-VOC infection have reduced neutralizing capabilities against Gamma and Delta variants that appeared subsequently and might have implications for immunity strategies.
MeSH term(s)	Humans ; Antibodies, Neutralizing ; SARS-CoV-2 ; COVID-19 ; Paraguay/epidemiology ; Antibodies, Viral
Chemical Substances	Antibodies, Neutralizing ; Antibodies, Viral
Language	English
Publishing date	2023-10-31
Publishing country	Italy
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2394024-4
ISSN	1972-2680 ; 2036-6590
ISSN (online)	1972-2680
ISSN	2036-6590
DOI	10.3855/jidc.16955
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Article: Impact of COVID-19 Pandemic in Antibiotic Consumption in Navarre (Spain): An Interrupted Time Series Analysis.

Alzueta, Natalia / Echeverría, Amaya / García, Patricia / Sanz, Lorea / Gil-Setas, Alberto / Beristain, Xabier / Aldaz, Pablo / Garjón, Javier

Antibiotics (Basel, Switzerland)

2023 Volume 12, Issue 2

Abstract: On 11 March 2020, the World Health Organization declared coronavirus disease 19 (COVID-19) a global pandemic. This exceptional situation changed the world not only in terms of mortality and morbidity, but also in terms of epidemiology and health system ... ...

Abstract	On 11 March 2020, the World Health Organization declared coronavirus disease 19 (COVID-19) a global pandemic. This exceptional situation changed the world not only in terms of mortality and morbidity, but also in terms of epidemiology and health system resources consumption. The objective of this work was to analyze the consumption of antibiotics during the period around the pandemic in our region. A drug utilization study was performed comparing the antibiotic consumption in the community during the years 2018, 2019, 2020, and 2021. Quarterly antibiotic use (defined daily doses (DDD) per 1000 inhabitants per day (DID)) and number of patients treated were the outcomes. Interrupted time series regression analysis was performed to estimate the statistical significance of the change in level of consumption before and after the COVID-19 pandemic. The drop of global antibiotic consumption was statistically significant, both in number of patients and in DID when analyzing pre-pandemic period versus pandemic period. The use of strategic antibiotics for respiratory infections such as amoxicillin, amoxicillin-clavulanic acid, and levofloxacin also decreased significantly. Seasonal pattern of use of antibiotics disappeared due to the global measures imposed over the world to work against COVID-19.
Language	English
Publishing date	2023-02-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2681345-2
ISSN	2079-6382
ISSN	2079-6382
DOI	10.3390/antibiotics12020318
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Article ; Online: La internacionalización de la investigación en países emergentes

Tania Isabel Lafont Castillo / Luisa Echeverría King / Olisney De Luque Montaño / Liliana Patricia Álvarez Ruíz / Andrea Lozada Cantillo

Revista Colombiana de Ciencias Sociales, Vol 14, Iss

perspectivas de gestores de internacionalización en Colombia

2023 Volume 1

Abstract: La internacionalización de la investigación se ha convertido para los países emergentes en una herramienta de cara al desarrollo de sus capacidades en ciencia, tecnología e innovación. Esta investigación buscó comprender cómo se gestionan los procesos de ...

Abstract	La internacionalización de la investigación se ha convertido para los países emergentes en una herramienta de cara al desarrollo de sus capacidades en ciencia, tecnología e innovación. Esta investigación buscó comprender cómo se gestionan los procesos de internacionalización de la investigación desde una perspectiva de gestores de la internacionalización de universidades colombianas, con el fin de exponer implicaciones para el desarrollo de este tema en países emergentes. Para esto, se realizó un grupo focal cuyos datos fueron analizados con el análisis cualitativo de contenido. Se debe trabajar en la construcción de capacidades para poder gestionar proyectos transnacionales. En Latinoamérica el bilingüismo es un reto, también la falta de competencias para publicar en revistas de impacto y la administración de recursos de la cooperación internacional. Para avanzar, las instituciones deben alinear los intereses de investigación con problemas trasnacionales, crear equipos internos de trabajo y realizar seguimientos y mediciones de impacto.
Keywords	Internacionalización de la educación superior ; Cooperación internacional ; Investigación y desarrollo ; Política de ciencia ; Visibilidad internacional ; Economías emergentes ; Social Sciences ; H ; Social sciences (General) ; H1-99
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	Universidad Católica Luis Amigó
Document type	Article ; Online
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Article ; Online: Gabapentinoides en indicaciones no autorizadas en la ficha técnica

Amaya Echeverría Gorriti / Natalia Alzueta Istúriz / Patricia García González / Julen Fernández González / Lorea Sanz Álvarez / Javier Garjón Parra

Gaceta Sanitaria, Vol 37, Iss , Pp 102283- (2023)

¿es necesaria una estrategia de desprescripción?

2023

Abstract: Resumen: Objetivo: Evaluar la adecuación de los tratamientos con gabapentina y pregabalina a las indicaciones autorizadas, analizar su uso en las no autorizadas e identificar los pacientes con más riesgo de sufrir depresión respiratoria. Método: Estudio ... ...

Abstract	Resumen: Objetivo: Evaluar la adecuación de los tratamientos con gabapentina y pregabalina a las indicaciones autorizadas, analizar su uso en las no autorizadas e identificar los pacientes con más riesgo de sufrir depresión respiratoria. Método: Estudio observacional retrospectivo que incluyó a los pacientes en tratamiento con gabapentina o pregabalina en 2020 en Navarra. Resultados: Se incluyeron 9778 pacientes en tratamiento con gabapentina o pregabalina durante el primer bimestre de 2020. En el 56% de los casos se prescribieron para indicaciones no autorizadas. El 60% tomaba concomitantemente al menos un depresor del sistema nervioso central (SNC), el 33% algún opiáceo, el 20% opiáceos combinados con depresores del SNC y el 4% algún antihistamínico. El 11% tenía diagnóstico de asma o enfermedad pulmonar obstructiva crónica. Estas prevalencias se mantuvieron constantes durante el resto del año. Conclusiones: Es necesario implementar una estrategia de desprescripción de gabapentinoides para adecuar su uso y disminuir los problemas de seguridad. Abstract: Objective: To evaluate gabapentin and pregabalin treatment adequacy to label indications, to analyze off-label use and to identify patients at high risk of respiratory depression. Method: An observational, retrospective study was performed. It included patients treated with pregabalin and gabapentin during 2020 in Navarre. Results: A total of 9778 patients were treated with gabapentin or pregabalin during the first two months of 2020. In 56% of the cases, gabapentinoids were prescribed for off-label uses. Sixty percent of patients were taking at least one central nervous system (CNS) depressant drug concomitantly, 33% of them opioids, 20% of them combined opioids with CNS depressants and 4% of them at least one systemic antihistamine. In addition, 11% of the patients had a diagnosis of asthma or COPD. Prevalences remained constant along the year. Conclusions: It is necessary to implement a gabapentinoid deprescription strategy to improve its use and reduce ...
Keywords	Gabapentin ; Pregabalin ; Off-label use ; Inappropriate prescribing ; Safety ; Respiratory depression ; Public aspects of medicine ; RA1-1270
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
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Article ; Online: Gabapentinoides en indicaciones no autorizadas en la ficha técnica: ¿es necesaria una estrategia de desprescripción?

Echeverría Gorriti, Amaya / Alzueta Istúriz, Natalia / García González, Patricia / Fernández González, Julen / Sanz Álvarez, Lorea / Garjón Parra, Javier

Gaceta sanitaria

2022 Volume 37, Page(s) 102283

Abstract: Objective: To evaluate gabapentin and pregabalin treatment adequacy to label indications, to analyze off-label use and to identify patients at high risk of respiratory depression.: Method: An observational, retrospective study was performed. It ... ...

Title translation	Off-label use of gabapentinoid drugs: is it necessary a deprescription strategy?
Abstract	Objective: To evaluate gabapentin and pregabalin treatment adequacy to label indications, to analyze off-label use and to identify patients at high risk of respiratory depression. Method: An observational, retrospective study was performed. It included patients treated with pregabalin and gabapentin during 2020 in Navarre. Results: A total of 9778 patients were treated with gabapentin or pregabalin during the first two months of 2020. In 56% of the cases, gabapentinoids were prescribed for off-label uses. Sixty percent of patients were taking at least one central nervous system (CNS) depressant drug concomitantly, 33% of them opioids, 20% of them combined opioids with CNS depressants and 4% of them at least one systemic antihistamine. In addition, 11% of the patients had a diagnosis of asthma or COPD. Prevalences remained constant along the year. Conclusions: It is necessary to implement a gabapentinoid deprescription strategy to improve its use and reduce safety problems.
MeSH term(s)	Humans ; Gabapentin/therapeutic use ; Pregabalin/therapeutic use ; Off-Label Use ; Analgesics, Opioid/therapeutic use ; Retrospective Studies ; Deprescriptions
Chemical Substances	Gabapentin (6CW7F3G59X) ; Pregabalin (55JG375S6M) ; Analgesics, Opioid
Language	Spanish
Publishing date	2022-12-22
Publishing country	Spain
Document type	Observational Study ; English Abstract ; Journal Article
ZDB-ID	1038713-4
ISSN	1578-1283 ; 0213-9111
ISSN (online)	1578-1283
ISSN	0213-9111
DOI	10.1016/j.gaceta.2022.102283
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Article ; Online: Prevalence, progression, and management of advanced chronic kidney disease in a cohort of people living with HIV.

Bonjoch, Anna / Juega, Javier / Echeverría, Patricia / Puig, Jordi / Perez-Alvarez, Nuria / Bonal, Jordi / Loste, Cora / Clotet, Bonaventura / Negredo, Eugènia

HIV medicine

2022 Volume 23, Issue 10, Page(s) 1078–1084

Abstract: Background: Advanced kidney disease is an emerging problem in people living with HIV despite sustained viral suppression.: Methods: We performed a prospective cohort study to identify people living with HIV with advanced kidney disease according to ... ...

Abstract	Background: Advanced kidney disease is an emerging problem in people living with HIV despite sustained viral suppression. Methods: We performed a prospective cohort study to identify people living with HIV with advanced kidney disease according to the Kidney Disease Improving Global Outcomes criteria and to assess disease progression over a 48-week period following the offer of targeted multidisciplinary management. Results: From our cohort of 3090 individuals, 55 (1.8%, 95% confidence interval [CI] 1.31-2.25) fulfilled the inclusion criteria. Most were male (83.6%), and the median (interquartile range [IQR]) age was 58 (53.25-66.75) years. Nadir CD4 T-cell count was 135.5 (IQR 43.5-262.75) cells/μl, current CD4 T-cell count was 574 (IQR 438.5-816) cells/μl, and 96% had maintained HIV viral suppression. The most frequent comorbidity was arterial hypertension (85.5%). Inadequate antiretroviral dose was detected in three individuals (5.5%), and drug-drug interactions were recorded in eight (14.5%), mainly involving the use of cobicistat (n = 5 [9%]). Four individuals (7%) required modification of their concomitant treatment. Seven (13%) had to start or resume follow-up with a nephrologist. Nine participants (16.4%) experienced an improvement in kidney disease stage, three individuals (5.5%) underwent renal transplantation, and one (2%) started haemodialysis. Conclusions: Our results show that a multidisciplinary approach, including a critical review of treatment and evaluation of specific requirements, could be useful for anticipating drug-drug interactions and toxicities and for reducing death and hospitalization in people living with HIV with advanced kidney disease.
MeSH term(s)	Aged ; CD4 Lymphocyte Count ; Cobicistat/therapeutic use ; Cohort Studies ; Female ; HIV Infections/complications ; HIV Infections/drug therapy ; HIV Infections/epidemiology ; Humans ; Male ; Middle Aged ; Prevalence ; Prospective Studies ; Renal Insufficiency, Chronic/epidemiology ; Renal Insufficiency, Chronic/therapy ; Viral Load
Chemical Substances	Cobicistat (LW2E03M5PG)
Language	English
Publishing date	2022-04-26
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2001932-4
ISSN	1468-1293 ; 1464-2662
ISSN (online)	1468-1293
ISSN	1464-2662
DOI	10.1111/hiv.13317
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Article ; Online: Remote Health Monitoring in the Workplace for Early Detection of COVID-19 Cases during the COVID-19 Pandemic Using a Mobile Health Application:

Echeverría, Patricia / Puig, Jordi / Ruiz, José María / Herms, Jordi / Sarquella, Maria / Clotet, Bonaventura / Negredo, Eugenia

International journal of environmental research and public health

2021 Volume 19, Issue 1

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	COVID-19 ; Humans ; Pandemics ; RNA, Viral ; SARS-CoV-2 ; Telemedicine ; Workplace
Chemical Substances	RNA, Viral
Language	English
Publishing date	2021-12-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph19010167
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Article: Down Syndrome-Basque Alzheimer Initiative (DS-BAI): Clinic-Biological Cohort.

Altuna, Miren / Estanga, Ainara / Garrido, Adolfo / Saldias, Jon / Cañada, Marta / Echeverria, Maitane / Larrea, José Ángel / Ayo, Patricia / Fiz, Ainhoa / Muñoz, María / Santa-Inés, José / García-Landarte, Valeria / García-Sebastián, Maite

Journal of clinical medicine

2024 Volume 13, Issue 4

Abstract: Background: Down syndrome (DS) is the most common genetically determined intellectual disability. In recent decades, it has experienced an exponential increase in life expectancy, leading to a rise in age-related diseases, including Alzheimer's disease ( ...

Abstract	Background: Down syndrome (DS) is the most common genetically determined intellectual disability. In recent decades, it has experienced an exponential increase in life expectancy, leading to a rise in age-related diseases, including Alzheimer's disease (AD). Specific health plans for the comprehensive care of the DS community are an unmet need, which is crucial for the early and accurate diagnosis of main medical comorbidities. We present the protocol of a newly created clinical and research cohort and its feasibility in real life. Methods: The Down Syndrome-Basque Alzheimer Initiative (DS-BAI) is a population-based, inclusive, multidisciplinary initiative for the clinical-assistance and clinical-biological research approach to aging in DS led by the CITA-Alzheimer Foundation (Donostia, Basque Country). It aims to achieve the following: (1) provide comprehensive care for adults with DS, (2) optimize access to rigorous and quality training for socio-family and healthcare references, and (3) create a valuable multimodal clinical-biological research platform. Results: During the first year, 114 adults with DS joined the initiative, with 36% of them showing symptoms indicative of AD. Furthermore, adherence to training programs for healthcare professionals and families has been high, and the willingness to collaborate in basic and translational research has been encouraging. Conclusion: Specific health plans for DS and conducting clinical and translational research on the challenges of aging, including AD, are necessary and feasible.
Language	English
Publishing date	2024-02-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm13041139
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Article ; Online: Remote Health Monitoring in the Workplace for Early Detection of COVID-19 Cases during the COVID-19 Pandemic Using a Mobile Health Application

Patricia Echeverría / Jordi Puig / José María Ruiz / Jordi Herms / Maria Sarquella / Bonaventura Clotet / Eugenia Negredo

International Journal of Environmental Research and Public Health, Vol 19, Iss 167, p

COVIDApp .

2022 Volume 167

Abstract: Background: COVIDApp is a platform created for management of COVID-19 in the workplace. Methods: COVIDApp was designed and implemented for the follow-up of 253 workers from seven companies in Catalonia. The assessment was based on two actions: first, the ...

Abstract	Background: COVIDApp is a platform created for management of COVID-19 in the workplace. Methods: COVIDApp was designed and implemented for the follow-up of 253 workers from seven companies in Catalonia. The assessment was based on two actions: first, the early detection and management of close contacts and potential cases of COVID-19, and second, the rapid remote activation of protocols. The main objectives of this strategy were to minimize the risk of transmission of COVID-19 infection in the work area through a new real-time communication channel and to avoid unnecessary sick leave. The parameters reported daily by workers were close contact with COVID cases and signs and/or symptoms of COVID-19. Results: Data were recorded between 1 May and 30 November 2020. A total of 765 alerts were activated by 76 workers: 127 green alarms (16.6%), 301 orange alarms (39.3%), and 337 red alarms (44.1%). Of all the red alarms activated, 274 (81.3%) were activated for symptoms potentially associated with COVID-19, and 63 (18.7%) for reporting close contact with COVID-19 cases. Only eight workers (3.1%) presented symptoms associated with COVID-19 infection. All of these workers underwent RT-PCR tests, which yielded negative results for SARS-CoV2. Three workers were considered to have had a risk contact with COVID-19 cases; only 1 (0.4%) asymptomatic worker had a positive RT-PCR test result, requiring the activation of protocols, isolation, and contact tracing. Conclusions: COVIDApp contributes to the early detection and rapid activation of protocols in the workplace, thus limiting the risk of spreading the virus and reducing the economic impact caused by COVID-19 in the productive sector. The platform shows the progression of infection in real time and can help design new strategies.
Keywords	COVID-19 ; health application ; workplace ; early detection ; remote health monitoring ; Medicine ; R
Subject code	600
Language	English
Publishing date	2022-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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